Research graph
References from A Mathematical Model for Comparison of Bolus Injection, Continuous Infusion, and Liposomal Delivery of Doxorubicin to Tumor Cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Pharmacokinetic-toxicodynamic relationships of adriamycin in rat: prediction of butylated hydroxyanisole-mediated reduction in anthracycline cardiotoxicity
10.1111/j.2042-7158.1996.tb03934.x · 1996 · External reference
Unresolved reference
1991 · External reference
Dose optimization of anthracyclines
1994 · External reference
Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion
10.7326/0003-4819-96-2-133 · 1982 · External reference
A risk-benefit assessment of anthracycline antibiotics in antineoplastic therapy
10.2165/00002018-199615060-00005 · 1996 · External reference
Decreased cardiac toxicity of doxorubicin administered by continuous intravenous infusion in combination chemotherapy for metastatic breast carcinoma
10.1002/1097-0142(19890101)63:1<37::aid-cncr2820630106>3.0.co;2-z · 1989 · External reference
Anthracyclines and anthrace nediones
1996 · External reference
A prospective randomized trial of adjuvant chemotherapy with bolus versus continuous infusion of doxorubicin in patients with high-grade extremity soft tissue sarcoma and an analysis of prognostic factors
10.1002/1097-0142(19910915)68:6<1221::aid-cncr2820680607>3.0.co;2-r · 1991 · External reference
Cellular pharmacokinetics of doxorubicin in patients with chronic lymphocytic leukemia: comparison of bolus administration and continuous infusion
10.1007/bf00735923 · 1993 · External reference
Liposomes: opportunities in drug delivery
10.2165/00003495-199700544-00004 · 1997 · External reference
A comparative study on the antitumor effect, cardiotoxicity and nephrotoxicity of doxorubicin given as a bolus, continuous infusion or entrapped in liposomes in the Lou/M Wsl rat
10.1007/bf00257439 · 1989 · External reference
Antibodytargeted delivery of doxorubicin entrapped in sterically stabilized liposomes can eradicate lung cancer in mice
1993 · External reference
Therapy of human ovarian carcinoma xenografts using doxorubicin encapsulated in sterically stabilized liposomes
10.1002/1097-0142(19931215)72:12<3671::aid-cncr2820721219>3.0.co;2-u · 1993 · External reference
Polyethylene glycol- liposomal doxorubicin. A review of its pharmacodynamic and pharmacokinetic properties, therapeutic efficacy in the management of AIDSrelated Kaposi's sarcoma
10.2165/00003495-199753030-00011 · 1997 · External reference
Phase II study of liposomal doxorubicin in refractory ovarian cancer: antitumor activity and toxicity modification by liposomal encapsulation
10.1200/jco.1997.15.3.987 · 1997 · External reference
Toxicity of doxorubicin entrapped within long-circulating liposomes
10.1016/s0168-3659(96)01501-5 · 1997 · External reference
Thermosensitive liposomes: extravasation and release of contents in tumor microvascular networks
10.1016/s0360-3016(96)00389-6 · 1996 · External reference
Enhanced therapeutic effect against liver W256 carcinosarcoma with temperature-sensitive liposomal adriamycin administered into the hepatic artery
1993 · External reference
Simultaneous measurement of liposome extravasation and content release in tumors
10.3109/10739689709148320 · 1997 · External reference
Hyperthermia-mediated targeted delivery of thermosensitive liposome-encapsulated melphalan in murine tumors
1995 · External reference
Intracellular uptake, retention and cytotoxic effect of adriamycin combined with hyperthermia in vitro
1986 · External reference
Enhancement of doxorubicin-induced cytotoxicity by hyperthermia in Ehrlich ascites cells
10.1159/000239191 · 1994 · External reference
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
10.1016/s0006-2952(98)00307-4 · 1999 · External reference
Pharmacokinetics of adriamycin in patients with breast cancer: correlation between pharmacokinetic parameters and clinical shortterm response
10.1016/0277-5379(82)90072-4 · 1982 · External reference
Flow cytometry studies of intracellular adriamycin in single cells in vitro
1981 · External reference
Doxorubicin resistance in P388 leukemia - evidence for reduced drug influx
10.1002/ijc.2910440328 · 1989 · External reference
The influence of tumor cell density on cellular accumulation of doxorubicin or cisplatin in vitro
10.1007/bf00685154 · 1991 · External reference
Laser flow cytometric studies on the intracellular fluorescence of anthracyclines
1980 · External reference
Comparative intracellular uptake of adriamycin and 4'-deoxydoxorubicin by nonsmall cell lung tumor cells in culture and its relationship to cell survival
10.1016/0006-2952(86)90195-4 · 1986 · External reference
Preliminary pharmacokinetic model for adriamycin
1975 · External reference
Theoretical models for drug delivery to solid tumors
10.1615/critrevbiomedeng.v25.i6.20 · 1997 · External reference
Prediction of adriamycin disposition in cancer patients using a physiologic, pharmacokinetic model
1978 · External reference
Intra-arterial infusion of anticancer drugs: theoretic aspects of drug delivery and review of responses
1980 · External reference
Optimal control analysis of a cancer chemotherapy problem
10.1093/imammb/4.2.171 · 1987 · External reference
General applications of optimal control theory in cancer chemotherapy
10.1093/imammb/5.4.303 · 1988 · External reference
Development of a pharmacokinetic/pharmacodynamic (PK/PD)-simulation system for doxorubicin in long circulating liposomes in mice using peritoneal P388
10.1016/s0168-3659(99)00103-0 · 1999 · External reference
Optimization of antitumor effect of liposomally encapsulated doxorubicin based on simulations by pharmacokinetic/pharmacodynamic modeling
10.1016/s0168-3659(99)00110-8 · 1999 · External reference
Cellular pharmacokinetics of doxorubicin in cultured mouse sarcoma cells originating from autochthonous tumors
10.1159/000225791 · 1984 · External reference
Anthracycline subcellular distribution in human leukemic cells by microspectrofluorometry: factors contributing to drug-induced cell death and reversal of multidrug resistance
10.1038/sj.leu.2400668 · 1997 · External reference
Infusional anthracyclines: is slower better? If so, why?
