Research graph
References from Unmasking programmed cell death in rhinovirus-driven asthma pathology. Local targets link to admitted publications; unresolved targets remain external evidence.
Asthma: definitions and pathophysiology
10.1002/alr.21609 · 2015 · External reference
Unresolved reference
2024 · External reference
Rhinovirus infections and their roles in asthma: etiology and exacerbations
10.1016/j.jaip.2022.01.006 · 2022 · External reference
The ABCs of rhinoviruses, wheezing, and asthma
10.1128/jvi.02290-09 · 2010 · External reference
Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study
10.1016/s0140-6736(02)07953-9 · 2002 · External reference
Persistence of rhinovirus RNA after asthma exacerbation in children
10.1111/j.1365-2222.2005.02244.x · 2005 · External reference
Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death
10.1038/s41419-018-0306-6 · 2018 · External reference
Human rhinovirus 2 induces the autophagic pathway and replicates more efficiently in autophagic cells
10.1128/jvi.00316-11 · 2011 · External reference
Human Rhinovirus 3C protease cleaves RIPK1, concurrent with caspase 8 activation
10.1038/s41598-018-19839-4 · 2018 · External reference
ZBP1 and TAK1: master regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and necroptosis (PAN-optosis)
10.3389/fcimb.2019.00406 · 2019 · External reference
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
10.1038/bjc.1972.33 · 1972 · External reference
Apoptosis: a review of programmed cell death
10.1080/01926230701320337 · 2007 · External reference
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
10.1038/s41418-017-0012-4 · 2018 · External reference
Mechanisms of BCL-2 family proteins in mitochondrial apoptosis
10.1038/s41580-023-00629-4 · 2023 · External reference
Rhinovirus and cell death
10.3390/v13040629 · 2021 · External reference
RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review)
10.3892/ijmm.2019.4244 · 2019 · External reference
Viral MLKL homologs subvert necroptotic cell death by sequestering cellular RIPK3
10.1016/j.celrep.2019.08.055 · 2019 · External reference
EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation
10.1038/nmicrobiol.2016.258 · 2017 · External reference
The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL
10.1038/s41419-022-04740-w · 2022 · External reference
The web of death: the expanding complexity of necroptotic signaling
10.1016/j.tcb.2022.05.008 · 2023 · External reference
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
10.1016/j.cell.2011.11.031 · 2012 · External reference
Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis
10.1073/pnas.1200012109 · 2012 · External reference
Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death
10.1038/cdd.2016.78 · 2017 · External reference
Necroptosis: a new way of dying?
10.1080/15384047.2016.1210732 · 2016 · External reference
Pyroptosis in inflammation-related respiratory disease
10.1007/s13105-022-00909-1 · 2022 · External reference
Role of pyroptosis in respiratory diseases and its therapeutic potential
10.2147/jir.s352563 · 2022 · External reference
GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
10.1073/pnas.1607769113 · 2016 · External reference
Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors
10.3389/fimmu.2023.1178662 · 2023 · External reference
Gasdermin-A3 pore formation propagates along variable pathways
10.1038/s41467-022-30232-8 · 2022 · External reference
Mechanism of membrane pore formation by human gasdermin-D
10.15252/embj.201798321 · 2018 · External reference
Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages
10.1111/j.1462-5822.2006.00751.x · 2006 · External reference
Indirect regulation of HMGB1 release by gasdermin D
10.1038/s41467-020-18443-3 · 2020 · External reference
NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
10.1038/nature16959 · 2016 · External reference
Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics
10.1016/j.biocel.2021.106013 · 2021 · External reference
Critical role for calcium mobilization in activation of the NLRP3 inflammasome
10.1073/pnas.1117765109 · 2012 · External reference
NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
10.1038/nri2725 · 2010 · External reference
Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT)
10.1073/pnas.2213777120 · 2023 · External reference
Human NLRP1 is a sensor for double-stranded RNA
10.1126/science.abd0811 · 2021 · External reference
Activation of the Nlrp1b inflammasome by reduction of cytosolic ATP
10.1128/iai.01003-12 · 2013 · External reference
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
10.1038/nature15514 · 2015 · External reference
Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells
10.1038/s41418-023-01143-y · 2023 · External reference
Regulating GSDMB pore formation: to ignite or inhibit?
