Research graph
References from The non-canonical CDK2 activator SPY1 uses separable mechanisms to activate phosphorylated and unphosphorylated CDK2. Local targets link to admitted publications; unresolved targets remain external evidence.
Core control principles of the eukaryotic cell cycle
10.1038/s41586-022-04798-8 · 2022 · External reference
Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2
10.1128/mcb.15.1.345 · 1995 · External reference
Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells
10.1016/j.molcel.2007.02.003 · 2007 · External reference
p21 is a universal inhibitor of cyclin kinases
10.1038/366701a0 · 1993 · External reference
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
10.1038/366704a0 · 1993 · External reference
Structural insights into the functional diversity of the CDK–cyclin family
10.1098/rsob.180112 · 2018 · External reference
Crystal structure of cyclin-dependent kinase 2
10.1038/363595a0 · 1993 · External reference
Mechanism of CDK activation revealed by the structure of a cyclinA–CDK2 complex
10.1038/376313a0 · 1995 · External reference
Structural basis of cyclin-dependent kinase activation by phosphorylation
10.1038/nsb0896-696 · 1996 · External reference
Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin
10.1126/science.270.5233.90 · 1995 · External reference
The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles
10.1038/sj.emboj.7600554 · 2005 · External reference
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
10.1038/382325a0 · 1996 · External reference
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
10.1038/emboj.2008.121 · 2008 · External reference
Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy
10.1038/s41523-022-00494-y · 2022 · External reference
Cryo-EM structures of the CDK11-cyclin L-SAP30BP complex reveal mechanisms of CDK11 regulation
10.1038/s41467-026-72329-4 · 2026 · External reference
Speedy: a novel cell cycle regulator of the G2/M transition
10.1093/emboj/18.7.1869 · 1999 · External reference
A novel p34(cdc2)-binding and activating protein that is necessary and sufficient to trigger G(2)/M progression in Xenopus oocytes
10.1101/gad.13.16.2177 · 1999 · External reference
Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins
10.4161/cc.4.1.1347 · 2005 · External reference
Evolution of the Cdk-activator Speedy/RINGO in vertebrates
10.1007/s00018-012-1050-1 · 2012 · External reference
Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2
10.1083/jcb.200109045 · 2002 · External reference
Differential regulation of Cdc2 and Cdk2 by RINGO and cyclins
10.1074/jbc.m104722200 · 2001 · External reference
Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins
10.15252/embj.201796905 · 2017 · External reference
Biochemical characterization of Cdk2-Speedy/Ringo A2
10.1186/1471-2091-6-19 · 2005 · External reference
Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation
10.1073/pnas.1618465114 · 2017 · External reference
Substrate specificity of CDK2-cyclin A. What is optimal?
10.1074/jbc.m306546200 · 2003 · External reference
Differences in binding affinity among cell-cycle CDK and cyclin pairs
10.1016/j.jmb.2025.168952 · 2025 · External reference
Allostery governs Cdk2 activation and differential recognition of CDK inhibitors
10.1038/s41589-020-00725-y · 2021 · External reference
Differences in the conformational energy landscape of CDK1 and CDK2 suggest a mechanism for achieving selective CDK inhibition
10.1016/j.chembiol.2018.10.015 · 2019 · External reference
Characterization of a new family of cyclin-dependent kinase activators
10.1042/bj20041779 · 2005 · External reference
The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases
10.1038/15674 · 1999 · External reference
The SUN1-SPDYA interaction plays an essential role in meiosis prophase I
10.1038/s41467-021-23550-w · 2021 · External reference
Discovery of AZD8421: a potent CDK2 inhibitor with selectivity against other CDK family members and the human kinome
10.1021/acs.jmedchem.5c01478 · 2025 · External reference
Profiling the activity of the potent and highly selective CDK2 inhibitor BLU-222 reveals determinants of response in CCNE1-aberrant ovarian and endometrial tumors
10.1158/0008-5472.can-24-2360 · 2025 · External reference
Human TPX2 is required for targeting Aurora-A kinase to the spindle
10.1083/jcb.200204155 · 2002 · External reference
Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states
10.1073/pnas.1811158115 · 2018 · External reference
Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding
10.1038/s41467-023-38732-x · 2023 · External reference
Human and yeast cdk-activating kinases (CAKs) display distinct substrate specificities
10.1091/mbc.9.9.2545 · 1998 · External reference
mtsslSuite: probing biomolecular conformation by spin-labeling studies
10.1016/bs.mie.2015.06.006 · 2015 · External reference
Spectral unmixing plate reader: high-throughput, high-precision FRET assays in living cells
10.1177/1087057116679637 · 2017 · External reference
How to measure and evaluate binding affinities
10.7554/elife.57264 · 2020 · External reference
