Research graph
References from Netrin-1 and UNC5H receptors: role in cell fate determination and carcinogenesis. Local targets link to admitted publications; unresolved targets remain external evidence.
Growth factor receptors: structure, mechanism, and drug discovery
10.1002/(sici)1097-0282(1997)43:5<339::aid-bip2>3.0.co;2-w · 1997 · External reference
Dependence receptors: a new paradigm in cell signaling and cancer therapy
10.1038/onc.2010.13 · 2010 · External reference
UNCovering the molecular machinery of dependence receptor signaling
10.1016/j.molcel.2010.12.015 · 2010 · External reference
Dependence receptors - the dark side awakens
10.1111/febs.14507 · 2018 · External reference
Netrin-1 acts as a survival factor via its receptors UNC5H and DCC
10.1093/emboj/20.11.2715 · 2001 · External reference
A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53
10.1016/j.bbrc.2008.03.152 · 2008 · External reference
The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis
10.1038/27441 · 1998 · External reference
Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog
10.1126/science.1085405 · 2003 · External reference
RGM and its receptor neogenin regulate neuronal survival
10.1038/ncb1157 · 2004 · External reference
The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease
10.1093/emboj/19.15.4056 · 2000 · External reference
The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm
10.1073/pnas.0701243104 · 2007 · External reference
EphrinB3 is an anti-apoptotic ligand that inhibits the dependence receptor functions of EphA4 receptors during adult neurogenesis
10.1016/j.bbamcr.2008.09.009 · 2009 · External reference
Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage
10.1128/mcb.24.23.10328-10339.2004 · 2004 · External reference
Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage
10.1128/mcb.01515-05 · 2006 · External reference
Potentiation of neuroblastoma metastasis by loss of caspase-8
10.1038/nature04323 · 2006 · External reference
Dependence receptors: between life and death
10.1007/s00018-004-3467-7 · 2004 · External reference
Dependence receptors and cancer: addiction to trophic ligands
10.1158/0008-5472.can-14-3652 · 2015 · External reference
UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans
10.1016/0092-8674(92)90357-i · 1992 · External reference
The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans
10.1016/0896-6273(90)90444-k · 1990 · External reference
Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers
10.1038/sj.bjc.6602656 · 2005 · External reference
Autoinhibition of UNC5b revealed by the cytoplasmic domain structure of the receptor
10.1016/j.molcel.2009.02.016 · 2009 · External reference
Netrin-1 and its dependence receptors as original targets for cancer therapy
10.1097/cco.0b013e328333dcd1 · 2010 · External reference
p53RDL1 regulates p53-dependent apoptosis
10.1038/ncb943 · 2003 · External reference
Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer
10.18632/oncotarget.8348 · 2016 · External reference
Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors
10.1523/jneurosci.19-12-04938.1999 · 1999 · External reference
Netrin-4 promotes mural cell adhesion and recruitment to endothelial cells
10.1186/2045-824x-6-1 · 2014 · External reference
Netrin-4 regulates thalamocortical axon branching in an activity-dependent fashion
10.1073/pnas.1402095111 · 2014 · External reference
Netrins: beyond the brain
10.1038/nrm2142 · 2007 · External reference
Netrins: versatile extracellular cues with diverse functions
10.1242/dev.044529 · 2011 · External reference
Structural decoding of the netrin-1/UNC5 interaction and its therapeutical implications in cancers
10.1016/j.ccell.2016.01.001 · 2016 · External reference
Neogenin suppresses tumor progression and metastasis via inhibiting Merlin/YAP signaling
10.1038/s41420-023-01345-w · 2023 · External reference
Netrin-1 promotes cell neural invasion in gastric cancer via its receptor neogenin
10.7150/jca.30230 · 2019 · External reference
Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling
10.1038/s41556-020-0483-2 · 2020 · External reference
Netrin1 blockade alleviates resistance to chemotherapy in pancreatic cancer
10.1038/s41586-026-10436-4 · 2026 · External reference
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
10.1074/jbc.272.29.17907 · 1997 · External reference
The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase
10.1038/sj.emboj.7600584 · 2005 · External reference
Serine/threonine phosphatases: mechanism through structure
10.1016/j.cell.2009.10.006 · 2009 · External reference
Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer
10.1016/j.canlet.2013.02.036 · 2013 · External reference
CIP2A inhibits PP2A in human malignancies
10.1016/j.cell.2007.04.044 · 2007 · External reference
The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase
10.1016/j.molcel.2010.11.021 · 2010 · External reference
Protein phosphatase 2A (PP2A) holoenzymes regulate death-associated protein kinase (DAPK) in ceramide-induced anoikis
10.1074/jbc.m109.085076 · 2010 · External reference
Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt
10.1074/jbc.m709585200 · 2008 · External reference
Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner
10.1091/mbc.e10-11-0923 · 2011 · External reference
A network map of netrin receptor UNC5B-mediated signaling
10.1007/s12079-018-0485-z · 2019 · External reference
Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis
10.1101/gad.437807 · 2007 · External reference
A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis
10.1038/s41467-021-24998-6 · 2021 · External reference
Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis
10.1016/j.devcel.2009.02.006 · 2009 · External reference
Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B
10.1016/j.devcel.2010.12.001 · 2011 · External reference
Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease
10.1007/s11684-019-0715-7 · 2020 · External reference
