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References from HSV-1-Based Vectors for Gene Therapy of Neurological Diseases and Brain Tumors: Part I. HSV-1 Structure, Replication and Pathogenesis. Local targets link to admitted publications; unresolved targets remain external evidence.
Neurological Disorders: An Overwiew
1998 · External reference
Benefits and risks of hosting animal cells in the human brain
10.1038/nm0997-964 · 1997 · External reference
Herpes Simplex Viruses and Their Replication
1996 · External reference
Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1
10.1016/0022-2836(85)90320-1 · 1985 · External reference
The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1
10.1099/0022-1317-69-7-1531 · 1988 · External reference
Regulation of herpesvirus macromolecular synthesis: I
1974 · External reference
Induction of both thymidine and deoxycytidine kinase activity by herpes viruses
10.1099/0022-1317-24-3-465 · 1974 · External reference
Biochemical studies on the herpes simplex virus-specified deoxypyrimidine kinase activity
10.1099/0022-1317-24-3-481 · 1974 · External reference
9-(2-Hydroxyethoxymethyl) guanine activity against viruses of the herpes group
10.1038/272583a0 · 1978 · External reference
Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy
1986 · External reference
Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir
1998 · External reference
Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography
10.1073/pnas.96.5.2333 · 1999 · External reference
Imaging HSV-1 vector replication and gene delivery in vivo
1999 · External reference
Quantitative autoradiographic mapping of herpes simplex virus encephalitis with a radiolabeled antiviral drug
10.1126/science.7112121 · 1982 · External reference
Imaging the expression of transfected genes in vivo
1995 · External reference
Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography
1998 · External reference
Identification and separation of the two subunits of the herpes simplex virus ribonucleotide reductase
10.1128/jvi.57.3.1177-1181.1986 · 1986 · External reference
Induction of uracil-DNA glycosylase and dUTP nucleotidohydrolase activity in herpes simplex virus-infected human cells
10.1016/s0021-9258(19)68704-1 · 1981 · External reference
Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates
10.1128/jvi.70.4.2075-2085.1996 · 1996 · External reference
Proteins specified by herpes simplex virus: XII
1974 · External reference
Proteins specified by herpes simplex virus: V
1972 · External reference
Herpes simplex virus glycoproteins associated with different morphological entities projecting from the virion envelope
10.1099/0022-1317-68-3-715 · 1987 · External reference
Glycoprotein C of herpes simplex virus type 1 plays a principal role in the adsorption of virus to cells and in infectivity
10.1128/jvi.65.3.1090-1098.1991 · 1991 · External reference
Herpes simplex virus type 1 entry through a cascade of virus-cell interactions requires different roles of gD and gH in penetration
10.1128/jvi.66.8.5002-5012.1992 · 1992 · External reference
Herpes simplex virus glycoprotein K promotes egress of virus particles
10.1128/jvi.69.9.5401-5413.1995 · 1995 · External reference
Herpes simplex virus glycoproteins E and I facilitate cell-to-cell spread in vivo and across junctions of cultured cells
10.1128/jvi.68.2.834-845.1994 · 1994 · External reference
Antigenic structure of soluble herpes simplex virus (HSV) glycoprotein D correlates with inhibition of HSV infection
10.1128/jvi.71.4.2940-2946.1997 · 1997 · External reference
The gH-gL complex of herpes simplex virus (HSV) stimulates neutralizing antibody and protects mice against HSV type 1 challenge
10.1128/jvi.72.1.65-72.1998 · 1998 · External reference
Glycoprotein C of herpes simplex virus 1 acts as a receptor for the C3b complement component on infected cells
10.1038/309633a0 · 1984 · External reference
Immune evasion properties of herpes simplex virus type 1 glycoprotein gC
10.1128/jvi.70.7.4253-4260.1996 · 1996 · External reference
Glycoprotein C of herpes simplex virus 1 is an inhibitor of the complement cascade
10.4049/jimmunol.137.5.1636 · 1986 · External reference
Glycoprotein C of herpes simplex virus type 1 is essential for the virus to evade antibody-independent complement-mediated virus inactivation and lysis of virus-infected cells
10.1099/0022-1317-72-4-915 · 1991 · External reference
Mechanism of complement inactivation by glycoprotein C of herpes simplex virus
10.4049/jimmunol.158.4.1763 · 1997 · External reference
Herpes simplex virus type 1 glycoprotein gC mediates immune evasion in vivo
10.1128/jvi.72.10.8257-8263.1998 · 1998 · External reference
Membrane proteins specified by herpes simplex viruses: V
1979 · External reference
