Research graph
References from Unlocking Iridium Chemical Space for Antibiotic Discovery through One-Pot Combinatorial Synthesis in a Direct-to-Biology Approach. Local targets link to admitted publications; unresolved targets remain external evidence.
Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050
10.1016/s0140-6736(24)01867-1 · 2024 · External reference
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
10.1016/s0140-6736(21)02724-0 · 2022 · External reference
Unresolved reference
External reference
The WHO Bacterial Priority Pathogens List 2024: a prioritisation study to guide research, development, and public health strategies against antimicrobial resistance
10.1016/s1473-3099(25)00118-5 · 2025 · External reference
Evaluation of Antibiotic Resistance Mechanisms in Gram-Positive Bacteria
10.3390/antibiotics13121197 · 2024 · External reference
Unresolved reference
External reference
A community-based approach to new antibiotic discovery
10.1038/nrd4706 · 2015 · External reference
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
10.1016/s0169-409x(96)00423-1 · 1997 · External reference
Metal complexes as a promising source for new antibiotics
10.1039/c9sc06460e · 2020 · External reference
Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
10.1021/jm901241e · 2009 · External reference
The potential of organometallic complexes in medicinal chemistry
10.1016/j.cbpa.2012.01.013 · 2012 · External reference
Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery
10.1039/c9sc05586j · 2020 · External reference
Metals to combat antimicrobial resistance
10.1038/s41570-023-00463-4 · 2023 · External reference
Recent advances in the development of metal complexes as antibacterial agents with metal-specific modes of action
10.1016/j.mib.2023.102347 · 2023 · External reference
Metal Complexes as Antifungals? From a Crowd-Sourced Compound Library to the First In Vivo Experiments
10.1021/jacsau.2c00308 · 2022 · External reference
Synthesis, Cellular Uptake and Biological Activity Against Pathogenic Microorganisms and Cancer Cells of Rhodium and Iridium N-Heterocyclic Carbene Complexes Bearing Charged Substituents
10.1002/ejic.201300820 · 2013 · External reference
The Discovery of an Iridium(III) Dimer Complex as a Potent Antibacterial Agent against Non-Replicating Mycobacterium smegmatis
10.3390/polym10030297 · 2018 · External reference
Simultaneous Ultrasensitive Detection and Elimination of Drug-Resistant Bacteria by Cyclometalated Iridium(III) Complexes
10.1021/acsami.0c11161 · 2020 · External reference
Dipyrrinato-Iridium(III) Complexes for Application in Photodynamic Therapy and Antimicrobial Photodynamic Inactivation
10.1002/chem.202004776 · 2021 · External reference
Application of Mono and Trinuclear Cyclometalated Iridium (III) Complexes in Differential Bacterial Imaging and Antimicrobial Photodynamic Therapy
10.1002/chem.202400646 · 2024 · External reference
Antibacterial activity of Au(I), Pt(II), and Ir(III) biotin conjugates prepared by the iClick reaction: influence of the metal coordination sphere on the biological activity
10.1007/s00775-024-02073-x · 2024 · External reference
808 nm Light-Triggered Cyanine-Decorated Iridium(III) Complexes for Antibacterial Photodynamic Therapy in Deep-Tissue
10.1021/acs.inorgchem.5c00232 · 2025 · External reference
Eradication of Antibiotic-Resistant Gram-Positive Bacteria and Biofilms by Rationally Designed AIE-Active Iridium(III) Complexes Derived from Cyclometalating 2-Phenylquinoline and Ancillary Bipyridyl Ligands
10.1021/acs.inorgchem.4c05064 · 2025 · External reference
Tetrazolium iridium complexes as potential antibacterial agents
10.1039/d4ra08525f · 2025 · External reference
D-Alanine functionalized Iridium(III) complexes as two-photon photo-antibiotics for bacteria-specific ablation in infected macrophages
10.1016/j.ejmech.2025.117758 · 2025 · External reference
A cyclometalated iridium(III) complex with 2-acetylpyridine-N(4)-ortho-chlorophenyl thiosemicarbazone: Potent antiproliferative and antibacterial activities