Endothelial Unc5B controls blood-brain barrier integrity
10.1038/s41467-022-28785-9 · 2022 · External reference
Interplay between Netrin-1 and Norrin controls arteriovenous zonation of blood-retina barrier integrity
10.1073/pnas.2408674121 · 2024 · External reference
Netrin-1 controls colorectal tumorigenesis by regulating apoptosis
10.1038/nature02788 · 2004 · External reference
The dependence receptors DCC and UNC5H as a link between neuronal guidance and survival
10.1016/s0248-4900(03)00072-8 · 2003 · External reference
Netrin-1 is a survival factor during commissural neuron navigation
10.1073/pnas.0803645105 · 2008 · External reference
Netrin-1 in the developing enteric nervous system and colorectal cancer
10.1016/j.molmed.2012.07.001 · 2012 · External reference
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B
10.1038/ncb1732 · 2008 · External reference
The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence
10.1038/s41380-019-0561-7 · 2020 · External reference
Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A
10.1016/0092-8674(90)90726-u · 1990 · External reference
Involvement of PP2A in viral and cellular transformation
10.1038/sj.onc.1209038 · 2005 · External reference
Polyoma small T antigen triggers cell death via mitotic catastrophe
10.1038/onc.2014.192 · 2015 · External reference
Polyomavirus small T antigen induces apoptosis in mammalian cells through the UNC5B pathway in a PP2A-dependent manner
10.1128/jvi.02187-19 · 2020 · External reference
The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment
10.1073/pnas.0738063100 · 2003 · External reference
Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer
10.1053/j.gastro.2007.08.074 · 2007 · External reference
Methylation of the UNC5C gene and its protein expression in colorectal cancer
10.1177/1010428317697564 · 2017 · External reference
Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies
10.1053/j.gastro.2007.08.009 · 2007 · External reference
Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer
10.1073/pnas.0709810105 · 2008 · External reference
Interference with netrin-1 and tumor cell death in non-small cell lung cancer
10.1093/jnci/djn491 · 2009 · External reference
Netrin-1 acts as a survival factor for aggressive neuroblastoma
10.1084/jem.20082299 · 2009 · External reference
Prognostic implications of netrin-1 expression and its receptors in patients with adenocarcinoma of the pancreas
10.1245/s10434-007-9469-6 · 2007 · External reference
Netrin-1 inducing antiapoptotic effect of acute myeloid leukemia cells in a concentration-dependent manner through the Unc-5 netrin receptor B-focal adhesion kinase axis
10.1080/15384047.2023.2200705 · 2023 · External reference
Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor
10.1038/s41418-023-01209-x · 2023 · External reference
Netrin-1 and its receptor DCC are causally implicated in melanoma progression
10.1158/0008-5472.can-18-1590 · 2020 · External reference
NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors
10.1053/j.gastro.2008.06.080 · 2008 · External reference
Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression
10.1073/pnas.0901767106 · 2009 · External reference
Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability
10.1073/pnas.1505917112 · 2015 · External reference
Netrin-1 promotes the collective cell migration of liver cancer cells in a 3D cell culture model
10.1007/s13105-019-00701-8 · 2019 · External reference
Netrin-1 interference potentiates epithelial-to-mesenchymal transition through the PI3K/AKT pathway under the hypoxic microenvironment conditions of non-small cell lung cancer
2019 · External reference
Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer
10.1038/s41586-023-06367-z · 2023 · External reference
Pharmacological targeting of netrin-1 inhibits EMT in cancer
10.1038/s41586-023-06372-2 · 2023 · External reference
Netrin-1: a new promising diagnostic marker for muscle invasion in bladder cancer
10.1016/j.urolonc.2020.02.006 · 2020 · External reference
Netrin-1-UNC5B/neogenin axis enhances the stemness of colorectal cancer cells
10.1186/s12964-025-02489-1 · 2025 · External reference
Netrin-1 regulates colorectal cancer stem cell self-renewal via a TFF3 dependent paracrine survival mechanism
10.1101/2025.04.28.650943 · 2025 · External reference
Combining chemotherapeutic agents and netrin-1 interference potentiates cancer cell death
10.1002/emmm.201302654 · 2013 · External reference
Blockade of netrin-1 is a promising strategy against
10.1038/d41586-023-02181-9 · 2023 · External reference
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
10.1126/science.270.5240.1326 · 1995 · External reference
FOXOs, cancer and regulation of apoptosis
10.1038/onc.2008.24 · 2008 · External reference
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
10.1016/s0092-8674(00)80595-4 · 1999 · External reference
Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function
10.1128/jvi.05034-11 · 2011 · External reference
Induction of apoptosis in fibroblasts by c-myc protein
10.1016/0092-8674(92)90123-t · 1992 · External reference
MYC and the control of apoptosis
10.1101/cshperspect.a014407 · 2014 · External reference
Distinct roles for E2F proteins in cell growth control and apoptosis
10.1073/pnas.94.14.7245 · 1997 · External reference
E2F and p53 make a nice couple: converging pathways in apoptosis
10.1038/sj.cdd.4401612 · 2005 · External reference
Greatwall maintains mitosis through regulation of PP2A
10.1038/emboj.2009.228 · 2009 · External reference
Phosphatases: providing safe passage through mitotic exit
10.1038/nrm3149 · 2011 · External reference
Protein phosphatases in the regulation of mitosis
10.1083/jcb.201809138 · 2019 · External reference
Safety, tolerability, and preliminary activity of lb-100, an inhibitor of protein phosphatase 2A, in patients with relapsed solid tumors: an open-label, dose escalation, first-in-human, phase I trial
10.1158/1078-0432.ccr-16-2299 · 2017 · External reference
