Research graph
References from The MICAL family at the Rho–Rab interface: coordinating actin dynamics through oxidation and scaffolding. Local targets link to admitted publications; unresolved targets remain external evidence.
Post-translational modification and regulation of actin
10.1016/j.ceb.2012.10.009 · 2012 · External reference
Posttranslational modifications of the cytoskeleton
10.1002/cm.21679 · 2021 · External reference
Oxidative stress: harms and benefits for human health
10.1155/2017/8416763 · 2017 · External reference
Biochemistry of oxidative stress
10.1042/bst0351147 · 2007 · External reference
Role of oxygen radicals in DNA damage and cancer incidence
10.1023/b:mcbi.0000049134.69131.89 · 2004 · External reference
Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment
10.2165/00002512-200118090-00004 · 2001 · External reference
Reactive oxygen species induce epigenetic instability through the formation of 8-hydroxydeoxyguanosine in human hepatocarcinogenesis
10.1159/000355245 · 2013 · External reference
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
10.1038/nrm2256 · 2007 · External reference
Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery
10.1021/cr300163e · 2013 · External reference
Methionine in proteins: The Cinderella of the proteinogenic amino acids
10.1002/pro.3698 · 2019 · External reference
The role of hydrogen peroxide in redox-dependent signaling: homeostatic and pathological responses in mammalian cells
10.3390/cells7100156 · 2018 · External reference
Redox regulation of tyrosine kinase signalling: more than meets the eye
10.1093/jb/mvz085 · 2020 · External reference
Redox regulation of protein tyrosine phosphatases: structural and chemical aspects
10.1089/ars.2010.3611 · 2011 · External reference
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
10.1128/mmbr.00031-10 · 2011 · External reference
Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer
10.1146/annurev.cellbio.17.1.615 · 2001 · External reference
MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics
10.3389/fcell.2023.1124202 · 2023 · External reference
Oxidation and reduction of actin: origin, impact in vitro and functional consequences in vivo
10.1016/j.ejcb.2022.151249 · 2022 · External reference
MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation
10.1016/j.molcel.2013.06.019 · 2013 · External reference
Emerging roles of MICAL family proteins—from actin oxidation to membrane trafficking during cytokinesis
10.1242/jcs.202028 · 2017 · External reference
F-actin dismantling through a redox-driven synergy between Mical and cofilin
10.1038/ncb3390 · 2016 · External reference
MICAL-family proteins: complex regulators of the actin cytoskeleton
10.1089/ars.2013.5487 · 2014 · External reference
MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion
10.1016/s0092-8674(02)00794-8 · 2002 · External reference
The MICALs are a family of F-actin dismantling oxidoreductases conserved from Drosophila to humans
10.1038/s41598-017-17943-5 · 2018 · External reference
Kinetic and spectroscopic characterization of the putative monooxygenase domain of human MICAL-1
10.1016/j.abb.2011.08.004 · 2011 · External reference
Direct redox regulation of F-actin assembly and disassembly by Mical
10.1126/science.1211956 · 2011 · External reference
Modulation of MICAL monooxygenase activity by its calponin homology domain: structural and mechanistic insights
10.1038/srep22176 · 2016 · External reference
Properties and catalytic activities of MICAL1, the flavoenzyme involved in cytoskeleton dynamics, and modulation by its CH, LIM and C-terminal domains
10.1016/j.abb.2016.01.016 · 2016 · External reference
Solution structure of calponin homology domain of human MICAL-1
10.1007/s10858-006-9062-5 · 2006 · External reference
Evolutionarily diverse LIM domain-containing proteins bind stressed actin filaments through a conserved mechanism
10.1073/pnas.2004656117 · 2020 · External reference