Herpes simplex virus type 1 encodes two Fc receptors which have different binding characteristics for monomeric immunoglobulin G (IgG) and IgG complexes
10.1128/jvi.64.6.2725-2731.1990 · 1990 · External reference
Herpes simplex virus type 1 Fc receptor protects infected cells from antibodydependent cellular cytotoxicity
10.1128/jvi.65.12.7046-7050.1991 · 1991 · External reference
A novel function of the herpes simplex virus type 1 Fc receptor: participation in bipolar bridging of antiviral immunoglobulin G
10.1128/jvi.63.11.4479-4488.1989 · 1989 · External reference
Herpes simplex virus immunoglobulin G Fc receptor activity depends on a complex of two viral glycoproteins, gE and gl
10.1128/jvi.62.4.1347-1354.1988 · 1988 · External reference
Direct evidence for antibody bipolar bridging on herpes simplex virus-infected cells
1992 · External reference
In vivo immune evasion mediated by the herpes simplex virus type 1 immunoglobulin G Fc receptor
10.1128/jvi.72.7.5351-5359.1998 · 1998 · External reference
Structural analysis of the capsid polypeptides of herpes simplex virus types 1 and 2
10.1128/jvi.34.2.521-531.1980 · 1980 · External reference
Identification and characterization of a herpes simplex virus gene product required for encapsidation of virus DNA
10.1128/jvi.45.3.1056-1064.1983 · 1983 · External reference
Three-dimensional structure of the HSV-1 nucleocapsid
10.1016/0092-8674(89)90587-4 · 1989 · External reference
Structure of the herpes simplex virus capsid: effects of extraction with guanidine hydrochloride and partial reconstitution of extracted capsids
10.1128/jvi.65.2.613-620.1991 · 1991 · External reference
Identification and genetic mapping of a herpes simplex virus capsid protein that binds DNA
10.1128/jvi.50.2.645-648.1984 · 1984 · External reference
Structure of the herpes simplex virus capsid
1993 · External reference
The herpes simplex virus procapsid: structure, conformational changes upon maturation, and roles of the triplex proteins VP19c and VP23 in assembly
10.1016/s0022-2836(96)80018-0 · 1996 · External reference
Finding a needle in a haystack: detection of a small protein (the 12-kDa VP26) in a large complex (the 200-MDa capsid of herpes simplex virus)
10.1073/pnas.91.12.5652 · 1994 · External reference
Hexon-only binding of VP26 reflects differences between the hexon and penton conformations of VP5, the major capsid protein of herpes simplex virus
10.1128/jvi.71.12.8955-8961.1997 · 1997 · External reference
Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes
10.1128/jvi.46.2.371-377.1983 · 1983 · External reference
Herpes simplex virus type 1 UL46 and UL47 deletion mutants lack VP11 and VP12 or VP13 and VP14, respectively, and exhibit altered viral thymidine kinase expression
10.1128/jvi.67.3.1482-1492.1993 · 1993 · External reference
Herpes simplex virus DNA replication
10.1146/annurev.biochem.66.1.347 · 1997 · External reference
Construction and properties of a recombinant herpes simplex virus i lacking both S-component origins of DNA synthesis
10.1128/jvi.67.4.2123-2132.1993 · 1993 · External reference
Characterization of the TRS/IRS origin of DNA replication of herpes simplex virus type 1
10.1016/0042-6822(83)90097-1 · 1983 · External reference
Cloning, sequencing, and functional analysis of oriL, a herpes simplex virus type 1 origin of DNA synthesis
10.1128/mcb.5.5.930 · 1985 · External reference
Properties of the novel herpes simplex virus type 1 origin binding protein, OBPC
10.1128/jvi.70.8.5673-5679.1996 · 1996 · External reference
Cellular protein interactions with herpes simplex virus type 1 oriS
10.1128/mcb.14.4.2545 · 1994 · External reference
The origin binding protein of herpes simplex virus i binds cooperatively to the viral origin of replication oris
10.1016/s0021-9258(17)44884-8 · 1990 · External reference
Elements in the transcriptional regulatory region flanking herpes simplex virus type 1 oriS stimulate origin function
10.1128/jvi.65.5.2601-2611.1991 · 1991 · External reference
Sp1 binds to promoter sequences and activates herpes simplex virus "immediate-early" gene transcription in vitro
10.1038/317179a0 · 1985 · External reference
Cellular transcription factors enhance herpes simplex virus type 1 oriS - dependent DNA replication
10.1128/jvi.72.5.3635-3645.1998 · 1998 · External reference
A complex formed between cell components and an HSV structural polypeptide binds to a viral immediate early gene regulatory DNA sequence
10.1016/s0092-8674(88)80035-7 · 1988 · External reference
Herpes simplex virus amplicon: cleavage of concatemeric DNA is linked to packaging and involves amplification of the terminally reiterated a sequence
10.1128/jvi.57.3.933-941.1986 · 1986 · External reference
Visualization of tegument-capsid interactions and DNA in intact herpes simplex virus type 1 virions
