Research graph
References from MUC17 and the intestinal glycocalyx: structure, regulation, and barrier function in health and disease. Local targets link to admitted publications; unresolved targets remain external evidence.
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system
10.1111/imr.12182 · 2014 · External reference
Membrane mucins of the intestine at a glance
10.1242/jcs.240929 · 2020 · External reference
The role of goblet cells and mucus in intestinal homeostasis
10.1038/s41575-022-00675-x · 2022 · External reference
The Mucins
10.1016/b978-0-128-24465-4.00099-5 · 2026 · External reference
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
10.1073/pnas.0803124105 · 2008 · External reference
Cloning of partial cDNA encoding differentiation and tumor-associated mucin glycoproteins expressed by human mammary epithelium
10.1073/pnas.84.17.6060 · 1987 · External reference
IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during weaning
10.1016/j.celrep.2021.108757 · 2021 · External reference
Discovery of a MUC3B gene reconstructs the membrane mucin gene cluster on human chromosome 7
10.1371/journal.pone.0275671 · 2022 · External reference
An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming mucins
10.1186/1471-2164-7-197 · 2006 · External reference
Bioinformatic identification of polymerizing and transmembrane mucins in the puffer fish Fugu rubripes
10.1093/glycob/cwh066 · 2004 · External reference
The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals
10.1038/s41598-018-35499-w · 2018 · External reference
The complete sequence of a human genome
10.1126/science.abj6987 · 2022 · External reference
Subunit structure of porcine submaxillary mucin
10.1021/bi00440a058 · 2002 · External reference
Porcine submaxillary gland apomucin contains tandemly repeated, identical sequences of 81 residues
10.1016/s0021-9258(19)35463-8 · 1988 · External reference
Mucins in cancer: protection and control of the cell surface
10.1038/nrc1251 · 2004 · External reference
Role of glycosylation on the conformation and chain dimensions of O-linked glycoproteins: light-scattering studies of ovine submaxillary mucin
10.1021/bi00439a029 · 2002 · External reference
Nanoarchitecture and dynamics of the mouse enteric glycocalyx examined by freeze-etching electron tomography and intravital microscopy
10.1038/s42003-019-0735-5 · 2020 · External reference
Mucins and the microbiome
10.1146/annurev-biochem-011520-105053 · 2020 · External reference
Subcellular organization of glycosylation in mammalian cells
10.1016/0304-4157(87)90018-9 · 1987 · External reference
Characterization of two different glycosylated domains from the insoluble mucin complex of rat small intestine
10.1016/s0021-9258(17)46696-8 · 1993 · External reference
A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase
10.1073/pnas.262438199 · 2002 · External reference
A family of UDP-GalNAc: polypeptide N-acetylgalactosaminyl-transferases control the initiation of mucin-type O-linked glycosylation
10.1093/glycob/6.6.635 · 1996 · External reference
Structural diversity and specific distribution of O-glycans in normal human mucins along the intestinal tract
10.1042/bj20040605 · 2004 · External reference
Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family
10.1093/glycob/cwr182 · 2012 · External reference
Initial glycosylation of proteins with acetylgalactosaminylserine linkages
10.1073/pnas.76.6.2694 · 1979 · External reference
Impact of structurally diverse polysaccharides on colonic mucin O-glycosylation and gut microbiota
10.1038/s41522-023-00468-3 · 2023 · External reference
Normalization of host intestinal mucus layers requires long-term microbial colonization
10.1016/j.chom.2015.10.007 · 2015 · External reference
The role of indigenous microflora in the development of murine intestinal fucosyl- and sialyltransferases
10.1096/fj.02-0031fje · 2003 · External reference
Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution
10.1152/ajpgi.00048.2013 · 2013 · External reference
Core-glycosylated mucin-like repeats from MUC1 are an apical targeting signal
10.1074/jbc.m111.289504 · 2011 · External reference
Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB)
10.1074/jbc.m113.459479 · 2013 · External reference
Core 1– and 3–derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice
10.1038/mi.2016.45 · 2017 · External reference
Glycan foraging in vivo by an intestine-adapted bacterial symbiont
10.1126/science.1109051 · 2005 · External reference
A molecular sensor that allows a gut commensal to control its nutrient foundation in a competitive ecosystem
10.1073/pnas.96.17.9833 · 1999 · External reference
A genetic system for Akkermansia muciniphila reveals a role for mucin foraging in gut colonization and host sterol biosynthesis gene expression
10.1038/s41564-023-01407-w · 2023 · External reference
Utilisation of mucin glycans by the human gut symbiont Ruminococcus gnavus is strain-dependent
10.1371/journal.pone.0076341 · 2013 · External reference
Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens
10.1038/nature12503 · 2013 · External reference
Mucin glycan foraging in the human gut microbiome
10.3389/fgene.2015.00081 · 2015 · External reference
Mucosal glycan degradation of the host by the gut microbiota
10.1093/glycob/cwaa097 · 2021 · External reference
Intestinal fucose as a mediator of host–microbe symbiosis
10.4049/jimmunol.1500395 · 2015 · External reference
Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice
10.1172/jci45538 · 2011 · External reference
Cosmc is an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk
10.1073/pnas.1612158114 · 2016 · External reference
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn’s disease
10.1093/hmg/ddq248 · 2010 · External reference
The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins
10.1111/j.1742-4658.2005.04711.x · 2005 · External reference
Membrane mucins of the intestine at a glance
10.1242/jcs.240929 · 2020 · External reference
Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin
10.1038/nsmb1035 · 2006 · External reference
The MUC1 SEA module is a self-cleaving domain
10.1074/jbc.m506047200 · 2005 · External reference
High-resolution structure of intramolecularly proteolyzed human mucin-1 SEA domain
10.1016/j.bbapap.2020.140361 · 2020 · External reference
Role of N-glycosylation of the SEA module of rodent Muc3 in posttranslational processing of its carboxy-terminal domain
10.1093/glycob/cwp095 · 2009 · External reference
Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell-protective device
10.1111/febs.12144 · 2013 · External reference
MUC1 limits Helicobacter pylori infection both by steric hindrance and by acting as a releasable decoy
10.1371/journal.ppat.1000617 · 2009 · External reference
Characteristics of rodent intestinal mucin Muc3 and alterations in a mouse model of human cystic fibrosis
10.1152/ajpgi.2001.280.6.g1321 · 2001 · External reference
Increased levels of mucins in the cystic fibrosis mouse small intestine, and modulator effects of the Muc1 mucin expression
10.1152/ajpgi.00491.2005 · 2006 · External reference
Detection of a secreted MUC1/SEC protein by MUC1 isoform specific monoclonal antibodies
10.1006/bbrc.1996.1625 · 1996 · External reference
Absence of CFTR is associated with pleiotropic effects on mucins in mouse gallbladder epithelial cells
10.1152/ajpgi.00547.2005 · 2006 · External reference
Mucin gene expression in intestinal epithelial cells in Crohn’s disease
10.1136/gut.49.4.544 · 2001 · External reference
MUC17, a novel membrane-tethered mucin
10.1006/bbrc.2002.6475 · 2002 · External reference
Characterization of human mucin MUC17
10.1074/jbc.m600302200 · 2006 · External reference
Membrane-bound mucin modular domains: from structure to function
10.1016/j.biochi.2012.11.005 · 2013 · External reference
The structure of a Ca2+-binding epidermal growth factor-like domain: Its role in protein–protein interactions
10.1016/0092-8674(95)90059-4 · 1995 · External reference
Protein modules
10.1016/0968-0004(91)90009-k · 1991 · External reference
Human intestinal MUC17 mucin augments intestinal cell restitution and enhances healing of experimental colitis
10.1016/j.biocel.2010.03.001 · 2010 · External reference
Autoproteolysis of the SEA module of rMuc3 C-terminal domain modulates its functional composition
10.1016/j.abb.2010.08.013 · 2010 · External reference
Human Breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
10.1126/science.3798106 · 1987 · External reference
EGF-containing membrane-bound mucins: a hidden ErbB2 targeting pathway?
10.1021/acs.jmedchem.9b02001 · 2020 · External reference
MUC13 interaction with receptor tyrosine kinase HER2 drives pancreatic ductal adenocarcinoma progression
10.1038/onc.2016.218 · 2017 · External reference
The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways
10.1371/journal.pone.0032232 · 2012 · External reference
The EGF domains of MUC4 oncomucin mediate HER2 binding affinity and promote pancreatic cancer cell tumorigenesis
10.3390/cancers13225746 · 2021 · External reference
Untangling the ErbB signalling network
10.1038/35052073 · 2001 · External reference
Cysteine-rich domains of Muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healing
10.1053/j.gastro.2006.09.006 · 2006 · External reference
CFTR anion channel modulates expression of human transmembrane mucin MUC3 through the PDZ protein GOPC
10.1242/jcs.076943 · 2011 · External reference
The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine
10.1042/bj20071068 · 2008 · External reference
The human transmembrane mucin MUC17 responds to TNFalpha by increased presentation at the plasma membrane
10.1042/bcj20190180 · 2019 · External reference
Display of the human mucinome with defined O-glycans by gene engineered cells
10.1038/s41467-021-24366-4 · 2021 · External reference
Evolutionary considerations in relating oligosaccharide diversity to biological function
10.1093/glycob/9.8.747 · 1999 · External reference
Microbial binding module employs sophisticated clustered saccharide patches to selectively adhere to mucins
10.1038/s41467-025-63756-w · 2025 · External reference
MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn’s disease
10.1172/jci.insight.181481 · 2024 · External reference
Enterocyte microvillus-derived vesicles detoxify bacterial products and regulate epithelial-microbial interactions
10.1016/j.cub.2012.02.022 · 2012 · External reference
MUC1 is a receptor for the Salmonella SiiE adhesin that enables apical invasion into enterocytes
10.1371/journal.ppat.1007566 · 2019 · External reference
A weaning reaction to microbiota is required for resistance to immunopathologies in the adult
10.1016/j.immuni.2019.02.014 · 2019 · External reference
Study of mucin turnover in the small intestine by in vivo labeling
10.1038/s41598-018-24148-x · 2018 · External reference
The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes
10.1042/bcj20240204 · 2025 · External reference
Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes
10.1152/ajpcell.00141.2013 · 2013 · External reference
Genetics and pathogenesis of inflammatory bowel disease
10.1038/nature10209 · 2011 · External reference
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
10.1038/ng1954 · 2007 · External reference
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
10.1126/science.1104911 · 2005 · External reference
Enhanced Escherichia coli adherence and invasion in Crohn’s disease and colon cancer
10.1053/j.gastro.2004.03.054 · 2004 · External reference
High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease
10.1053/j.gastro.2004.04.061 · 2004 · External reference
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon
10.1016/j.immuni.2023.01.002 · 2023 · External reference
Glyco-TRAPP: a real-time glycocalyx permeability assay for assessing transmembrane mucin barrier function in live and fixed tissues
10.1016/bs.mie.2026.03.008 · 2026 · External reference