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References from p38γ and p38δ MAP kinases in inflammation. Local targets link to admitted publications; unresolved targets remain external evidence.
p38 MAP-kinases pathway regulation, function and role in human diseases
10.1016/j.bbamcr.2007.03.010 · 2007 · External reference
p38γ and p38δ: from spectators to key physiological players
10.1016/j.tibs.2017.02.008 · 2017 · External reference
Evolutionary analysis of p38 stress-activated kinases in unicellular relatives of animals suggests an ancestral function in osmotic stress
10.1098/rsob.220314 · 2023 · External reference
Diversity and versatility of p38 kinase signalling in health and disease
10.1038/s41580-020-00322-w · 2021 · External reference
Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update
10.1152/physrev.00028.2011 · 2012 · External reference
Mechanisms and functions of p38 MAPK signalling
10.1042/bj20100323 · 2010 · External reference
Knocking out p38α+p38β+p38γ is required to abort the myogenic program in C2C12 myoblasts and to impose uncontrolled proliferation
10.1016/j.jbc.2025.108281 · 2025 · External reference
Pro-oncogenic role of alternative p38 mitogen-activated protein kinases p38γ and p38δ, linking inflammation and cancer in colitis-associated colon cancer
10.1158/0008-5472.can-14-0870 · 2014 · External reference
Targeting innate immunity protein kinase signalling in inflammation
10.1038/nrd2829 · 2009 · External reference
p38γ and p38δ mitogen activated protein kinases (MAPKs), new stars in the MAPK galaxy
10.3389/fcell.2016.00031 · 2016 · External reference
TPL2 kinase expression is regulated by the p38γ/p38δ-dependent association of aconitase-1 with TPL2 mRNA
10.1073/pnas.2204752119 · 2022 · External reference
A novel role of p38 alpha MAPK in mitotic progression independent of its kinase activity
10.4161/cc.4.11.2125 · 2005 · External reference
Differential activation of p38MAPK isoforms by MKK6 and MKK3
10.1016/j.cellsig.2009.11.020 · 2010 · External reference
Mitogen-activated protein kinases in innate immunity
10.1038/nri3495 · 2013 · External reference
New insights into the p38γ and p38δ MAPK pathways
10.1155/2012/520289 · 2012 · External reference
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
10.1038/nsb770 · 2002 · External reference
BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo
10.1074/jbc.m414221200 · 2005 · External reference
Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity
10.15252/emmm.201708485 · 2018 · External reference
p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock
10.1242/jcs.066514 · 2010 · External reference
p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation
10.1073/pnas.1207290109 · 2012 · External reference
Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase
10.1038/cr.2010.173 · 2011 · External reference
p38γ and p38δ modulate innate immune response by regulating MEF2D activation
10.7554/elife.86200 · 2023 · External reference
p38δ controls Mitogen- and Stress-activated Kinase-1 (MSK1) function in response to toll-like receptor activation in macrophages
10.3389/fcell.2023.1083033 · 2023 · External reference
A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38δ
10.1093/emboj/20.16.4360 · 2001 · External reference
Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis
10.1172/jci65124 · 2013 · External reference
p38δ MAPK: a novel regulator of NLRP3 inflammasome activation with increased expression in coronary atherogenesis
10.1161/atvbaha.115.307312 · 2016 · External reference
Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung
10.1084/jem.20120677 · 2012 · External reference
p38γ MAPK is required for inflammation-associated colon tumorigenesis
10.1038/onc.2015.158 · 2016 · External reference
PTPH1 dephosphorylates and cooperates with p38γ MAPK to increase Ras oncogenesis through PDZ-mediated interaction
10.1158/0008-5472.can-09-3229 · 2010 · External reference
p38γ MAPK is essential for aerobic glycolysis and pancreatic tumorigenesis
10.1158/0008-5472.can-19-3281 · 2020 · External reference
P38γ drives aerobic glycolysis in liver sinusoidal endothelial cells and regulates alcoholic liver disease via the PFKFB3 signaling pathway
10.1007/s11033-026-11853-4 · 2026 · External reference
