Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Solution structures of glycosaminoglycan-bound CXCL8 complexes determined by small-angle X-ray scattering (SAXS). Local targets link to admitted publications; unresolved targets remain external evidence.
Evolution of glycosaminoglycans: comparative biochemical study
10.4161/cib.4.2.14547 · 2011 · External reference
The glycosaminoglycan interactome 2.0
10.1152/ajpcell.00095.2022 · 2022 · External reference
Deciphering functional glycosaminoglycan motifs in development
10.1016/j.sbi.2018.03.011 · 2018 · External reference
Glycosaminoglycan-protein interactions and their roles in human disease
10.3389/fmolb.2021.639666 · 2021 · External reference
A systems view of the heparan sulfate interactome
10.1369/0022155420988661 · 2021 · External reference
Heparan sulfate: a complex polymer charged with biological activity
10.1021/cr010213m · 2005 · External reference
A review of chondroitin sulfate’s preparation, properties, functions, and applications
10.3390/molecules28207093 · 2023 · External reference
The sweet spot: how GAGs help chemokines guide migrating cells
10.1189/jlb.3mr0915-440r · 2016 · External reference
Structural basis for FGF hormone signalling
10.1038/s41586-023-06155-9 · 2023 · External reference
Glycosaminoglycans: what remains to be deciphered?
10.1021/jacsau.2c00569 · 2023 · External reference
Computational analysis of interactions in structurally available protein-glycosaminoglycan complexes
10.1093/glycob/cww055 · 2016 · External reference
Solution NMR spectroscopy for characterizing protein-glycosaminoglycan interactions
10.1007/978-1-0716-1398-6_2 · 2022 · External reference
NMR characterization of the interactions between glycosaminoglycans and proteins
10.3389/fmolb.2021.646808 · 2021 · External reference
So you think computational approaches to understanding glycosaminoglycan-protein interactions are too dry and too rigid? Think again!
10.1016/j.sbi.2017.12.004 · 2018 · External reference
Molecular dynamics simulations to understand glycosaminoglycan interactions in the free- and protein-bound states
10.1016/j.sbi.2022.102356 · 2022 · External reference
Modeling glycosaminoglycan-protein complexes
10.1016/j.sbi.2022.102332 · 2022 · External reference
Benchmarking water models in molecular dynamics of protein-glycosaminoglycan complexes
10.1021/acs.jcim.4c00030 · 2024 · External reference
Structural basis of chemokine interactions with heparan sulfate, chondroitin sulfate, and dermatan sulfate
10.1074/jbc.ra119.009879 · 2019 · External reference
Structural insights into how proteoglycans determine chemokine-CXCR1/CXCR2 interactions: progress and challenges
10.3389/fimmu.2020.00660 · 2020 · External reference
Structural diversity of heparan sulfate binding domains in chemokines
10.1073/pnas.032497699 · 2002 · External reference
Defining the interleukin-8-binding domain of heparan sulfate
10.1074/jbc.273.25.15487 · 1998 · External reference
Docking of glycosaminoglycans to heparin-binding proteins: validation for aFGF, bFGF, and antithrombin and application to IL-8
10.1021/ja983319g · 1999 · External reference
Molecular dynamics simulations of CXCL-8 and its interactions with a receptor peptide, heparin fragments, and sulfated linked cyclitols
10.1021/ci1003366 · 2011 · External reference
Identification of a glycosaminoglycan binding surface on human interleukin-8
10.1021/bi972867o · 1998 · External reference
Comparative bindings of glycosaminoglycans with CXCL8 monomer and dimer: insights from conformational dynamics and kinetics of hydrogen bonds
10.1021/acs.jpcb.4c03670 · 2024 · External reference
Differentiation of CC vs CXC chemokine dimers with GAG octasaccharide binding partners: an ion mobility mass spectrometry approach
10.1021/ja310915m · 2013 · External reference
Characterization of the interaction of interleukin-8 with hyaluronan, chondroitin sulfate, dermatan sulfate and their sulfated derivatives by spectroscopy and molecular modeling
10.1093/glycob/cwr120 · 2012 · External reference
Solution NMR characterization of chemokine CXCL8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions
10.1042/bj20150059 · 2015 · External reference
Structural basis of chemokine CXCL8 monomer and dimer binding to chondroitin sulfate: insights into specificity and plasticity
10.3390/biom16010124 · 2026 · External reference
Methods, development and applications of small-angle X-ray scattering to characterize biological macromolecules in solution
10.1016/j.crstbi.2020.08.004 · 2020 · External reference
Methods for SAXS-based structure determination of biomolecular complexes
10.1002/adma.201304475 · 2014 · External reference
Practical aspects of 1H transverse paramagnetic relaxation enhancement measurements on macromolecules
10.1016/j.jmr.2006.10.003 · 2007 · External reference
Glycosaminoglycan-protein interactions by nuclear magnetic resonance (NMR) spectroscopy
10.3390/molecules23092314 · 2018 · External reference
New developments in the ATSAS program package for small-angle scattering data analysis
10.1107/s0021889812007662 · 2012 · External reference
DAMMIF, a program for rapid ab-initio shape determination in small-angle scattering
10.1107/s0021889809000338 · 2009 · External reference
Determination of domain structure of proteins from X-ray solution scattering
10.1016/s0006-3495(01)76260-1 · 2001 · External reference
Advanced ensemble modelling of flexible macromolecules using X-ray solution scattering
10.1107/s205225251500202x · 2015 · External reference
Solution NMR characterization of WT CXCL8 monomer and dimer binding to CXCR1 N-terminal domain
