Research graph
References from Loss of O-GlcNAc transferase activity impairs the dynamic formation of protective stress granules in ischemic cardiomyocytes. Local targets link to admitted publications; unresolved targets remain external evidence.
Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease
10.1146/annurev-biochem-060608-102511 · 2011 · External reference
O-GlcNAc cycling: how a single sugar post-translational modification is changing the way we think about signaling networks
10.1002/jcb.20676 · 2006 · External reference
The human O-GlcNAcome database and meta-analysis
10.1038/s41597-021-00810-4 · 2021 · External reference
A little sugar goes a long way: the cell biology of O-GlcNAc
10.1083/jcb.201501101 · 2015 · External reference
GlcNAcylation of histone H2B facilitates its monoubiquitination
10.1038/nature10656 · 2011 · External reference
Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells
10.1016/j.molcel.2012.12.019 · 2013 · External reference
O-GlcNAc regulates gene expression by controlling detained intron splicing
10.1093/nar/gkaa263 · 2020 · External reference
O-GlcNAcylation of ribosome-associated proteins is concomitant with translational reprogramming during proteotoxic stress
10.1016/j.jbc.2024.107877 · 2024 · External reference
O-GlcNAcylation of core components of the translation initiation machinery regulates protein synthesis
10.1073/pnas.1813026116 · 2019 · External reference
O-GlcNAcylation of α-synuclein at serine 87 reduces aggregation without affecting membrane binding
10.1021/acschembio.7b00113 · 2017 · External reference
O-GlcNAcylation is essential for autophagy in cardiomyocytes
10.1155/2020/5602396 · 2020 · External reference
O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity
10.1038/s41557-021-00648-8 · 2021 · External reference
O-GlcNAc modification is an endogenous inhibitor of the proteasome
10.1016/s0092-8674(03)00974-7 · 2003 · External reference
Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress: a survival response of mammalian cells
10.1074/jbc.m403773200 · 2004 · External reference
Integration of O-GlcNAc into stress response pathways
10.3390/cells11213509 · 2022 · External reference
Stress-induced O-GlcNAcylation: an adaptive process of injured cells
10.1042/bst20160153 · 2017 · External reference
Myocardial ischemia-reperfusion injury: a neglected therapeutic target
10.1172/jci62874 · 2013 · External reference
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
10.1038/nature13909 · 2014 · External reference
What is the mitochondrial permeability transition pore?
10.1016/j.yjmcc.2009.02.021 · 2009 · External reference
Increased O-GlcNAc levels during reperfusion lead to improved functional recovery and reduced calpain proteolysis
10.1152/ajpheart.00285.2007 · 2007 · External reference
Glucosamine cardioprotection in perfused rat hearts associated with increased O-linked N-acetylglucosamine protein modification and altered p38 activation
10.1152/ajpheart.01091.2006 · 2007 · External reference
Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is cardioprotective in an O-GlcNAc-dependent manner
10.1152/ajpheart.00337.2010 · 2010 · External reference
Cardioprotection by N-acetylglucosamine linkage to cellular proteins
10.1161/circulationaha.107.730515 · 2008 · External reference
O-linked beta-N-acetylglucosamine transferase is indispensable in the failing heart
10.1073/pnas.1001907107 · 2010 · External reference
The intra-mitochondrial O-GlcNAcylation system rapidly modulates OXPHOS function and ROS release in the heart
10.1038/s42003-022-03282-3 · 2022 · External reference
Non-canonical glycosyltransferase modulates post-hypoxic cardiac myocyte death and mitochondrial permeability transition
10.1016/j.yjmcc.2008.04.009 · 2008 · External reference
Augmented O-GlcNAc signaling attenuates oxidative stress and calcium overload in cardiomyocytes
10.1007/s00726-010-0728-7 · 2011 · External reference
Modification of STIM1 by O-linked N-acetylglucosamine attenuates store-operated calcium entry in neonatal cardiomyocytes
10.1074/jbc.m112.383778 · 2012 · External reference
Stress granules and processing bodies in translational control
10.1101/cshperspect.a032813 · 2019 · External reference
Molecular mechanisms of stress granule assembly and disassembly
10.1016/j.bbamcr.2020.118876 · 2021 · External reference
Principles and properties of stress granules
10.1016/j.tcb.2016.05.004 · 2016 · External reference
RNA-induced conformational switching and clustering of G3BP drive stress granule assembly by condensation
