Research graph
References from HELQ & Hel308: ancient enzymes of DNA repair and recombination. Local targets link to admitted publications; unresolved targets remain external evidence.
Structure and mechanism of helicases and nucleic acid translocases
10.1146/annurev.biochem.76.052305.115300 · 2007 · External reference
On helicases and other motor proteins
10.1016/j.sbi.2008.01.007 · 2008 · External reference
Protein superfamily evolution and the last universal common ancestor (LUCA)
10.1007/s00239-005-0289-7 · 2006 · External reference
Evolution and classification of P-loop kinases and related proteins
10.1016/j.jmb.2003.08.040 · 2003 · External reference
Evolutionary history and higher order classification of AAA+ ATPases
10.1016/j.jsb.2003.10.010 · 2004 · External reference
The crystal structure of the Thermus aquaticus DnaB helicase monomer
10.1093/nar/gkm507 · 2007 · External reference
Crystal structure of a near-full-length archaeal MCM: functional insights for an AAA+ hexameric helicase
10.1073/pnas.0808037105 · 2008 · External reference
Distantly related sequences in the a- and b-subunits of ATP synthase, myosin, kinase and other ATP-requiring enzymes and a common nucleotide binding fold
10.1002/j.1460-2075.1982.tb01276.x · 1982 · External reference
The structure of the E. coli recA protein monomer and polymer
10.1038/355318a0 · 1992 · External reference
Crystal structure of a DExx box DNA helicase
10.1038/384379a0 · 1996 · External reference
A novel superfamily of nucleoside triphosphate-binding motif containing proteins which are probably involved in duplex unwinding in DNA and RNA replication and recombination
10.1016/0014-5793(88)81226-2 · 1988 · External reference
Modularity and specialization in superfamily 1 and 2 helicases
10.1128/jb.184.7.1819-1826.2002 · 2002 · External reference
Special issue: DNA helicases: mechanisms, biological pathways, and disease relevance
10.3390/genes12030356 · 2021 · External reference
Structure of the DNA repair helicase hel308 reveals DNA binding and autoinhibitory domains
10.1074/jbc.m707548200 · 2008 · External reference
Structural basis for DNA duplex separation by a superfamily-2 helicase
10.1038/nsmb1246 · 2007 · External reference
Atomic structures and functional implications of the archaeal RecQ-like helicase Hjm
10.1186/1472-6807-9-2 · 2009 · External reference
DNA binding and unwinding by Hel308 helicase requires dual functions of a winged helix domain
10.1016/j.dnarep.2017.07.005 · 2017 · External reference
The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core
10.1093/narcan/zcaa043 · 2021 · External reference
Genome-wide identification of SF1 and SF2 helicases from archaea
10.1016/j.gene.2015.10.007 · 2016 · External reference
Evolutionary and functional insights into the Ski2-like helicase family in Archaea: a comparison of Thermococcales ASH-Ski2 and Hel308 activities
10.1093/nargab/lqae026 · 2024 · External reference
Identification of a novel helicase activity unwinding branched DNAs from the hyperthermophilic archaeon, Pyrococcus furiosus
10.1074/jbc.m413417200 · 2005 · External reference
Helicases that interact with replication forks: new candidates from archaea
10.1042/bst0331471 · 2005 · External reference
Archaeal Hel308 helicase targets replication forks in vivo and in vitro and unwinds lagging strands
10.1093/nar/gki685 · 2005 · External reference
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
10.1038/nature06617 · 2008 · External reference
Asgard archaea illuminate the origin of eukaryotic cellular complexity
10.1038/nature21031 · 2017 · External reference
Complex archaea that bridge the gap between prokaryotes and eukaryotes
10.1038/nature14447 · 2015 · External reference
Asgard archaea are the closest prokaryotic relatives of eukaryotes
10.1371/journal.pgen.1007080 · 2018 · External reference
Inference and reconstruction of the heimdallarchaeial ancestry of eukaryotes
10.1038/s41586-023-06186-2 · 2023 · External reference
A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308
10.1074/jbc.m110271200 · 2002 · External reference
The archaeal Hjm helicase has recQ-like functions, and may be involved in repair of stalled replication fork
10.1111/j.1365-2443.2006.00925.x · 2006 · External reference
Molecular biology of Hel308 helicase in archaea
10.1042/bst0370074 · 2009 · External reference
Subangstrom single-molecule measurements of motor proteins using a nanopore
10.1038/nbt.3357 · 2015 · External reference
Increasing the accuracy of nanopore DNA sequencing using a time-varying cross membrane voltage
10.1038/s41587-019-0096-0 · 2019 · External reference
Determining the effects of DNA sequence on Hel308 helicase translocation along single-stranded DNA using nanopore tweezers
10.1093/nar/gkz004 · 2019 · External reference
Revealing dynamics of helicase translocation on single-stranded DNA using high-resolution nanopore tweezers
10.1073/pnas.1711282114 · 2017 · External reference
An information theory approach to quantifying the sequence-dependent response of nucleic acid motors with applications to nanopore DNA sequencing
10.1038/s41467-026-69867-2 · 2026 · External reference
Strand annealing and motor driven activities of SMARCAL1 and ZRANB3 are stimulated by RAD51 and the paralog complex
10.1093/nar/gkac583 · 2022 · External reference
HARP is an ATP-driven annealing helicase
10.1126/science.1161233 · 2008 · External reference
Mechanism of single-stranded DNA annealing by RAD52–RPA complex
10.1038/s41586-024-07347-7 · 2024 · External reference
Polymerase theta-helicase promotes end joining by stripping single-stranded DNA-binding proteins and bridging DNA ends
10.1093/nar/gkac119 · 2022 · External reference
Human polymerase theta helicase positions DNA microhomologies for double-strand break repair
10.1038/s41594-025-01514-8 · 2025 · External reference
Structural basis for Polθ-helicase DNA binding and microhomology-mediated end-joining
