Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Probing biomolecular condensates with a minimally perturbative experimental readout framework. Local targets link to admitted publications; unresolved targets remain external evidence.
Biomolecular condensates: organizers of cellular biochemistry
10.1038/nrm.2017.7 · 2017 · External reference
Liquid phase condensation in cell physiology and disease
10.1126/science.aaf4382 · 2017 · External reference
A framework for understanding the functions of biomolecular condensates across scales
10.1038/s41580-020-00303-z · 2021 · External reference
Current practices in the study of biomolecular condensates: a community comment
10.1038/s41467-025-62055-8 · 2025 · External reference
The rheology and interfacial properties of biomolecular condensates
10.1007/s12551-025-01326-6 · 2025 · External reference
The dynamic and heterogeneous composition of biomolecular condensates and its functional relevance
10.1038/s41580-025-00897-2 · 2026 · External reference
Thermal cycling resets the irreversible liquid-to-solid transition of peptide condensates during aging
10.1021/acsami.5c06248 · 2025 · External reference
A liquid-to-solid phase transition of the ALS protein FUS accelerated by disease mutation
10.1016/j.cell.2015.07.047 · 2015 · External reference
Protein condensates as aging Maxwell fluids
10.1126/science.aaw4951 · 2020 · External reference
The liquid-to-solid transition of FUS is promoted by the condensate surface
10.1073/pnas.2301366120 · 2023 · External reference
Functional biomaterials derived from protein liquid–liquid phase separation and liquid-to-solid transition
10.1002/adma.202414703 · 2025 · External reference
ALS/FTD mutation-induced phase transition of FUS liquid droplets and reversible hydrogels into irreversible hydrogels impairs RNP granule function
10.1016/j.neuron.2015.10.030 · 2015 · External reference
Role of aberrant phase separation in pathological protein aggregation
10.1016/j.sbi.2023.102678 · 2023 · External reference
From fundamental amyloid protein self-assembly to development of bioplastics
10.1021/acs.biomac.3c01129 · 2024 · External reference
Tuning the state: matching condensate material properties with physiological demands and pathological dysfunction
10.1016/j.cellin.2026.100309 · 2026 · External reference
Essence determines phenomenon: assaying the material properties of biological condensates
10.1016/j.jbc.2022.101782 · 2022 · External reference
Shear relaxation governs fusion dynamics of biomolecular condensates
10.1038/s41467-021-26274-z · 2021 · External reference
Label-free techniques for probing biomolecular condensates
10.1021/acsnano.4c01534 · 2024 · External reference
Microscopy-based techniques for studying the material properties of biomolecular condensates in the cellular environment
10.1007/s12551-025-01343-5 · 2025 · External reference
Fluorescent protein tags affect the condensation properties of a phase-separating viral protein
10.1091/mbc.e24-01-0013 · 2024 · External reference
Fluorescent protein tagging promotes phase separation and alters the aggregation pathway of huntingtin exon-1
10.1016/j.jbc.2023.105585 · 2024 · External reference
A label-free method for measuring the composition of multicomponent biomolecular condensates
10.1038/s41557-025-01928-3 · 2025 · External reference
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates
10.1038/s42004-025-01659-z · 2025 · External reference
Regulation of biomolecular condensates by interfacial protein clusters
10.1126/science.abg7071 · 2021 · External reference
Biomolecular condensates in contact with membranes
10.1146/annurev-biophys-030722-121518 · 2024 · External reference
Matter over mind: liquid phase separation and neurodegeneration
10.1074/jbc.rev118.001188 · 2019 · External reference
Viscoelastic phase separation in biological cells
10.1038/s42005-022-00947-7 · 2022 · External reference
The exchange dynamics of biomolecular condensates
10.7554/elife.91680.3 · 2024 · External reference
Using single molecule imaging to explore intracellular heterogeneity
10.1016/j.biocel.2023.106455 · 2023 · External reference
Dynamic arrest and aging of biomolecular condensates are modulated by low-complexity domains, RNA and biochemical activity
10.1038/s41467-022-30521-2 · 2022 · External reference
Visualizing molecular architectures of cellular condensates: hints of complex coacervation scenarios
10.1016/j.devcel.2020.09.003 · 2020 · External reference
Dynamic structural organization of biomolecular condensates in Escherichia coli cells
10.1021/jacsau.5c00600 · 2025 · External reference
Quantitative phase imaging in biomedicine
10.1038/s41566-018-0253-x · 2018 · External reference