10.1038/s41418-023-01163-8 · 2023 · External reference
Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein
10.1073/pnas.1616783114 · 2017 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Nutrition needs of mammalian cells in tissue culture
10.1126/science.122.3168.501 · 1955 · External reference
Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress
10.1016/0896-6273(89)90043-3 · 1989 · External reference
Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis
10.1038/s41419-020-03118-0 · 2020 · External reference
Iron metabolism: pathophysiology and pharmacology
10.1016/j.tips.2021.05.001 · 2021 · External reference
Role of GPX4 in ferroptosis and its pharmacological implication
10.1016/j.freeradbiomed.2018.09.014 · 2019 · External reference
Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides
10.1016/0005-2760(82)90150-3 · 1982 · External reference
The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1
10.1016/j.redox.2023.102703 · 2023 · External reference
Apoptotic events induced by human rhinovirus infection
10.1099/vir.0.80754-0 · 2005 · External reference
The life cycle of non-polio enteroviruses and how to target it
10.1038/s41579-018-0005-4 · 2018 · External reference
Human rhinoviruses
10.1128/cmr.00077-12 · 2013 · External reference
Analysis of the complete genome sequences of human rhinovirus
10.1016/j.jaci.2010.04.010 · 2010 · External reference
The major apoptotic pathway activated and suppressed by poliovirus
10.1128/jvi.77.1.45-56.2003 · 2003 · External reference
Bcl-2 and Bcl-xL overexpression inhibits cytochrome c release, activation of multiple caspases, and virus release following coxsackievirus B3 infection
10.1016/s0042-6822(03)00242-3 · 2003 · External reference
Poliovirus induces apoptosis in the mouse central nervous system
10.1128/jvi.73.7.6066-6072.1999 · 1999 · External reference
Theiler's murine encephalomyelitis virus kills restrictive but not permissive cells by apoptosis
10.1128/jvi.70.10.6856-6861.1996 · 1996 · External reference
Apoptosis and disease: regulation and clinical relevance of programmed cell death
10.1146/annurev.med.48.1.267 · 1997 · External reference
Cardiomyocyte apoptosis in experimental coxsackievirus B3 myocarditis
10.1016/s1054-8807(03)00077-2 · 2003 · External reference
Viruses and apoptosis
10.1111/j.1365-2613.2001.iep195.x · 2001 · External reference
NuMA and nuclear lamins are cleaved during viral infection–inhibition of caspase activity prevents cleavage and rescues HeLa cells from measles virus-induced but not from rhinovirus 1B-induced cell death
10.1016/j.virol.2003.11.026 · 2004 · External reference
Induction of apoptosis and subsequent phagocytosis of virus-infected cells as an antiviral mechanism
10.3389/fimmu.2017.01220 · 2017 · External reference
Early host defense against virus infections
10.1016/j.celrep.2024.115070 · 2024 · External reference
Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
10.1084/jem.20041901 · 2005 · External reference
Nucleocytoplasmic transport in apoptosis
10.1038/sj.cdd.4401626 · 2005 · External reference
Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transport
10.1128/jvi.01748-08 · 2009 · External reference
Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirus
10.1128/jvi.76.17.8787-8796.2002 · 2002 · External reference
Rhinovirus 3C protease facilitates specific nucleoporin cleavage and mislocalisation of nuclear proteins in infected host cells
10.1371/journal.pone.0071316 · 2013 · External reference
Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma
10.1183/09031936.02.00226302 · 2002 · External reference
Differential disruption of nucleocytoplasmic trafficking pathways by rhinovirus 2a proteases
10.1128/jvi.02472-16 · 2017 · External reference
Differential processing of nuclear pore complex proteins by rhinovirus 2A proteases from different species and serotypes
10.1128/jvi.00718-11 · 2011 · External reference
RIPK1 is cleaved by 3C protease of rhinovirus a and b strains and minor and major groups
10.3390/v13122402 · 2021 · External reference
Functional analysis of picornavirus 2B proteins: effects on calcium homeostasis and intracellular protein trafficking
10.1128/jvi.02076-07 · 2008 · External reference
Topology and biological function of enterovirus non-structural protein 2B as a member of the viroporin family
10.1186/s13567-014-0087-6 · 2014 · External reference
Host immune responses to rhinovirus: mechanisms in asthma
10.1016/j.jaci.2008.08.013 · 2008 · External reference
