References

Harnessing Endogenous Formate for Antibacterial Prodrug Activation by in cellulo Ruthenium-Mediated Transfer Hydrogenation Reaction

10.1002/anie.202000173 · ExternalCitation · doi-reference

Introducing the Perfluorinated Cp* Ligand into Coordination Chemistry

10.1002/anie.202211147 · ExternalCitation · doi-reference

A Semi-Automated, High-Throughput Approach for the Synthesis and Identification of Highly Photo-Cytotoxic Iridium Complexes

10.1002/anie.202401808 · ExternalCitation · doi-reference

Expedited SARS-CoV-2 Main Protease Inhibitor Discovery through Modular ‘Direct-to-Biology’ Screening

10.1002/anie.202418314 · ExternalCitation · doi-reference

High-Throughput Combinatorial Metal Complex Synthesis

10.1002/anie.202420204 · ExternalCitation · doi-reference

Preparation and Bioactivity of Iridium(III) Phenanthroline Complexes with Halide Ions and Pyridine Leaving Groups

10.1002/cbic.202000511 · ExternalCitation · doi-reference

Organometallic Conjugates of the Drug Sulfadoxine for Combatting Antimicrobial Resistance

10.1002/chem.201801090 · ExternalCitation · doi-reference

Dipyrrinato-Iridium(III) Complexes for Application in Photodynamic Therapy and Antimicrobial Photodynamic Inactivation

10.1002/chem.202004776 · ExternalCitation · doi-reference

Application of Mono and Trinuclear Cyclometalated Iridium (III) Complexes in Differential Bacterial Imaging and Antimicrobial Photodynamic Therapy

10.1002/chem.202400646 · ExternalCitation · doi-reference

Synthesis, Cellular Uptake and Biological Activity Against Pathogenic Microorganisms and Cancer Cells of Rhodium and Iridium N-Heterocyclic Carbene Complexes Bearing Charged Substituents

10.1002/ejic.201300820 · ExternalCitation · doi-reference

Improved Synthesis of Dinuclear [M(μ-X)(η5-Cp*)X]2 Precursors for Half-Sandwich Complexes (M=Rh or Ir; X=Br or I)

10.1002/open.202500026 · ExternalCitation · doi-reference

Hydrophobicity: The door to drug delivery

10.1002/psc.3558 · ExternalCitation · doi-reference

Design of Multifunctional IridiumIII Compounds as a Potential Therapeutic Agents from Basic Molecular Scaffolds

10.1002/slct.201600882 · ExternalCitation · doi-reference

Kidney-based in vitro models for drug-induced toxicity testing

10.1007/s00204-019-02598-0 · ExternalCitation · doi-reference

Antibacterial activity of Au(I), Pt(II), and Ir(III) biotin conjugates prepared by the iClick reaction: influence of the metal coordination sphere on the biological activity

10.1007/s00775-024-02073-x · ExternalCitation · doi-reference

The potential of organometallic complexes in medicinal chemistry

10.1016/j.cbpa.2012.01.013 · ExternalCitation · doi-reference

Combinatorial chemistry in drug discovery

10.1016/j.cbpa.2017.03.017 · ExternalCitation · doi-reference

Antimicrobial evaluation of neutral and cationic iridium(III) and rhodium(III) aminoquinoline-benzimidazole hybrid complexes

10.1016/j.ejmech.2020.112694 · ExternalCitation · doi-reference

D-Alanine functionalized Iridium(III) complexes as two-photon photo-antibiotics for bacteria-specific ablation in infected macrophages

10.1016/j.ejmech.2025.117758 · ExternalCitation · doi-reference

In vitro synergy of polymyxins with other antibiotics for Acinetobacter baumannii: A systematic review and meta-analysis

10.1016/j.ijantimicag.2014.10.002 · ExternalCitation · doi-reference

A cyclometalated iridium(III) complex with 2-acetylpyridine-N(4)-ortho-chlorophenyl thiosemicarbazone: Potent antiproliferative and antibacterial activities

