Research graph
References from The Apoptosome: Heart and Soul of the Cell Death Machine. Local targets link to admitted publications; unresolved targets remain external evidence.
Genetic instabilities in human cancers
10.1038/25292 · 1988 · External reference
The NB-ARC domain: A novel signalling motif shared by plant resistance gene products and regulators of cell death in animals [letter]
10.1016/s0960-9822(98)70145-9 · 1998 · External reference
Caspases and programmed cell death in the hypersensitive response of plants to pathogens [In Process Citation]
10.1016/s0960-9822(07)00555-6 · 1998 · External reference
Role of CED-4 in the activation of CED-3 [letter] [see comments]
10.1038/41913 · 1997 · External reference
Apoptosis in the pathogenesis and treatment of disease
10.1126/science.7878464 · 1995 · External reference
The Bcl-2 protein family: Arbiters of cell survival
10.1126/science.281.5381.1322 · 1998 · External reference
Caspases: Enemies within
10.1126/science.281.5381.1312 · 1998 · External reference
Death receptors: Signaling and modulation
10.1126/science.281.5381.1305 · 1998 · External reference
Apoptosis signaling by death receptors
10.1046/j.1432-1327.1998.2540439.x · 1998 · External reference
The cell-death machine
10.1016/s0960-9822(02)00541-9 · 1996 · External reference
Cell suicide for beginners [news]
10.1038/24055 · 1998 · External reference
A matter of life and cell death
10.1126/science.281.5381.1317 · 1998 · External reference
Mitochondria and apoptosis
10.1126/science.281.5381.1309 · 1998 · External reference
Caenorhabditis elegans gene ced-9 protects cells from programmed cell death
10.1038/356494a0 · 1992 · External reference
The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death
10.1242/dev.116.2.309 · 1992 · External reference
The Celegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1b-converting enzyme
10.1016/0092-8674(93)90485-9 · 1993 · External reference
Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis
10.1016/s0960-9822(06)00216-8 · 1997 · External reference
Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9
10.1074/jbc.272.34.21449 · 1997 · External reference
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
10.1016/s0092-8674(00)80501-2 · 1997 · External reference
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
10.1016/0092-8674(94)90506-1 · 1994 · External reference
Mechanisms and functions of cell death
10.1146/annurev.cb.07.110191.003311 · 1991 · External reference
Molecular ordering of the cell death pathway: bcl-2 and bcl-xL function upstream of the CED-3-like apoptotic proteases
10.1074/jbc.271.9.4573 · 1996 · External reference
Fas-induced activation of the cell death-related protease CPP32 Is Inhibited by Bcl-2 and ICE family protease inhibitors
10.1074/jbc.271.28.16850 · 1996 · External reference
Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities
10.1101/gad.10.5.578 · 1996 · External reference
Interaction and regulation of subcellular localization of CED-4 by CED-9 [see comments]
10.1126/science.275.5303.1126 · 1997 · External reference
CED-4 induces chromatin condensation in Schizosaccharaomyces pombe and is inhibited by direct physical association with CED-9
10.1016/s0960-9822(06)00120-5 · 1997 · External reference
Interaction between the C. elegans cell-death regulators CED-9 and CED-4
10.1038/385653a0 · 1997 · External reference
Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
10.1074/jbc.273.10.5841 · 1998 · External reference
Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
10.1073/pnas.95.8.4386 · 1998 · External reference
Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death
10.1126/science.275.5303.1122 · 1997 · External reference
The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4
10.1093/emboj/17.4.1029 · 1998 · External reference
Mutational analysis of of the interacting cell death regulators CED-9 and CED-4
10.1038/sj.cdd.4400288 · 1997 · External reference
The death inhibitory molecules CED-9 and CED-4L use a common mechanism to inhibit the CED-3 death protease
10.1074/jbc.273.28.17708 · 1998 · External reference
Direct physical interaction between the Caenorhabditis elegans ‘death proteins’ CED-3 and CED-4
10.1016/s0014-5793(97)00271-8 · 1997 · External reference
Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
10.1016/s0092-8674(00)80085-9 · 1996 · External reference
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
10.1016/s0092-8674(00)80434-1 · 1997 · External reference
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
10.1016/s0092-8674(00)81476-2 · 1998 · External reference
Differential [39] Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES (1998)
1998 · External reference
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
10.1016/s0092-8674(00)81732-8 · 1998 · External reference
Apaf1 is required for mitochondrial pathways of apoptosis and brain development
10.1016/s0092-8674(00)81733-x · 1998 · External reference
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycyctic kidneys and hypopigmented hair
10.1016/0092-8674(93)80065-m · 1993 · External reference
Massive cell death of immature hematopoeitic cells and neurons in Bcl-x-deficient mice
10.1126/science.7878471 · 1995 · External reference
The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
10.1016/s0092-8674(00)81182-4 · 1998 · External reference
Caenorhabditis elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation [In Process Citation]
10.1074/jbc.273.50.33495 · 1998 · External reference
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
10.1016/s0092-8674(00)81590-1 · 1998 · External reference
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
10.1016/s0092-8674(00)81589-5 · 1998 · External reference
Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death
10.1074/jbc.274.2.1156 · 1999 · External reference
An induced proximity model for caspase-8 activation
10.1074/jbc.273.5.2926 · 1998 · External reference
Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal
10.1074/jbc.273.8.4345 · 1998 · External reference
Essential role of CED-4 oligomerization in CED-3 activation and apoptosis [see comments]
10.1126/science.281.5381.1355 · 1998 · External reference
WD-40 repeat region regulates apaf-1 self-association and procaspase-9 activation [In Process Citation]
10.1074/jbc.273.50.33489 · 1998 · External reference
Viral proteins containing the purine NTP-binding sequence pattern
10.1093/nar/17.21.8413 · 1989 · External reference
Programmed cell death: A way of life for plants
10.1073/pnas.93.22.12094 · 1996 · External reference
Unresolved reference
1988 · External reference
Cytochrome c activation of CPP32-like proteolysis plays a critical tole in Xenopus cell-free apoptosis system
10.1093/emboj/16.15.4639 · 1997 · External reference
Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
10.1093/emboj/17.1.37 · 1998 · External reference
The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
10.1126/science.275.5303.1132 · 1997 · External reference
Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
10.1126/science.275.5303.1129 · 1997 · External reference
Caspase cleaved BID targets mitochondria and is required for cytochrome c release, Bcl-XL prevents this release but not tumor necrosis factor R1/Fas Death
10.1074/jbc.274.2.1156 · 1999 · External reference
Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria [see comments]
10.1016/s0092-8674(00)80450-x · 1997 · External reference
Mitochondria as regulators of apoptosis: doubt no more
10.1016/s0005-2728(98)00110-8 · 1998 · External reference
The central executioner of apoptosis: Multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis
10.1084/jem.186.1.25 · 1997 · External reference
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis
10.1093/emboj/17.14.3878 · 1998 · External reference
Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c
10.1074/jbc.273.26.16589 · 1998 · External reference
Two CD95 (APO-1/Fas) signaling pathways
10.1093/emboj/17.6.1675 · 1998 · External reference
Bcl-xL functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells
10.1074/jbc.273.8.4523 · 1998 · External reference
