Research graph
References from Causes and Effects of Heterogeneous Perfusion in Tumors. Local targets link to admitted publications; unresolved targets remain external evidence.
Tumor pathophysiology: the perfusion model
10.1159/000386057 · 1980 · External reference
The Eugene M
1997 · External reference
Blood flow, oxygen consumption and tissue oxygenation of human tumors
10.1007/978-1-4684-8181-5_103 · 1990 · External reference
MRI of extracranial masses in children: the usefulness of gadolinium-chelate enhancement
10.1007/s002470050364 · 1998 · External reference
Dynamic contrast-enhanced imaging and analysis at high spatial resolution of MCF7 human breast tumors
10.1006/jmre.1997.1220 · 1997 · External reference
Modeling tracer kinetics in dynamic Gd-DTPA MR imaging
10.1002/jmri.1880070113 · 1997 · External reference
Angiogenesis of uterine cervical carcinoma: characterization by pharmacokinetic magnetic resonance parameters and histological microvessel density with correlation to lymphatic involvement
1997 · External reference
Pharmacokinetic MRI for assessment of malignant glioma response to stereotactic radiotherapy: initial results
10.1002/jmri.1880080406 · 1998 · External reference
Pharmacokinetic changes induced by vasomodulators in kidneys, livers, muscles, and implanted tumors in rats as measured by dynamic Gd-DTPA-enhanced MRI
10.1002/mrm.1910360609 · 1996 · External reference
Assessment of tumor microcirculation: a new role of dynamic contrast MR imaging
10.1002/jmri.1880070115 · 1997 · External reference
Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging
1991 · External reference
Water diffusion and exchange as they influence contrast enhancement
10.1002/jmri.1880070114 · 1997 · External reference
Improving MR quantification of regional blood volume with intravascular Ti contrast agents: accuracy, precision, and water exchange
10.1002/mrm.1910360608 · 1996 · External reference
Dynamic Gd-DTPA enhanced MRI measurement of tissue cell volume fraction
10.1002/mrm.1910340320 · 1995 · External reference
Analysis of dynamic contrast enhanced MRI in tumors: relationship of derived parameters with physiologic factors
1998 · External reference
Dynamic contrast-enhanced MR imaging evaluation of osteosarcoma response to neoadjuvant chemotherapy
10.1002/jmri.1880050612 · 1995 · External reference
Fast dynamic contrast enhanced MR imaging of cervical carcinoma
10.1016/s0009-9260(98)80098-6 · 1998 · External reference
Evaluation of chemotherapy in advanced urinary bladder cancer with fast dynamic contrast-enhanced MR imaging
10.1148/radiology.207.3.9609906 · 1998 · External reference
Staging urinary bladder cancer after transurethral biopsy: value of fast dynamic contrastenhanced MR imaging
10.1148/radiology.201.1.8816542 · 1996 · External reference
Tumor perfusion studies using fast magnetic resonance imaging technique in advanced cervical cancer: a new noninvasive predictive assay
10.1016/s0360-3016(97)85090-0 · 1996 · External reference
Prediction of tumor control in patients with cervical cancer: analysis of combined volume and dynamic enhancement pattern by MR imaging
10.2214/ajr.170.1.9423627 · 1998 · External reference
Factor analysis of dynamic magnetic resonance imaging in predicting the response of osteosarcoma to chemotherapy
10.1097/00004424-199210000-00016 · 1992 · External reference
Magnetic resonance imaging in musculoskeletal primary malignant tumors
1987 · External reference
Blood perfusion measurements in human tumours, evaluation of laser Doppler methods
10.3109/02656739009141139 · 1990 · External reference
Tumor blood flow
1998 · External reference
Transplantable tumors grown in transparent chambers in skinflaps of mice
1943 · External reference
Differential response of normal and tumor microcirculation to hyperthermia
1984 · External reference
Temporal effects of 5.0 Gy radiation in healing subcutaneous microvasculature of a dorsal flap window chamber
10.2307/3577110 · 1987 · External reference
Concepts of oxygen transport at the microcirculatory level
10.1016/s1053-4296(98)80040-4 · 1998 · External reference
Temporal changes in PO2 of R3230AC tumors in Fischer-344 rats
10.1016/s0360-3016(98)00304-6 · 1998 · External reference
Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma
1996 · External reference
The molecular basis of the hypoxia response pathway: tumour hypoxia as a therapy target
10.1023/a:1006002419244 · 1998 · External reference
MIBG inhibits respiration: potential for radio- and hyperthermic sensitization
10.1016/s0360-3016(98)00334-4 · 1998 · External reference
Will hyperthermia conquer the elusive hypoxic cell? Implications of heat effects on tumor and normal-tissue microcirculation
10.1148/radiology.137.3.7003650 · 1980 · External reference
Interlaboratory variation in oxygen tension measurement by Eppendorf “Histograph” and comparison with hypoxic marker
10.1002/(sici)1096-9098(199709)66:1<30::aid-jso7>3.0.co;2-o · 1997 · External reference
Measurement of differences in pO2 in response to perfluorocarbon/carbogen in FSa and NFSa murine fibrosarcomas with low-frequency electron paramagnetic resonance oximetry
10.2307/3579280 · 1996 · External reference
Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water
10.1161/01.str.27.9.1648 · 1996 · External reference
Regional tumor oxygen tension: fluorine echo planar imaging of hexafluorobenzene reveals heterogeneity of dynamics
10.1016/s0360-3016(98)00306-x · 1998 · External reference
Hexafluorobenzene: a sensitive 19F NMR indicator of tumor oxygenation
10.1002/(sici)1099-1492(199605)9:3<125::aid-nbm405>3.0.co;2-f · 1996 · External reference
Correlation of magnetic resonance and oxygen microelectrode measurements of carbogen-induced changes in tumor oxygenation
10.1016/s0360-3016(98)00038-8 · 1998 · External reference
Spectroscopic imaging of the water resonance with short repetition time to study tumor response to hyperoxia
10.1002/mrm.1910380106 · 1997 · External reference
Pharmacokinetics of SPECT radiopharmaceuticals for imaging hypoxic tissues
1996 · External reference
Imaging of hypoxia in human tumors with (F-18)fluoromisonidazole
10.1016/0360-3016(92)91001-4 · 1992 · External reference
Comparing techniques of measuring tumor hypoxia in different murine tumors: Eppendorf pO2 Histograph, (3H)misonidazole binding and paired survival assay
10.2307/3579071 · 1996 · External reference
Quantifying regional hypoxia in human tumors with positron emission tomography of (18F)fluoromisonida zole: a pretherapy study of 37 patients
10.1016/s0360-3016(96)00325-2 · 1996 · External reference
Cells at intermediate oxygen levels can be more important that the “hypoxic fraction” in determining tumor response to fractionated radiotherapy
10.2307/3579620 · 1997 · External reference
On the origin of cancer cells
10.1126/science.123.3191.309 · 1956 · External reference
The relevance of tumour pH to the treatment of malignant disease
10.1016/s0167-8140(84)80077-8 · 1984 · External reference
31P-MRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate
10.1152/ajpcell.1994.267.1.c195 · 1994 · External reference
The effect of blood flow modification on ontra- and extracellular pH measured by 31 P magnetic resonance spectroscopy in murine tumours
10.1038/bjc.1995.431 · 1995 · External reference
Cellular ion homeostasis in Morris hepatoma 9618a in vivo after host carbogen (95% O2/ 5 % CO2) breathing
1995 · External reference
In vivo utilization of oxygen and glucose by neoplastic tissue
10.1007/978-1-4684-3273-2_62 · 1976 · External reference
Glucose consumption by transplanted tumors in vivo
1967 · External reference
Utilization of oxygen by transplanted tumors in vivo
1967 · External reference
Relationship between oxygen and glucose consumption by transplanted tumors in vivo
1967 · External reference
Proliferative and clonogenic heterogeneity of cells from EMT6/Ro multicellular spheroids induced by the glucose and oxygen supply
1986 · External reference
The histological structure of some human lung cancers and the possible implications for radiotherapy
10.1038/bjc.1955.55 · 1955 · External reference
The rate of diffusion of gases through animal tissues, with some remarks on the coefficient of invasion
10.1113/jphysiol.1919.sp001838 · 1919 · External reference
The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue
10.1113/jphysiol.1919.sp001839 · 1919 · External reference
A reduction in the in situ of oxygen and glucose consumption of cells in EMT6/RO spheroids during growth
10.1002/jcp.1041240323 · 1985 · External reference