10.1016/j.cell.2020.03.049 · 2020 · External reference
G3BP1 is a tunable switch that triggers phase separation to assemble stress granules
10.1016/j.cell.2020.03.046 · 2020 · External reference
RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules
10.1083/jcb.147.7.1431 · 1999 · External reference
Stress granule assembly is mediated by prion-like aggregation of TIA-1
10.1091/mbc.e04-08-0715 · 2004 · External reference
G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits
10.1083/jcb.201508028 · 2016 · External reference
A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly
10.1038/ncb1783 · 2008 · External reference
Combined antibody/lectin enrichment identifies extensive changes in the O-GlcNAc sub-proteome upon oxidative stress
10.1021/acs.jproteome.6b00369 · 2016 · External reference
Protein substrates engage the lumen of O-GlcNAc transferase’s tetratricopeptide repeat domain in different ways
10.1021/acs.biochem.0c00981 · 2021 · External reference
Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex
10.1038/s41467-023-42427-8 · 2023 · External reference
Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization
10.1016/j.cell.2015.09.015 · 2015 · External reference
Distinct stages in stress granule assembly and disassembly
10.7554/elife.18413 · 2016 · External reference
Research progress on the structure and function of G3BP
10.3389/fimmu.2021.718548 · 2021 · External reference
A Ras-GTPase-activating protein SH3-domain-binding protein
10.1128/mcb.16.6.2561 · 1996 · External reference
The multi-functional RNA-binding protein G3BP1 and its potential implication in neurodegenerative disease
10.1111/jnc.15280 · 2021 · External reference
Competing protein–RNA interaction networks control multiphase intracellular organization
10.1016/j.cell.2020.03.050 · 2020 · External reference
G3bp1 - microRNA-1 axis regulates cardiomyocyte hypertrophy
10.1016/j.cellsig.2022.110245 · 2022 · External reference
GTPase activating protein (Sh3 Domain) binding protein 1 regulates the processing of microRNA-1 during cardiac hypertrophy
10.1371/journal.pone.0145112 · 2015 · External reference
Stress granule activation attenuates lipopolysaccharide-induced cardiomyocyte dysfunction
10.1186/s12872-023-03281-0 · 2023 · External reference
Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways
10.1038/ncb1791 · 2008 · External reference
Stress granules and neurodegeneration
10.1038/s41583-019-0222-5 · 2019 · External reference
Stress granules inhibit apoptosis by reducing reactive oxygen species production
10.1128/mcb.00763-12 · 2013 · External reference
Stress granules and acute ischemic stroke: beyond mRNA translation
10.3390/ijms23073747 · 2022 · External reference
Stress granule induction after brain ischemia is independent of eukaryotic translation initiation factor (eIF) 2α phosphorylation and is correlated with a decrease in eIF4B and eIF4E proteins
10.1074/jbc.m116.738989 · 2016 · External reference
Presence and function of stress granules in atrial fibrillation
10.1371/journal.pone.0213769 · 2019 · External reference
DDX3X/MAVS alleviates doxorubicin-induced cardiotoxicity by regulating stress granules
10.3892/mmr.2025.13602 · 2025 · External reference
Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP
10.1016/j.yjmcc.2020.01.010 · 2020 · External reference
Loss of O-GlcNAcylation in cardiac myocytes triggers the integrated stress response, contributing to heart failure
10.1016/j.jbc.2025.110818 · 2025 · External reference
Stress granules: functions and mechanisms in cancer
10.1186/s13578-023-01030-6 · 2023 · External reference
Decoding ALS: from genes to mechanism
10.1038/nature20413 · 2016 · External reference
Stress granules: emerging players in neurodegenerative diseases
10.1186/s40035-025-00482-9 · 2025 · External reference
Stress granules in cancer: adaptive dynamics and therapeutic implications
10.1016/j.isci.2024.110359 · 2024 · External reference
The role of posttranslational modifications in the assembly of stress granules
10.1002/wrna.23 · 2010 · External reference
O-GlcNAc modification of eIF4GI acts as a translational switch in heat shock response
10.1038/s41589-018-0120-6 · 2018 · External reference
ATPase-modulated stress granules contain a diverse proteome and substructure
10.1016/j.cell.2015.12.038 · 2016 · External reference
DEAD-box ATPases as regulators of biomolecular condensates and membrane-less organelles
10.1016/j.tibs.2022.10.001 · 2023 · External reference
Bioinformatic prediction of putative conveyers of O-GlcNAc transferase intellectual disability