Rab13 small G protein and junctional Rab13-binding protein (JRAB) orchestrate actin cytoskeletal organization during epithelial junctional development
10.1074/jbc.m112.383653 · 2012 · External reference
Release of MICAL autoinhibition by semaphorin-plexin signaling promotes interaction with collapsin response mediator protein
10.1523/jneurosci.5646-07.2008 · 2008 · External reference
Oxidation of F-actin controls the terminal steps of cytokinesis
10.1038/ncomms14528 · 2017 · External reference
bMERB domains are bivalent Rab8 family effectors evolved by gene duplication
10.7554/elife.18675 · 2016 · External reference
Structural basis of MICAL autoinhibition
10.1038/s41467-024-54131-2 · 2024 · External reference
Autoinhibition and relief mechanisms for MICAL monooxygenases in F-actin disassembly
10.1038/s41467-024-50940-7 · 2024 · External reference
MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling
10.1091/mbc.e09-06-0535 · 2009 · External reference
Alternative splicing for members of human mosaic domain superfamilies. I. the CH and LIM domains containing group of proteins
10.1007/s11033-008-9281-9 · 2009 · External reference
Unresolved reference
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Unresolved reference
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Extracellular inhibitors, repellents, and semaphorin/plexin/MICAL-mediated actin filament disassembly
10.1002/cm.20527 · 2011 · External reference
A novel splicing variant in MICAL-1 gene is associated with epilepsy
10.1016/j.ejmg.2024.104946 · 2024 · External reference
MICAL-1 isoforms, novel rab1 interacting proteins
10.1016/s0006-291x(03)00918-5 · 2003 · External reference
Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high gleason score and prostate cancer progression
10.1158/1078-0432.ccr-05-1995 · 2006 · External reference
MICAL2 Promotes Pancreatic Cancer Growth and Metastasis
10.1101/2024.06.26.600548 · 2025 · External reference
Actin isoform composition and binding factors fine-tune regulatory impact of mical enzymes
10.3390/ijms242316651 · 2023 · External reference
Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2 and growth cone collapse
10.1126/scisignal.2001127 · 2011 · External reference
NADPH-dependent oxidation of CRMP2 through a MICAL1-Prx1 redox relay controls neurite outgrowth
10.21203/rs.3.rs-712397/v1 · 2021 · External reference
MICAL1 controls cell invasive phenotype via regulating oxidative stress in breast cancer cells
10.1186/s12885-016-2553-1 · 2016 · External reference
MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours
10.1016/j.canlet.2021.07.039 · 2021 · External reference
GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508
10.1083/jcb.201811014 · 2020 · External reference
Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8
10.7554/elife.102375.1.sa2 · 2024 · External reference
Human MICAL1: Activation by the small GTPase Rab8 and small-angle X-ray scattering studies on the oligomerization state of MICAL1 and its complex with Rab8
10.1002/pro.3512 · 2019 · External reference
Rab11FIP1 maintains Rab35 at the intercellular bridge to promote actin removal and abscission
10.1242/jcs.244384 · 2021 · External reference
Differential regulation of actin microfilaments by human MICAL proteins
10.1242/jcs.089367 · 2012 · External reference
Mechanistic principles underlying regulation of the actin cytoskeleton by phosphoinositides
10.1073/pnas.1705032114 · 2017 · External reference
Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides
10.1152/physrev.00036.2009 · 2010 · External reference
The Ras superfamily at a glance
10.1242/jcs.01660 · 2005 · External reference
Cytoskeletal dynamics: a view from the membrane
10.1083/jcb.201502062 · 2015 · External reference
The plasma membrane potential and the organization of the actin cytoskeleton of epithelial cells
10.1155/2012/121424 · 2012 · External reference
Actin on trafficking: could actin guide directed receptor transport?