Determination of diffusion constants for metabolites in multicell tumor spheroids
1983 · External reference
Selfdiffusion of water in multicellular spheroids measured by magnetic resonance microimaging
1991 · External reference
Proton NMR microscopy of multicellular tumor spheroid morphology
10.1002/mrm.1910160304 · 1990 · External reference
Interstitial pH and PO2 Gradients in Solid Tumors in vivo: High-Resolution Measurements Reveal a Lack of Correlation
10.1038/nm0297-177 · 1997 · External reference
Unresolved reference
1994 · External reference
Non-invasive assessment of human tumour hypoxia with 123l-iodoazomycin arabinoside: preliminary report of a clinical study
10.1038/bjc.1992.17 · 1992 · External reference
A posteffect of oxygen in irradiated bacteria: A submillisecond fast mixing study
10.2307/3573702 · 1973 · External reference
Role of hypoxia in photodynamic therapy of tumors
10.1177/030089168507100306 · 1985 · External reference
Predictions of mathematical models of tissue oxygenation and generation of singlet oxygen during photodynamic therapy
10.2307/3579524 · 1997 · External reference
Are cancer cells acidic?
10.1038/bjc.1991.326 · 1991 · External reference
Intracellular pH: Methods and applications
10.1016/b978-0-12-152509-5.50009-9 · 1978 · External reference
Weak acids, weak bases and intracellular pH
10.1016/0034-5687(78)90080-4 · 1978 · External reference
pH and Drug Resistance II
1999 · External reference
Acid pH in Tumors and Its Potential for Therapeutic Exploitation
1989 · External reference
Lower electrical membrane potential and altered pHi homeostasis in multidrugresistant (MDR) cells: further characterization of a series of MDR cell lines expressing different levels of p-glycoprotein
10.1021/bi00092a014 · 1993 · External reference
Intracellular pH and the control of multidrug resistance
1994 · External reference
Cellular pH gradient in tumor versus normal tissue: Potential for exploitation for the treatment of cancer
1996 · External reference
Enhancement of chemotherapy by manipulation of tumor pH
10.1038/sj.bjc.6690455 · 1999 · External reference
Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line
10.1038/bjc.1991.202 · 1991 · External reference
Cell biological mechanisms of multidrug resistance in tumors
10.1073/pnas.91.9.3497 · 1994 · External reference
Enhanced morphological transformation of early passage syrian hamster embryo cells cultured in medium with a reduced bicarbonate concentration and pH
10.1093/carcin/8.5.689 · 1987 · External reference
Enhanced morphological and neoplastic transformation of syrian hamster embryo cells cultured at pH 6.70
1990 · External reference
An interlaboratory comparison of enhanced morphological transformation of syrian hamster embryo cells cultured under conditions of reduced bicarbonate concentration and pH
10.1016/0165-1218(89)90136-5 · 1989 · External reference
Clastogenicity of low pH to various cultured mammalian cells
10.1016/0027-5107(92)90235-t · 1992 · External reference
Evaluation of clastogenicity of formic acid, acetic acid, and lactic acid on cultured mammalian cells
10.1016/0165-1218(90)90058-a · 1990 · External reference
Genetic instability induced by the tumor microenvironment
1996 · External reference
Acidic pH Enhances The Invasive Behavior of Human Melanoma Cells
10.1007/bf00121214 · 1996 · External reference
Glucose starvation and acidosis: effect on experimental metastasic potential, DNA content and MTX resistance of murine tumour cells
10.1038/bjc.1991.378 · 1991 · External reference
Breast Cancer Cells Have a High Capacity To Acidify Extracellular Milieu by a Dual Mechanism
10.1023/a:1018446104071 · 1997 · External reference
Pericellular pH affects distribution and secretion of cathepsin B in Malignant Cells
1994 · External reference
Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion
10.1023/a:1018428105463 · 1997 · External reference
An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasisassociated genes in murine tumor cells
10.1023/a:1018470709523 · 1997 · External reference
Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression
10.1002/(sici)1097-0215(19990209)80:4<617::aid-ijc22>3.0.co;2-c · 1999 · External reference