Rhinovirus enters but does not replicate inside monocytes and airway macrophages
10.4049/jimmunol.156.2.621 · 1996 · External reference
IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo
10.1164/rccm.201406-1039oc · 2014 · External reference
Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33
10.1186/s12967-015-0645-3 · 2015 · External reference
Rhinoviruses, allergic inflammation, and asthma
10.1111/j.1600-065x.2011.01031.x · 2011 · External reference
The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells
10.1371/journal.pone.0063365 · 2013 · External reference
Accumulation of cytosolic calcium induces necroptotic cell death in human neuroblastoma
10.1158/0008-5472.can-13-1283 · 2014 · External reference
Rhinovirus-induced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells
10.1165/rcmb.2013-0032oc · 2013 · External reference
Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia
10.1126/science.aay2002 · 2020 · External reference
Diverse viral proteases activate the NLRP1 inflammasome
10.7554/elife.60609 · 2021 · External reference
Enterovirus 71 inhibits pyroptosis through cleavage of gasdermin D
10.1128/jvi.01069-17 · 2017 · External reference
Reciprocal regulation between enterovirus 71 and the NLRP3 inflammasome
10.1016/j.celrep.2015.05.047 · 2015 · External reference
EV71 3D protein binds with NLRP3 and enhances the assembly of inflammasome complex
10.1371/journal.ppat.1006123 · 2017 · External reference
Gasdermin E is required for induction of pyroptosis and severe disease during enterovirus 71 infection
10.1016/j.jbc.2022.101850 · 2022 · External reference
ROS is involved in disruption of tight junctions of human nasal epithelial cells induced by HRV16
10.1002/lary.27510 · 2018 · External reference
Rhinovirus wheezing illness and genetic risk of childhood-onset asthma
10.1056/nejmoa1211592 · 2013 · External reference
17q21 variants modify the association between early respiratory infections and asthma
10.1183/09031936.00154509 · 2010 · External reference
17q21 variants disturb mucosal host defense in childhood asthma
10.1164/rccm.202305-0934oc · 2024 · External reference
Orosomucoid-like protein 3, rhinovirus and asthma
10.5492/wjccm.v10.i5.170 · 2021 · External reference
Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study
10.1016/s2213-2600(20)30011-4 · 2020 · External reference
Ferroptosis in viral infection: the unexplored possibility
10.1038/s41401-021-00814-1 · 2022 · External reference
Theirs but to die and do: primary lysis of eosinophils and free eosinophil granules in asthma
10.1164/rccm.201311-2069oe · 2014 · External reference
The shedding of the mucosa of the bronchial tree in asthma
10.1136/thx.17.1.69 · 1962 · External reference
Resolution of airway disease: removal of inflammatory cells through apoptosis, egression or both?
10.1016/j.tips.2006.07.006 · 2006 · External reference
Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation
10.1016/j.jaci.2013.03.024 · 2013 · External reference
Primary lysis of eosinophils in severe desquamative asthma
10.1111/cea.12255 · 2014 · External reference
Selective eosinophil necroptosis contributes to airway inflammation and remodeling in asthma
10.1111/all.15448 · 2022 · External reference
T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma
10.1067/mai.2002.121460 · 2002 · External reference
Epithelial apoptosis and loss in airways of children with asthma
10.3109/02770903.2011.565848 · 2011 · External reference
Epithelial cell proliferation contributes to airway remodeling in severe asthma
10.1164/rccm.200607-1062oc · 2007 · External reference
Apoptosis and the airway epithelium
10.1155/2011/948406 · 2011 · External reference
Airway remodeling in asthma
10.3389/fmed.2020.00191 · 2020 · External reference
Creola bodies in wheezing infants predict the development of asthma
10.1111/j.1399-3038.2004.00155.x · 2004 · External reference
Creola bodies in infancy with respiratory syncytial virus bronchiolitis predict the development of asthma
10.2332/allergolint.09-oa-0165 · 2010 · External reference
Corticosteroid-induced apoptosis in mouse airway epithelium: effect in normal airways and after allergen-induced airway inflammation
10.1067/mai.2003.117 · 2003 · External reference
Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis
10.1186/1465-9921-14-141 · 2013 · External reference
Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammation
10.1165/rcmb.2001-0014oc · 2002 · External reference
Eosinophil apoptosis as a therapeutic target in allergic asthma
10.1111/bcpt.12163 · 2014 · External reference