10.4161/cam.21373 · 2012 · External reference
Multiple roles for actin in secretory and endocytic pathways
10.1016/j.cub.2021.03.038 · 2021 · External reference
Actin dynamics drive membrane reorganization and scission in clathrin-independent endocytosis
10.1016/j.cell.2010.01.010 · 2010 · External reference
Actin dynamics at intracellular membranes: The Spir/formin nucleator complex
10.1016/j.ejcb.2010.10.011 · 2011 · External reference
Multiple mechanisms driving F-actin-dependent transport of organelles to and from secretory sites in bovine chromaffin cells
10.3389/fncel.2018.00344 · 2018 · External reference
The GTPase superfamily: conserved structure and molecular mechanism
10.1038/349117a0 · 1991 · External reference
The Ras protein superfamily: Evolutionary tree and role of conserved amino acids
10.1083/jcb.201103008 · 2012 · External reference
Ras family signaling: therapeutic targeting
10.4161/cbt.306 · 2002 · External reference
GTPases in intracellular trafficking: an overview
10.1016/j.semcdb.2010.12.004 · 2010 · External reference
Roles of Rho GTPases in intracellular transport and cellular transformation
10.3390/ijms14047089 · 2013 · External reference
Rab GTPases and membrane trafficking in neurodegeneration
10.1016/j.cub.2018.02.010 · 2018 · External reference
Role of Rab GTPases in membrane traffic and cell physiology
10.1152/physrev.00059.2009 · 2011 · External reference
Rho GTPases and their effector proteins
10.1042/bj3480241 · 2000 · External reference
Controlling the location and activation of Rab GTPases
10.1016/j.ceb.2004.06.014 · 2004 · External reference
The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins
10.1038/ncb2394 · 2011 · External reference
RAS proteins and their regulators in human disease
10.1016/j.cell.2017.06.009 · 2017 · External reference
Rab family of small GTPases: an updated view on their regulation and functions
10.1111/febs.15453 · 2021 · External reference
Rab proteins as membrane organizers
10.1038/35052055 · 2001 · External reference
The RHO family GTPases: mechanisms of regulation and signaling
10.3390/cells10071831 · 2021 · External reference
Rho GTPases: regulation and roles in cancer cell biology
10.1080/21541248.2016.1232583 · 2016 · External reference
Role of Rab GTPases in membrane traffic and cell physiology
10.1152/physrev.00059.2009 · 2011 · External reference
The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production
10.1073/pnas.122187699 · 2002 · External reference
Expression of Rab5a in hepatocellular carcinoma: possible involvement in epidermal growth factor signaling
10.1111/j.1872-034x.2007.00143.x · 2007 · External reference
A small Rho GTPase RAB25 with a potential role in chemotherapy resistance in pancreatic cancer
10.3233/cbm-220214 · 2023 · External reference
FOXA1 and RAB25 as biomarkers of breast cancer cell response to CYP1A1-activated prodrugs: insights from CEU-938
10.3390/ph19030357 · 2026 · External reference
Rab25-mediated EGFR recycling causes tumor acquired radioresistance
10.1016/j.isci.2020.100997 · 2020 · External reference
Direct interaction between Rab5a and Rab4a enhanced epidermal growth factor-stimulated proliferation of gastric cancer cells
10.4251/wjgo.v13.i10.1492 · 2021 · External reference
RAB5A in triple-negative breast cancer: a critical role in macrophage reshaping in an exosomal miR-21-dependent manner
10.1530/erc-23-0257 · 2024 · External reference
Rab7 is associated with poor prognosis of gastric cancer and promotes proliferation, invasion, and migration of gastric cancer cells
10.12659/msm.922217 · 2020 · External reference
High RAS-related protein Rab-7a (RAB7A) expression is a poor prognostic factor in pancreatic adenocarcinoma
10.1038/s41598-022-22355-1 · 2022 · External reference
Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy
10.1086/367847 · 2003 · External reference
RAB23 Mutations in carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity
10.1086/518047 · 2007 · External reference