Stimulation of plasminogen activator inhibitor-1 expression in immortalized human trophoblast cells cultured under low levels of oxygen
10.1006/excr.1998.4240 · 1998 · External reference
Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
1996 · External reference
Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix
10.1038/bjc.1998.586 · 1998 · External reference
Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions
1997 · External reference
Regulation of angiogenesis by hypoxic stress: from solid tumours to the ovarian follicle
10.1046/j.1365-2613.1997.d01-247.x · 1997 · External reference
Angiogenesis and neoplastic growth
1983 · External reference
Angiogenesis and oncogenesis
1978 · External reference
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
10.1016/s0092-8674(00)80108-7 · 1996 · External reference
Oxygen tension regulates the expression of angiogenesis factor by macrophages
10.1126/science.6612342 · 1983 · External reference
Role of the hypoxia sensing system, acidity and reproductive hormones in the variability of vascular endothelial growth factor induction in human breast carcinoma cell lines
10.1002/(sici)1097-0215(19980302)75:5<706::aid-ijc8>3.0.co;2-2 · 1998 · External reference
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
10.1038/359843a0 · 1992 · External reference
Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis
10.1073/pnas.92.3.768 · 1995 · External reference
Vascular permeability factor expression influences tumor angiogenesis in human melanoma lines xenografted to nude mice
1995 · External reference
Targeting the tumor vasculature: inhibition of tumor growth by a vascular endothelial growth factor-toxin conjugate
10.1002/(sici)1097-0215(19971210)73:6<865::aid-ijc17>3.0.co;2-3 · 1997 · External reference
Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal
10.1073/pnas.94.16.8761 · 1996 · External reference
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
10.1172/jci5028 · 1999 · External reference
Vascular endothelial growth factor is essential for initial but not continued in vivo growth of human breast carcinoma cells
1997 · External reference
Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes
10.1128/mcb.15.10.5363 · 1995 · External reference
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
10.1038/28867 · 1998 · External reference
Modulation of VEGF production by pH and glucose in retinal Muller cells
10.1076/ceyr.17.9.875.5134 · 1998 · External reference
The influence of oxygen tension and pH on the expression of plateletderived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown in vitro and in vivo
1997 · External reference
Hypoxia induces capillary network formation in cultured bovine pulmonary microvessel endothelial cells
1995 · External reference
Hypoxiamediated induction of acidic/basic fibroblast growth factor and platelet derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells
10.1073/pnas.92.10.4606 · 1995 · External reference
Spatial and temporal expression of angiogenic molecules during tumor growth and progression
1998 · External reference
The angiopoietins: Yin and Yang in angiogenesis
1999 · External reference
Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
10.1016/s0092-8674(00)81812-7 · 1996 · External reference
Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia
10.1161/01.res.83.8.852 · 1998 · External reference
Recherches expérimentales sur le mouvement des liquides dans les tubes de très petits diamètres
1846 · External reference
Resistance to blood flow in microvessels in vivo
10.1161/01.res.75.5.904 · 1994 · External reference
Geometric resistance and microvascular network architecture of human colorectal carcinoma
10.3109/10739689709148315 · 1997 · External reference
Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue
1993 · External reference
1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors
10.1007/bf02648108 · 1996 · External reference
Morphologic and hemodynamic comparison of tumor and healing normal tissue microvasculature
10.1016/0360-3016(89)90375-1 · 1989 · External reference
A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model
10.1016/0360-3016(93)90348-y · 1993 · External reference
A pial window model for the intracranial study of human glioma microvascular function
