Research graph
References from Dial 9-1-1 for p53: Mechanisms of p53 Activation by Cellular Stress. Local targets link to admitted publications; unresolved targets remain external evidence.
p53, the cellular gatekeeper for growth and division
10.1016/s0092-8674(00)81871-1 · 1997 · External reference
Sunburn and p53 in the onset of skin cancer
10.1038/372773a0 · 1994 · External reference
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis
1990 · External reference
Apoptosis in cancer therapy: crossing the threshold
10.1016/0092-8674(94)90518-5 · 1994 · External reference
Structure and function of the p53tumor suppressor gene: clues for rational cancer therapeutic strategies
10.1093/jnci/88.20.1442 · 1996 · External reference
The 1993 Walter Hubert lecture: the role of the p53 tumoursuppressor gene in tumorigenesis
10.1038/bjc.1994.76 · 1994 · External reference
p53: puzzle and paradigm
10.1101/gad.10.9.1054 · 1996 · External reference
Role of p53 in apoptosis
10.1016/s1054-3589(08)61068-6 · 1997 · External reference
COOH-terminal domain of p53 modulates p53-mediated transcriptional transactivation, cell growth, and apoptosis
1999 · External reference
UV irradiation stimulates levels of p53 cellular antigen in nontransformed mouse cells
10.1128/mcb.4.9.1689 · 1984 · External reference
Induction of nuclear accumulation of the tumor suppressor protein p53 by DNA-damaging agents
1993 · External reference
Regulation of the specific DNA binding function of p53
10.1016/0092-8674(92)90562-q · 1992 · External reference
Regulation of p53 protein function through alterations in protein-folding pathways
10.1007/s000180050272 · 1999 · External reference
Regulation of the p53 protein by the MDM2 oncoprotein — thirty-eighth G.H.A
1999 · External reference
p53-mediated protective responses to UV irradiation
10.1073/pnas.94.23.12255 · 1997 · External reference
Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses
10.1038/sj.onc.1202676 · 1999 · External reference
Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element
10.1101/gad.6.7.1143 · 1992 · External reference
Wild-type p53 activates transcription in vitro
10.1038/358083a0 · 1992 · External reference
Wild-type p53 can downmodulate the activity of various promoters
10.1073/pnas.88.22.9979 · 1991 · External reference
Wild-type p53 binds to the TATA-binding protein and repress transcription
10.1073/pnas.89.24.12028 · 1992 · External reference
Reversal of in vitro p53 squelching by both TFIIB and TFIID
10.1128/mcb.15.11.6474 · 1995 · External reference
p53 represses ribosomal gene transcription
10.1038/sj.onc.1202402 · 1999 · External reference
Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a
10.1101/gad.13.19.2490 · 1999 · External reference
The p21 cdk-interacting protein Cipi is a potent inhibitor of G1 cyclindependent kinases
10.1016/0092-8674(93)90499-g · 1993 · External reference
p53-dependent inhibition of cyclindependent kinase activities in human fibroblasts during radiationinduced G1 arrest
10.1016/0092-8674(94)90379-4 · 1994 · External reference
Involvement of the p53 tumor suppressor in repair of UV-type DNA damage
1995 · External reference
Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance
10.1073/pnas.92.19.8876 · 1995 · External reference
Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts
10.1074/jbc.272.44.28073 · 1997 · External reference
Wild-type p53 is required for heat shock and ultraviolet-light-enhanced repair of a UV-damaged reporter gene
10.1093/carcin/18.2.245 · 1997 · External reference
Expression of the p48xeroderma pig mentosum gene is p53 -dependent and is involved in global genomic repair
10.1073/pnas.96.2.424 · 1999 · External reference
Potential roles for p53 in nucleotide excision repair
10.1093/carcin/20.8.1389 · 1999 · External reference
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16(INK4a)
10.1016/s0092-8674(00)81902-9 · 1997 · External reference
10.1038/sj.neo.7900028 · 1999 · Admitted local publication
p53 is required for radiation-induced apoptosis in mouse thymocytes
10.1038/362847a0 · 1993 · External reference
Thymocyte apoptosis induced by p53-dependent and independent pathways
10.1038/362849a0 · 1993 · External reference
Differential induction of transcriptionally active p53 following UV or ionizing radiation – defects in chromosome instability syndromes?