Pan-cancer analyses identify oncogenic drivers, expression signatures, and therapeutic vulnerabilities in RHO GTPase pathway genes
10.3389/fbinf.2025.1708800 · 2025 · External reference
The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1
10.1016/j.ccr.2014.01.025 · 2014 · External reference
Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis
10.1534/genetics.111.127910 · 2011 · External reference
ARHGEF10L expression regulates cell proliferation and migration in gastric tumorigenesis
10.1080/09168451.2020.1737503 · 2020 · External reference
ARHGEF10L promotes cervical tumorigenesis via RhoA-mediated signaling
10.1155/2021/6683264 · 2021 · External reference
Regulation of leukaemia associated Rho GEF (LARG/ARHGEF12)
10.1080/21541248.2021.1951590 · 2022 · External reference
Regulation and functions of the DLC family of RhoGAP proteins: implications for development and cancer
10.1016/j.cellsig.2024.111505 · 2025 · External reference
The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells
10.1038/s41598-020-79270-6 · 2020 · External reference
Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis
10.18632/oncotarget.8794 · 2016 · External reference
Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor α (GDI)/Rab11 pathway
10.1074/mcp.m900271-mcp200 · 2010 · External reference
MICAL-like1 mediates epidermal growth factor receptor endocytosis
10.1091/mbc.e11-01-0030 · 2011 · External reference
Actin cytoskeletal reorganization function of JRAB/MICAL-L2 is fine-tuned by intramolecular interaction between first LIM zinc finger and C-terminal coiled-coil domains
10.1038/s41598-019-49232-8 · 2019 · External reference
Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers
10.1016/j.cub.2011.04.030 · 2011 · External reference
MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a
10.1111/j.1600-0854.2011.01294.x · 2011 · External reference
F-actin disassembly factor MICAL1 binding to Myosin Va mediates cargo unloading during cytokinesis
10.1126/sciadv.abb1307 · 2020 · External reference
The MICAL proteins and rab1: a possible link to the cytoskeleton?
10.1016/j.bbrc.2004.12.182 · 2005 · External reference
MICAL-L1: an unusual Rab effector that links EHD1 to tubular recycling endosomes
10.4161/cib.3.2.10845 · 2010 · External reference
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions
10.1091/mbc.e07-06-0551 · 2008 · External reference
Overexpression of NEDD9 promotes cell invasion and metastasis in hepatocellular carcinoma
10.1016/j.clinre.2017.04.011 · 2017 · External reference
siRNA suppression of NEDD9 inhibits proliferation and enhances apoptosis in renal cell carcinoma
10.3727/096504015x14386062091442 · 2015 · External reference
NEDD9 facilitates hypoxia-induced gastric cancer cell migration via MICAL1 related Rac1 activation
10.3389/fphar.2019.00291 · 2019 · External reference
Cas and NEDD9 contribute to tumor progression through dynamic regulation of the cytoskeleton
10.1177/1947601912458585 · 2012 · External reference
Deregulation of HEF1 impairs M-Phase progression by disrupting the RhoA activation cycle
10.1091/mbc.e05-03-0237 · 2006 · External reference
The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42
10.4049/jimmunol.170.2.969 · 2003 · External reference
Rac activation and inactivation control plasticity of tumor cell movement
10.1016/j.cell.2008.09.043 · 2008 · External reference
MICAL, a novel CasL interacting molecule, associates with vimentin
10.1074/jbc.m111842200 · 2002 · External reference
Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-κb
10.1038/sj.onc.1205036 · 2002 · External reference
NEDD9 stimulated MMP9 secretion is required for invadopodia formation in oral squamous cell carcinoma
10.18632/oncotarget.25347 · 2018 · External reference
The intracellular redox protein MICAL-1 regulates the development of hippocampal mossy fibre connections
10.1038/ncomms5317 · 2014 · External reference
Kalopanaxsaponin A inhibits the invasion of human oral squamous cell carcinoma by reducing metalloproteinase-9 mRNA stability and protein trafficking
