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References from Nuclear envelope rupture and resealing: mechanisms, consequences, and disease implications. Local targets link to admitted publications; unresolved targets remain external evidence.
Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy
10.1091/mbc.e15-07-0461 · 2015 · External reference
Nuclear lamins
10.1101/cshperspect.a000547 · 2010 · External reference
The molecular architecture of lamins in somatic cells
10.1038/nature21382 · 2017 · External reference
Laminopathies and the long strange trip from basic cell biology to therapy
10.1172/jci37679 · 2009 · External reference
The lamin protein family
10.1186/gb-2011-12-5-222 · 2011 · External reference
Modulation of cytoskeleton in cardiomyopathy caused by mutations in LMNA gene
10.1152/ajpcell.00471.2022 · 2023 · External reference
LeDucq-funded programme: from pathomechanisms to personalized therapy of cardio-laminopathy
10.1093/eurheartj/ehaf821 · 2026 · External reference
Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy
10.1038/s41467-021-24849-4 · 2021 · External reference
Mechanosensing by the Lamina protects against nuclear rupture, DNA damage, and cell-cycle arrest
10.1016/j.devcel.2019.04.020 · 2019 · External reference
Loss of lamin A/C expression revealed by immuno-electron microscopy in dilated cardiomyopathy with atrioventricular block caused by LMNA gene defects
10.1007/s00428-003-0865-4 · 2003 · External reference
Autosomal dominant dilated cardiomyopathy with atrioventricular block: a lamin A/C defect-related disease
10.1016/s0735-1097(02)01724-2 · 2002 · External reference
In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients
10.1136/jmg.2004.023283 · 2005 · External reference
Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice
10.1016/j.celrep.2024.114284 · 2024 · External reference
Microtubule forces drive nuclear damage in LMNA cardiomyopathy
10.1038/s44161-025-00727-w · 2025 · External reference
Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells
10.1038/s41563-019-0563-5 · 2020 · External reference
Nuclear factor-κB pathway mediates the molecular pathogenesis of LMNA-related muscular dystrophies
10.1007/s10528-020-09989-4 · 2020 · External reference
Nuclear membrane ruptures underlie the vascular pathology in a mouse model of Hutchinson-Gilford progeria syndrome
10.1172/jci.insight.151515 · 2021 · External reference
Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages
10.1038/s43587-023-00488-w · 2023 · External reference
Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies
10.1093/hmg/ddh295 · 2004 · External reference
Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies
10.1093/hmg/ddr344 · 2011 · External reference
In silico synchronization reveals regulators of nuclear ruptures in lamin A/C deficient model cells
10.1038/srep30325 · 2016 · External reference
Modeling of lamin A/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells
10.18632/aging.100503 · 2012 · External reference
An absence of lamin B1 in migrating neurons causes nuclear membrane ruptures and cell death
10.1073/pnas.1917225116 · 2019 · External reference
Increased expression of LAP2β eliminates nuclear membrane ruptures in nuclear lamin–deficient neurons and fibroblasts
10.1073/pnas.2107770118 · 2021 · External reference
Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures
10.1073/pnas.1812622115 · 2018 · External reference
Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina
10.1038/s41467-020-20049-8 · 2020 · External reference
The tethering of chromatin to the nuclear envelope supports nuclear mechanics
10.1038/ncomms8159 · 2015 · External reference
Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins
10.1091/mbc.e17-06-0410 · 2018 · External reference
Heterogeneous force response of chromatin in isolated nuclei
10.1016/j.celrep.2024.114852 · 2024 · External reference
Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus
10.1091/mbc.e16-09-0653 · 2017 · External reference
Spatial organizations of heterochromatin underpin nuclear structural integrity of ventricular cardiomyocytes against mechanical stress
10.1016/j.celrep.2024.115048 · 2024 · External reference
Lamins A and C but not lamin B1 regulate nuclear mechanics
10.1074/jbc.m513511200 · 2006 · External reference
Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation
10.1126/science.1240104 · 2013 · External reference
Lamin A/C expression is a marker of mouse and human embryonic stem cell differentiation
10.1634/stemcells.2004-0159 · 2006 · External reference
LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation
10.1016/j.cell.2013.01.009 · 2013 · External reference
A conserved phosphatase cascade that regulates nuclear membrane biogenesis
10.1073/pnas.0702099104 · 2007 · External reference
Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway
10.1074/jbc.m111.324350 · 2012 · External reference
Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability
10.1038/s41467-023-36400-8 · 2023 · External reference
A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope
10.1083/jcb.202304026 · 2023 · External reference
A high-content screen reveals new regulators of nuclear membrane stability
10.1038/s41598-024-56613-1 · 2024 · External reference
The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations
10.7554/elife.16011 · 2016 · External reference
Upregulated expression of lamin B receptor increases cell proliferation and suppresses genomic instability: implications for cellular immortalization
10.1111/febs.17113 · 2024 · External reference
Lamin B receptor upregulation in metastatic melanoma causes nuclear envelope fragility in confined migration during cancer invasion
10.1073/pnas.2513031123 · 2026 · External reference
ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death
10.1126/science.aad7611 · 2016 · External reference
Nuclear envelope rupture and repair during cancer cell migration
10.1126/science.aad7297 · 2016 · External reference
Nuclear rupture in confined cell migration triggers nuclear actin polymerization to limit chromatin leakage
10.1038/s44318-025-00566-2 · 2025 · External reference
Fine control of nuclear confinement identifies a threshold deformation leading to lamina rupture and induction of specific genes
10.1039/c2ib20056b · 2012 · External reference
Nuclear deformation causes DNA damage by increasing replication stress
10.1016/j.cub.2020.11.037 · 2021 · External reference
Nuclear envelope rupture and DNA damage driven by high pressure are mediated by F-actin and induce hepatocyte inflammation via cGAS-STING
10.1016/j.intimp.2025.115841 · 2026 · External reference
Nuclear envelope rupture is induced by actin-based nucleus confinement
10.1083/jcb.201603053 · 2016 · External reference
Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments
10.1038/ncomms10997 · 2016 · External reference
Local, transient tensile stress on the nuclear membrane causes membrane rupture
10.1091/mbc.e18-09-0604 · 2019 · External reference
Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle
10.1083/jcb.201811100 · 2019 · External reference
Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate
10.1080/19491034.2022.2045726 · 2022 · External reference
Lamin B loss in nuclear blebs is rupture dependent whereas increased DNA damage is rupture independent
10.1242/jcs.263945 · 2025 · External reference
Actin contraction controls nuclear blebbing and rupture independent of actin confinement
10.1091/mbc.e23-07-0292 · 2024 · External reference
Immune cells adapt to confined environments in vivo to optimise nuclear plasticity for migration
10.1038/s44319-025-00381-0 · 2025 · External reference
Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion
10.1016/j.cell.2021.08.035 · 2021 · External reference
Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability
10.1038/ncomms16013 · 2017 · External reference
Role of ANC-1 in tethering nuclei to the actin cytoskeleton
10.1126/science.1075119 · 2002 · External reference
Coupling of the nucleus and cytoplasm: role of the LINC complex
10.1083/jcb.200509124 · 2006 · External reference
The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope
10.1242/jcs.02471 · 2005 · External reference
Keeping the LINC: the importance of nucleocytoskeletal coupling in intracellular force transmission and cellular function
10.1042/bst20110686 · 2011 · External reference
The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeleton
10.1074/jbc.m111.233700 · 2011 · External reference
The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation
10.7554/elife.58541 · 2021 · External reference
A balance between intermediate filaments and microtubules maintains nuclear architecture in the cardiomyocyte
10.1161/circresaha.119.315582 · 2020 · External reference
Small lipid droplets are rigid enough to indent a nucleus, dilute the lamina, and cause rupture
10.1083/jcb.202208123 · 2023 · External reference
Nuclear rupture at sites of high curvature compromises retention of DNA repair factors
10.1083/jcb.201711161 · 2018 · External reference
Transcription inhibition suppresses nuclear blebbing and rupture independently of nuclear rigidity
10.1242/jcs.261547 · 2023 · External reference
Transcriptional activity generates chromatin motion that drives nuclear blebbing
10.1101/2025.05.20.655131 · 2025 · External reference
DNA damage follows repair factor depletion and portends genome variation in cancer cells after pore migration
10.1016/j.cub.2016.11.049 · 2017 · External reference
RNA polymerase loss by nuclear rupture drives LMNA cardiomyopathy
10.64898/2026.04.03.716433 · 2026 · External reference
DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C
10.1016/j.molcel.2023.09.023 · 2023 · External reference