10.1016/j.jinorgbio.2025.113179 · ExternalCitation · doi-reference

Pyridine-containing iridium complexes as gram-negative bacteria specific therapeutic agents with low resistance development

10.1016/j.jinorgbio.2026.113274 · ExternalCitation · doi-reference

Recent advances in the development of metal complexes as antibacterial agents with metal-specific modes of action

10.1016/j.mib.2023.102347 · ExternalCitation · doi-reference

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

10.1016/s0140-6736(21)02724-0 · ExternalCitation · doi-reference

Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050

10.1016/s0140-6736(24)01867-1 · ExternalCitation · doi-reference

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

10.1016/s0169-409x(96)00423-1 · ExternalCitation · doi-reference

The WHO Bacterial Priority Pathogens List 2024: a prioritisation study to guide research, development, and public health strategies against antimicrobial resistance

10.1016/s1473-3099(25)00118-5 · ExternalCitation · doi-reference

Eradication of Antibiotic-Resistant Gram-Positive Bacteria and Biofilms by Rationally Designed AIE-Active Iridium(III) Complexes Derived from Cyclometalating 2-Phenylquinoline and Ancillary Bipyridyl Ligands

10.1021/acs.inorgchem.4c05064 · ExternalCitation · doi-reference

Discovery of Phototoxic Metal Complexes with Antibacterial Properties via a Combinatorial Approach

10.1021/acs.inorgchem.4c05414 · ExternalCitation · doi-reference

808 nm Light-Triggered Cyanine-Decorated Iridium(III) Complexes for Antibacterial Photodynamic Therapy in Deep-Tissue

10.1021/acs.inorgchem.5c00232 · ExternalCitation · doi-reference

Half-Sandwich Iridium and Ruthenium Complexes: Effective Tracking in Cells and Anticancer Studies

10.1021/acs.inorgchem.8b02161 · ExternalCitation · doi-reference

Combinatorial Synthesis to Identify a Potent, Necrosis-Inducing Rhenium Anticancer Agent

10.1021/acs.inorgchem.8b03552 · ExternalCitation · doi-reference

Integrated Direct-to-Biology Platform for the Nanoscale Synthesis and Biological Evaluation of PROTACs

10.1021/acs.jmedchem.3c01604 · ExternalCitation · doi-reference

Peroxiredoxin Depletion and Oxidative Stress by Cyclometalated Ir(III)-Isatin Complexes Renders Ferroptosis and Autophagic Cell Death in Triple-Negative Breast Cancer

10.1021/acs.jmedchem.5c01150 · ExternalCitation · doi-reference

Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity

10.1021/acs.jmedchem.8b00906 · ExternalCitation · doi-reference

Synthesis, Characterization, and Antimicrobial Activity of RhIII and IrIII N-Heterocyclic Carbene Piano-Stool Complexes

10.1021/acs.organomet.1c00166 · ExternalCitation · doi-reference

Synthesis, Characterization, and Antimicrobial Activity of RhIII and IrIII β-Diketonato Piano-Stool Compounds

10.1021/acs.organomet.7b00742 · ExternalCitation · doi-reference

Simultaneous Ultrasensitive Detection and Elimination of Drug-Resistant Bacteria by Cyclometalated Iridium(III) Complexes

10.1021/acsami.0c11161 · ExternalCitation · doi-reference

High-throughput Synthesis and Screening of Iridium(III) Photocatalysts for the Fast and Chemoselective Dehalogenation of Aryl Bromides

10.1021/acscatal.0c02247 · ExternalCitation · doi-reference

Cyclometalated Iridium(III) Complexes with eDNA-Degrading Activity for Combating Gram-Positive Bacterial Biofilms