10.1227/00006123-199505000-00014 · 1995 · External reference
Prognostic value of intratumoral microvessel density, a measure of tumor angiogenesis, in node-negative breast carcinoma-results of a multiparametric study
10.1007/bf00666041 · 1995 · External reference
Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors
10.1007/bf00666038 · 1995 · External reference
Intratumor microvessel density as a prognostic factor in cancer
1995 · External reference
Angiogenesis and neoplastic progression in vitro
1982 · External reference
Angiogenesis as a marker of preneoplastic lesions of the human breast
10.1002/1097-0142(197801)41:1<239::aid-cncr2820410133>3.0.co;2-x · 1978 · External reference
Tumoral vascularity as a prognostic factor in cancer
1996 · External reference
Angiogenesis and cancer metastases: therapeutic approaches
10.1016/1040-8428(94)00142-g · 1995 · External reference
Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors
10.3109/02841869509093981 · 1995 · External reference
Theoretical simulation of oxygen transport to tumors by three-dimensional networks of microvessels
10.1007/978-1-4615-4863-8_74 · 1998 · External reference
Neovascularization induced growth of implanted C6 glioma multicellular spheroids: magnetic resonance microimaging
1995 · External reference
Quantification of longitudinal tissue PO2 gradients in window chamber tumours: impact on tumour hypoxia
10.1038/sj.bjc.6690273 · 1999 · External reference
Structural adaptation and stability of microvascular networks: theory and simulations
1998 · External reference
Tumor oxygenation: a matter of supply and demand
1996 · External reference
Role of the hypoxia sensing system, acidity and reproductive hormones in the variability of vascular endothelial growth factor induction in human breast carcinoma cell lines
10.1002/(sici)1097-0215(19980302)75:5<706::aid-ijc8>3.0.co;2-2 · 1998 · External reference
Erythrocyte flux in capillary networks during maturation: implications for oxygen delivery
1996 · External reference
Arteriolar control of capillary cell flow in striated muscle
10.1161/01.res.64.1.112 · 1989 · External reference
Measurements of the perivascular PO2 in the vicinity of the pial vessels of the cat
10.1007/bf00584471 · 1979 · External reference
pO2 measurements in arteriolar networks
10.1006/mvre.1996.0021 · 1996 · External reference
Functional capillary organization in striated muscle
1995 · External reference
Effect of diameter variability along a microvessel segment on pressure drop
10.1006/mvre.1993.1020 · 1993 · External reference
Fluctuations in microvascular blood flow parameters caused by hemodynamic mechanisms
1994 · External reference
Growth regulation of the vascular system: evidence for a metabolic hypothesis
1990 · External reference
Microcirculation of Tumors Part 1: anatomy, function and Necrosis
10.1016/s0009-9260(66)80027-2 · 1966 · External reference
In vivo analysis of tumor vascularization in the rat
10.1111/j.1349-7006.1990.tb02562.x · 1999 · External reference
Paclitaxel/carboplatin administration along with antiangiogenic therapy in non-small-cell lung and breast carcinoma models
10.1007/s002800050773 · 1998 · External reference
Optimal scheduling of interleukin-12 and fractionated radiation therapy in the murine Lewis lung carcinoma
10.1002/(sici)1520-6823(1998)6:2<71::aid-roi2>3.0.co;2-e · 1998 · External reference
Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents
10.1023/a:1005718628223 · 1997 · External reference
Antiangiogenic treatment (TNP-470/minocycline) increases tissue levels of anticancer drugs in mice bearing Lewis lung carcinoma
1995 · External reference
Combined effects of angiostatin and ionizing radiation in antitumour therapy
10.1038/28412 · 1998 · External reference
Uterine cervical carcinoma: comparison of standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival
1998 · External reference
Analysis of subcutaneous angiogenesis by gradient echo magnetic resonance imaging
10.1002/mrm.1910390519 · 1998 · External reference
The response of human tumors to carbogen breathing, monitored by Gradient-Recalled Echo Magnetic Resonance Imaging
10.1016/s0360-3016(97)00326-x · 1997 · External reference
Physiological properties of malignant tumours
10.1002/nbm.1940050505 · 1992 · External reference
