References

SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours

10.1038/bjc.1993.220 · 1993 · External reference

Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data

10.1016/0360-3016(84)90301-8 · 1984 · External reference

Oxygenation status of human tumors: a reappraisal using computerized pO2 histography

1995 · External reference

Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin

1993 · External reference

Cisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin [In Process Citation]

10.1038/sj.bjc.6690492 · 1999 · External reference

Survival benefit from tirazone (tirapazamine) and cisplatin in advanced non-small cell lung cancer (NSCLC) patients: final results from the international phase III CATAPULT 1 trial

1998 · External reference

SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells

10.1016/0360-3016(86)90267-1 · 1986 · External reference

Reoxygenation and rehypoxiation in the SCCVII mouse tumor

10.1016/0360-3016(94)90444-8 · 1994 · External reference

Physiological and cytotoxic effects of tirapazamine in tumor-bearing mice

10.1002/(sici)1520-6823(1997)5:5<213::aid-roi1>3.0.co;2-0 · 1997 · External reference

Concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy

10.1259/0007-1285-26-312-638 · 1953 · External reference

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

10.1016/0360-3016(88)90002-8 · 1988 · External reference

Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck

10.1016/s0167-8140(96)01811-7 · 1996 · External reference

Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

10.1016/s0360-3016(97)00101-6 · 1997 · External reference

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix

1996 · External reference

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma

1996 · External reference

Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors

1990 · External reference

Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation

10.1016/0360-3016(91)90057-b · 1991 · External reference

Concurrent tirapazamine and radiotherapy for advanced head and neck carcinomas: a phase II study

10.1016/s0360-3016(98)00310-1 · 1998 · External reference

Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity toward hypoxic tumour cells in vitro

10.1038/bjc.1996.187 · 1996 · External reference

Use of the comet assay to identify cells sensitive to tirapazamine in multicell spheroids and tumors in mice

1996 · External reference

Tirapazamineinduced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia

1997 · External reference

Oxygen tension measurements of tumors growing in mice

10.1016/s0360-3016(99)00157-1 · 1999 · External reference

Oxygen tension measurements of head and neck cancers

10.1001/archotol.1994.01880270031006 · 1994 · External reference

Tissue oxygen distribution in head and neck cancer patients

10.1002/(sici)1097-0347(199903)21:2<146::aid-hed8>3.0.co;2-u · 1999 · External reference

A new mouse tumor model system (RIF-1) for comparison of end-point studies

1980 · External reference

Effect of partition coefficient on the ability of nitroimidazoles to enhance the cytotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea

1983 · External reference

Factors influencing DNA migration from individual cells subjected to gel electrophoresis

10.1016/0014-4827(92)90378-l · 1992 · External reference

Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the “comet” assay

10.2307/3577587 · 1990 · External reference

Tirapazamine: laboratory data relevant to clinical activity

1998 · External reference

Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin

1993 · External reference

SR 4233: A tumor specific radiosensitizer active in fractionated radiation regimes

10.1016/0167-8140(91)90203-s · 1991 · External reference

Therapeutic advantage of hypoxic cells in tumors: a theoretical study

10.1093/jnci/83.3.178 · 1991 · External reference

Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose escalation strategy in a phase I trial

10.1007/s002800050617 · 1997 · External reference

Tirapazamine is metabolized to its DNA damaging radical by intranuclearenzymes

1998 · External reference

Measurement of human tumour oxygenation status by a polarographic needle electrode

10.3109/02841869409098433 · 1994 · External reference

Oxygenation of head and neck tumors

10.1002/1097-0142(19930401)71:7<2319::aid-cncr2820710724>3.0.co;2-c · 1993 · External reference

Cells at intermediate oxygen levels can be more important than the “hypoxic fraction” in determining tumor response to fractionated radiotherapy

10.2307/3579620 · 1997 · External reference

Stable translocations detected by fluorescence in situ hybridization: a rapid surrogate end point to evaluate the efficacy of a potentiator of tumor response to radiotherapy

1997 · External reference

Detection of etoposide resistance by measuring DNA damage in individual Chinese hamster cells

10.1093/jnci/82.9.779 · 1990 · External reference

Detection of DNA-crosslinking agents with the alkaline comet assay

10.1002/(sici)1098-2280(1996)27:3<196::aid-em4>3.0.co;2-d · 1996 · External reference

Measuring DNA damage in individual cells of heterogeneous mixtures: a novel application of an immunological typing technique

10.1016/0027-5107(94)90213-5 · 1994 · External reference