Research graph
References from The pan-AMPK activator MK-8722 outperforms the AMPK activators SC4 and A-769662 in human endothelial cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Endothelial cell metabolism in cardiovascular physiology and disease
10.1038/s41569-025-01162-x · 2025 · External reference
A systems view of the vascular endothelium in health and disease
10.1016/j.cell.2024.07.012 · 2024 · External reference
Endothelial dysfunction in cardiovascular diseases: mechanisms and in vitro models
10.1007/s11010-025-05289-w · 2025 · External reference
Shear stress-induced AMP-activated protein kinase modulation in endothelial cells: its role in metabolic adaptions and cardiovascular disease
10.3390/ijms25116047 · 2024 · External reference
AMP-activated protein kinase: an ubiquitous signaling pathway with key roles in the cardiovascular system
10.1161/circresaha.117.309633 · 2017 · External reference
New insights into activation and function of the AMPK
10.1038/s41580-022-00547-x · 2023 · External reference
The metabolic sensor AMPK: Twelve enzymes in one
10.1016/j.molmet.2024.102042 · 2024 · External reference
AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation
10.1016/j.cmet.2013.08.019 · 2013 · External reference
The regulation of AMP-activated protein kinase by upstream kinases
10.1038/ijo.2008.124 · 2008 · External reference
AMPK: guardian of metabolism and mitochondrial homeostasis
10.1038/nrm.2017.95 · 2018 · External reference
AMP-activated protein kinase—an energy sensor that regulates all aspects of cell function
10.1101/gad.17420111 · 2011 · External reference
Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells
10.1161/circresaha.109.201590 · 2009 · External reference
Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase*
10.1074/jbc.m110.108688 · 2010 · External reference
AMP-activated protein kinase restricts zika virus replication in endothelial cells by potentiating innate antiviral responses and inhibiting glycolysis
10.4049/jimmunol.1901310 · 2020 · External reference
PRKAA/AMPK restricts HBV replication through promotion of autophagic degradation
10.1080/15548627.2016.1191857 · 2016 · External reference
AMPK protects endothelial cells against HSV-1 replication via inhibition of mTORC1 and ACC1
10.1128/spectrum.00417-23 · 2023 · External reference
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
10.2337/diabetes.51.8.2420 · 2002 · External reference
Protective effects of metformin in various cardiovascular diseases: clinical evidence and ampk -dependent mechanisms
10.1111/jcmm.17519 · 2022 · External reference
AMP-activated protein kinase: the current landscape for drug development
10.1038/s41573-019-0019-2 · 2019 · External reference
AMPK activation protects against diet-induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue
10.1038/s42255-019-0036-9 · 2019 · External reference
AMP-activated protein kinase: a target for drugs both ancient and modern
10.1016/j.chembiol.2012.08.019 · 2012 · External reference
AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives
10.1111/j.1748-1716.2009.01970.x · 2009 · External reference
AMPK, insulin resistance, and the metabolic syndrome
10.1172/jci67227 · 2013 · External reference
AMPK activators: mechanisms of action and physiological activities
10.1038/emm.2016.16 · 2016 · External reference
Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms
10.1016/j.str.2014.06.009 · 2014 · External reference
Promise and challenges for direct small molecule AMPK activators
10.1016/j.bcp.2018.01.049 · 2018 · External reference
Structural basis of AMPK regulation by small molecule activators
10.1038/ncomms4017 · 2013 · External reference
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
10.1016/j.cmet.2006.05.005 · 2006 · External reference
Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family
10.1074/jbc.m706543200 · 2007 · External reference
Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling
10.1016/j.chembiol.2014.03.006 · 2014 · External reference
Discovery of MK-8722: a systemic, direct pan-activator of AMP-activated protein kinase
10.1021/acsmedchemlett.7b00417 · 2018 · External reference
Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
10.1126/science.aah5582 · 2017 · External reference
Structural determinants for small-molecule activation of skeletal muscle AMPK α2β2γ1 by the glucose importagog SC4
10.1016/j.chembiol.2018.03.008 · 2018 · External reference
GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis
10.1042/bcj20160980 · 2017 · External reference
Hallmarks of endothelial cell metabolism in health and disease
10.1016/j.cmet.2019.08.011 · 2019 · External reference
AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress
10.1074/jbc.m300643200 · 2003 · External reference
Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase β
10.1128/mcb.00383-06 · 2006 · External reference
VEGF triggers transient induction of autophagy in endothelial cells via AMPKα1
10.3390/cells9030687 · 2020 · External reference
Protein kinase A negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495
10.1042/bcj20200555 · 2020 · External reference
Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator
10.1042/bcj20220067 · 2022 · External reference
Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase
10.1128/mcb.02222-06 · 2007 · External reference
AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform
10.1042/bj3340177 · 1998 · External reference
AMPKα1 regulates the antioxidant status of vascular endothelial cells
10.1042/bj20090613 · 2009 · External reference
Subunit composition of AMPK trimers present in the cytokinetic apparatus: implications for drug target identification
10.4161/cc.11.5.19412 · 2012 · External reference
BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I
10.1002/cam4.112 · 2013 · External reference
An inhibitor of oxidative phosphorylation exploits cancer vulnerability
10.1038/s41591-018-0052-4 · 2018 · External reference
Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle
10.1016/s0021-9258(19)75283-1 · 1977 · External reference
Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation
10.1093/cvr/cvn184 · 2008 · External reference
Exercise training differentially affects skeletal muscle mitochondria in rats with inherited high or low exercise capacity
10.3390/cells13050393 · 2024 · External reference
Spectrophotometric assay for Complex I of the respiratory chain in tissue samples and cultured fibroblasts
10.1373/clinchem.2006.078873 · 2007 · External reference
Decreased activities of ubiquinol:ferricytochrome c oxidoreductase (complex III) and ferrocytochrome c:oxygen oxidoreductase (complex IV) in liver mitochondria from rats with hydroxycobalamin[c-lactam]-induced methylmalonic aciduria
10.1016/s0021-9258(18)54810-9 · 1991 · External reference
Biochemical assays of respiratory chain complex activity
10.1016/s0091-679x(06)80004-x · 2007 · External reference
[45]Cytochrome oxidase from beef heart mitochondria
10.1016/0076-6879(67)10048-7 · 1967 · External reference
In vivo and in organello assessment of OXPHOS activities
10.1016/s1046-2023(02)00036-1 · 2002 · External reference
Relationship between the envelope and the infectivity of herpes simplex virus
10.3181/00379727-115-29045 · 1964 · External reference
A simple method of estimating fifty per cent endpoints
10.1093/oxfordjournals.aje.a118408 · 1938 · External reference
Multiplexed Optical Sensors in Arrayed Islands of Cells for multimodal recordings of cellular physiology
10.1038/s41467-020-17607-5 · 2020 · External reference
Accurate whole human genome sequencing using reversible terminator chemistry
10.1038/nature07517 · 2008 · External reference
TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
10.1186/gb-2013-14-4-r36 · 2013 · External reference
Ensembl 2018
10.1093/nar/gkx1098 · 2018 · External reference
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
10.1093/bioinformatics/btt656 · 2014 · External reference
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
10.1093/nar/30.1.207 · 2002 · External reference