10.1016/0092-8674(93)90496-d · 1993 · External reference
Apaf-1 and caspase-9 in p53dependent apoptosis and tumor inhibition
10.1126/science.284.5411.156 · 1999 · External reference
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
10.1016/0092-8674(95)90412-3 · 1995 · External reference
Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression
10.1128/mcb.15.6.3032 · 1995 · External reference
KILLER/DR5isaDNA damage- inducible p53-regulated death receptor gene
1997 · External reference
Induction of apoptosis in HeLa cells by transactivation-deficient p53
10.1101/gad.9.17.2170 · 1995 · External reference
Reactive oxygen species are downstream mediators of p53-dependent apoptosis
10.1073/pnas.93.21.11848 · 1996 · External reference
A model for p53-induced apoptosis
10.1038/38525 · 1997 · External reference
p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2
10.1093/emboj/18.21.6027 · 1999 · External reference
Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis
10.1126/science.282.5387.290 · 1998 · External reference
Ultraviolet-radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1)
10.1074/jbc.272.41.25783 · 1997 · External reference
Fas ligand: a sensor for DNA damage critical in skin cancer etiology
10.1126/science.285.5429.898 · 1999 · External reference
10.1038/sj.neo.7900003 · 1999 · Admitted local publication
Caspases: the proteases of the apoptotic pathway
10.1038/sj.onc.1202581 · 1998 · External reference
The cellular response to p53: the decision between life and death
10.1038/sj.onc.1203130 · 1999 · External reference
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
10.1016/0092-8674(90)90409-8 · 1990 · External reference
Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway
10.1128/mcb.14.3.1997 · 1994 · External reference
In vivo ubiquitination and proteasome-mediated degradation of p53
1996 · External reference
Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation
10.1128/mcb.17.1.355 · 1997 · External reference
Mechanism of p53 degradation
1997 · External reference
The ubiquitin system
10.1016/s0968-0004(97)01122-5 · 1997 · External reference
Proteasomes: destruction as a programme
10.1016/s0968-0004(96)10012-8 · 1996 · External reference
How the cyclin became a cyclin: regulated proteolysis in the cell cycle
10.1016/s0092-8674(00)80753-9 · 1999 · External reference
Structure and functions of the 20S and 26S proteosomes
10.1146/annurev.bi.65.070196.004101 · 1996 · External reference
Mdm2 promotes the rapid degradation of p53
10.1038/387296a0 · 1997 · External reference
Regulation of p53 stability by Mdm2
10.1038/387299a0 · 1997 · External reference
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
10.1016/s0014-5793(97)01480-4 · 1997 · External reference
Mdm2 association with p53 targets its ubiquitination
10.1038/sj.onc.1202200 · 1998 · External reference
Regulation of Mdm2-directed degradation by the C-terminus of p53
10.1128/mcb.18.10.5690 · 1998 · External reference
p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding
10.1038/sj.onc.1201459 · 1997 · External reference
JNK targets p53 ubiquitination and degradation in nonstressed cells
10.1101/gad.12.17.2658 · 1998 · External reference
Stress-activated kinases regulate protein stability
10.1038/sj.onc.1202184 · 1998 · External reference
Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability
10.1128/mcb.17.1.460 · 1997 · External reference
Proteolysis by calpains: a possible contribution to degradation of p53
10.1128/mcb.17.5.2806 · 1997 · External reference
On the involvement of calpains in the degradation of the tumor suppressor protein p53
10.1016/s0014-5793(97)00225-1 · 1997 · External reference
Inhibition of RNA polymerase II as a trigger for the p53 response
10.1038/sj.onc.1202356 · 1999 · External reference
UV-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle
1994 · External reference
Blockage of RNA polymerase as a possible trigger for UV light-induced apoptosis
1996 · External reference
Prolonged p53 protein accumulation in trichothiodystrophy fibroblasts dependent on unrepaired pyrimidine dimers on the transcribed strands of cellular genes
10.1002/(sici)1098-2744(199712)20:4<340::aid-mc3>3.0.co;2-n · 1997 · External reference
Persistent DNA damage induced by ultraviolet light inhibits p21 (waft) and bax expression: implications for DNA repair, UV sensitivity and the induction of apoptosis
10.1038/sj.onc.1201963 · 1998 · External reference
Gene and transcription mapping by radiation effects
10.1146/annurev.ge.12.120178.001553 · 1978 · External reference
Transcription preferentially inhibits nucleotide excision repair of the template DNA strand in vitro
10.1016/s0021-9258(17)45364-6 · 1990 · External reference
Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template
10.1073/pnas.91.18.8502 · 1994 · External reference
The M015 cell cycle kinase is associated with the TFIIH transcription DNA repair factor
10.1016/0092-8674(94)90039-6 · 1994 · External reference
p53 is phosphorylated by CDK7-cyclin H in a p36 (MATT)-dependent manner
10.1128/mcb.17.12.7220 · 1997 · External reference
The CDK7-cycHp36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro
10.1128/mcb.17.10.5923 · 1997 · External reference
TAFII250 is a bipartite protein kinase that phosphorylates the basal transcription factor RAP74
10.1016/s0092-8674(00)81055-7 · 1996 · External reference
The TAF(II)250 subunit of TRID has histone acetyltransferase activity
10.1016/s0092-8674(00)81821-8 · 1996 · External reference
The MDM2 C-terminal region binds to TAF (II) 250 and is required for MDM2 regulation of the cyclin A promoter
10.1074/jbc.272.49.30651 · 1997 · External reference
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
10.1016/s0092-8674(00)80521-8 · 1997 · External reference
DNA damage activates p53 through a phosphorylation-acetylation cascade
10.1101/gad.12.18.2831 · 1998 · External reference
Drug and metabolite-induced perturbations in nuclear structure and function: a review
10.1139/o90-059 · 1990 · External reference
Inhibition of RNA polymerase II transcription causes chromatin decondensation, loss of nucleolar structure, and dispersion of chromosomal domains
10.1006/excr.1996.0124 · 1996 · External reference
Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53
10.1128/mcb.19.5.3704 · 1999 · External reference
Chemical changes induced in DNA by ionizing radiation
10.1016/s0079-6603(08)60347-5 · 1985 · External reference
DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and repairability
10.1016/s0079-6603(08)60611-x · 1988 · External reference
Repair of radiation-induced DNA strand breaks does not occur preferentially in transcriptionally active DNA
10.2307/3580230 · 1999 · External reference
DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall
10.1016/0092-8674(85)90150-3 · 1985 · External reference
Participation of p53 protein in the cellular response to DNA damage
1991 · External reference
DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways
10.1128/mcb.14.3.1815 · 1994 · External reference
Localized torsional tension in the DNA of human cells
10.1073/pnas.89.13.6055 · 1992 · External reference
Presence of negative torsional tension in the promoter region of the transcriptionally poised dihydrofolate reductase gene in vivo
10.1093/nar/23.10.1782 · 1995 · External reference
Altered telomere nuclear matrix interactions and nucleosomal periodicity in ataxia telangiectasia cells before and after ionizing radiation treatment
10.1128/mcb.19.10.6963 · 1999 · External reference
Sensitivity and selectivity of the DNA damage sensor responsible for activating p53dependent G (1) arrest
10.1073/pnas.93.10.4827 · 1996 · External reference
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
10.1038/21690 · 1999 · External reference
Interaction of cAbl and p73 alpha and their collaboration to induce apoptosis
10.1038/21697 · 1999 · External reference
P73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
10.1038/21704 · 1999 · External reference
c-Abl neutralizes the inhibitory effect of Mdm2 on p53
10.1074/jbc.274.13.8371 · 1999 · External reference
Defective induction of stress-activated protein kinase activity in ataxia telangiectasia cells exposed to ionizing radiation
1995 · External reference
ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
10.1038/542 · 1998 · External reference
Inhibitors of the proteosome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
10.1016/s0092-8674(94)90462-6 · 1994 · External reference
Activation of the cell death program by nitric oxide involves inhibition of the proteasome
10.1074/jbc.274.28.19581 · 1999 · External reference
Excess beta-catenin promotes accumulation of transcriptionally active p53
10.1093/emboj/18.11.3054 · 1999 · External reference
Spectrum of DNAplatinum adduct recognition by prokaryotic and eukaryotic DNAdependent RNA polymerases
10.1021/bi00084a027 · 1993 · External reference
DNA adducts of cis-diamminedichloroplatinum(II) and its trans-isomer inhibit RNA polymerase II differentially in vivo
10.1021/bi00045a020 · 1995 · External reference
Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents
10.1073/pnas.96.19.10764 · 1999 · External reference
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia telangiectasia
10.1016/0092-8674(92)90593-2 · 1992 · External reference
Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation
10.1128/mcb.17.9.5016 · 1997 · External reference
The hMreii/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to cellular DNA damage response
10.1016/s0092-8674(00)81175-7 · 1998 · External reference
Ionizing radiation and UV induction of p53 by different pathways in ataxia telangiectasia cells
1993 · External reference
Requirement of ATM-dependent phosphorylation of Brca-1 in the DNA damage response to double-strand breaks
10.1126/science.286.5442.1162 · 1999 · External reference
Purification and DNA binding properties of the ataxia telangiectasia gene product ATM
10.1073/pnas.96.20.11134 · 1999 · External reference
Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation
10.1074/jbc.274.36.25571 · 1999 · External reference
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
10.1126/science.281.5383.1677 · 1998 · External reference
Enhanced phosphorylation of p53 by ATN in response to DNA damage
10.1126/science.281.5383.1674 · 1998 · External reference
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine
1999 · External reference
Caffeine inhibits the checkpoint kinase ATM
10.1016/s0960-9822(99)80486-2 · 1999 · External reference
Phosphorylation of p53 serine 15 increases interaction with CBP
10.1074/jbc.273.49.33048 · 1998 · External reference
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity
10.1038/sj.onc.1202656 · 1999 · External reference
Phosphorylation of p53: a novel pathway for p53 inactivation in human T-cell lymphotropic virus type 1-transformed cells
10.1128/jvi.72.8.6348-6355.1998 · 1998 · External reference
Inhibition of phosphoinostide 3-kinase related kinases by the radiosenzitizing agent, wortmannin
1998 · External reference
A role for ATR in the DNA damage-induced phosphorylation of p53
10.1101/gad.13.2.152 · 1999 · External reference
Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control
10.1073/pnas.95.13.7445 · 1998 · External reference
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
10.1093/emboj/17.1.159 · 1998 · External reference
The ataxia telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53
10.1038/sj.onc.1202973 · 1999 · External reference
Covalent and noncovalent modifiers of the p53 protein
10.1007/s000180050271 · 1999 · External reference
The ability of p53 to activate downstream genes p21WAF1/cip1 and MDM2, and cell cycle arrest following DNA damage is delayed and attenuated in scid cells deficient in the DNAdependent protein
10.1074/jbc.274.19.13111 · 1999 · External reference
Phosphorylation of p53 protein in response to ionizing radiation occurs at multiple sites in both normal and DNA- PK deficient cells
10.1038/sj.onc.1202454 · 1999 · External reference
Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells
1999 · External reference
DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage
10.1038/21913 · 1999 · External reference
P53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts
1996 · External reference
DNA-dependent protein kinase inhibitor (OK-1035) suppresses p21 expression in HCT116 cells containing wild-type p53 induced by adriamycin
10.1006/bbrc.1996.0575 · 1996 · External reference
JNKI, JNK2 and JNK3 are p53 N -terminal serine 34 kinases
10.1038/sj.onc.1201401 · 1997 · External reference
p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c -Jun kinase, JNK1
10.1074/jbc.270.10.5511 · 1995 · External reference
MEKKI /JNK signaling stabilizes and activates p53
10.1073/pnas.95.18.10541 · 1998 · External reference
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
10.1101/gad.7.11.2135 · 1993 · External reference
Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
10.1038/387516a0 · 1997 · External reference
Interaction between ATM protein and c-Abl in response to DNA damage
10.1038/387520a0 · 1997 · External reference
Functional interaction between DNA- PK and c-Abl in response to DNA damage
10.1038/386732a0 · 1997 · External reference
p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs
10.1038/sj.onc.1201541 · 1997 · External reference
The p53 tumor suppressor protein is phosphorylated at serine 389 by casein kinase II
10.1002/j.1460-2075.1990.tb07524.x · 1990 · External reference
Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation
10.1093/nar/24.6.1119 · 1996 · External reference
Two distinct signaling pathways activate the latent DNA binding function of p53 in a casein kinase IIindependent manner
10.1074/jbc.270.30.18165 · 1995 · External reference
Casein kinase 2 inhibits the renaturation of complementary DNA strands mediated by p53 protein
10.1042/bj3160331 · 1996 · External reference
Mapping of the interaction sites of the growth suppressor protein p53 with the regulatory b-subunit of protein kinase CK2
1995 · External reference
Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53
10.1021/bi970759w · 1997 · External reference
MATT, cdk7 and cyclin H form a complex which is UV light-sensitive upon association with TFIIH
10.1002/j.1460-2075.1996.tb00538.x · 1996 · External reference
Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases
10.1074/jbc.270.10.5405 · 1995 · External reference
Regulation of the p53 protein by protein kinase Cα and protein kinase Cξ
10.1006/bbrc.1998.8471 · 1998 · External reference
Downregulation of protein kinase C suppresses induction of apoptosis in human prostatic carcinoma cells
10.1006/excr.1996.0127 · 1996 · External reference
Murine p53 is phosphorylated within the PAb421 epitope by protein kinase C in vitro, but not in vivo, even after stimulation with the phorbol ester o-tetradecanoylphorbol 13-acetate
1996 · External reference
Induction of protein kinase C activity by ultraviolet radiation
10.1093/carcin/11.2.229 · 1990 · External reference
Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2
10.1073/pnas.87.12.4766 · 1990 · External reference
p53 interacts with p34cdc2 in mammalian cells: implica tions for the cell cycle control and oncogenesis
1990 · External reference
cdk2 kinase phosphorylates serine 315 of human p53 in vitro
1995 · External reference
Fine mapping and regulation of the association of p53 with p34 (Cdc2)
10.1038/sj.onc.1201510 · 1998 · External reference
Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases
10.1038/376088a0 · 1995 · External reference
Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation
10.1126/science.8493533 · 1993 · External reference
Ultraviolet B irradiation-induced G2 cell cycle arrest in human keratinocytes by inhibitory phosphorylation of the cdc2 cell cycle kinase
1995 · External reference
Cyclindependent kinases are inactivated by a combination of p21 and Thr14/Tyr-15 phosphorylation after UV-induced DNA damage
10.1074/jbc.271.22.13283 · 1996 · External reference
The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells
1997 · External reference
p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389
10.1074/jbc.274.18.12229 · 1999 · External reference
The double-stranded RNA activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53
10.1128/mcb.19.4.2475 · 1999 · External reference
The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro
10.1038/sj.onc.1202620 · 1999 · External reference
DNA damage -inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization
10.1093/emboj/18.7.1815 · 1999 · External reference
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
10.1093/emboj/18.7.1805 · 1999 · External reference
Raf phosphorylates p53 in vitro and potentiates p53-dependent transcriptional transactivation in vivo
1995 · External reference
Activation of Raf by ionizing radiation
10.1038/382813a0 · 1996 · External reference
UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase
10.1002/j.1460-2075.1993.tb05741.x · 1993 · External reference
The mammalian ultraviolet response is triggered by activation of Src tyrosine kinase
10.1016/s0092-8674(05)80058-3 · 1992 · External reference
Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation
10.1074/jbc.272.24.15220 · 1997 · External reference
Regulation of protein kinase cascades by protein phosphatase 2A
10.1016/s0968-0004(99)01375-4 · 1999 · External reference
Serine/threonine protein phosphatase type 5 acts upstream of p53 to regulate the induction of p21 WAFi ic'pi and mediate growth arrest
10.1074/jbc.273.20.12250 · 1998 · External reference
A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast
10.1074/jbc.272.47.29403 · 1997 · External reference
Role for p300 in stabilization of p53 in the response to DNA damage
10.1074/jbc.274.4.1883 · 1999 · External reference
p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
10.1128/mcb.19.2.1202 · 1999 · External reference
Function for p300 and not CBP in the apoptotic response to DNA damage
10.1038/sj.onc.1202930 · 1999 · External reference
ADP-ribosylation of p53 tumor suppressor protein: mutant but not wild-type p53 is modified
10.1002/(sici)1097-4644(199607)62:1<90::aid-jcb10>3.0.co;2-j · 1996 · External reference
ADPribosylation of wild-type p53 in vitro: binding of p53 protein to specific p53 consensus sequence prevents its modification
10.1006/bbrc.1996.0990 · 1996 · External reference
Effects of 3-aminobenzamide on the rejoining of DNA-strand breaks in mammalian cells exposed to methyl methanesulphonate; role of poly (ADP-ribose) polymerase
1988 · External reference
Poly ADP-ribosylation: a DNA break signal mechanism
10.1023/a:1006975002262 · 1999 · External reference
DNA repair: PARP - another guardian angel?