DNA damage alters nuclear mechanics through chromatin reorganization
10.1093/nar/gkaa1202 · 2021 · External reference
DNA damage causes ATM-dependent heterochromatin loss leading to nuclear softening, blebbing, and rupture
10.1091/mbc.e24-05-0232 · 2025 · External reference
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
10.1038/ni.3558 · 2016 · External reference
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation
10.1038/s41556-020-0537-5 · 2020 · External reference
Micronuclear collapse from oxidative damage
10.1126/science.adj8691 · 2024 · External reference
cGAS surveillance of micronuclei links genome instability to innate immunity
10.1038/nature23449 · 2017 · External reference
cGAS is essential for cellular senescence
10.1073/pnas.1705499114 · 2017 · External reference
Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS-chemokine-myeloid axis
10.1126/sciadv.aeb1611 · 2026 · External reference
Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING
10.1016/j.molcel.2024.04.017 · 2024 · External reference
Micronucleus is not a potent inducer of the cGAS/STING pathway
10.26508/lsa.202302424 · 2024 · External reference
A novel biosensor for the spatiotemporal analysis of STING activation during innate immune responses to dsDNA
10.1038/s44318-025-00370-y · 2025 · External reference
Nuclear rupture induced by capillary constriction forces promotes differential effects on metastatic and normal breast cells
10.1038/s41598-024-64733-x · 2024 · External reference
Nuclear envelope rupture in cardiomyocytes orchestrates early transcriptomic changes and immune activation in LMNA -DCM that are reversed by LINC complex disruption
10.1101/2024.06.11.598511 · 2025 · External reference
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
10.1038/nature07710 · 2009 · External reference
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
10.1038/nature07725 · 2009 · External reference
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity
10.7554/elife.00047 · 2012 · External reference
Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN
10.4049/jimmunol.1003389 · 2011 · External reference
Repair of nuclear ruptures requires barrier-to-autointegration factor
10.1083/jcb.201901116 · 2019 · External reference
LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells
10.1073/pnas.1613916114 · 2017 · External reference
ESCRT-III controls nuclear envelope reformation
10.1038/nature14503 · 2015 · External reference
BAF facilitates interphase nuclear membrane repair through recruitment of nuclear transmembrane proteins
10.1091/mbc.e20-01-0009 · 2020 · External reference
Dynein pulling forces counteract lamin-mediated nuclear stability during nuclear envelope repair
10.1091/mbc.e17-06-0374 · 2018 · External reference
Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS
10.1083/jcb.202201024 · 2022 · External reference
Crosstalk between mitotic reassembly and repair of the nuclear envelope
10.1080/19491034.2024.2352203 · 2024 · External reference
Barrier-to-autointegration factor: a first responder for repair of nuclear ruptures
10.1080/15384101.2021.1892320 · 2021 · External reference
A new microscopy pipeline for studying the initial stages of nuclear and micronuclear rupture and repair
10.3389/fcell.2024.1475095 · 2024 · External reference
2D and 3D multiplexed subcellular profiling of nuclear instability in human cancer
10.1101/2023.11.07.566063 · 2023 · External reference
Nuclear poly-glutamine aggregates rupture the nuclear envelope and hinder its repair
10.1083/jcb.202307142 · 2024 · External reference
Lamin B1 curtails early human papillomavirus infection by safeguarding nuclear compartmentalization and autophagic capacity
10.1007/s00018-024-05194-3 · 2024 · External reference
An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system
10.7554/elife.45284 · 2019 · External reference
LRRC59 cooperates with nuclear transporters to restrain the nuclear envelope repair machinery and safeguard genome integrity
10.1038/s41467-025-65994-4 · 2025 · External reference
Nuclear envelope rupture is enhanced by loss of p53 or Rb
10.1158/1541-7786.mcr-17-0084 · 2017 · External reference
Torsin ATPase deficiency leads to defects in nuclear pore biogenesis and sequestration of MLF2
10.1083/jcb.201910185 · 2020 · External reference
Mitosis sets nuclear homeostasis of cancer cells under confinement
10.7554/elife.94975.1 · 2024 · External reference
Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex
10.1073/pnas.150240197 · 2000 · External reference
DNA cross-bridging shapes a single nucleus from a set of mitotic chromosomes
10.1016/j.cell.2017.07.038 · 2017 · External reference
LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation
10.1038/s41586-020-2232-x · 2020 · External reference
A protein-DNA surface hydrogel mechanically reinforces the cell nucleus and protects the genome