10.1016/j.jinorgbio.2025.113179 · 2026 · External reference
Cyclometalated Iridium(III) Complexes with eDNA-Degrading Activity for Combating Gram-Positive Bacterial Biofilms
10.1021/acsinfecdis.5c01131 · 2026 · External reference
Pyridine-containing iridium complexes as gram-negative bacteria specific therapeutic agents with low resistance development
10.1016/j.jinorgbio.2026.113274 · 2026 · External reference
Synthesis, Characterization, and Antimicrobial Activity of RhIII and IrIII N-Heterocyclic Carbene Piano-Stool Complexes
10.1021/acs.organomet.1c00166 · 2021 · External reference
Transition Metal−α-Amino Acid Complexes with Antibiotic Activity against Mycobacterium spp
10.1128/aac.00452-13 · 2013 · External reference
Transition metal diamine complexes with antimicrobial activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA)
10.1039/c5md00228a · 2015 · External reference
Design of Multifunctional IridiumIII Compounds as a Potential Therapeutic Agents from Basic Molecular Scaffolds
10.1002/slct.201600882 · 2016 · External reference
Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance
10.1002/chem.201801090 · 2018 · External reference
Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity
10.1021/acs.jmedchem.8b00906 · 2018 · External reference
Synthesis, Characterization, and Antimicrobial Activity of RhIII and IrIII β-Diketonato Piano-Stool Compounds
10.1021/acs.organomet.7b00742 · 2018 · External reference
Iridium piano stool complexes with activity against S. aureus and MRSA: it is past time to truly think outside of the box
10.1039/c9md00140a · 2019 · External reference
Antimicrobial evaluation of neutral and cationic iridium(III) and rhodium(III) aminoquinoline-benzimidazole hybrid complexes
10.1016/j.ejmech.2020.112694 · 2020 · External reference
Antimicrobial properties of half-sandwich Ir(III) cyclopentadienyl complexes with pyridylbenzimidazole ligands
10.1039/d0dt00451k · 2020 · External reference
Preparation and Bioactivity of Iridium(III) Phenanthroline Complexes with Halide Ions and Pyridine Leaving Groups
10.1002/cbic.202000511 · 2021 · External reference
Targeting Multiresistant Gram-Positive Bacteria by Ruthenium, Osmium, Iridium and Rhodium Half-Sandwich Type Complexes With Bidentate Monosaccharide Ligands
10.3389/fchem.2022.868234 · 2022 · External reference
Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria
10.1039/d3dt01678a · 2023 · External reference
Antimicrobial study of ruthenium and iridium half-sandwich complexes containing fluorenyl hydrazonothiazole derivative ligands
10.1080/00958972.2023.2264461 · 2023 · External reference
Discovery of antibacterial manganese(I) tricarbonyl complexes through combinatorial chemistry
10.1039/d3sc05326a · 2024 · External reference
Combinatorial chemistry in drug discovery
10.1016/j.cbpa.2017.03.017 · 2017 · External reference
Accelerated Luminophore Discovery through Combinatorial Synthesis
10.1021/ja047156+ · 2004 · External reference
High-throughput Synthesis and Screening of Iridium(III) Photocatalysts for the Fast and Chemoselective Dehalogenation of Aryl Bromides
10.1021/acscatal.0c02247 · 2020 · External reference
A Semi-Automated, High-Throughput Approach for the Synthesis and Identification of Highly Photo-Cytotoxic Iridium Complexes
10.1002/anie.202401808 · 2024 · External reference
Discovery of Phototoxic Metal Complexes with Antibacterial Properties via a Combinatorial Approach
10.1021/acs.inorgchem.4c05414 · 2025 · External reference
High-throughput triazole-based combinatorial click chemistry for the synthesis and identification of functional metal complexes
10.1038/s41467-025-67341-z · 2025 · External reference
Discovery and Investigation of Anticancer Ruthenium–Arene Schiff-Base Complexes via Water-Promoted Combinatorial Three-Component Assembly
10.1021/jm500455p · 2014 · External reference
Apoptosis-independent organoruthenium anticancer complexes that overcome multidrug resistance: self-assembly and phenotypic screening strategies