10.1128/jvi.73.4.3210-3218.1999 · 1999 · External reference
Sequential isolation of proteoglycan synthesis mutants by using herpes simplex virus as a selective agent: evidence for a proteoglycan-independent virus entry pathway
10.1128/jvi.69.6.3290-3298.1995 · 1995 · External reference
Glycoprotein C-independent binding of herpes simplex virus to cells requires cell surface heparan sulphate and glycoprotein B
10.1099/0022-1317-75-6-1211 · 1994 · External reference
Heparan sulfate proteoglycan binding by herpes simplex virus type 1 glycoproteins B and C, which differ in their contributions to virus attachment, penetration, and cell-to-cell spread
10.1128/jvi.72.7.6119-6130.1998 · 1998 · External reference
Cell surface receptors for herpes simplex virus are heparan sulfate proteoglycans
10.1083/jcb.116.5.1273 · 1992 · External reference
Initial interaction of herpes simplex virus with cells is binding to heparan sulfate
10.1128/jvi.63.1.52-58.1989 · 1989 · External reference
Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion
10.1128/jvi.62.8.2596-2604.1988 · 1988 · External reference
Identification of functional regions of herpes simplex virus glycoprotein gD by using linker-insertion mutagenesis
10.1128/jvi.68.4.2529-2543.1994 · 1994 · External reference
Monoclonal antibodies define a domain on herpes simplex virus glycoprotein B involved in virus penetration
10.1128/jvi.62.6.1881-1888.1988 · 1988 · External reference
A herpes simplex virus mutant in which glycoprotein D sequences are replaced by beta-galactosidase sequences binds to but is unable to penetrate into cells
10.1128/jvi.62.5.1486-1494.1988 · 1988 · External reference
A mutant herpes simplex virus type 1 unable to express glycoprotein L cannot enter cells, and its particles lack glycoprotein H
10.1128/jvi.67.4.2285-2297.1993 · 1993 · External reference
Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family
10.1016/s0092-8674(00)81363-x · 1996 · External reference
Monoclonal antibodies to distinct sites on herpes simplex virus (HSV) glycoprotein D block HSV binding to HVEM
10.1128/jvi.72.5.3595-3601.1998 · 1998 · External reference
Glycoprotein D of herpes simplex virus (HSV) binds directly to HVEM, a member of the tumor necrosis factor receptor superfamily and a mediator of HSV entry
10.1128/jvi.71.8.6083-6093.1997 · 1997 · External reference
The V domain of herpesvirus Ig-like receptor (HlgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D
10.1073/pnas.95.26.15700 · 1998 · External reference
Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor
10.1126/science.280.5369.1618 · 1998 · External reference
Herpes simplex virus glycoprotein D can bind to poliovirus receptor related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry
10.1128/jvi.72.9.7064-7074.1998 · 1998 · External reference
A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus
10.1006/viro.1998.9218 · 1998 · External reference
Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1
10.1074/jbc.272.22.14029 · 1997 · External reference
Functional region IV of glycoprotein D from herpes simplex virus modulates glycoprotein binding to the herpesvirus entry mediator
10.1128/jvi.72.9.7091-7098.1998 · 1998 · External reference
Examination of the kinetics of herpes simplex virus glycoprotein D binding to the herpes-virus entry mediator, using surface plasmon resonance
10.1128/jvi.72.7.5937-5947.1998 · 1998 · External reference
Herpesvirus entry mediator HVEM mediates cell cell spread in BHK(TK-) cell clones
10.1128/jvi.72.2.1411-1417.1998 · 1998 · External reference
HveA (herpesvirus entry mediator A), a co-receptor for herpes simplex virus entry, also participates in virus-induced cell fusion
10.1128/jvi.72.7.5802-5810.1998 · 1998 · External reference
A novel herpes simplex virus glycoprotein, gL, forms a complex with glycoprotein H (gH) and affects normal folding and surface expression of gH
10.1128/jvi.66.4.2240-2250.1992 · 1992 · External reference
Cell-specific kinetics and efficiency of herpes simplex virus type 1 entry are determined by two distinct phases of attachment
10.1006/viro.1994.1081 · 1994 · External reference
Structural and antigenic analysis of a truncated form of the herpes simplex virus glycoprotein gH-gL complex
10.1128/jvi.72.7.6092-6103.1998 · 1998 · External reference
Glycoproteins gB, gD, and gHgL of herpes simplex virus type 1 are necessary and sufficient to mediate membrane fusion in a Cos cell transfection system
10.1128/jvi.72.1.873-875.1998 · 1998 · External reference
Penetration of cells by herpes simplex virus does not require a low pH-dependent endocytic pathway
10.1016/0168-1702(91)90024-p · 1991 · External reference
Microtubulemediated transport of incoming herpes simplex virus 1 capsids to the nucleus