In situ secondary structure imaging of protein phase separation and aggregation by hyperspectral stimulated Raman scattering microscopy
10.1038/s41467-025-63894-1 · 2025 · External reference
Single-droplet surface-enhanced Raman scattering decodes the molecular determinants of liquid–liquid phase separation
10.1038/s41467-022-32143-0 · 2022 · External reference
Single-fluorogen imaging reveals distinct environmental and structural features of biomolecular condensates
10.1038/s41567-025-02827-7 · 2025 · External reference
A multi-step nucleation process determines the kinetics of prion-like domain phase separation
10.1038/s41467-021-24727-z · 2021 · External reference
Molecular determinants of condensate composition
10.1016/j.molcel.2024.12.021 · 2025 · External reference
Small-molecule properties define partitioning into biomolecular condensates
10.1038/s41557-024-01630-w · 2024 · External reference
Biomolecular condensates sustain pH gradients at equilibrium through charge neutralization
10.1038/s41557-025-02039-9 · 2026 · External reference
Selective ion binding and uptake shape the microenvironment of biomolecular condensates
10.1021/jacs.5c07295 · 2025 · External reference
A calibration-free model of micropipette aspiration for measuring properties of protein condensates
10.1016/j.bpj.2023.09.018 · 2024 · External reference
Theory of rheology and aging of protein condensates
10.1103/prxlife.1.013006 · 2023 · External reference
Wetting and complex remodeling of membranes by biomolecular condensates
10.1038/s41467-023-37955-2 · 2023 · External reference
Functional specificity in biomolecular condensates revealed by genetic complementation
10.1038/s41576-024-00780-4 · 2025 · External reference
Higher-order organization of biomolecular condensates
10.1098/rsob.210137 · 2021 · External reference
Optogenetic control of condensates: principles and applications
10.1016/j.jmb.2024.168835 · 2024 · External reference
Targeted perturbation of signaling-driven condensates
10.1016/j.molcel.2023.10.023 · 2023 · External reference
Differential dynamic microscopy: probing wave vector dependent dynamics with a microscope
10.1103/physrevlett.100.188102 · 2008 · External reference
Differential dynamic microscopy: diffusion measurements where you want them
10.1021/acs.macromol.3c01166 · 2024 · External reference
Nanoscale domains govern local diffusion and ageing within fused-in-sarcoma condensates
10.1038/s41565-025-02077-x · 2026 · External reference
Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates
10.1038/s41467-025-58736-z · 2025 · External reference
Probing chromatin condensation dynamics in live cells using interferometric scattering correlation spectroscopy
10.1038/s42003-024-06457-2 · 2024 · External reference
Fourier transform infrared spectroscopy: a power full method for creating fingerprint of molecules of nanomaterials
10.1016/j.molstruc.2024.140454 · 2025 · External reference
Direct imaging of intracellular RNA, DNA, and liquid–liquid phase separated membraneless organelles with Raman microspectroscopy
10.1038/s42003-022-04342-4 · 2022 · External reference
Raman spectroscopy and imaging of protein droplet formation and aggregation
10.1016/j.sbi.2025.103041 · 2025 · External reference
Label-free quantitative analysis of coacervates via 3D phase imaging
10.1002/adom.202100697 · 2021 · External reference
Background-deflection Brillouin microscopy reveals altered biomechanics of intracellular stress granules by ALS protein FUS
10.1038/s42003-018-0148-x · 2018 · External reference
Brillouin microscopy: an emerging tool for mechanobiology
10.1038/s41592-019-0543-3 · 2019 · External reference
Brillouin microscopy
10.1038/s43586-023-00286-z · 2024 · External reference
Water content, not stiffness, dominates Brillouin spectroscopy measurements in hydrated materials
10.1038/s41592-018-0076-1 · 2018 · External reference
Active microrheology of protein condensates using colloidal probe-AFM
10.1016/j.jcis.2022.11.071 · 2023 · External reference
Surface tension and viscosity of protein condensates quantified by micropipette aspiration
10.1016/j.bpr.2021.100011 · 2021 · External reference
Adaptable P body physical states differentially regulate bicoid mRNA storage during early Drosophila development
10.1016/j.devcel.2021.09.021 · 2021 · External reference
Determining thermodynamic and material properties of biomolecular condensates by confocal microscopy and optical tweezers
10.1007/978-1-0716-2663-4_12 · 2023 · External reference
Determinants for fusion speed of biomolecular droplets
10.1002/anie.202006711 · 2020 · External reference
Programmable viscoelasticity in protein–RNA condensates with disordered sticker-spacer polypeptides