10.1248/bpb.35.289 · 2012 · External reference
PAK1, PAK1Δ15, and PAK2: similarities, differences and mutual interactions
10.1038/s41598-019-53665-6 · 2019 · External reference
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1
10.1016/s1097-2765(01)00428-2 · 2002 · External reference
PAK signaling in oncogenesis
10.1038/onc.2009.119 · 2009 · External reference
MICAL1 activation by PAK1 mediates actin filament disassembly
10.1016/j.celrep.2022.111442 · 2022 · External reference
Characterization of Graf, the GTPase-activating protein for Rho associated with focal adhesion kinase
10.1074/jbc.273.14.8063 · 1998 · External reference
Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover
10.1242/jcs.113.20.3673 · 2000 · External reference
Variants in the WDR44 WD40-repeat domain cause a spectrum of ciliopathy by impairing ciliogenesis initiation
10.1038/s41467-023-44611-2 · 2024 · External reference
Molecular basis for the recruitment of the Rab effector protein WDR44 by the GTPase Rab11
10.1016/j.jbc.2022.102764 · 2022 · External reference
Identification of a putative effector protein for rab11 that participates in transferrin recycling
10.1073/pnas.96.6.2840 · 1999 · External reference
WD40 repeat proteins: signalling scaffold with diverse functions
10.1007/s10930-018-9785-7 · 2018 · External reference
MICAL3 Flavoprotein monooxygenase forms a complex with centralspindlin and regulates cytokinesis
10.1074/jbc.m116.748186 · 2016 · External reference
Spatiotemporal recruitment of RhoGTPase protein GRAF inhibits actomyosin ring constriction in Drosophila cellularization
10.7554/elife.63535 · 2021 · External reference
GRAF1 forms a complex with MICAL-L1 and EHD1 to cooperate in tubular recycling endosome vesiculation
10.3389/fcell.2014.00022 · 2014 · External reference
Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis
10.1091/mbc.e13-01-0026 · 2013 · External reference
Novel functions for the endocytic regulatory proteins MICAL-L1 AND EHD1 in mitosis
10.1111/tra.12234 · 2014 · External reference
Regulation of Src trafficking and activation by the endocytic regulatory proteins MICAL-L1 and EHD1
10.1242/jcs.133892 · 2014 · External reference
Src: coordinating metabolism in cancer
10.1038/s41388-022-02487-4 · 2022 · External reference
Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling
10.1091/mbc.e06-06-0533 · 2006 · External reference
Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase
10.1242/jcs.01193 · 2004 · External reference
Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors
10.1038/sj.embor.7401097 · 2007 · External reference
Myosin V from head to tail
10.1007/s00018-008-7507-6 · 2008 · External reference
Autoinhibition and activation mechanisms revealed by the triangular-shaped structure of myosin Va
10.1126/sciadv.add4187 · 2022 · External reference
Vesicle-mediated transport of ALIX and ESCRT-III to the intercellular bridge during cytokinesis
10.1007/s00018-023-04864-y · 2023 · External reference
A complex of Rab13 with MICAL-L2 and α-actinin-4 is essential for insulin-dependent GLUT4 exocytosis
10.1091/mbc.e15-05-0319 · 2016 · External reference
Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells
10.1091/mbc.e13-08-0493 · 2014 · External reference
Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle
10.1016/j.cellsig.2011.05.022 · 2011 · External reference
Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance
10.1074/jbc.m113.467647 · 2013 · External reference
α-Actinin-4 is selectively required for insulin-induced GLUT4 translocation
10.1074/jbc.m801750200 · 2008 · External reference
Centralspindlin: at the heart of cytokinesis
10.1002/cm.21065 · 2012 · External reference
Structural basis of ELKS/Rab6B interaction and its role in vesicle capturing enhanced by liquid–liquid phase separation
10.1016/j.jbc.2023.104808 · 2023 · External reference
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