10.1083/jcb.136.5.1007 · 1997 · External reference
Induced extrusion of DNA from the capsid of herpes simplex virus type 1
10.1128/jvi.68.1.433-440.1994 · 1994 · External reference
Demonstration of circularization of herpes simplex virus DNA following infection using pulsed field gel electrophoresis
10.1006/viro.1993.1612 · 1993 · External reference
Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription
10.1016/0022-2836(84)90427-3 · 1984 · External reference
A modular system for the assay of transcription regulatory signals: the sequence TAATGARAT is required for herpes simplex virus immediate early gene activation
10.1093/nar/13.21.7847 · 1985 · External reference
Regulation of alpha genes of herpes simplex virus: the alpha 27 gene promoter-thymidine kinase chimera is positively regulated in converted L cells
10.1128/jvi.43.3.1015-1023.1982 · 1982 · External reference
Regulation of alpha genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with alpha gene promoters
10.1016/0092-8674(81)90346-9 · 1981 · External reference
The octamer-binding proteins form multiprotein-DNA complexes with the HSV alpha TIF regulatory protein
10.1002/j.1460-2075.1989.tb08608.x · 1989 · External reference
Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)
10.1016/s0021-9258(18)53282-8 · 1993 · External reference
The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, lu man, in its interaction with HCF
10.1128/jvi.72.8.6291-6297.1998 · 1998 · External reference
Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins
10.1073/pnas.84.20.7061 · 1987 · External reference
Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation
10.1016/s0092-8674(88)80036-9 · 1988 · External reference
The Oct-1 homeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16
10.1038/341624a0 · 1989 · External reference
The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein
10.1016/0092-8674(93)90299-6 · 1993 · External reference
The TAATGARAT motif in the herpes simplex virus immediate-early gene promoters can confer both positive and negative responses to cellular octamer-binding proteins when it is located within the viral genome
10.1128/jvi.72.4.3495-3500.1998 · 1998 · External reference
Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription
10.1128/jvi.72.7.5626-5637.1998 · 1998 · External reference
Transcription of herpes simplex virus immediate-early and early genes is inhibited by roscovitine, an inhibitor specific for cellular cyclin-dependent kinases
10.1128/jvi.73.3.2161-2172.1999 · 1999 · External reference
A viral inhibitor of peptide transporters for antigen presentation
10.1038/375415a0 · 1995 · External reference
Herpes simplex virus turns off the TAP to evade host immunity
10.1038/375411a0 · 1995 · External reference
A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes
10.1016/0092-8674(94)90215-1 · 1994 · External reference
Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4
10.1128/jvi.56.2.558-570.1985 · 1985 · External reference
Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4
10.1128/mcb.5.8.1997 · 1985 · External reference
Alpha 4, the major regulatory protein of herpes simplex virus type 1, is stably and specifically associated with promoter-regulatory domains of alpha genes and of selected other viral genes
10.1073/pnas.83.10.3218 · 1986 · External reference
Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA-deficient
10.1128/jvi.63.1.18-27.1989 · 1989 · External reference
The DNA-binding properties of the major regulatory protein alpha 4 of herpes simplex viruses
10.1126/science.2832940 · 1988 · External reference
Herpes simplex virus type 1 ICP27 is an essential regulatory protein
10.1128/jvi.55.3.796-805.1985 · 1985 · External reference
A herpes simplex virus type 1 function continuously required for early and late virus RNA synthesis
10.1038/285329a0 · 1980 · External reference
Trans activation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity
10.1002/j.1460-2075.1984.tb02270.x · 1984 · External reference
Herpes simplex virus infected cell polypeptide 4 preferentially represses Sp1-activated over basal transcription from its own promoter
10.1073/pnas.90.20.9528 · 1993 · External reference
Three trans-acting regulatory proteins of herpes simplex virus modulate immediate-early gene expression in a pathway involving positive and negative feedback regulation
10.1128/jvi.56.3.723-733.1985 · 1985 · External reference
Interaction of the viral activator protein ICP4 with TFIID through TAF250
10.1128/mcb.16.6.3085 · 1996 · External reference
ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB
10.1128/jvi.67.8.4676-4687.1993 · 1993 · External reference
The herpes simplex virus major regulatory protein ICP4 blocks apoptosis induced by the virus or by hyperthermia
