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References from KDM2B controls HIF levels and activity through its JmjC and CxxC domains. Local targets link to admitted publications; unresolved targets remain external evidence.
Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity
10.1126/science.aba3512 · 2020 · External reference
Cellular adaptation to hypoxia through hypoxia inducible factors and beyond
10.1038/s41580-020-0227-y · 2020 · External reference
Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity
10.1136/bmjonc-2023-000154 · 2024 · External reference
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
10.1016/j.molcel.2008.04.009 · 2008 · External reference
Roles of HIF and 2-oxoglutarate-dependent dioxygenases in controlling gene expression in hypoxia
10.3390/cancers13020350 · 2021 · External reference
Oxygen sensing by HIF hydroxylases
10.1038/nrm1366 · 2004 · External reference
Role of hypoxia in the control of the cell cycle
10.3390/ijms22094874 · 2021 · External reference
Non-canonical mechanisms regulating hypoxia-inducible factor 1 alpha in cancer
10.3389/fonc.2017.00286 · 2017 · External reference
Translating the hypoxic response—the role of hif protein translation in the cellular response to low oxygen
10.3390/cells8020114 · 2019 · External reference
Rethinking the role of HIF in hepatocellular carcinoma
10.1111/febs.70440 · 2026 · External reference
Regulation of hypoxia-inducible factor-1alpha by NF-kappaB
10.1042/bj20080476 · 2008 · External reference
Evolutionary conserved regulation of HIF-1beta by NF-kappaB
10.1371/journal.pgen.1001285 · 2011 · External reference
HIF-1alpha restricts NF-kappaB-dependent gene expression to control innate immunity signals
10.1242/dmm.017285 · 2015 · External reference
TNFSF14/LIGHT, a non-canonical NF-kappaB stimulus, induces the HIF pathway
10.3390/cells7080102 · 2018 · External reference
Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site
10.1161/01.atv.0000258979.92828.bc · 2007 · External reference
Histone demethylases in chromatin biology and beyond
10.15252/embr.201541113 · 2015 · External reference
Molecular mechanisms and potential functions of histone demethylases
10.1038/nrm3327 · 2012 · External reference
Hypoxia induces rapid changes to histone methylation and reprograms chromatin
10.1126/science.aau5870 · 2019 · External reference
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
10.1126/science.aaw1026 · 2019 · External reference
Epigenetic regulation by histone demethylases in hypoxia
10.2217/epi.15.24 · 2015 · External reference
Functional crosstalk between chromatin and hypoxia signalling
10.1016/j.cellsig.2023.110660 · 2023 · External reference
Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth
10.1128/mcb.00444-09 · 2010 · External reference
Histone demethylase JMJD1A promotes urinary bladder cancer progression by enhancing glycolysis through coactivation of hypoxia inducible factor 1alpha
10.1038/onc.2017.13 · 2017 · External reference
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
10.1073/pnas.1217394109 · 2012 · External reference
KDM2 family members are regulated by HIF-1 in hypoxia
10.3390/cells6010008 · 2017 · External reference
The critical role of histone lysine demethylase KDM2B in cancer
2018 · External reference
KDM2A/B lysine demethylases and their alternative isoforms in development and disease
10.1080/19491034.2018.1498707 · 2018 · External reference
Biological functions of the KDM2 family of histone demethylases
10.1007/978-3-031-38176-8_3 · 2023 · External reference
NF-kappaB is a central regulator of hypoxia-induced gene expression
10.1038/s44319-025-00651-x · 2026 · External reference
SWI/SNF regulates the cellular response to hypoxia
10.1074/jbc.m808491200 · 2009 · External reference
KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity
10.1093/nar/gkz607 · 2019 · External reference
KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs
10.1172/jci64535 · 2013 · External reference
KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling
10.1038/s41423-019-0251-z · 2020 · External reference
Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4
10.1016/j.metabol.2023.155719 · 2024 · External reference
The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH
10.1091/mbc.e11-02-0163 · 2011 · External reference
Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene
10.1038/sj.bjc.6605450 · 2010 · External reference
The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer
10.1038/bjc.2014.604 · 2015 · External reference
Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers
10.1158/0008-5472.can-06-3322 · 2007 · External reference
The role of hypoxia-inducible factor post-translational modifications in regulating its localisation, stability, and activity
10.3390/ijms22010268 · 2020 · External reference
SiRNA screening to identify ubiquitin and ubiquitin-like system regulators of biological pathways in cultured mammalian cells
10.3791/51572 · 2014 · External reference
PBRM1 cooperates with YTHDF2 to control HIF-1alpha protein translation
10.3390/cells10061425 · 2021 · External reference
PERK/eIF2alpha signaling inhibits HIF-induced gene expression during the unfolded protein response via YB1-dependent regulation of HIF1alpha translation
10.1093/nar/gky127 · 2018 · External reference
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands
10.7554/elife.00205 · 2012 · External reference
Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation
10.1016/j.molcel.2013.01.016 · 2013 · External reference
Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes
10.1038/ncb2702 · 2013 · External reference
Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation
10.1016/j.cell.2014.05.004 · 2014 · External reference
KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation
10.1038/onc.2015.482 · 2016 · External reference
KDM2B regulates inflammation and oxidative stress of sepsis via targeting NF-kappaB and AP-1 pathways
10.1002/iid3.985 · 2023 · External reference
KDM2B overexpression prevents myocardial ischemia-reperfusion injury in rats through regulating inflammatory response via the TLR4/NF-kappaB p65 axis
10.3892/etm.2021.11077 · 2022 · External reference
CpG island reconfiguration for the establishment and synchronization of polycomb functions upon exit from naive pluripotency
10.1016/j.molcel.2022.01.027 · 2022 · External reference
Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis
10.1172/jci84014 · 2016 · External reference
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
10.1101/gad.12.2.149 · 1998 · External reference
HIF-1 alpha is required for solid tumor formation and embryonic vascularization
10.1093/emboj/17.11.3005 · 1998 · External reference
Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha
10.1016/j.cardiores.2003.07.003 · 2003 · External reference
KDM2B mediates the Wnt/beta-catenin pathway through transcriptional activation of PKMYT1 via microRNA-let-7b-5p/EZH2 to affect the development of non-small cell lung cancer
10.1016/j.yexcr.2022.113208 · 2022 · External reference
Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway
10.1080/21655979.2021.2005931 · 2021 · External reference
The role of KDM2B and EZH2 in regulating the stemness in colorectal cancer through the PI3K/AKT pathway
10.3389/fonc.2021.637298 · 2021 · External reference
Inhibition of cell proliferation and induction of autophagy by KDM2B/FBXL10 knockdown in gastric cancer cells
10.1016/j.cellsig.2017.05.011 · 2017 · External reference
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
10.1128/mcb.00166-09 · 2009 · External reference
Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif
10.1074/jbc.m611782200 · 2007 · External reference
mTORC1 drives HIF-1alpha and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3
10.1038/onc.2014.164 · 2015 · External reference
Akt-dependent regulation of NF-kappaB is controlled by mTOR and Raptor in association with IKK
10.1101/gad.1662308 · 2008 · External reference
The activity of JmjC histone lysine demethylase KDM4A is highly sensitive to oxygen concentrations
10.1021/acschembio.6b00958 · 2017 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
10.1006/meth.2001.1262 · 2001 · External reference
GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis
10.1093/nar/gkz430 · 2019 · External reference
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
10.1158/2159-8290.cd-12-0095 · 2012 · External reference
KDM2B controls HIF levels and activity through its JmjC and CxxC domains—source data
10.6084/m9.figshare.33154961 · 2026 · External reference