10.1002/pro.2590 · 2015 · External reference
Proline mutagenesis as a strategy for design of monomeric proteins
10.1016/j.bpj.2013.08.008 · 2013 · External reference
1H NMR solution structure of an active monomeric interleukin-8
10.1021/bi00040a008 · 1995 · External reference
Three-dimensional structure of interleukin 8 in solution
10.1021/bi00459a004 · 1990 · External reference
Dynamics-derived insights into complex formation between the CXCL8 monomer and CXCR1 N-terminal domain: an NMR study
10.3390/molecules23112825 · 2018 · External reference
Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: implications for gradients and neutrophil trafficking
10.1098/rsob.170168 · 2017 · External reference
Probing receptor binding activity of interleukin-8 dimer using a disulfide trap
10.1021/bi0605944 · 2006 · External reference
CXCL1/MGSA is a novel glycosaminoglycan (GAG)-binding chemokine: structural evidence for two distinct non-overlapping binding domains
10.1074/jbc.m115.697888 · 2016 · External reference
Molecular basis of chemokine CXCL5-glycosaminoglycan interactions
10.1074/jbc.m116.745265 · 2016 · External reference
Direct detection and characterization of lysine side chain NH3+ in protein-heparin complexes using NMR spectroscopy
10.1039/c7an01406f · 2018 · External reference
Structural basis of native CXCL7 monomer binding to CXCR2 receptor N-domain and glycosaminoglycan heparin
10.3390/ijms18030508 · 2017 · External reference
A model of GAG/MIP-2/CXCR2 interfaces and its functional effects
10.1021/bi3001566 · 2012 · External reference
Structural basis, stoichiometry, and thermodynamics of chemokines KC/mCXCL1 and MIP2/mCXCL2 binding to glycosaminoglycan heparin
10.1074/jbc.ra118.004866 · 2018 · External reference
Platelet-derived chemokine CXCL7 dimer preferentially exists in the glycosaminoglycan-bound form: implications for neutrophil-platelet crosstalk
10.3389/fimmu.2017.01248 · 2017 · External reference
Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation
10.1126/scitranslmed.aah6650 · 2017 · External reference
Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant
10.1093/jleuko/qiad097 · 2023 · External reference
The heterodimerization of platelet-derived chemokines
10.1016/j.bbapap.2012.09.010 · 2013 · External reference
Chemokine CXCL7 heterodimers: structural insights, CXCR2 receptor function, and glycosaminoglycan interactions
10.3390/ijms18040748 · 2017 · External reference
Structural basis of a chemokine heterodimer binding to glycosaminoglycans
10.1042/bcj20200927 · 2021 · External reference
Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib
10.1042/bcj20160985 · 2017 · External reference
Solution NMR structure of a human FGF-1 monomer, activated by a hexasaccharide heparin-analogue
10.1111/j.1742-4658.2006.05474.x · 2006 · External reference
Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization
10.1016/s1097-2765(00)00073-3 · 2000 · External reference
Influence of heparin mimetics on assembly of the FGF-FGFR4 signaling complex
10.1074/jbc.m109.095109 · 2010 · External reference
Structure of a heparin-linked biologically active dimer of fibroblast growth factor
10.1038/31741 · 1998 · External reference
Heparan sulfate selectively inhibits the collagenase activity of cathepsin K
10.1016/j.matbio.2024.03.005 · 2024 · External reference
The crystal and molecular structures of a cathepsin K:chondroitin sulfate complex
10.1016/j.jmb.2008.07.038 · 2008 · External reference
Structural basis of collagen fiber degradation by cathepsin K
10.1073/pnas.1414126111 · 2014 · External reference
Vascular endothelial growth factor
10.1161/atvbaha.108.179663 · 2009 · External reference
Heparin, heparan sulphate and the TGF-β cytokine superfamily
10.3390/molecules22050713 · 2017 · External reference
Mechanism of action and in vivo role of platelet-derived growth factor
10.1152/physrev.1999.79.4.1283 · 1999 · External reference
The structure and function of the endothelial glycocalyx layer
10.1146/annurev.bioeng.9.060906.151959 · 2007 · External reference
Basement membrane proteoglycans: from cellar to ceiling
10.1038/nrm1702 · 2005 · External reference
Binding of interleukin-8 to heparan sulfate and chondroitin sulfate in lung tissue
10.1165/rcmb.2002-0084oc · 2003 · External reference
A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils
10.1182/blood-2010-01-266072 · 2010 · External reference
Conformational states of exchange protein directly activated by cAMP (EPAC1) revealed by ensemble modeling and integrative structural biology
10.3390/cells9010035 · 2019 · External reference
NMRPipe: a multidimensional spectral processing system based on UNIX pipes
10.1007/bf00197809 · 1995 · External reference
NMR View: a computer program for the visualization and analysis of NMR data
10.1007/bf00404272 · 1994 · External reference
Ensemble approach for NMR structure refinement against 1H paramagnetic relaxation enhancement data arising from a flexible paramagnetic group attached to a macromolecule
10.1021/ja031580d · 2004 · External reference
SASBDB: towards an automatically curated and validated repository for biological scattering data
10.1002/pro.3731 · 2020 · External reference
SAXS-derived structure of heparin octasaccharide
2026 · External reference
SAXS-derived structure of chondroitin sulfate octasaccharide
2026 · External reference
SAXS-derived structure of CXCL8 dimer
2026 · External reference
SAXS-derived structure of CXCL8-chondroitin sulphate complex
2026 · External reference
SAXS-derived structure of CXCL8-heparin complex
2026 · External reference