10.1073/pnas.93.18.9583 · 1996 · External reference
The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus
10.1073/pnas.94.15.7891 · 1997 · External reference
The repressing and enhancing functions of the herpes simplex virus regulatory protein ICP27 map to C-terminal regions and are required to modulate viral gene expression very early in infection
10.1128/jvi.64.7.3471-3485.1990 · 1990 · External reference
Herpes simplex virus alpha protein ICP27 possesses separable positive and negative regulatory activities
10.1128/jvi.63.8.3399-3407.1989 · 1989 · External reference
Functional interactions between herpes simplex virus immediate-early proteins during infection: gene expression as a consequence of ICP27 and different domains of ICP4
10.1128/jvi.69.9.5705-5715.1995 · 1995 · External reference
Herpes simplex ICP27 mutant viruses exhibit reduced expression of specific DNA replication genes
10.1128/jvi.70.3.1969-1980.1996 · 1996 · External reference
Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect
10.1128/jvi.68.12.7790-7799.1994 · 1994 · External reference
The herpes simplex virus type 1 regulatory protein ICP27 co-immunoprecipitates with anti-Sm antiserum, and the C terminus appears to be required for this interaction
10.1128/jvi.70.1.108-118.1996 · 1996 · External reference
The herpes simplex virus immediate-early protein ICP27 shuttles between nucleus and cytoplasm
10.1006/viro.1997.9006 · 1998 · External reference
ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif
10.1101/gad.12.6.868 · 1998 · External reference
Shuttling of the herpes simplex virus type 1 regulatory protein ICP27 between the nucleus and cytoplasm mediates the expression of late proteins
10.1128/jvi.71.12.9188-9197.1997 · 1997 · External reference
Analysis of the phosphorylation sites of herpes simplex virus type 1 regulatory protein ICP27
10.1128/jvi.73.4.3246-3257.1999 · 1999 · External reference
Functional anatomy of herpes simplex virus 1 overlapping genes encoding infected-cell protein 22 and US1.5 protein
10.1128/jvi.73.5.4305-4315.1999 · 1999 · External reference
Alternatively spliced mRNAs predicted to yield frame-shift proteins and stable intron 1 RNAs of the herpes simplex virus 1 regulatory gene alpha 0 accumulate in the cytoplasm of infected cells
10.1073/pnas.93.22.12535 · 1996 · External reference
Processing of the herpes simplex virus regulatory protein alpha 22 mediated by the UL13 protein kinase determines the accumulation of a subset of alpha and gamma mRNAs and proteins in infected cells
10.1073/pnas.90.14.6701 · 1993 · External reference
Herpes simplex virus immediate-early protein ICP22 is required for viral modification of host RNA polymerase II and establishment of the normal viral transcription program
10.1128/jvi.69.9.5550-5559.1995 · 1995 · External reference
Herpes simplex virus 1 regulatory protein ICP22 interacts with a new cell cycle-regulated factor and accumulates in a cell cycle-dependent fashion in infected cells
10.1128/jvi.72.11.8525-8531.1998 · 1998 · External reference
A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICPO is modified in a cell-type specific manner and is recruited to the nucleus after infection
10.1128/jvi.73.5.3810-3817.1999 · 1999 · External reference
Association of herpes simplex virus regulatory protein ICP22 with transcriptional complexes containing EAP, ICP4, RNA polymerase II, and viral DNA requires posttranslational modification by the U(L)13 protein kinase
10.1128/jvi.71.2.1133-1139.1997 · 1997 · External reference
The herpes simplex virus type 1 regulatory protein ICPO enhances virus replication during acute infection and reactivation from latency
10.1128/jvi.67.12.7501-7512.1993 · 1993 · External reference
Activation of gene expression by herpes simplex virus type 1 ICPO occurs at the level of mRNA synthesis
10.1128/jvi.71.9.6850-6862.1997 · 1997 · External reference
Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency
10.1128/jvi.63.2.759-768.1989 · 1989 · External reference
The herpes simplex virus immediate-early protein ICPO affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27
10.1128/jvi.71.6.4614-4625.1997 · 1997 · External reference
Herpes simplex virus 1 alpha regulatory protein ICPO interacts with and stabilizes the cell cycle regulator cyclin D3
10.1128/jvi.71.10.7328-7336.1997 · 1997 · External reference
Interaction of herpes simplex virus 1 alpha regulatory protein ICPO with elongation factor I delta: ICPO affects translational machinery
10.1128/jvi.71.2.1019-1024.1997 · 1997 · External reference
Eukaryotic elongation factor idelta is hyperphosphorylated by the protein kinase encoded by the U(L)13 gene of herpes simplex virus 1
10.1128/jvi.72.3.1731-1736.1998 · 1998 · External reference