P38γ modulates the lipid metabolism in non-alcoholic fatty liver disease by regulating the JAK-STAT signaling pathway
10.1096/fj.202200939rr · 2023 · External reference
The roles of SQSTM1/p62 in selective autophagy and oncogenic signaling
10.3390/ijms27052342 · 2026 · External reference
Microbially produced imidazole propionate impairs insulin signaling through mTORC1
10.1016/j.cell.2018.09.055 · 2018 · External reference
Amino acid activation of mTORC1 by a PB1-domain-driven kinase complex cascade
10.1016/j.celrep.2015.07.045 · 2015 · External reference
The CARM1 epigenetic enzyme inhibits cross-presenting dendritic cell function in cancer immunity
10.1126/science.aea1200 · 2026 · External reference
CARM1 phosphorylation at S595 by p38γ MAPK drives ROS-mediated cellular senescence
10.1016/j.redox.2024.103344 · 2024 · External reference
B cell development and T-dependent antibody response are regulated by p38γ and p38δ
10.3389/fcell.2020.00189 · 2020 · External reference
p38γ MAPK inflammatory and metabolic signaling in physiology and disease
10.3390/cells12131674 · 2023 · External reference
P38 kinase in gastrointestinal cancers
10.1038/s41417-023-00622-1 · 2023 · External reference
Differential tissue expression and activation of p38 MAPK alpha, beta, gamma, and delta isoforms in rheumatoid arthritis
10.1002/art.22080 · 2006 · External reference
p38γ and p38δ as biomarkers in the interplay of colon cancer and inflammatory bowel diseases
10.1002/cac2.12331 · 2022 · External reference
The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis
10.1136/ard.2007.074278 · 2008 · External reference
Alternative p38 MAPKs are essential for collagen-induced arthritis
10.1002/art.38327 · 2014 · External reference
The p38 mitogen-activated protein kinase critically regulates human keratinocyte inflammasome activation
10.1016/j.jid.2017.10.037 · 2018 · External reference
The mitogen-activated protein kinases p38 and ERK1/2 are increased in lesional psoriatic skin
10.1111/j.1365-2133.2004.06304.x · 2005 · External reference
Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis
10.18632/oncotarget.4320 · 2015 · External reference
Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis
10.1016/j.cell.2008.11.018 · 2009 · External reference
p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration
10.15252/embj.201591857 · 2016 · External reference
IL-13-induced airway mucus production is attenuated by MAPK13 inhibition
10.1172/jci64896 · 2012 · External reference
Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ
10.1038/srep29881 · 2016 · External reference
Phenotype-based screens with conformation-specific inhibitors reveal p38 gamma and delta as targets for HCC polypharmacology
10.1158/1535-7163.mct-18-0571 · 2019 · External reference
Targeting the non-ATP-binding pocket of the MAP kinase p38γ mediates a novel mechanism of cytotoxicity in cutaneous T-cell lymphoma (CTCL)
10.1002/1873-3468.14186 · 2021 · External reference
Mitogen-activated protein kinase-guided drug discovery for post-viral and related types of lung disease
10.1183/16000617.0220-2023 · 2024 · External reference
A first-in-kind MAPK13 inhibitor corrects stem cell reprogramming and muco-obstructive lung disease
10.1101/2024.08.21.608990 · 2025 · External reference
Multi-kinase inhibitor with anti-p38γ activity in cutaneous T-cell lymphoma
10.1016/j.jid.2018.04.030 · 2018 · External reference
Diagnostic significance of p38 Isoforms (p38α, p38β, p38γ, p38δ) in head and neck squamous cell carcinoma: comparative serum level evaluation and design of novel peptide inhibitor targeting the same
10.4143/crt.2018.105 · 2019 · External reference
Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
10.1038/s41467-018-08027-7 · 2019 · External reference
Pirfenidone for idiopathic pulmonary fibrosis: a systematic review and meta-analysis
10.1371/journal.pone.0136160 · 2015 · External reference
p38γ is essential for cell cycle progression and liver tumorigenesis
10.1038/s41586-019-1112-8 · 2019 · External reference
Identification of potential p38γ inhibitors via in silico screening, in vitro bioassay and molecular dynamics simulation studies
10.3390/ijms24087360 · 2023 · External reference
Kinase Profiling Inhibitor Database | International Centre for Kinase Profiling [Internet]
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