10.1038/s41467-021-26733-7 · 2021 · External reference
Chapter six—methods for characterizing the material properties of biomolecular condensates
2021 · External reference
Particle-based microrheology as a tool for characterizing protein-based materials
10.1021/acsbiomaterials.2c00035 · 2022 · External reference
Multi-frequency passive and active microrheology with optical tweezers
10.1038/s41598-021-93130-x · 2021 · External reference
Microrheology with optical tweezers: peaks & troughs
10.1016/j.cocis.2019.02.006 · 2019 · External reference
Measuring age-dependent viscoelasticity of organelles, cells and organisms with time-shared optical tweezer microrheology
10.1038/s41565-024-01830-y · 2025 · External reference
Non-invasive measurement of biomolecular condensate interfacial tension and bending rigidity
10.1016/j.crmeth.2025.101223 · 2025 · External reference
Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition
10.1038/s41565-020-0731-4 · 2020 · External reference
Biomolecular condensate phase diagrams with a combinatorial microdroplet platform
10.1038/s41467-022-35265-7 · 2022 · External reference
Identifying phase-separating biomolecular condensates in cells
10.1038/s41557-024-01503-2 · 2024 · External reference
Germline P granules are liquid droplets that localize by controlled dissolution/condensation
10.1126/science.1172046 · 2009 · External reference
Multiphasic condensates formed with mono-component of tetrapeptides via phase separation
10.1038/s41467-025-58060-6 · 2025 · External reference
DNA partitioning modulates liquid-to-solid transitions and the internal microstructure of FUS condensates
10.1101/2025.06.03.657213 · 2025 · External reference
Decoupling phase separation and fibrillization preserves activity of biomolecular condensates
10.1038/s41467-026-69244-z · 2026 · External reference
Noncontact three-dimensional mapping of intracellular hydromechanical properties by Brillouin microscopy
10.1038/nmeth.3616 · 2015 · External reference
Confocal Brillouin microscopy for three-dimensional mechanical imaging
10.1038/nphoton.2007.250 · 2008 · External reference
Correlative all-optical quantification of mass density and mechanics of subcellular compartments with fluorescence specificity
10.7554/elife.68490 · 2022 · External reference
Stabilized real-time Brillouin microscopy reveals fractal organization of protein condensates in living cells
10.1038/s41467-026-68984-2 · 2026 · External reference
Hyperspectral analysis applied to micro-Brillouin maps of amyloid-beta plaques in Alzheimer’s disease brains
10.1039/c8an01291a · 2018 · External reference
Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis
10.1142/s1793545817420019 · 2017 · External reference
Ultrafast spectroscopy reveals slow water dynamics in biocondensates
10.1021/jacs.3c10862 · 2023 · External reference
Interaction-dependent secondary structure of peptides in biomolecular condensates
10.1021/jacs.4c11226 · 2024 · External reference
Liquid–liquid phase separation of the intrinsically disordered domain of the fused in sarcoma protein results in substantial slowing of hydration dynamics
10.1021/acs.jpclett.3c02790 · 2023 · External reference
Stimulated Raman scattering microscopy: an emerging tool for drug discovery
10.1039/c5cs00693g · 2016 · External reference
Unveiling intracellular phase separation: advances in optical imaging of biomolecular condensates
10.1016/j.tibs.2024.06.014 · 2024 · External reference
Liquid–liquid phase separation from the viewpoint of molecular crowding environment: a Raman imaging study
10.1021/acs.jpcb.5c02288 · 2025 · External reference
Stimulated Raman scattering from organic liquids
10.1103/physrevlett.9.455 · 1962 · External reference
Broadband coherent anti-Stokes Raman scattering (BCARS) microscopy for rapid, label-free biological imaging
10.1063/5.0253841 · 2025 · External reference
Ballistic diffusion fronts in biomolecular condensates
10.1038/s41565-025-01941-0 · 2025 · External reference
Raman spectra of pyridine adsorbed at a silver electrode
10.1016/0009-2614(74)85388-1 · 1974 · External reference
Surface-enhanced Raman spectroscopy for biomedical applications: recent advances and future challenges
10.1021/acsami.4c17502 · 2025 · External reference
Chemically specific coherent raman imaging of liquid–liquid phase separation and its sequelae
10.1021/acs.analchem.4c03923 · 2025 · External reference
Label-free single-molecule imaging with numerical-aperture-shaped interferometric scattering microscopy
10.1021/acsphotonics.6b00912 · 2017 · External reference
Interferometric scattering microscopy: seeing single nanoparticles and molecules via Rayleigh scattering