10.1016/s0960-9822(98)70032-6 · 1997 · External reference
Functional interactions of p53 with poly (ADP-ribose) polymerase (PARP) during apoptosis following DNA damage: covalent poly (ADP-ribosyl)ation of p53 by exogenous PARP and noncovalent binding of p53 to the Mr 85,000 proteolytic fragment
1998 · External reference
Modulation of (±) -anti-BPDE mediated p53 accumulation by inhibitors of protein kinase C and poly (ADP-ribose) polymerase
10.1038/sj.onc.1200890 · 1997 · External reference
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the posttranslational activation of p53 protein involving poly (ADP-ribose) polymerase
10.1093/emboj/16.19.6018 · 1997 · External reference
Reduced stability of regularly spliced but not alternatively spliced p53 protein in PARP-deficient mouse fibroblasts
1999 · External reference
Poly (ADP -ribosyl)ation of p53 during apoptosis in human osteosarcoma cells
1999 · External reference
Poly (ADP- ribosyl)ation is required for p53-dependent signal transduction induced by radiation
10.1038/sj.onc.1202216 · 1998 · External reference
Involvement of NAD-poly(ADP-ribose) metabolism in p53 regulation and its consequences
1995 · External reference
Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-kappaB and Myc/ Max
10.1038/sj.onc.1202626 · 1999 · External reference
YYi and NF1 both activate the human p53 promoter by alternatively binding to a composite element, and YYi and EIA cooperate to amplify p53 promoter activity
10.1128/mcb.16.10.5933 · 1996 · External reference
Loss of p53 function through PAX-mediated transcriptional repression
10.1002/j.1460-2075.1995.tb00251.x · 1995 · External reference
Transcriptional repression of p53 by human T-cell leukemia virus type I tax protein
10.1074/jbc.270.48.28503 · 1995 · External reference
Control of cell cycle progression by c-Jun is p53-dependent
10.1101/gad.13.5.607 · 1999 · External reference
Wild-type p53 regulates its own transcription in a cell-type specific manner
10.1089/dna.1995.14.759 · 1995 · External reference
Identification of a novel p53 promoter element involved in genotoxic stress- inducible p53 gene expression
10.1128/mcb.15.8.4489 · 1995 · External reference
Participation of the human p53 3' UTR in translational repression and activation following gammairradiation
10.1093/emboj/16.13.4117 · 1997 · External reference
Negative feedback regulation of wild-type p53 biosynthesis
10.1002/j.1460-2075.1995.tb00123.x · 1995 · External reference
Translational regulation of human p53 gene expression
10.1002/j.1460-2075.1996.tb00812.x · 1996 · External reference
Regulation of p53 expression by thymidylate synthase
10.1073/pnas.96.7.3769 · 1999 · External reference
Functions of the MDM2 oncoprotein
10.1007/s000180050273 · 1999 · External reference
Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
10.1128/mcb.18.12.7288 · 1998 · External reference
Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53
1997 · External reference
The Ink4a tumor suppressor gene product, pi 9(Arf), interacts with MDM2 and neutralizes MDM2's inhibition of p53
10.1016/s0092-8674(00)81400-2 · 1998 · External reference
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
10.1016/s0092-8674(00)81401-4 · 1998 · External reference
The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2
10.1093/emboj/17.17.5001 · 1998 · External reference
Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
10.1093/emboj/18.1.22 · 1999 · External reference
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
10.1016/s0092-8674(00)80452-3 · 1997 · External reference
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
10.1101/gad.12.15.2424 · 1998 · External reference
p19ARF links the tumour suppressor p53 to Ras
10.1038/25870 · 1998 · External reference
p14ARF links the tumour suppressors RB and p53
10.1038/25867 · 1998 · External reference
EIA signaling to p53 involves the p19ARF tumor suppressor
10.1101/gad.12.15.2434 · 1998 · External reference
INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53
10.1101/gad.13.20.2670 · 1999 · External reference
The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and downregulated by wild-type p53
10.1128/mcb.18.11.6457 · 1998 · External reference
DNA damageinduced phosphorylation of p53 alleviates inhibition by MDM2
10.1016/s0092-8674(00)80416-x · 1997 · External reference
DNA damage induces phosphorylation of the amino terminus of p53
10.1101/gad.11.24.3471 · 1997 · External reference