10.1016/j.jbc.2022.102276 · 2022 · External reference
O-GlcNAcylation of the intellectual disability protein DDX3X exerts proteostatic cell cycle control
10.1098/rsob.250064 · 2025 · External reference
Cellular stress orchestrates the localization of hnRNP H to stress granules
10.1016/j.yexcr.2020.112111 · 2020 · External reference
hnRNP A1 relocalization to the stress granules reflects a role in the stress response
10.1128/mcb.00224-06 · 2006 · External reference
The effect of O-GlcNAcylation on hnRNP A1 translocation and interaction with transportin1
10.1016/j.yexcr.2016.11.023 · 2017 · External reference
Role(s) of G3BPs in human pathogenesis
10.1124/jpet.122.001538 · 2023 · External reference
The stress granule protein G3BP1 recruits protein kinase R to promote multiple innate immune antiviral responses
10.1128/jvi.02791-14 · 2015 · External reference
Stress granules regulate double-stranded RNA-dependent protein kinase activation through a complex containing G3BP1 and Caprin1
10.1128/mbio.02486-14 · 2015 · External reference
Liquid–liquid phase separation in biology
10.1146/annurev-cellbio-100913-013325 · 2014 · External reference
Biomolecular condensates: organizers of cellular biochemistry
10.1038/nrm.2017.7 · 2017 · External reference
O-linked-N-acetylglucosaminylation of the RNA-binding protein EWS N-terminal low complexity region reduces phase separation and enhances condensate dynamics
10.1021/jacs.1c04194 · 2021 · External reference
Evidence that only EWS among the FET proteins acquires a low partitioning property for the hyperosmotic stress response by O-GlcNAc glycosylation on its low-complexity domain
10.1016/j.yexcr.2023.113504 · 2023 · External reference
Interaction hot spots for phase separation revealed by NMR studies of a CAPRIN1 condensed phase
10.1073/pnas.2104897118 · 2021 · External reference
O-GlcNAcylation modulates liquid-liquid phase separation of SynGAP/PSD-95
10.1038/s41557-022-00946-9 · 2022 · External reference
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins
10.1038/s41556-023-01258-x · 2023 · External reference
O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells
10.1038/s41467-025-59371-4 · 2025 · External reference
RNA Binding protein motif 3 Inhibits oxygen-glucose deprivation/reoxygenation-induced apoptosis through promoting stress granules formation in PC12 cells and rat primary cortical neurons
10.3389/fncel.2020.559384 · 2020 · External reference
Muscone alleviates neuronal injury via increasing stress granules formation and reducing apoptosis in acute ischemic stroke
10.1016/j.expneurol.2024.114678 · 2024 · External reference
Prolonged translation arrest in reperfused hippocampal cornu Ammonis 1 is mediated by stress granules
10.1016/j.neuroscience.2005.05.047 · 2005 · External reference
Convergence of stress granules and protein aggregates in hippocampal cornu ammonis 1 at later reperfusion following global brain ischemia
10.1016/j.neuroscience.2007.01.050 · 2007 · External reference
Stress granules are formed in renal proximal tubular cells during metabolic stress and ischemic injury for cell survival
10.1152/ajprenal.00139.2019 · 2019 · External reference
Intracellular energy controls dynamics of stress-induced ribonucleoprotein granules
10.1038/s41467-022-33079-1 · 2022 · External reference
Inhibition of cap-initiation complexes linked to a novel mechanism of eIF4G depletion in acute myocardial ischemia
10.1038/sj.cdd.4401854 · 2006 · External reference
TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis
10.1038/ncomms10252 · 2016 · External reference
Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases
10.1016/j.cub.2023.04.012 · 2023 · External reference
Sequestration of TRAF2 into stress granules interrupts tumor necrosis factor signaling under stress conditions
10.1128/mcb.25.6.2450-2462.2005 · 2005 · External reference
Stress granules counteract senescence by sequestration of PAI-1
10.15252/embr.201744722 · 2018 · External reference
RhoA/ROCK1 signaling regulates stress granule formation and apoptosis
10.1016/j.cellsig.2009.12.001 · 2010 · External reference
Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA
10.1016/j.molcel.2023.03.010 · 2023 · External reference
Calcium signaling from damaged lysosomes induces cytoprotective stress granules
10.1038/s44318-024-00292-1 · 2024 · External reference
Cytosolic stress granules relieve the ubiquitin-proteasome system in the nuclear compartment
10.15252/embj.2022111802 · 2023 · External reference
Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms
10.1038/sj.onc.1204436 · 2001 · External reference
Staurosporine-induced apoptosis in cardiomyocytes: a potential role of caspase-3
10.1006/jmcc.1997.0614 · 1998 · External reference
p21 upregulation through the stress granule-associated protein CUGBP1 confers resistance to bortezomib-mediated apoptosis
10.1371/journal.pone.0020254 · 2011 · External reference
Inhibition of IL-1β secretion and mitochondria respiration by arsenite which acts on myocardial ischemia-reperfusion injury
10.35248/2161-0495.21.11.487 · 2021 · External reference
Preconditioning with sodium arsenite inhibits apoptotic cell death in rat kidney with ischemia/reperfusion or cyclosporine-induced Injuries. The possible role of heat-shock protein 70 as a mediator of ischemic tolerance
10.1159/000052623 · 2001 · External reference
Role of heat shock protein 70 in hepatic ischemia-reperfusion injury in mice
10.1152/ajpgi.00491.2006 · 2007 · External reference
Arsenic induces apoptosis of human umbilical vein endothelial cells through mitochondrial pathways
10.1007/s12012-010-9073-z · 2010 · External reference
Arsenic trioxide-induced apoptosis in H9c2 cardiomyocytes: implications in cardiotoxicity
10.1111/j.1742-7843.2007.00150.x · 2008 · External reference
NADH oxidase activation is involved in arsenite-induced oxidative DNA damage in human vascular smooth muscle cells
10.1161/01.res.86.5.514 · 2000 · External reference
Inorganic arsenic induces sex-dependent pathological hypertrophy in the heart
10.1152/ajpheart.00435.2020 · 2021 · External reference
Chronic low-level arsenite exposure through drinking water increases blood pressure and promotes concentric left ventricular hypertrophy in female mice
10.1177/0192623311432297 · 2012 · External reference
Inorganic arsenic exposure induces sex-disparate effects and exacerbates ischemia–reperfusion injury in the female heart
10.1152/ajpheart.00364.2018 · 2019 · External reference
Arsenic-induced interstitial myocardial fibrosis reveals a new insight into drug-induced long QT syndrome
10.1093/cvr/cvs230 · 2012 · External reference
Arsenic exposure and cardiovascular disease: an updated systematic review
10.1007/s11883-012-0280-x · 2012 · External reference
Glucosamine protects neonatal cardiomyocytes from ischemia-reperfusion injury via increased protein-associated O-GlcNAc
10.1152/ajpcell.00162.2006 · 2007 · External reference
Thiamet G mediates neuroprotection in experimental stroke by modulating microglia/macrophage polarization and inhibiting NF-κB p65 signaling
10.1177/0271678x16679671 · 2017 · External reference
O-GlcNAcylation reduces ischemia-reperfusion-induced brain injury
10.1038/s41598-017-10635-0 · 2017 · External reference
Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation: novel mechanism of cardiac stress modulation by PDE5 inhibition
10.1016/j.yjmcc.2009.11.015 · 2010 · External reference
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
10.1038/nm1175 · 2005 · External reference
Mitochondrial instability during regional ischemia–reperfusion underlies arrhythmias in monolayers of cardiomyocytes
10.1016/j.yjmcc.2014.09.024 · 2015 · External reference
Novel antibodies for the simple and efficient enrichment of native O-GlcNAc modified peptides
10.1016/j.mcpro.2021.100167 · 2021 · External reference
Combining high-energy C-trap dissociation and electron transfer dissociation for protein O-GlcNAc modification site assignment
10.1021/pr2002726 · 2011 · External reference
Methods for enrichment and assignment of N-acetylglucosamine modification sites
10.1074/mcp.r120.002206 · 2021 · External reference
Generation of an induced pluripotent stem cell line, JHUi008-A, from a healthy female donor
10.1016/j.scr.2025.103819 · 2025 · External reference
Innate immune activation and mitochondrial ROS induce acute and persistent cardiac conduction system dysfunction after COVID-19
10.1172/jci.insight.193164 · 2025 · External reference
Optimization of metabolic oligosaccharide engineering with Ac(4)GalNAlk and Ac(4)GlcNAlk by an engineered pyrophosphorylase
10.1021/acschembio.1c00034 · 2021 · External reference
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners
10.1073/pnas.1114356109 · 2012 · External reference
Anomeric fatty acid functionalization prevents nonenzymatic S-glycosylation by monosaccharide metabolic chemical reporters
10.1021/acschembio.1c00470 · 2021 · External reference
Inhibiting O-GlcNAcylation impacts p38 and Erk1/2 signaling and perturbs cardiomyocyte hypertrophy
10.1016/j.jbc.2023.102907 · 2023 · External reference
