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References from A non-catalytic interaction surface mediates recognition of spliceosomal factors by the Toxoplasma gondii cyclophilin TgCyp23. Local targets link to admitted publications; unresolved targets remain external evidence.
Nuclear cyclophilins affect spliceosome assembly and function in vitro
10.1042/bj20150396 · 2015 · External reference
The cyclophilins
10.1186/gb-2005-6-7-226 · 2005 · External reference
Structural and Kinetic Variability of Pathogen Cyclophilins: Functional Diversification and Therapeutic Potential
10.1021/acsinfecdis.6c00016 · 2026 · External reference
Immunophilins: structures, mechanisms and ligands
10.2174/1874467208666150519113427 · 2015 · External reference
A cyclophilin functions in pre-mRNA splicing
10.1093/emboj/21.3.470 · 2002 · External reference
Structural and functional insights into human nuclear cyclophilins
10.3390/biom8040161 · 2018 · External reference
Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide
10.1016/s0022-2836(03)00684-3 · 2003 · External reference
The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein
10.1371/journal.pone.0010013 · 2010 · External reference
A large intrinsically disordered region in SKIP and its disorder-order transition induced by PPIL1 binding revealed by NMR
10.1074/jbc.m109.087528 · 2010 · External reference
Solution structure of the splicing factor motif of the human Prp18 protein
10.1002/prot.24003 · 2012 · External reference
The spliceosomal PRP19 complex of trypanosomes
10.1111/mmi.12910 · 2015 · External reference
Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase
10.1126/scitranslmed.abn3231 · 2022 · External reference
The splicing factor SR2 is an important virulence factor of Toxoplasma gondii
10.3389/fmicb.2023.1302512 · 2023 · External reference
Transcript maturation in apicomplexan parasites
10.1016/j.mib.2014.05.012 · 2014 · External reference
Deletion of splicing factor Cdc5 in Toxoplasma disrupts transcriptome integrity, induces abortive bradyzoite formation, and prevents acute infection in mice
10.1038/s41467-025-58805-3 · 2025 · External reference
Overproduction of Toxoplasma gondii cyclophilin-18 regulates host cell migration and enhances parasite dissemination in a CCR5-independent manner
10.1186/1471-2180-14-76 · 2014 · External reference
Toxoplasma gondii cyclophilin 18 regulates the proliferation and migration of murine macrophages and spleen cells
10.1128/cvi.00128-10 · 2010 · External reference
Toxoplasma gondii cyclophilin 18-mediated production of nitric oxide induces Bradyzoite conversion in a CCR5-dependent manner
10.1128/iai.00361-09 · 2009 · External reference
Redox-dependent activity and thioredoxin interaction of cyclophilin TgCyp21 from Toxoplasma gondii
10.1016/j.ijbiomac.2025.148019 · 2025 · External reference
Structural basis for cyclosporin isoform-specific inhibition of cyclophilins from Toxoplasma gondii
10.1021/acsinfecdis.2c00566 · 2023 · External reference
The cyclophilin D (CypD) of Toxoplasma gondii is involved in the parasite’s response to oxidative stress damage
10.1007/s00436-024-08412-w · 2024 · External reference
Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases
10.1371/journal.pbio.1000439 · 2010 · External reference
Evaluating the potential of non-immunosuppressive cyclosporin analogs for targeting Toxoplasma gondii cyclophilin: insights from structural studies
10.1002/pro.5157 · 2024 · External reference
Two protein–protein interaction sites on the spliceosome-associated human cyclophilin CypH
10.1093/nar/gkg660 · 2003 · External reference
Identification of transient intermediates during spliceosome activation by single molecule fluorescence microscopy
10.1073/pnas.2206815119 · 2022 · External reference
The spliceosomal proteins PPIH and PRPF4 exhibit bi-partite binding
10.1042/bcj20170366 · 2017 · External reference
A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation
10.1126/science.aaw5569 · 2019 · External reference
Cryo-EM structure of a human spliceosome activated for step 2 of splicing
10.1038/nature21079 · 2017 · External reference
The Prp18 protein stabilizes the interaction of both exons with the U5 snRNA during the second step of pre-mRNA splicing
10.1101/gad.1538207 · 2007 · External reference
Spliceosome structure and function
10.1101/cshperspect.a003707 · 2011 · External reference
Discovery and molecular basis of subtype-selective cyclophilin inhibitors
10.1038/s41589-022-01116-1 · 2022 · External reference
Small molecule inhibitors of cyclophilin D to protect mitochondrial function as a potential treatment for acute pancreatitis
10.1021/acs.jmedchem.5b01801 · 2016 · External reference
Data processing and analysis with the autoPROC toolbox
10.1107/s0907444911007773 · 2011 · External reference
XDS
10.1107/s0907444909047337 · 2010 · External reference
How good are my data and what is the resolution?
10.1107/s0907444913000061 · 2013 · External reference
Overview of the CCP4 suite and current developments
10.1107/s0907444910045749 · 2011 · External reference
The CCP4 suite: integrative software for macromolecular crystallography
10.1107/s2059798323003595 · 2023 · External reference
REFMAC5 for the refinement of macromolecular crystal structures
10.1107/s0907444911001314 · 2011 · External reference
Towards automated crystallographic structure refinement with phenix.refine
10.1107/s0907444912001308 · 2012 · External reference
PHENIX: a comprehensive Python-based system for macromolecular structure solution
10.1107/s0907444909052925 · 2010 · External reference
The interplay of self-assembly and target binding in centrin 1 from Toxoplasma gondii
10.1042/bcj20210295 · 2021 · External reference
Conformational Plasticity of Centrin 1 from Toxoplasma gondii in Binding to the Centrosomal Protein SFI1
10.3390/biom12081115 · 2022 · External reference
SAC3B is a target of CML19, the centrin 2 of Arabidopsis thaliana
10.1042/bcj20190674 · 2020 · External reference
Role of myristoylation in modulating PCaP1 interaction with calmodulin
10.1016/j.plaphy.2023.108003 · 2023 · External reference
Distinct calcium binding and structural properties of two centrin isoforms from Toxoplasma gondii
10.3390/biom10081142 · 2020 · External reference
Determination of kinetic constants for peptidyl prolyl cis–trans isomerases by an improved spectrophotometric assay
10.1021/bi00239a007 · 1991 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB
10.1021/acs.jctc.5b00255 · 2015 · External reference
Unresolved reference
2018 · External reference
PTRAJ and CPPTRAJ: software for processing and analysis of molecular dynamics trajectory data
10.1021/ct400341p · 2013 · External reference
Structural plasticity and functional implications of internal cavities in distal mutants of type 1 non-symbiotic hemoglobin AHb1 from Arabidopsis thaliana
10.1021/jp9074477 · 2009 · External reference
MM-ISMSA: an ultrafast and accurate scoring function for protein–protein docking
10.1021/ct300497z · 2012 · External reference
Crystal structure of TgCyp23 cyclophilin in complex with TgPRP4 peptide
10.2210/pdb29gr/pdb · 2026 · External reference
Crystal structure of TgCyp23 cyclophilin in complex with TgPRP4 peptide and cyclosporin A
10.2210/pdb29gs/pdb · 2026 · External reference