10.1038/s41467-025-58441-x · 2025 · External reference
Archaeal Hel308 domain V couples DNA binding to ATP hydrolysis and positions DNA for unwinding over the helicase ratchet
10.1016/j.jmb.2007.10.004 · 2007 · External reference
Archaeal Hel308 suppresses recombination through a catalytic switch that controls DNA annealing
10.1093/nar/gkad572 · 2023 · External reference
HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis
10.1038/nature12565 · 2013 · External reference
Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs
10.1038/ncomms3338 · 2013 · External reference
Helq acts in parallel to Fancc to suppress replication-associated genome instability
10.1093/nar/gkt676 · 2013 · External reference
Human HEL308 localizes to damaged replication forks and unwinds lagging strand structures
10.1074/jbc.m111.228189 · 2011 · External reference
Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways
10.1016/j.dnarep.2008.03.021 · 2008 · External reference
Helicase Q promotes homology-driven DNA double-strand break repair and prevents tandem duplications
10.1038/s41467-021-27408-z · 2021 · External reference
Overlapping mechanisms promote postsynaptic RAD-51 filament disassembly during meiotic double-strand break repair
10.1016/j.molcel.2009.12.026 · 2010 · External reference
Division of labor by the HELQ, BLM, and FANCM helicases during homologous recombination repair in Drosophila melanogaster
10.3390/genes13030474 · 2022 · External reference
HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51
10.1038/s41586-021-04261-0 · 2022 · External reference
CRISPR-Cas induced self-targeting identifies key players in archaeal microhomology-mediated end joining
10.1093/femsml/uqaf015 · 2025 · External reference
Defining a cancer dependency map
10.1016/j.cell.2017.06.010 · 2017 · External reference
Helicase POLQ-like (HELQ) as a novel indicator of platinum-based chemoresistance for epithelial ovarian cancer
10.1016/j.ygyno.2018.03.006 · 2018 · External reference
DNA repair protein HELQ and XAB2 as chemoresponse and prognosis biomarkers in ascites tumor cells of high-grade serous ovarian cancer
10.1155/2022/7521934 · 2022 · External reference
HELQ upregulates PARP1 to drive platinum resistance and predict therapeutic response in ovarian cancer
10.1016/j.tranon.2025.102416 · 2025 · External reference
Hallmarks of cancer: the next generation
10.1016/j.cell.2011.02.013 · 2011 · External reference
Break-induced replication is highly inaccurate
10.1371/journal.pbio.1000594 · 2011 · External reference
Migrating bubble during break-induced replication drives conservative DNA synthesis
10.1038/nature12584 · 2013 · External reference
DNA polymerase delta synthesizes both strands during break-induced replication
10.1016/j.molcel.2019.07.033 · 2019 · External reference
Break-induced replication is a source of mutation clusters underlying kataegis
10.1016/j.celrep.2014.04.053 · 2014 · External reference
Physical interaction between archaeal DNA repair helicase Hel308 and replication protein A (RPA)
10.1016/j.dnarep.2010.12.001 · 2011 · External reference
Interaction of human HelQ with DNA polymerase delta halts DNA synthesis and stimulates DNA single-strand annealing
10.1093/nar/gkad032 · 2023 · External reference
Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells
10.1038/s41467-023-35992-5 · 2023 · External reference
Mitotic DNA synthesis in untransformed human cells preserves common fragile site stability via a FANCD2-driven mechanism that requires HELQ
10.1016/j.jmb.2023.168294 · 2023 · External reference
Accelerated growth in the absence of DNA replication origins
10.1038/nature12650 · 2013 · External reference
Role of RadA and DNA polymerases in recombination-associated DNA synthesis in hyperthermophilic archaea
10.3390/biom10071045 · 2020 · External reference
Communication between DNA polymerases and replication protein A within the archaeal replisome
10.1038/s41467-024-55365-w · 2024 · External reference
Hjm/Hel308A DNA helicase from Sulfolobus tokodaii promotes replication fork regression and interacts with Hjc endonuclease in vitro
10.1128/jb.01662-07 · 2008 · External reference
The archaeal ATPase PINA interacts with the helicase Hjm via its carboxyl terminal KH domain remodeling and processing replication fork and Holliday junction
10.1093/nar/gky451 · 2018 · External reference
The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution
10.1098/rsob.240112 · 2025 · External reference
XRCC2 and XRCC3 regulate the balance between short- and long-tract gene conversions between sister chromatids
10.1128/mcb.01406-08 · 2009 · External reference
Differential regulation of short- and long-tract gene conversion between sister chromatids by Rad51C
10.1128/mcb.01235-06 · 2006 · External reference
XRCC3 controls the fidelity of homologous recombination: roles for XRCC3 in late stages of recombination
10.1016/s1097-2765(02)00595-6 · 2002 · External reference
Control of homologous recombination by the HROB-MCM8-MCM9 pathway
10.1101/gad.329508.119 · 2019 · External reference
MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
10.1038/s41467-020-16718-3 · 2020 · External reference
Complete sequencing and characterization of 21,243 full-length human cDNAs
10.1038/ng1285 · 2004 · External reference
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)
10.1101/gr.2596504 · 2004 · External reference
PhosphoSitePlus, 2014: mutations, PTMs and recalibrations
10.1093/nar/gku1267 · 2015 · External reference
Substrate specificities and identification of putative substrates of ATM kinase family members
10.1074/jbc.274.53.37538 · 1999 · External reference
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
10.1126/science.1140321 · 2007 · External reference
A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 protein
10.1107/s1399004715001005 · 2015 · External reference