10.1021/acsinfecdis.5c01131 · ExternalCitation · doi-reference

Using Nanoscopy To Probe the Biological Activity of Antimicrobial Leads That Display Potent Activity against Pathogenic, Multidrug Resistant, Gram-Negative Bacteria

10.1021/acsnano.8b08440 · ExternalCitation · doi-reference

Novel Molecular Mechanism for Actinomycin D Activity as an Oncogenic Promoter G-Quadruplex Binder

10.1021/bi9006836 · ExternalCitation · doi-reference

Torsional Barriers and Equilibrium Angle of Biphenyl: Reconciling Theory with Experiment

10.1021/ct800182e · ExternalCitation · doi-reference

Cyclopentadienyl Ligand Effects on Enthalpies of Protonation of the Ru–Ru Bond in Cp‘2Ru2(CO)4 Complexes

10.1021/ic970181e · ExternalCitation · doi-reference

Accelerated Luminophore Discovery through Combinatorial Synthesis

10.1021/ja047156+ · ExternalCitation · doi-reference

Discovery of Biologically Optimized Polymyxin Derivatives Facilitated by Peptide Scanning and In Situ Screening Chemistry

10.1021/jacs.2c12971 · ExternalCitation · doi-reference

Targeting Pathogenic Formate-Dependent Bacteria with a Bioinspired Metallo–Nitroreductase Complex

10.1021/jacs.3c00237 · ExternalCitation · doi-reference

Targeted Antibacterial Strategy Based on Reactive Oxygen Species Generated from Dioxygen Reduction Using an Organoruthenium Complex

10.1021/jacsau.1c00262 · ExternalCitation · doi-reference

Metal Complexes as Antifungals? From a Crowd-Sourced Compound Library to the First In Vivo Experiments

10.1021/jacsau.2c00308 · ExternalCitation · doi-reference

Organometallic Half-Sandwich Iridium Anticancer Complexes

10.1021/jm2000932 · ExternalCitation · doi-reference

Discovery and Investigation of Anticancer Ruthenium–Arene Schiff-Base Complexes via Water-Promoted Combinatorial Three-Component Assembly

10.1021/jm500455p · ExternalCitation · doi-reference

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

10.1021/jm901241e · ExternalCitation · doi-reference

Organometallic Iridium(III) Cyclopentadienyl Anticancer Complexes Containing C,N-Chelating Ligands

10.1021/om2005468 · ExternalCitation · doi-reference

Predictive compound accumulation rules yield a broad-spectrum antibiotic

10.1038/nature22308 · ExternalCitation · doi-reference

A community-based approach to new antibiotic discovery

10.1038/nrd4706 · ExternalCitation · doi-reference

High-throughput triazole-based combinatorial click chemistry for the synthesis and identification of functional metal complexes

10.1038/s41467-025-67341-z · ExternalCitation · doi-reference

Expanding the DNA damaging potential of artificial metallo-nucleases with click chemistry

10.1038/s41467-026-68911-5 · ExternalCitation · doi-reference

Metals to combat antimicrobial resistance

10.1038/s41570-023-00463-4 · ExternalCitation · doi-reference

A platinum butterfly effect: small changes turn an anticancer drug into a non-toxic metalloantibiotic with in vivo efficacy

10.1038/s44259-026-00211-w · ExternalCitation · doi-reference

Iron homeostasis and management of oxidative stress response in bacteria

10.1039/c1mt00022e · ExternalCitation · doi-reference

A new phenanthroline–oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction

10.1039/c3cc38710k · ExternalCitation · doi-reference

Transition metal diamine complexes with antimicrobial activity against Staphylococcus aureus and methicillin-resistant S. aureus (MRSA)

10.1039/c5md00228a · ExternalCitation · doi-reference

Apoptosis-independent organoruthenium anticancer complexes that overcome multidrug resistance: self-assembly and phenotypic screening strategies

10.1039/c7sc00497d · ExternalCitation · doi-reference

Iridium piano stool complexes with activity against S. aureus and MRSA: it is past time to truly think outside of the box