10.1039/c7sc00497d · 2017 · External reference
Harnessing Endogenous Formate for Antibacterial Prodrug Activation by in cellulo Ruthenium-Mediated Transfer Hydrogenation Reaction
10.1002/anie.202000173 · 2020 · External reference
Targeting Pathogenic Formate-Dependent Bacteria with a Bioinspired Metallo–Nitroreductase Complex
10.1021/jacs.3c00237 · 2023 · External reference
Targeted Antibacterial Strategy Based on Reactive Oxygen Species Generated from Dioxygen Reduction Using an Organoruthenium Complex
10.1021/jacsau.1c00262 · 2021 · External reference
Combinatorial Synthesis to Identify a Potent, Necrosis-Inducing Rhenium Anticancer Agent
10.1021/acs.inorgchem.8b03552 · 2019 · External reference
Systematically altering the lipophilicity of rhenium(I) tricarbonyl anticancer agents to tune the rate at which they induce cell death
10.1039/d0dt01097a · 2020 · External reference
Integrated Direct-to-Biology Platform for the Nanoscale Synthesis and Biological Evaluation of PROTACs
10.1021/acs.jmedchem.3c01604 · 2023 · External reference
Expedited SARS-CoV-2 Main Protease Inhibitor Discovery through Modular ‘Direct-to-Biology’ Screening
10.1002/anie.202418314 · 2025 · External reference
A direct-to-biology high-throughput chemistry approach to reactive fragment screening
10.1039/d1sc03551g · 2021 · External reference
Discovery of Biologically Optimized Polymyxin Derivatives Facilitated by Peptide Scanning and In Situ Screening Chemistry
10.1021/jacs.2c12971 · 2023 · External reference
High-Throughput Combinatorial Metal Complex Synthesis
10.1002/anie.202420204 · 2025 · External reference
Improved Synthesis of Dinuclear [M(μ-X)(η5-Cp*)X]2 Precursors for Half-Sandwich Complexes (M=Rh or Ir; X=Br or I)
10.1002/open.202500026 · 2025 · External reference
Organometallic Half-Sandwich Iridium Anticancer Complexes
10.1021/jm2000932 · 2011 · External reference
Predictive compound accumulation rules yield a broad-spectrum antibiotic
10.1038/nature22308 · 2017 · External reference
Introducing the Perfluorinated Cp* Ligand into Coordination Chemistry
10.1002/anie.202211147 · 2022 · External reference
Cyclopentadienyl Ligand Effects on Enthalpies of Protonation of the Ru–Ru Bond in Cp‘2Ru2(CO)4 Complexes
10.1021/ic970181e · 1997 · External reference
Torsional Barriers and Equilibrium Angle of Biphenyl: Reconciling Theory with Experiment
10.1021/ct800182e · 2008 · External reference
The Gram-negative permeability barrier: tipping the balance of the in and the out
10.1128/mbio.01205-23 · 2023 · External reference
Hydrophobicity: The door to drug delivery
10.1002/psc.3558 · 2024 · External reference
Main-chain flexibility and hydrophobicity of ionenes strongly impact their antimicrobial activity: an extended study on drug resistance strains and Mycobacterium
10.1039/d2ra04121a · 2022 · External reference
Kidney-based in vitro models for drug-induced toxicity testing
10.1007/s00204-019-02598-0 · 2019 · External reference
Agents that increase the permeability of the outer membrane
10.1128/mr.56.3.395-411.1992 · 1992 · External reference
Polymyxin B nonapeptide potentiates the eradication of Gram-negative bacterial persisters
10.1128/spectrum.03687-23 · 2024 · External reference
Principles of bacteriostatic and bactericidal antibiotics at subinhibitory concentrations
10.1128/mbio.02066-25 · 2025 · External reference
Organometallic Iridium(III) Cyclopentadienyl Anticancer Complexes Containing C,N-Chelating Ligands
10.1021/om2005468 · 2011 · External reference
Dissecting antibiotic effects on the cell envelope using bacterial cytological profiling: a phenotypic analysis starter kit
10.1128/spectrum.03275-23 · 2024 · External reference
Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules
10.1073/pnas.1311066110 · 2013 · External reference
A platinum butterfly effect: small changes turn an anticancer drug into a non-toxic metalloantibiotic with in vivo efficacy
10.1038/s44259-026-00211-w · 2026 · External reference