Cellular elongation factor 1delta is modified in cells infected with representative alpha-, beta-, or gammaherpesviruses
10.1128/jvi.73.5.4456-4460.1999 · 1999 · External reference
HSV-1 IE protein Vmw110 causes redistribution of PML
10.1002/j.1460-2075.1994.tb06835.x · 1994 · External reference
Specific destruction of kinetochore protein CENP-C and disruption of cell division by herpes simplex virus immediate-early protein Vmw110
10.1093/emboj/18.6.1526 · 1999 · External reference
Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICPO
10.1128/jvi.70.11.7471-7477.1996 · 1996 · External reference
Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase
10.1128/jvi.73.1.650-657.1999 · 1999 · External reference
A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein
10.1093/emboj/16.7.1519 · 1997 · External reference
A viral activator of gene expression functions via the ubiquitin-proteasome pathway
10.1093/emboj/17.24.7161 · 1998 · External reference
The ability of herpes simplex virus type 1 immediate-early protein Vmw110 to bind to a ubiquitin-specific protease contributes to its roles in the activation of gene expression and stimulation of virus replication
10.1128/jvi.73.1.417-426.1999 · 1999 · External reference
Herpes simplex virus infection of human fibroblasts and keratinocytes inhibits recognition by cloned CD8+ cytotoxic T lymphocytes
10.1172/jci116317 · 1993 · External reference
Herpes simplex virus type 1 renders infected cells resistant to cytotoxic T-lymphocyte-induced apoptosis
10.1128/jvi.72.1.436-441.1998 · 1998 · External reference
Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner
10.1073/pnas.95.7.3931 · 1998 · External reference
Herpes simplex virus 1 blocks caspase-3-independent and caspase-dependent pathways to cell death
10.1128/jvi.73.4.3219-3226.1999 · 1999 · External reference
Herpes simplex virus 1 helicase-primase: a complex of three herpes-encoded gene products
10.1073/pnas.86.7.2186 · 1989 · External reference
The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity
10.1128/jvi.64.12.5976-5987.1990 · 1990 · External reference
Genetic analysis of temperature-sensitive mutants which define the gene for the major herpes simplex virus type 1 DNA-binding protein
10.1128/jvi.45.1.354-366.1983 · 1983 · External reference
Herpes simplex virus DNA replication: the UL9 gene encodes an origin-binding protein
10.1073/pnas.85.15.5414 · 1988 · External reference
Interaction between the herpes simplex virus type 1 origin-binding and DNA polymerase accessory proteins
10.1006/viro.1997.8953 · 1998 · External reference
Anatomy of herpes simplex virus DNA: XII
1979 · External reference
Rolling circle DNA replication by extracts of herpes simplex virus type 1-infected human cells
10.1128/jvi.70.2.1132-1136.1996 · 1996 · External reference
Inversion events in the HSV-1 genome are directly mediated by the viral DNA replication machinery and lack sequence specificity
10.1016/0092-8674(88)90200-0 · 1988 · External reference
Branched structures in the intracellular DNA of herpes simplex virus type 1
10.1128/jvi.70.5.3169-3175.1996 · 1996 · External reference
Functional domains within the a sequence involved in the cleavage-packaging of herpes simplex virus DNA
10.1128/jvi.59.3.605-618.1986 · 1986 · External reference
Assembly of the herpes simplex virus capsid: characterization of intermediates observed during cell-free capsid formation
10.1006/jmbi.1996.0587 · 1996 · External reference
Assembly of the herpes simplex virus procapsid from purified components and identification of small complexes containing the major capsid and scaffolding proteins
10.1128/jvi.73.5.4239-4250.1999 · 1999 · External reference
Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins
10.1099/0022-1317-77-9-2251 · 1996 · External reference
Assembly of the herpes simplex virus capsid: preformed triplexes bind to the nascent capsid
10.1128/jvi.72.5.3944-3951.1998 · 1998 · External reference
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10.1073/pnas.79.5.1423 · 1982 · External reference
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10.1099/0022-1317-71-10-2377 · 1990 · External reference
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Characterization of an essential HSV-1 protein encoded by the UL25 gene reported to be involved in virus penetration and capsid assembly
10.1006/viro.1996.0061 · 1996 · External reference
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Physical and functional interactions between the herpes simplex virus UL15 and UL28 DNA cleavage and packaging proteins
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10.1006/viro.1996.0668 · 1996 · External reference
The herpes simplex virus type 1 cleavage/packaging protein, UL32, is involved in efficient localization of capsids to replication compartments
