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References from Integrated omics-driven discovery reveals synphilin-1-mediated anoikis resistance through p53 down-regulation. Local targets link to admitted publications; unresolved targets remain external evidence.
Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions
10.1038/8820 · 1999 · External reference
Synphilin-1 is present in Lewy bodies in Parkinson’s disease
10.1002/1531-8249(200004)47:4<521::aid-ana18>3.0.co;2-b · 2000 · External reference
Synphilin-1 exhibits trophic and protective effects against Rotenone toxicity
10.1016/j.neuroscience.2009.10.042 · 2010 · External reference
Synphilin-1 has neuroprotective effects on MPP(+)-induced Parkinson’s disease model cells by inhibiting ROS production and apoptosis
10.1016/j.neulet.2018.10.020 · 2019 · External reference
Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model
10.1093/hmg/ddq086 · 2010 · External reference
Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson’s disease models
10.1093/hmg/ddv504 · 2016 · External reference
Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice
10.1093/hmg/ddt467 · 2014 · External reference
Disruption of epithelial cell-matrix interactions induces apoptosis
10.1083/jcb.124.4.619 · 1994 · External reference
Anoikis molecular pathways and its role in cancer progression
10.1016/j.bbamcr.2013.06.026 · 2013 · External reference
Anoikis mechanisms
10.1016/s0955-0674(00)00251-9 · 2001 · External reference
Anoikis
10.1038/sj.cdd.4401723 · 2005 · External reference
Clinging to life: cell to matrix adhesion and cell survival
10.1007/s10555-005-5134-3 · 2005 · External reference
Anoikis: a necessary death program for anchorage-dependent cells
10.1016/j.bcp.2008.07.023 · 2008 · External reference
Anoikis: an emerging hallmark in health and diseases
10.1002/path.3000 · 2012 · External reference
A diagnostic model for Parkinson’s disease based on anoikis-related genes
10.1007/s12035-023-03753-6 · 2024 · External reference
Glucomannan from Aloe vera gel maintains intestinal barrier integrity via mitigating anoikis mediated by Nrf2-mitochondria axis
10.1016/j.ijbiomac.2023.123803 · 2023 · External reference
Involvement of anoikis in dissociated optic nerve fiber layer appearance
10.3390/ijms22041724 · 2021 · External reference
BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus
10.1038/cddis.2009.13 · 2010 · External reference
Lessons from glaucoma: rethinking the fluid-brain barriers in common neurodegenerative disorders
10.4103/1673-5374.249215 · 2019 · External reference
Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells
10.1096/fj.01-0995fje · 2002 · External reference
Synphilin-1 degradation by the ubiquitin-proteasome pathway and effects on cell survival
10.1046/j.1471-4159.2002.01136.x · 2002 · External reference
Synphilin-1 regulates mechanotransduction in rigidity sensing through interaction with zyxin
10.1186/s12951-025-03429-4 · 2025 · External reference
YADA: a tool for taking the most out of high-resolution spectra
10.1093/bioinformatics/btp489 · 2009 · External reference
DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics
10.1021/pr015504q · 2002 · External reference
Effect of silica-coated magnetic nanoparticles on rigidity sensing of human embryonic kidney cells
10.1186/s12951-020-00730-2 · 2020 · External reference
Decrease in membrane fluidity and traction force induced by silica-coated magnetic nanoparticles
10.1186/s12951-020-00765-5 · 2021 · External reference
Spatial organization of PI3K-PI(3,4,5)P(3)-AKT signaling by focal adhesions
10.1016/j.molcel.2024.10.010 · 2024 · External reference
Role of the PI3K/AKT signaling pathway in the cellular response to Tumor Treating Fields (TTFields)
10.1038/s41419-025-07546-8 · 2025 · External reference
Multiomic analyses of dopaminergic neurons isolated from human substantia nigra in Parkinson’s disease: a descriptive and exploratory study
10.1007/s10571-021-01146-8 · 2022 · External reference
Synphilin-1 interacts with AMPK and increases AMPK phosphorylation
10.3390/ijms21124352 · 2020 · External reference
Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway
10.1074/jbc.m508619200 · 2006 · External reference
Cellular fibronectin exacerbates alpha-synuclein aggregation via integrin alpha4beta1 mediated PARP1 and SCD elevation
10.1016/j.neurot.2025.e00729 · 2025 · External reference
Extracellular matrix regulation in physiology and in brain disease
10.3390/ijms24087049 · 2023 · External reference
Stopping transformed cancer cell growth by rigidity sensing
10.1038/s41563-019-0507-0 · 2020 · External reference
RNA-seq analysis of HEK293 and synphilin-1 overexpressing HEK293 cell line
2025 · External reference
Synphilin-1 upregulates RBL2 expression and causes a G0/G1 phase cell cycle arrest in the neurons
2022 · External reference
