Research graph
References from Driving p53 Response to Bax Activation Greatly Enhances Sensitivity to Taxol by Inducing Massive Apoptosis. Local targets link to admitted publications; unresolved targets remain external evidence.
p53: puzzle and paradigm
1996 · External reference
p53, the cellular gatekeeper for growth and division
10.1016/s0092-8674(00)81871-1 · 1997 · External reference
p53: upstream, downstream and off stream
1996 · External reference
p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
10.1101/gad.10.19.2438 · 1996 · External reference
p53 in signaling checkpoint arrest or apoptosis
10.1016/s0959-437x(96)90004-0 · 1996 · External reference
Cell-cycle arrest versus cell death in cancer therapy [see comments]
10.1038/nm0997-1034 · 1997 · External reference
WAFT, a potential mediator of p53 tumor suppression
10.1016/0092-8674(93)90500-p · 1993 · External reference
The p21 Cdk-interacting protein Cipi is a potent inhibitor of G1 cyclindependent kinases
10.1016/0092-8674(93)90499-g · 1993 · External reference
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
10.1016/0092-8674(93)90509-o · 1993 · External reference
Binding and modulation of p53 by p300/CBP coactivators
10.1038/42981 · 1997 · External reference
Inactivation of p53 in a human ovarian cancer cell line increases the sensitivity to paclitaxel by inducing G2/M arrest and apoptosis
10.1006/excr.1998.4018 · 1998 · External reference
Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis
10.1038/nm0196-72 · 1996 · External reference
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline
1995 · External reference
p21 is necessary for the p53-mediated G1 arrest in human cancer cells
1995 · External reference
Overexpression of baxsensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis
10.1002/(sici)1097-0215(19960703)67:1<101::aid-ijc17>3.0.co;2-h · 1996 · External reference
Bax suppresses tumorigenesis and stimulates apoptosis in vivo
10.1038/385637a0 · 1997 · External reference
BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway
10.1073/pnas.93.24.14094 · 1996 · External reference
Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
10.1038/35160 · 1998 · External reference
p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel
1997 · External reference
DDP-induced cytotoxicity is not influenced by p53 in nine human ovarian cancer cell lines with different p53 status
10.1038/bjc.1997.412 · 1997 · External reference
Unresolved reference
1989 · External reference
Phase II preclinical drug screening in human tumor xenografts: a first European multicenter collaborative study
1992 · External reference
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
10.1016/0092-8674(95)90412-3 · 1995 · External reference
Reduced expression of proapoptotic gene bax is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma
1995 · External reference
Bax homodimerization is not required for Bax to accelerate chemotherapy-induced cell death
10.1074/jbc.271.50.32073 · 1996 · External reference
Overexpression of bax gene sensitizes K562 erythroleukemia cells to apoptosis induced by selective chemotherapeutic agents
10.1038/sj.onc.1201681 · 1998 · External reference
Paclitaxel (taxol)
10.1056/nejm199504133321507 · 1995 · External reference
Prevention of apoptosis by bcl-2: release of cytochrome c from mitochondria blocked
10.1126/science.275.5303.1129 · 1997 · External reference
Antitumor activity of taxol (NSC-125973) in human ovarian carcinomas growing in the peritoneal cavity of nude mice
10.1093/oxfordjournals.annonc.a058419 · 1993 · External reference
Conformation-dependent phosphorylation of p53
10.1073/pnas.94.5.1686 · 1997 · External reference
Differential activation of p53 targets in cells treated with ultraviolet radiation that undergo both apoptosis and growth arrest
10.2307/3579567 · 1997 · External reference
Differential effects of phosphorylation of rat p53 on transactivation of promoters derived from different p53 responsive genes
1996 · External reference
DNA damage induces phosphorylation of the amino terminus of p53
10.1101/gad.11.24.3471 · 1997 · External reference
DNA damageinduced phosphorylation of p53 alleviates inhibition by MDM2
10.1016/s0092-8674(00)80416-x · 1997 · External reference