10.1039/c9md00140a · ExternalCitation · doi-reference

Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery

10.1039/c9sc05586j · ExternalCitation · doi-reference

Metal complexes as a promising source for new antibiotics

10.1039/c9sc06460e · ExternalCitation · doi-reference

Antimicrobial properties of half-sandwich Ir(III) cyclopentadienyl complexes with pyridylbenzimidazole ligands

10.1039/d0dt00451k · ExternalCitation · doi-reference

Systematically altering the lipophilicity of rhenium(I) tricarbonyl anticancer agents to tune the rate at which they induce cell death

10.1039/d0dt01097a · ExternalCitation · doi-reference

Hydroxyl radical is a significant player in oxidative DNA damage in vivo

10.1039/d1cs00044f · ExternalCitation · doi-reference

A direct-to-biology high-throughput chemistry approach to reactive fragment screening

10.1039/d1sc03551g · ExternalCitation · doi-reference

Main-chain flexibility and hydrophobicity of ionenes strongly impact their antimicrobial activity: an extended study on drug resistance strains and Mycobacterium

10.1039/d2ra04121a · ExternalCitation · doi-reference

Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria

10.1039/d3dt01678a · ExternalCitation · doi-reference

Discovery of antibacterial manganese(I) tricarbonyl complexes through combinatorial chemistry

10.1039/d3sc05326a · ExternalCitation · doi-reference

Tetrazolium iridium complexes as potential antibacterial agents

10.1039/d4ra08525f · ExternalCitation · doi-reference

Membrane potential is important for bacterial cell division

10.1073/pnas.1005485107 · ExternalCitation · doi-reference

Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules

10.1073/pnas.1311066110 · ExternalCitation · doi-reference

Antimicrobial study of ruthenium and iridium half-sandwich complexes containing fluorenyl hydrazonothiazole derivative ligands

10.1080/00958972.2023.2264461 · ExternalCitation · doi-reference

Transition Metal−α-Amino Acid Complexes with Antibiotic Activity against Mycobacterium spp

10.1128/aac.00452-13 · ExternalCitation · doi-reference

The Gram-negative permeability barrier: tipping the balance of the in and the out

10.1128/mbio.01205-23 · ExternalCitation · doi-reference

Principles of bacteriostatic and bactericidal antibiotics at subinhibitory concentrations

10.1128/mbio.02066-25 · ExternalCitation · doi-reference

Agents that increase the permeability of the outer membrane

10.1128/mr.56.3.395-411.1992 · ExternalCitation · doi-reference

Dissecting antibiotic effects on the cell envelope using bacterial cytological profiling: a phenotypic analysis starter kit

10.1128/spectrum.03275-23 · ExternalCitation · doi-reference

Polymyxin B nonapeptide potentiates the eradication of Gram-negative bacterial persisters

10.1128/spectrum.03687-23 · ExternalCitation · doi-reference

A computational knowledge-base elucidates the response of Staphylococcus aureus to different media types

10.1371/journal.pcbi.1006644 · ExternalCitation · doi-reference

Analysis of Antimicrobial-Triggered Membrane Depolarization Using Voltage Sensitive Dyes

10.3389/fcell.2016.00029 · ExternalCitation · doi-reference

Targeting Multiresistant Gram-Positive Bacteria by Ruthenium, Osmium, Iridium and Rhodium Half-Sandwich Type Complexes With Bidentate Monosaccharide Ligands

10.3389/fchem.2022.868234 · ExternalCitation · doi-reference

Evaluation of Antibiotic Resistance Mechanisms in Gram-Positive Bacteria

10.3390/antibiotics13121197 · ExternalCitation · doi-reference

The Discovery of an Iridium(III) Dimer Complex as a Potent Antibacterial Agent against Non-Replicating Mycobacterium smegmatis

10.3390/polym10030297 · ExternalCitation · doi-reference