10.1021/acs.nanolett.9b01822 · 2019 · External reference
Direct optical sensing of single unlabelled proteins and super-resolution imaging of their binding sites
10.1038/ncomms5495 · 2014 · External reference
Chromatin compaction during confined cell migration induces and reshapes nuclear condensates
10.1038/s41467-024-54120-5 · 2024 · External reference
Micropipette aspiration reveals differential RNA-dependent viscoelasticity of nucleolar subcompartments
10.1073/pnas.2407423122 · 2025 · External reference
Single-molecule techniques to visualize and to characterize liquid–liquid phase separation and phase transition
10.3724/abbs.2023028 · 2023 · External reference
Mechanical mapping of nanobubbles by PeakForce atomic force microscopy
10.1039/c3sm50942g · 2013 · External reference
Engineered droplet-forming peptide as photocontrollable phase modulator for fused in sarcoma protein
10.1038/s41467-024-50025-5 · 2024 · External reference
Scanning probe microscopy elucidates gelation and rejuvenation of biomolecular condensates
10.1016/j.xcrp.2025.102430 · 2025 · External reference
Scanning probe microscopy for rheological analysis of biomolecular condensates
10.1016/j.xpro.2025.104170 · 2025 · External reference
Optical-Tweezers-integrating-Differential-Dynamic-Microscopy maps the spatiotemporal propagation of nonlinear strains in polymer blends and composites
10.1038/s41467-022-32876-y · 2022 · External reference
Thermodynamically driven assemblies and liquid–liquid phase separations in biology
10.1039/c8sm02285b · 2019 · External reference
Pushing the limits of microfluidic droplet production efficiency: engineering microchannels with seamlessly implemented 3D inverse colloidal crystals
10.1039/d3lc00913k · 2024 · External reference
Droplet microfluidics for biomedical applications: emerging trends and future developments
10.1038/s41378-026-01175-7 · 2026 · External reference
Grand challenges in microfluidics: a call for biological and engineering action
10.3389/fsens.2020.583035 · 2020 · External reference
Interfacial tension measurements in microfluidic quasi-static extensional flows
10.3390/mi12030272 · 2021 · External reference
Hybrid microfluidic device for on-demand control of droplet coalescence and testing of emulsion stability
10.1007/s10404-025-02838-z · 2025 · External reference
Independent active and thermodynamic processes govern the nucleolus assembly in vivo
10.1073/pnas.1615395114 · 2017 · External reference
Rheology and viscoelasticity of proteins and nucleic acids condensates
10.1021/jacsau.2c00055 · 2022 · External reference
Optical characterization of molecular interaction strength in protein condensates
10.1091/mbc.e24-03-0128 · 2024 · External reference
Quantifying surface tension and viscosity in biomolecular condensates by FRAP-ID
10.1016/j.bpj.2024.07.043 · 2024 · External reference
Controlled liquid–liquid phase separation via the simulation-guided, targeted engineering of the RNA-binding protein PARCL
10.1016/j.isci.2025.112852 · 2025 · External reference
Label-free identification of protein aggregates using deep learning
10.1038/s41467-023-43440-7 · 2023 · External reference
Self-driving microscopy detects the onset of protein aggregation and enables intelligent Brillouin imaging
10.1038/s41467-025-60912-0 · 2025 · External reference
A solid beta-sheet structure is formed at the surface of FUS droplets during aging
10.1038/s41589-024-01573-w · 2024 · External reference
Characterisation of biocondensate microfluidic flow using array-detector FCS
10.1016/j.bbagen.2024.130673 · 2024 · External reference
Automated navigation of condensate phase behavior with active machine learning
10.1038/s41467-025-64617-2 · 2025 · External reference
A high-throughput, flow cytometry approach to measure phase behavior and exchange in biomolecular condensates
10.1038/s41467-025-68093-6 · 2026 · External reference
The filamentous ultrastructure of the PopZ condensate is required for its cellular function
10.1038/s41594-025-01742-y · 2026 · External reference
Convolutional neural networks applied to differential dynamic microscopy reduces noise when quantifying heterogeneous dynamics
10.1039/d4sm00881b · 2024 · External reference
Machine learning in microscopy—insights, opportunities and challenges
10.1242/jcs.262095 · 2024 · External reference
FUS and TDP-43 phases in health and disease
10.1016/j.tibs.2020.12.005 · 2021 · External reference
Modulating biomolecular condensates: a novel approach to drug discovery
10.1038/s41573-022-00505-4 · 2022 · External reference
Transcription activation is enhanced by multivalent interactions independent of phase separation
10.1016/j.molcel.2022.04.017 · 2022 · External reference