Neutrophils in asthma—a review
10.1016/j.resp.2014.12.004 · 2015 · External reference
Prosurvival activity for airway neutrophils in severe asthma
10.1136/thx.2009.120741 · 2010 · External reference
The role of IL-25 in the reduction of oxidative stress and the apoptosis of airway epithelial cells with specific immunotherapy in an asthma mouse model
2017 · External reference
Global strategy for asthma management and prevention: GINA executive summary
10.1183/09031936.00138707 · 2008 · External reference
Mitogen-activated protein kinases as therapeutic targets for asthma
10.1016/j.pharmthera.2017.02.024 · 2017 · External reference
MUC1 intracellular bioactivation mediates lung fibrosis
10.1136/thoraxjnl-2018-212735 · 2020 · External reference
MUC1 downregulation promotes TNF-alpha-induced necroptosis in human bronchial epithelial cells via regulation of the RIPK1/RIPK3 pathway
10.1002/jcp.28148 · 2019 · External reference
Mucin 1 downregulation impairs the anti-necroptotic effects of glucocorticoids in human bronchial epithelial cells
10.1016/j.lfs.2019.02.013 · 2019 · External reference
Necroptosis plays a role in TL1A-induced airway inflammation and barrier damage in asthma
10.1186/s12931-024-02900-4 · 2024 · External reference
Mechanisms and treatments for severe, steroid-resistant allergic airway disease and asthma
10.1111/imr.12543 · 2017 · External reference
Chromosome 17q21 SNP and severe asthma
10.1038/jhg.2010.134 · 2011 · External reference
A large-scale, consortium-based genomewide association study of asthma
10.1056/nejmoa0906312 · 2010 · External reference
Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation
10.1183/13993003.01232-2023 · 2024 · External reference
Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways
10.1016/j.jaci.2020.07.030 · 2021 · External reference
Bronchial epithelial pyroptosis promotes airway inflammation in a murine model of toluene diisocyanate-induced asthma
10.1016/j.biopha.2020.109925 · 2020 · External reference
Blockade of the NLRP3/Caspase-1 axis ameliorates airway neutrophilic inflammation in a toluene diisocyanate-induced murine asthma model
10.1093/toxsci/kfz099 · 2019 · External reference
Schisandrin B Attenuates Airway Inflammation and airway remodeling in asthma by inhibiting NLRP3 inflammasome activation and reducing pyroptosis
10.1007/s10753-021-01494-z · 2021 · External reference
Targeting NLRP3 inflammasome activation in severe asthma
10.3390/jcm8101615 · 2019 · External reference
Oxidative stress in asthma
10.1097/wox.0b013e318232389e · 2011 · External reference
Oxidative stress stimulation leads to cell-specific oxidant and antioxidant responses in airway resident and inflammatory cells
10.1016/j.lfs.2022.121358 · 2023 · External reference
Oxidative stress in asthma: part of the puzzle
10.1111/pai.12965 · 2018 · External reference
Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma
10.1183/13993003.01340-2019 · 2020 · External reference
Innate immunity in the pathogenesis of virus-induced asthma exacerbations
10.1513/pats.200701-030aw · 2007 · External reference
Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype
10.1111/j.1365-2222.2008.03157.x · 2009 · External reference
Association between human rhinovirus C and severity of acute asthma in children
10.1183/09031936.00092410 · 2011 · External reference
Transforming growth factor-beta enhances rhinovirus infection by diminishing early innate responses
10.1165/rcmb.2008-0316oc · 2009 · External reference
Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma
10.1136/thx.2009.125930 · 2010 · External reference
Transcriptomic profiling of bronchial epithelium reveals dysregulated interferon and inflammatory responses to rhinovirus in exacerbation-prone pediatric asthma
10.1101/2025.10.19.683298 · 2025 · External reference
Impaired innate interferon induction in severe therapy resistant atopic asthmatic children
10.1038/mi.2012.118 · 2013 · External reference
Impaired airway epithelial cell responses from children with asthma to rhinoviral infection
10.1111/cea.12767 · 2016 · External reference
Interferon-beta deficiency at asthma exacerbation promotes MLKL mediated necroptosis
10.1038/s41598-018-22557-6 · 2018 · External reference
Caspase-1 deficiency reduces eosinophilia and interleukin-33 in an asthma exacerbation model
10.1183/23120541.00047-2017 · 2017 · External reference
The ORMDL3 asthma gene regulates ICAM1 and has multiple effects on cellular inflammation
10.1164/rccm.201803-0438oc · 2019 · External reference