Subcellular distribution of the p53 protein during the cell cycle of Balb/c 3T3 cells
1990 · External reference
Cell cycle-dependent regulation of nuclear p53 traffic occurs in one subclass of human tumor cells and in untransformed cells
1996 · External reference
Intracellular localization of p53 tumor suppressor protein in gamma-irradiated cells is cell cycle regulated and determined by the nucleus
1997 · External reference
Cooperation of a single lysine mutation and a C-terminal domain in the cytoplasmic sequestration of the p53 protein
10.1074/jbc.273.31.19817 · 1998 · External reference
The nuclear import of p53 is determined by the presence of a basic domain and its relative position to the nuclear localization signal
10.1038/sj.onc.1202350 · 1999 · External reference
A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxylterminal domain
10.1074/jbc.274.46.32699 · 1999 · External reference
Nucleocytoplasmic transport: signals, mechanisms and regulation
10.1038/386779a0 · 1997 · External reference
Getting across the nuclear pore complex
10.1016/s0962-8924(99)01608-6 · 1999 · External reference
Transport pathways of macromolecules between the nucleus and the cytoplasm
10.1016/s0955-0674(99)80056-8 · 1999 · External reference
A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking
10.1093/emboj/18.6.1660 · 1999 · External reference
Two distinct mechanism alter p53 in breast cancer: mutation and nuclear exclusion
10.1073/pnas.89.15.7262 · 1992 · External reference
Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors
10.1073/pnas.92.10.4407 · 1995 · External reference
c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle
10.1073/pnas.91.13.5878 · 1994 · External reference
Bcl-2 inhibits p53 nuclear import following DNA damage
10.1038/sj.onc.1201464 · 1997 · External reference
Regulation of transcription factor localization: fine-tuning of gene expression
10.1016/s0968-0004(96)80182-4 · 1996 · External reference
Characterization of sequence elements involved in p53 stability regulation reveals cell type dependence for p53 degradation
10.1038/sj.onc.1202282 · 1998 · External reference
DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation
10.1038/sj.onc.1202480 · 1999 · External reference
Regulation of p53 function and stability by phosphorylation
10.1128/mcb.19.3.1751 · 1999 · External reference
The phosphotase Cdc14 triggers mitotic exit by reversal of Cdkdependent phosphorylation
10.1016/s1097-2765(00)80286-5 · 1998 · External reference
Small peptides activate the latent sequence-specific DNA binding function of p53
10.1016/0092-8674(95)90165-5 · 1995 · External reference
An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to UIA-positive nuclear bodies associated with the PODS
10.1006/excr.1999.4433 · 1999 · External reference
Identification of redox/repair protein Ref-1 as a potent activator of p53
10.1101/gad.11.5.558 · 1997 · External reference
High mobility group protein-1 (HMG-1) is a unique activator of p53
10.1101/gad.12.4.462 · 1998 · External reference
Synergistic activation of transcription by CBP and p53
10.1038/42972 · 1997 · External reference
Binding and modulation of p53 by p300/CBP coactivators
10.1038/42981 · 1997 · External reference
CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein
1997 · External reference
Recruitment of p300/CBP in p53-dependent signal pathways
10.1016/s0092-8674(00)80304-9 · 1997 · External reference
Cooperative DNA binding of p53 with TRID (TBP) - a possible mechanism for transcriptional activation
10.1101/gad.7.10.1837 · 1993 · External reference
p53 binds to the TATA-binding protein-TATA complexes
10.1016/s0021-9258(19)38619-3 · 1993 · External reference
Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53
10.1128/mcb.14.10.7013 · 1994 · External reference
Functional interactions between p53 and the TFIIH complex are affected by tumour-associated mutations
10.1002/j.1460-2075.1996.tb00506.x · 1996 · External reference
Functional interaction between p53, the TATA-binding protein (TBP), and TBP-associated factors in vivo
10.1128/mcb.16.8.4295 · 1996 · External reference
p53 and Spi interact and cooperate in the tumor necrosis factor-induced transcriptional activation of the HIV-1 long terminal repeat
10.1074/jbc.270.34.19680 · 1995 · External reference
A novel cofactor for p300 that regulates the p53 response
10.1016/s1097-2765(00)80338-x · 1999 · External reference
The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53
10.1073/pnas.96.18.10355 · 1999 · External reference
