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References from Manipulation of the cell cycle by HIV-1. Local targets link to admitted publications; unresolved targets remain external evidence.
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Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis
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Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56lck
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Regulated degradation of the HIV-1 Vpu protein through a βTrCP-independent pathway limits the release of viral particles
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Induction of cell differentiation by human immunodeficiency virus 1 vpr
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Human immunodeficiency virus vpr product is a virion-associated regulatory protein
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Cell cycle arrest by Vpr in HIV-1 virions and insensitivity to antiretroviral agents
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A leucine triplet repeat sequence (LXX)4 in p6gag is important for Vpr incorporation into human immunodeficiency virus type 1 particles
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Identification of residues in the N-terminal acidic domain of HIV-1 Vpr essential for virion incorporation
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Open reading frame vpr of simian immunodeficiency virus encodes a virion-associated protein
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Extracellular Vpr protein increases cellular permissiveness to human immunodeficiency virus replication and reactivates virus from latency
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Functional and structural characterization of synthetic HIV-1 Vpr that transduces cells, localizes to the nucleus, and induces G2 cell cycle arrest
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Human immunodeficiency virus type 1 Vpr protein is incorporated into the virion in significantly smaller amounts than gag and is phosphorylated in infected cells
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HIV-1 Gag recruits oligomeric Vpr via two binding sites in p6, but both mature p6 and Vpr are rapidly lost upon target cell entry
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Vpr stimulates viral expression and induces cell killing in human immunodeficiency virus type 1-infected dividing Jurkat T cells
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Mutational analysis of the human immunodeficiency virus vpr open reading frame
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Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA
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The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr
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Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing
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HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteins
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HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages
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Promiscuous targeting of cellular proteins by Vpr drives systems-level proteomic remodeling in HIV-1 infection
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HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137
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Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B
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Biochemical mechanism of HIV-1 Vpr function. Oligomerization mediated by the N-terminal domain
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HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivo
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HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase
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HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system
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DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest
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The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor
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HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase
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HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle
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HIV-1 Vif and Vpr cooperatively modulate the cell cycle to maximize per-cell virion production
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Human immunodeficiency virus type 1 Vif induces cell cycle delay via recruitment of the same E3 ubiquitin ligase complex that targets APOBEC3 proteins for degradation
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Bimodal expression patterns, and not viral burst sizes, predict the effects of Vpr on HIV-1 proviral populations in jurkat cells
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HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells
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