Analysis of Antimicrobial-Triggered Membrane Depolarization Using Voltage Sensitive Dyes
10.3389/fcell.2016.00029 · 2016 · External reference
Membrane potential is important for bacterial cell division
10.1073/pnas.1005485107 · 2010 · External reference
Novel Molecular Mechanism for Actinomycin D Activity as an Oncogenic Promoter G-Quadruplex Binder
10.1021/bi9006836 · 2009 · External reference
A new phenanthroline–oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction
10.1039/c3cc38710k · 2013 · External reference
Expanding the DNA damaging potential of artificial metallo-nucleases with click chemistry
10.1038/s41467-026-68911-5 · 2026 · External reference
A computational knowledge-base elucidates the response of Staphylococcus aureus to different media types
10.1371/journal.pcbi.1006644 · 2019 · External reference
Using Nanoscopy To Probe the Biological Activity of Antimicrobial Leads That Display Potent Activity against Pathogenic, Multidrug Resistant, Gram-Negative Bacteria
10.1021/acsnano.8b08440 · 2019 · External reference
Hydroxyl radical is a significant player in oxidative DNA damage in vivo
10.1039/d1cs00044f · 2021 · External reference
Peroxiredoxin Depletion and Oxidative Stress by Cyclometalated Ir(III)-Isatin Complexes Renders Ferroptosis and Autophagic Cell Death in Triple-Negative Breast Cancer
10.1021/acs.jmedchem.5c01150 · 2025 · External reference
Half-Sandwich Iridium and Ruthenium Complexes: Effective Tracking in Cells and Anticancer Studies
10.1021/acs.inorgchem.8b02161 · 2018 · External reference
Iron homeostasis and management of oxidative stress response in bacteria
10.1039/c1mt00022e · 2011 · External reference
In vitro synergy of polymyxins with other antibiotics for Acinetobacter baumannii: A systematic review and meta-analysis
10.1016/j.ijantimicag.2014.10.002 · 2015 · External reference
Harnessing Endogenous Formate for Antibacterial Prodrug Activation by in cellulo Ruthenium-Mediated Transfer Hydrogenation Reaction
10.1002/anie.202000173 · ExternalCitation · doi-reference
Introducing the Perfluorinated Cp* Ligand into Coordination Chemistry
10.1002/anie.202211147 · ExternalCitation · doi-reference
A Semi-Automated, High-Throughput Approach for the Synthesis and Identification of Highly Photo-Cytotoxic Iridium Complexes
10.1002/anie.202401808 · ExternalCitation · doi-reference
Expedited SARS-CoV-2 Main Protease Inhibitor Discovery through Modular ‘Direct-to-Biology’ Screening
10.1002/anie.202418314 · ExternalCitation · doi-reference
High-Throughput Combinatorial Metal Complex Synthesis
10.1002/anie.202420204 · ExternalCitation · doi-reference
Preparation and Bioactivity of Iridium(III) Phenanthroline Complexes with Halide Ions and Pyridine Leaving Groups
10.1002/cbic.202000511 · ExternalCitation · doi-reference
Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance
10.1002/chem.201801090 · ExternalCitation · doi-reference
Dipyrrinato-Iridium(III) Complexes for Application in Photodynamic Therapy and Antimicrobial Photodynamic Inactivation
10.1002/chem.202004776 · ExternalCitation · doi-reference
Application of Mono and Trinuclear Cyclometalated Iridium (III) Complexes in Differential Bacterial Imaging and Antimicrobial Photodynamic Therapy
10.1002/chem.202400646 · ExternalCitation · doi-reference
Synthesis, Cellular Uptake and Biological Activity Against Pathogenic Microorganisms and Cancer Cells of Rhodium and Iridium N-Heterocyclic Carbene Complexes Bearing Charged Substituents
10.1002/ejic.201300820 · ExternalCitation · doi-reference
Improved Synthesis of Dinuclear [M(μ-X)(η5-Cp*)X]2 Precursors for Half-Sandwich Complexes (M=Rh or Ir; X=Br or I)
10.1002/open.202500026 · ExternalCitation · doi-reference
Hydrophobicity: The door to drug delivery
10.1002/psc.3558 · ExternalCitation · doi-reference
Design of Multifunctional IridiumIII Compounds as a Potential Therapeutic Agents from Basic Molecular Scaffolds
10.1002/slct.201600882 · ExternalCitation · doi-reference