10.1101/2025.05.21.655270 · 2025 · External reference
DNA-induced liquid phase condensation of cGAS activates innate immune signaling
10.1126/science.aat1022 · 2018 · External reference
Factors promoting nuclear envelope assembly independent of the canonical ESCRT pathway
10.1083/jcb.201908232 · 2020 · External reference
Components of an ESCRT-independent nuclear envelope assembly pathway
10.64898/2026.02.01.703137 · 2026 · External reference
Direct binding of ESCRT protein Chm7 to phosphatidic acid-rich membranes at nuclear envelope herniations
10.1083/jcb.202004222 · 2021 · External reference
Disordered region of nuclear membrane protein Bqt4 recruits phosphatidic acid to the nuclear envelope to maintain its structural integrity
10.1016/j.jbc.2024.107430 · 2024 · External reference
The very-long-chain fatty acid elongase Elo2 rescues lethal defects associated with loss of the nuclear barrier function in fission yeast cells
10.1242/jcs.229021 · 2019 · External reference
Parvoviruses cause nuclear envelope breakdown by activating key enzymes of mitosis
10.1371/journal.ppat.1003671 · 2013 · External reference
The NSL complex maintains nuclear architecture stability via lamin A/C acetylation
10.1038/s41556-019-0397-z · 2019 · External reference
Mechanisms of A-type Lamin targeting to nuclear ruptures are disrupted in LMNA- and BANF1-associated progerias
10.3390/cells11050865 · 2022 · External reference
Scaling laws indicate distinct nucleation mechanisms of holes in the nuclear lamina
10.1038/s41567-019-0506-8 · 2019 · External reference
Lem2 is essential for cardiac development by maintaining nuclear integrity
10.1093/cvr/cvad061 · 2023 · External reference
Primordial germ cells experience increasing physical confinement and DNA damage during migration in the mouse embryo
10.1126/sciadv.aec7919 · 2026 · External reference
Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease
10.1056/nejm199912023412302 · 1999 · External reference
Unresolved reference
2022 · External reference
Doubly heterozygous LMNA and TTN mutations revealed by exome sequencing in a severe form of dilated cardiomyopathy
10.1038/ejhg.2013.16 · 2013 · External reference
Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity
10.1186/s12967-023-04542-4 · 2023 · External reference
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome
10.1038/nature01629 · 2003 · External reference
Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging
10.1161/atvbaha.110.209460 · 2010 · External reference
Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival
10.1083/jcb.201308029 · 2014 · External reference
Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions
10.1074/jbc.m112.441535 · 2013 · External reference
Nuclear deformability constitutes a rate-limiting step during cell migration in 3-D environments
10.1007/s12195-014-0342-y · 2014 · External reference
Cell confinement initiates a delayed but heritable loss of chromosomes
10.1016/j.celrep.2026.117053 · 2026 · External reference
Disruption of nuclear envelope integrity as a possible initiating event in tauopathies
10.1016/j.celrep.2022.111249 · 2022 · External reference
Tau modulates nuclear integrity, chromatin, and cholesterol synthesis genes via the nuclear envelope
10.64898/2025.12.05.692577 · 2025 · External reference
Protein aggregation and neurodegenerative disease
10.1038/nm1066 · 2004 · External reference
Neuronal α-synuclein toxicity is the key driver of neurodegeneration in multiple system atrophy
10.1093/brain/awaf030 · 2025 · External reference
Pathological α-synuclein perturbs nuclear integrity
10.1016/j.nbd.2025.107028 · 2025 · External reference
Tau oligomerization induces nuclear lamina invagination and chromatin remodeling in Alzheimer’s disease
10.1007/s00401-026-03018-1 · 2026 · External reference
Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity
10.1016/j.stem.2021.01.015 · 2021 · External reference
Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis
10.15252/embj.2020105819 · 2021 · External reference
Loss of lamin-B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus
10.1111/acel.13521 · 2022 · External reference
Disruption of nuclear envelope integrity as a possible initiating event in tauopathies
10.1016/j.celrep.2022.111249 · 2022 · External reference
Cellular mechanisms of NETosis
10.1146/annurev-cellbio-020520-111016 · 2020 · External reference
Chromatin swelling drives neutrophil extracellular trap release
10.1038/s41467-018-06263-5 · 2018 · External reference
Nuclear envelope rupture and NET formation is driven by PKCα-mediated lamin B disassembly
10.15252/embr.201948779 · 2020 · External reference
Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs
10.1038/s43587-022-00323-8 · 2023 · External reference
Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia
10.1016/j.cell.2014.10.028 · 2014 · External reference