10.1038/s41392-021-00762-6 · 2022 · External reference
Wnt signaling in development and disease
10.1016/j.nbd.2009.09.003 · 2009 · External reference
Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances
10.1038/s41392-025-02142-w · 2025 · External reference
Wnt signaling in cancer
10.1038/onc.2016.304 · 2016 · External reference
Wnt signaling in cardiac development and heart diseases
10.1007/s11626-024-00917-z · 2024 · External reference
Wnt–β-catenin signalling in liver development, health and disease
10.1038/s41575-018-0075-9 · 2018 · External reference
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel formin homology protein Daam1
10.1016/s0092-8674(01)00614-6 · 2001 · External reference
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation
10.1101/gad.1022203 · 2003 · External reference
AKT and AMP-activated protein kinase regulate TBC1D1 through phosphorylation and its interaction with the cytosolic tail of insulin-regulated aminopeptidase IRAP
10.1074/jbc.ra118.005040 · 2018 · External reference
MICAL1 facilitates pancreatic cancer proliferation, migration, and invasion by activating WNT/β-catenin pathway
10.1186/s12967-022-03749-1 · 2022 · External reference
TBC1D1 interacting proteins, VPS13A and VPS13C, regulate GLUT4 homeostasis in C2C12 myotubes
10.1038/s41598-020-74661-1 · 2020 · External reference
Wnt/β-catenin-driven EMT regulation in human cancers
10.1007/s00018-023-05099-7 · 2024 · External reference
Silencing of MICAL-L2 suppresses malignancy of ovarian cancer by inducing mesenchymal–epithelial transition
10.1016/j.canlet.2015.04.002 · 2015 · External reference
MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer
10.1186/s12964-022-00984-3 · 2022 · External reference
E3 ubiquitin ligase TRIM21 targets TIF1γ to regulate β-catenin signaling in glioblastoma
10.7150/thno.85662 · 2023 · External reference
The β-catenin destruction complex
10.1101/cshperspect.a007898 · 2013 · External reference
MICAL-L2 potentiates Cdc42-dependent EGFR stability and promotes gastric cancer cell migration
10.1111/jcmm.14353 · 2019 · External reference
Comprehensive analysis of MICALL2 reveals its potential roles in EGFR stabilization and ovarian cancer cell invasion
10.3390/ijms25010518 · 2024 · External reference
A comprehensive pathway map of epidermal growth factor receptor signaling
10.1038/msb4100014 · 2005 · External reference
An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis
10.1038/onc.2015.45 · 2015 · External reference
Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation
10.1016/s0092-8674(03)00688-3 · 2003 · External reference
Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation
10.1091/mbc.e06-02-0142 · 2006 · External reference
MICAL-L2, as an estrogen-responsive gene, is involved in ER-positive breast cancer cell progression and tamoxifen sensitivity via the AKT/mTOR pathway
10.1016/j.bcp.2024.116256 · 2024 · External reference
Role of epidermal growth factor receptor in breast cancer
10.1007/s10549-012-2289-9 · 2012 · External reference
Loss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor α
10.1093/jnci/djr058 · 2011 · External reference
MICAL2 contributes to gastric cancer cell migration via Cdc42-dependent activation of E-cadherin/β-catenin signaling pathway
10.1186/s12964-022-00952-x · 2022 · External reference
MICAL2 promotes pancreatic cancer growth and metastasis
10.1158/0008-5472.can-24-0744 · 2025 · External reference
FAMSA: fast and accurate multiple sequence alignment of huge protein families
10.1038/srep33964 · 2016 · External reference
ClipKIT: a multiple sequence alignment trimming software for accurate phylogenomic inference
10.1371/journal.pbio.3001007 · 2020 · External reference
Very Fast Tree: speeding up the estimation of phylogenies for large alignments through parallelization and vectorization strategies
10.1093/bioinformatics/btaa582 · 2020 · External reference
An improved general amino acid replacement matrix
10.1093/molbev/msn067 · 2008 · External reference