Kidney-based in vitro models for drug-induced toxicity testing
10.1007/s00204-019-02598-0 · ExternalCitation · doi-reference
Antibacterial activity of Au(I), Pt(II), and Ir(III) biotin conjugates prepared by the iClick reaction: influence of the metal coordination sphere on the biological activity
10.1007/s00775-024-02073-x · ExternalCitation · doi-reference
The potential of organometallic complexes in medicinal chemistry
10.1016/j.cbpa.2012.01.013 · ExternalCitation · doi-reference
Combinatorial chemistry in drug discovery
10.1016/j.cbpa.2017.03.017 · ExternalCitation · doi-reference
Antimicrobial evaluation of neutral and cationic iridium(III) and rhodium(III) aminoquinoline-benzimidazole hybrid complexes
10.1016/j.ejmech.2020.112694 · ExternalCitation · doi-reference
D-Alanine functionalized Iridium(III) complexes as two-photon photo-antibiotics for bacteria-specific ablation in infected macrophages
10.1016/j.ejmech.2025.117758 · ExternalCitation · doi-reference
In vitro synergy of polymyxins with other antibiotics for Acinetobacter baumannii: A systematic review and meta-analysis
10.1016/j.ijantimicag.2014.10.002 · ExternalCitation · doi-reference
A cyclometalated iridium(III) complex with 2-acetylpyridine-N(4)-ortho-chlorophenyl thiosemicarbazone: Potent antiproliferative and antibacterial activities
10.1016/j.jinorgbio.2025.113179 · ExternalCitation · doi-reference
Pyridine-containing iridium complexes as gram-negative bacteria specific therapeutic agents with low resistance development
10.1016/j.jinorgbio.2026.113274 · ExternalCitation · doi-reference
Recent advances in the development of metal complexes as antibacterial agents with metal-specific modes of action
10.1016/j.mib.2023.102347 · ExternalCitation · doi-reference
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
10.1016/s0140-6736(21)02724-0 · ExternalCitation · doi-reference
Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050
10.1016/s0140-6736(24)01867-1 · ExternalCitation · doi-reference
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
10.1016/s0169-409x(96)00423-1 · ExternalCitation · doi-reference
The WHO Bacterial Priority Pathogens List 2024: a prioritisation study to guide research, development, and public health strategies against antimicrobial resistance
10.1016/s1473-3099(25)00118-5 · ExternalCitation · doi-reference
Eradication of Antibiotic-Resistant Gram-Positive Bacteria and Biofilms by Rationally Designed AIE-Active Iridium(III) Complexes Derived from Cyclometalating 2-Phenylquinoline and Ancillary Bipyridyl Ligands
10.1021/acs.inorgchem.4c05064 · ExternalCitation · doi-reference
Discovery of Phototoxic Metal Complexes with Antibacterial Properties via a Combinatorial Approach
10.1021/acs.inorgchem.4c05414 · ExternalCitation · doi-reference
808 nm Light-Triggered Cyanine-Decorated Iridium(III) Complexes for Antibacterial Photodynamic Therapy in Deep-Tissue
10.1021/acs.inorgchem.5c00232 · ExternalCitation · doi-reference
Half-Sandwich Iridium and Ruthenium Complexes: Effective Tracking in Cells and Anticancer Studies
10.1021/acs.inorgchem.8b02161 · ExternalCitation · doi-reference
Combinatorial Synthesis to Identify a Potent, Necrosis-Inducing Rhenium Anticancer Agent
10.1021/acs.inorgchem.8b03552 · ExternalCitation · doi-reference
Integrated Direct-to-Biology Platform for the Nanoscale Synthesis and Biological Evaluation of PROTACs
10.1021/acs.jmedchem.3c01604 · ExternalCitation · doi-reference
Peroxiredoxin Depletion and Oxidative Stress by Cyclometalated Ir(III)-Isatin Complexes Renders Ferroptosis and Autophagic Cell Death in Triple-Negative Breast Cancer
10.1021/acs.jmedchem.5c01150 · ExternalCitation · doi-reference
Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity
10.1021/acs.jmedchem.8b00906 · ExternalCitation · doi-reference
Synthesis, Characterization, and Antimicrobial Activity of RhIII and IrIII N-Heterocyclic Carbene Piano-Stool Complexes
10.1021/acs.organomet.1c00166 · ExternalCitation · doi-reference