Activation of mammalian gene expression by the UV component of sunlight - from models to reality
10.1002/bies.950180210 · 1996 · External reference
Transcriptional cross talk between NF- kappaB and p53
10.1128/mcb.19.5.3485 · 1999 · External reference
CREB-binding protein is a nuclear integrator of nuclear factor-kappaB and p53 signaling
10.1074/jbc.274.4.1879 · 1999 · External reference
A viral mechanism for inhibition of p300 and PCAF acetyl transferase activity
10.1016/s0092-8674(00)80552-8 · 1999 · External reference
Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein EIA
10.1016/s0092-8674(00)80553-x · 1999 · External reference
Attenuated response of p53 and p21 in primary cultures of human prostatic epithelial cells exposed to DNA-damaging agents
1995 · External reference
ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage
10.1016/s0960-9822(98)70061-2 · 1998 · External reference
Human mammary epithelial cells exhibit a differential p53-mediated response following exposure to ionizing radiation or UV light
10.1038/sj.onc.1202977 · 1999 · External reference
Arsenic disrupts cellular levels of p53 and mdm2: a potential mechanism of carcinogenesis
10.1006/bbrc.1999.1395 · 1999 · External reference
Cadmium induces conformational modifications of wild-type p53 and suppresses p53 response to DNA damage in cultured cells
10.1074/jbc.274.44.31663 · 1999 · External reference
Simian virustransformed cells express new species of proteins precipitable by anti-simian virus 40 tumor serum
10.1128/jvi.31.2.472-483.1979 · 1979 · External reference
T antigen is bound to a host protein in SV40-transformed cells
10.1038/278261a0 · 1979 · External reference
Characterization of a 54K dalton cellular SV40 tumour antigen present in SV40 transformed cells and uninfected embryonal carcinoma cells
10.1016/0092-8674(79)90293-9 · 1979 · External reference
A reversible, p53-dependent G(0) /G(1) cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
10.1101/gad.10.8.934 · 1996 · External reference
Enhancement of DNA repair in human skin cells by thymidine dinucleotides: evidence for a p53-mediated mammalian SOS response
10.1073/pnas.94.23.12627 · 1997 · External reference
Induction of cellular p53 activity by DNA-damaging agents and growth arrest
10.1128/mcb.13.7.4242 · 1993 · External reference
Hypoxia induces accumulation of p53 protein, but activation of a G(I)-phase checkpoint by low-oxygen conditions is independent of p53 status
10.1128/mcb.14.9.6264 · 1994 · External reference
Flavonoids activate wild-type p53
1996 · External reference
Antioxidant action via p53-mediated apoptosis
1998 · External reference
Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents
1993 · External reference
p53 proteins accumulated by heat stress associate with heat shock proteins HSP72/HSC73 in human glioblastoma cells lines
10.1016/0304-3835(94)90407-3 · 1994 · External reference
p53dependent induction of WAFT by cold shock in human glioma cells
10.1038/sj.onc.1201663 · 1998 · External reference
Wild-type p53 mediates apoptosis by EIA which is inhibited by El B
10.1101/gad.7.4.546 · 1993 · External reference
Rb regulates the stability and the apoptotic function of p53 via MDM2
1999 · External reference
Phosphorylation of human p53 by p38 kinase coordinates N-terminal Phosphorylation and apoptosis in response to UV irradiation
10.1093/emboj/18.23.6845 · 1999 · External reference
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
10.1073/pnas.96.24.13777 · 1999 · External reference
The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53
10.1074/jbc.275.4.2410 · 2000 · External reference
Apoptosis induction resulting from proteasome inhibition
10.1042/bj3170385 · 1996 · External reference
Activation of the cell death program by inhibition of proteasome function
10.1073/pnas.94.3.855 · 1997 · External reference
The human homologs of checkpoint kinases chki and cdsi (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
10.1101/gad.14.3.289 · 2000 · External reference
Chk2/ hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
10.1101/gad.14.3.278 · 2000 · External reference
DNA damage-induced activation of p53 by the checkpoint kinase chk2
10.1126/science.287.5459.1824 · 2000 · External reference
Role of human Cdsi (Chk2) kinase in DNA damage checkpoint and its regulation by p53
10.1074/jbc.274.44.31463 · 1999 · External reference
hCdsi-mediated phosphorylation of BRCA1 regulates the DNA damage response
10.1038/35004614 · 2000 · External reference