10.1128/jvi.72.3.2463-2473.1998 · 1998 · External reference
The product of the herpes simplex virus type 1 UL25 gene is required for encapsidation but not for cleavage of replicated viral DNA
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Isolation and characterization of herpes simplex virus type 1 mutants defective in the UL6 gene
10.1006/viro.1996.0098 · 1996 · External reference
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The herpes simplex virus 1 UL17 gene is required for localization of capsids and major and minor capsid proteins to intranuclear sites where viral DNA is cleaved and packaged
10.1006/viro.1998.9439 · 1998 · External reference
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Origin of unenveloped capsids in the cytoplasm of cells infected with herpes simplex virus 1
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10.1128/jvi.66.1.554-561.1992 · 1992 · External reference
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10.1128/jvi.73.1.377-387.1999 · 1999 · External reference
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The phospholipid composition of extracellular herpes simplex virions differs from that of host cell nuclei
10.1006/viro.1994.1252 · 1994 · External reference
Herpes simplex virus gD and virions accumulate in endosomes by mannose 6-phosphate-dependent and -independent mechanisms
10.1128/jvi.72.4.3330-3339.1998 · 1998 · External reference
Redistribution of microtubules and Golgi apparatus in herpes simplex virus-infected cells and their role in viral exocytosis
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Fragmentation and dispersal of Golgi proteins and redistribution of glycoproteins and glycolipids processed through the Golgi apparatus after infection with herpes simplex virus 1
10.1073/pnas.90.7.2798 · 1993 · External reference
Glycoproteins E and I facilitate neuron-to-neuron spread of herpes simplex virus
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The herpes simplex virus gE-gl complex facilitates cell-to-cell spread and binds to components of cell junctions
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Incorporation of the green fluorescent protein into the herpes simplex virus type 1 capsid
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Glycoprotein D of herpes simplex virus encodes a domain which precludes penetration of cells expressing the glycoprotein by superinfecting herpes simplex virus
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10.1128/jvi.58.3.843-850.1986 · 1986 · External reference
Characterization of the herpes simplex virus type 1 strain 17+ neurovirulence gene RL1 and its expression in a bacterial system
10.1099/0022-1317-75-4-733 · 1994 · External reference
The herpes simplex virus virulence factor ICP34.5 and the cellular protein MyD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5, MyD116, and GADD34
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The carboxyl terminus of the murine MyD116 gene substitutes for the corresponding domain of the gamma(1)34.5 gene of herpes simplex virus to preclude the premature shut-off of total protein synthesis in infected human cells
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Cell type and cell state determine differential in vitro growth of non-neurovirulent ICP34.5-negative herpes simplex virus types 1 and 2
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10.1099/0022-1317-73-4-971 · 1992 · External reference
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Biological characterization of a herpes simplex virus intertypic recombinant which is completely and specifically non-neurovirulent
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Peripheral replication and latency reactivation kinetics of the non- neurovirulent herpes simplex virus type 1 variant 1716
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The herpes simplex virus US11 protein effectively compensates for the gamma(1)34.5 gene if present before activation of protein kinase R by precluding its phosphorylation and that of the alpha subunit of eukaryotic translation initiation factor 2
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The gamma(1)34.5 gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programmed cell death in neuronal cells
10.1073/pnas.89.8.3266 · 1992 · External reference
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During latency, herpes simplex virus type 1 DNA is associated with nucleosomes in a chromatin structure
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Detection of herpes simplex virus-specific DNA sequences in latently infected mice and in humans