Synthesis, Characterization, and Antimicrobial Activity of RhIII and IrIII β-Diketonato Piano-Stool Compounds
10.1021/acs.organomet.7b00742 · ExternalCitation · doi-reference
Simultaneous Ultrasensitive Detection and Elimination of Drug-Resistant Bacteria by Cyclometalated Iridium(III) Complexes
10.1021/acsami.0c11161 · ExternalCitation · doi-reference
High-throughput Synthesis and Screening of Iridium(III) Photocatalysts for the Fast and Chemoselective Dehalogenation of Aryl Bromides
10.1021/acscatal.0c02247 · ExternalCitation · doi-reference
Cyclometalated Iridium(III) Complexes with eDNA-Degrading Activity for Combating Gram-Positive Bacterial Biofilms
10.1021/acsinfecdis.5c01131 · ExternalCitation · doi-reference
Using Nanoscopy To Probe the Biological Activity of Antimicrobial Leads That Display Potent Activity against Pathogenic, Multidrug Resistant, Gram-Negative Bacteria
10.1021/acsnano.8b08440 · ExternalCitation · doi-reference
Novel Molecular Mechanism for Actinomycin D Activity as an Oncogenic Promoter G-Quadruplex Binder
10.1021/bi9006836 · ExternalCitation · doi-reference
Torsional Barriers and Equilibrium Angle of Biphenyl: Reconciling Theory with Experiment
10.1021/ct800182e · ExternalCitation · doi-reference
Cyclopentadienyl Ligand Effects on Enthalpies of Protonation of the Ru–Ru Bond in Cp‘2Ru2(CO)4 Complexes
10.1021/ic970181e · ExternalCitation · doi-reference
Accelerated Luminophore Discovery through Combinatorial Synthesis
10.1021/ja047156+ · ExternalCitation · doi-reference
Discovery of Biologically Optimized Polymyxin Derivatives Facilitated by Peptide Scanning and In Situ Screening Chemistry
10.1021/jacs.2c12971 · ExternalCitation · doi-reference
Targeting Pathogenic Formate-Dependent Bacteria with a Bioinspired Metallo–Nitroreductase Complex
10.1021/jacs.3c00237 · ExternalCitation · doi-reference
Targeted Antibacterial Strategy Based on Reactive Oxygen Species Generated from Dioxygen Reduction Using an Organoruthenium Complex
10.1021/jacsau.1c00262 · ExternalCitation · doi-reference
Metal Complexes as Antifungals? From a Crowd-Sourced Compound Library to the First In Vivo Experiments
10.1021/jacsau.2c00308 · ExternalCitation · doi-reference
Organometallic Half-Sandwich Iridium Anticancer Complexes
10.1021/jm2000932 · ExternalCitation · doi-reference
Discovery and Investigation of Anticancer Ruthenium–Arene Schiff-Base Complexes via Water-Promoted Combinatorial Three-Component Assembly
10.1021/jm500455p · ExternalCitation · doi-reference
Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
10.1021/jm901241e · ExternalCitation · doi-reference
Organometallic Iridium(III) Cyclopentadienyl Anticancer Complexes Containing C,N-Chelating Ligands
10.1021/om2005468 · ExternalCitation · doi-reference
Predictive compound accumulation rules yield a broad-spectrum antibiotic
10.1038/nature22308 · ExternalCitation · doi-reference
A community-based approach to new antibiotic discovery
10.1038/nrd4706 · ExternalCitation · doi-reference
High-throughput triazole-based combinatorial click chemistry for the synthesis and identification of functional metal complexes
10.1038/s41467-025-67341-z · ExternalCitation · doi-reference
Expanding the DNA damaging potential of artificial metallo-nucleases with click chemistry
10.1038/s41467-026-68911-5 · ExternalCitation · doi-reference
Metals to combat antimicrobial resistance
10.1038/s41570-023-00463-4 · ExternalCitation · doi-reference
A platinum butterfly effect: small changes turn an anticancer drug into a non-toxic metalloantibiotic with in vivo efficacy
10.1038/s44259-026-00211-w · ExternalCitation · doi-reference
Iron homeostasis and management of oxidative stress response in bacteria
10.1039/c1mt00022e · ExternalCitation · doi-reference
A new phenanthroline–oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction
10.1039/c3cc38710k · ExternalCitation · doi-reference
Transition metal diamine complexes with antimicrobial activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA)
10.1039/c5md00228a · ExternalCitation · doi-reference
