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References from Indomethacin-Induced Apoptosis in Esophageal Adenocarcinoma Cells Involves Upregulation of Bax and Translocation of Mitochondrial Cytochrome C Independent of COX-2 Expression. Local targets link to admitted publications; unresolved targets remain external evidence.
The changing epidemiology of esophageal cancer
1999 · External reference
Aspirin use and reduced risk of fatal colon cancer
10.1056/nejm199112053252301 · 1991 · External reference
NSAID use and decreased risk of gastrointestinal cancers
10.1016/s0889-8553(05)70250-8 · 1996 · External reference
Inhibition of development of methylnitrosourea-induced rat colon tumors by indomethacin treatment
1981 · External reference
Chemoprevention of spontaneous intestinal adenomas in the adenomatous polyposis coli Min mouse model with aspirin
10.1016/s0016-5085(98)70305-1 · 1998 · External reference
The role of cyclooxygenases in inflammation, cancer, development
10.1038/sj.onc.1203286 · 1999 · External reference
Identification of a phorbol ester-repressible v-src-inducible gene
10.1073/pnas.86.4.1178 · 1989 · External reference
Expression of cyclooxygenase-1 and -2 inhuman colorectal cancer
1995 · External reference
Cyclooxygenase-2 expression in human pancreatic adenocarcinomas
10.1093/carcin/21.2.139 · 2000 · External reference
Overexpression of cyclooxygenase-2 in human prostate adenocarcinoma
10.1002/(sici)1097-0045(20000101)42:1<73::aid-pros9>3.0.co;2-g · 2000 · External reference
Cyclooxygenase-2 expression in human esophageal carcinoma
1999 · External reference
Expression of cyclooxygenase-2 in human lung carcinoma
1998 · External reference
Cyclooxygenase-2 as a therapeutic target
10.1007/s000110050287 · 1998 · External reference
Suppression of intestinal polyposis in ApcΔ716 knockout mice by inhibition of cyclooxygenase-2 (COX-2)
10.1016/s0092-8674(00)81988-1 · 1996 · External reference
Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
10.1016/0092-8674(95)90127-2 · 1995 · External reference
Sulindac suppresses tumorigenesis in the Min mouse
10.1093/carcin/17.8.1757 · 1996 · External reference
Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis
10.1056/nejm199305063281805 · 1993 · External reference
Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent
1995 · External reference
Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis
1995 · External reference
Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, induces apoptosis in HT-29 colon adenocarcinoma cells
10.1172/jci118060 · 1995 · External reference
Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels
1997 · External reference
Reduction of carcinogenicity of N-nitrosomethylurea by indomethacin and failure of resuming effect of prostaglandin E2 (PGE2) against indomethacin
10.1007/bf00402475 · 1984 · External reference
Apoptosis primarily accounts forthe growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, p53 induction
1997 · External reference
Evidence that prostaglandins do not have a role in the cytostatic action of anti-inflammatory drugs
10.1016/0006-2952(80)90506-7 · 1980 · External reference
Nonsteroidal anti-inflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts
10.1073/pnas.92.17.7961 · 1995 · External reference
Cyclooxygenase-2 inhibitors: a new class of anti-inflammatory agents that spare the gastrointestinal tract
10.1016/s0889-8553(05)70252-1 · 1996 · External reference
Caspases: the proteases of the apoptotic pathway
10.1038/sj.onc.1202581 · 1998 · External reference
Lack of cell surface Fas/APO-1 expression in pulmonary adenocarcinomas
10.1172/jci1692 · 1998 · External reference
Fas/APO-1 is not translocated to the cell membrane in esophageal adenocarcinoma
1997 · External reference
Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1)
10.1074/jbc.272.41.25783 · 1997 · External reference
Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-XL
10.1074/jbc.274.4.2225 · 1999 · External reference
Apoptosis in the pathogenesis and treatment of disease
10.1126/science.7878464 · 1995 · External reference
Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis
1996 · External reference
Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis
1998 · External reference
Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflamma tory drug: independence from COX-2 protein expression
1997 · External reference
Cyclooxygenase-2 expression is increased in the stroma of colon carcinomas from IL-10 (-/-) mice
10.1016/s0016-5085(00)70216-2 · 2000 · External reference
The Bcl-2 protein family: arbiters of cell survival
10.1126/science.281.5381.1322 · 1998 · External reference
Mitochondria and apoptosis
10.1126/science.281.5381.1309 · 1998 · External reference
Apoptotic cytosol facilitates Bax translocation to mitochondria that involves cytosolic factor regulated by Bcl-2
1999 · External reference