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Physical state of the latent herpes simplex virus genome in a mouse model system: evidence suggesting an episomal state
10.1016/0042-6822(87)90198-x · 1987 · External reference
Detection of HSV-1 genome in central nervous system of latently infected mice
10.1038/302523a0 · 1983 · External reference
Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence for intra-axonal transport of infection
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Comprehensive quantification of herpes simplex virus latency at the single-cell level
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Latent herpes simplex virus in human trigeminal ganglia
1987 · External reference
Latent herpes simplex virus type 1 transcripts in peripheral and central nervous system tissues of mice map to similar regions of the viral genome
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Herpes simplex virus latency-associated transcript is a stable intron
10.1073/pnas.88.3.790 · 1991 · External reference
The latency-associated transcripts of herpes simplex virus: RNA in search of function
10.1016/0042-6822(92)90160-q · 1992 · External reference
Detection of herpes simplex virus type 1 transcripts during latent infection in mice
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RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons
10.1126/science.2434993 · 1987 · External reference
Prominence of the herpes simplex virus latency-associated transcript in trigeminal ganglia from seropositive humans
10.1093/infdis/158.1.117 · 1988 · External reference
Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse
10.1073/pnas.86.19.7596 · 1989 · External reference
Herpes simplex virus type 1 latency-associated transcripts are evidently not essential for latent infection
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A 348-base-pair region in the latencyassociated transcript facilitates herpes simplex virus type 1 reactivation
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In vivo epinephrine reactivation of ocular herpes simplex virus type 1 in the rabbit is correlated to a 370-base-pair region located between the promoter and the 5′ end of the 2.0 kilobase latency-associated transcript
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A437-base-pair deletion at the beginning of the latency-associated transcript promoter significantly reduced adrenergically induced herpes simplex virus type 1 ocular reactivation in latently infected rabbits
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The region of the herpes simplex virus type 1 LAT gene that is co-linear with the ICP34.5 gene is not involved in spontaneous reactivation
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Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical sitedependent establishment and reactivation from latency
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The latencyassociated promoter of herpes simplex virus type 1 requires a region downstream of the transcription start site for long-term expression during latency
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Localization of cis-acting sequence requirements in the promoter of the latency-associated transcript of herpes simplex virus type 1 required for cell-typespecific activity
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Identification of the latency-associated transcript promoter by expression of rabbit beta globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus
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In vivo deletion analysis of the herpes simplex virus type 1 latencyassociated transcript promoter
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A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats
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Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections
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A cellular factor binding to the TAATGARAT DNA sequence prevents the expression of the HSV immediate-early genes following infection of nonpermissive cell lines derived from dorsal root ganglion neurons
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The herpes simplex virus type 1 immediate-early protein ICPO is necessary forthe efficient establishment of latent infection
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Reactivation of latent herpes simplex virus by adenovirus recombinants encoding mutant IE-0 gene products
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Replication, establishment of latency, and induced reactivation of herpes simplex virus gamma(1)34.5 deletion mutants in rodent models
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Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons
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