Apoptosis-independent organoruthenium anticancer complexes that overcome multidrug resistance: self-assembly and phenotypic screening strategies
10.1039/c7sc00497d · ExternalCitation · doi-reference
Iridium piano stool complexes with activity against S. aureus and MRSA: it is past time to truly think outside of the box
10.1039/c9md00140a · ExternalCitation · doi-reference
Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery
10.1039/c9sc05586j · ExternalCitation · doi-reference
Metal complexes as a promising source for new antibiotics
10.1039/c9sc06460e · ExternalCitation · doi-reference
Antimicrobial properties of half-sandwich Ir(III) cyclopentadienyl complexes with pyridylbenzimidazole ligands
10.1039/d0dt00451k · ExternalCitation · doi-reference
Systematically altering the lipophilicity of rhenium(I) tricarbonyl anticancer agents to tune the rate at which they induce cell death
10.1039/d0dt01097a · ExternalCitation · doi-reference
Hydroxyl radical is a significant player in oxidative DNA damage in vivo
10.1039/d1cs00044f · ExternalCitation · doi-reference
A direct-to-biology high-throughput chemistry approach to reactive fragment screening
10.1039/d1sc03551g · ExternalCitation · doi-reference
Main-chain flexibility and hydrophobicity of ionenes strongly impact their antimicrobial activity: an extended study on drug resistance strains and Mycobacterium
10.1039/d2ra04121a · ExternalCitation · doi-reference
Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria
10.1039/d3dt01678a · ExternalCitation · doi-reference
Discovery of antibacterial manganese(I) tricarbonyl complexes through combinatorial chemistry
10.1039/d3sc05326a · ExternalCitation · doi-reference
Tetrazolium iridium complexes as potential antibacterial agents
10.1039/d4ra08525f · ExternalCitation · doi-reference
Membrane potential is important for bacterial cell division
10.1073/pnas.1005485107 · ExternalCitation · doi-reference
Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules
10.1073/pnas.1311066110 · ExternalCitation · doi-reference
Antimicrobial study of ruthenium and iridium half-sandwich complexes containing fluorenyl hydrazonothiazole derivative ligands
10.1080/00958972.2023.2264461 · ExternalCitation · doi-reference
Transition Metal−α-Amino Acid Complexes with Antibiotic Activity against Mycobacterium spp
10.1128/aac.00452-13 · ExternalCitation · doi-reference
The Gram-negative permeability barrier: tipping the balance of the in and the out
10.1128/mbio.01205-23 · ExternalCitation · doi-reference
Principles of bacteriostatic and bactericidal antibiotics at subinhibitory concentrations
10.1128/mbio.02066-25 · ExternalCitation · doi-reference
Agents that increase the permeability of the outer membrane
10.1128/mr.56.3.395-411.1992 · ExternalCitation · doi-reference
Dissecting antibiotic effects on the cell envelope using bacterial cytological profiling: a phenotypic analysis starter kit
10.1128/spectrum.03275-23 · ExternalCitation · doi-reference
Polymyxin B nonapeptide potentiates the eradication of Gram-negative bacterial persisters
10.1128/spectrum.03687-23 · ExternalCitation · doi-reference
A computational knowledge-base elucidates the response of Staphylococcus aureus to different media types
10.1371/journal.pcbi.1006644 · ExternalCitation · doi-reference
Analysis of Antimicrobial-Triggered Membrane Depolarization Using Voltage Sensitive Dyes
10.3389/fcell.2016.00029 · ExternalCitation · doi-reference
Targeting Multiresistant Gram-Positive Bacteria by Ruthenium, Osmium, Iridium and Rhodium Half-Sandwich Type Complexes With Bidentate Monosaccharide Ligands
10.3389/fchem.2022.868234 · ExternalCitation · doi-reference
Evaluation of Antibiotic Resistance Mechanisms in Gram-Positive Bacteria
10.3390/antibiotics13121197 · ExternalCitation · doi-reference
The Discovery of an Iridium(III) Dimer Complex as a Potent Antibacterial Agent against Non-Replicating Mycobacterium smegmatis
10.3390/polym10030297 · ExternalCitation · doi-reference