10.1093/oxfordjournals.annonc.a058282 · 1992 · External reference
Doxorubicin and doxorubicinol pharmacokinetics and tissue concentrations following bolus injection and continuous infusion of doxorubicin in the rabbit
10.1007/bf00685876 · 1993 · External reference
Transport of fluid and macromolecules in tumors: I. Role of interstitial pressure and convection
10.1016/0026-2862(89)90074-5 · 1989 · External reference
Unresolved reference
1986 · External reference
Unresolved reference
1985 · External reference
Radiologic assessment of intranodal vascularity in head and neck squamous cell carcinoma. Correlation with histologic vascular density
10.1097/00004424-199611000-00001 · 1996 · External reference
Vascularization of malignant testicular tumors
10.1016/0090-4295(85)90252-3 · 1985 · External reference
Unresolved reference
1992 · External reference
Multiple cycles of high-dose doxorubicin and cyclophosphamide with G-CSF mobilized peripheral blood progenitor cell support in patients with metastatic breast cancer
10.1023/a:1008259518263 · 1997 · External reference
High-dose doxorubicin, etoposide, cyclophosphamide with stem cell reinfusion in patients with metastatic or high-risk primary breast cancer
10.1002/1097-0142(19940315)73:6<1678::aid-cncr2820730621>3.0.co;2-u · 1994 · External reference
Unresolved reference
1971 · External reference
Unresolved reference
1965 · External reference
Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice
1992 · External reference
Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encap sulated in polyethylene-glycol coated liposomes
1994 · External reference
Accumulation of liposomal lipid and encapsulated doxorubicin in murine Lewis lung carcinoma: the lack of beneficial effects by coating liposomes with poly (ethylene glycol)
1997 · External reference
Influence of vesicle size, lipid composition, drugto-lipid ratio on the biological activity of liposomal doxorubicin in mice
1989 · External reference
Role of drug release and liposome-mediated drug delivery in governing the therapeutic activity of liposomal mitoxantrone used to treat human A431 and LS180 solid tumors
2000 · External reference
The role of tumor-associated macrophages in the delivery of liposomal doxorubicin to solid murine fibrosarcoma tumors
1997 · External reference
Safety aspects of pegylatedliposomal doxorubicin in patients with cancer
10.2165/00003495-199700544-00007 · 1997 · External reference
Clinical efficacy and prospects for use of pegylated liposomal doxorubicin in the treatment of ovarian and breast cancers
10.2165/00003495-199700544-00006 · 1997 · External reference
Direct measurement of doxorubicin concentration in the intact, living single cancer cell during hyperthermia
10.1002/(sici)1097-0142(19970115)79:2<214::aid-cncr3>3.0.co;2-k · 1997 · External reference
Interaction between adriamycin cytotoxicity and hyperthermia: growth-phase-dependent thermal sensitization
10.3109/02656739409012374 · 1994 · External reference
Reduced adriamycin concentration in rat mammary tumors treated previously with hyperthermia
10.2307/3578306 · 1993 · External reference
Modulation of adriamycin transport by hyperthermia as measured by fluorescence-activated cell sorting
10.1007/bf00570481 · 1987 · External reference
Tissue perfusion inhomogeneity during early tumor growth in rats
1979 · External reference
Diffusion and convection in normal and neoplastic tissues
1974 · External reference
Transport of molecules in the tumor interstitium: a review
1987 · External reference
Measurement of material extravasation in microvascular networks using fluorescence video-microscopy
10.1006/mvre.1993.1049 · 1993 · External reference
Unresolved reference
1980 · External reference
