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References from Genes, fuel, and fate in lung cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Critical role for a high-plasticity cell state in lung cancer
10.1038/s41586-025-09985-x · 2026 · External reference
Lineage plasticity in cancer: a shared pathway of therapeutic resistance
10.1038/s41571-020-0340-z · 2020 · External reference
EMT
10.1016/j.cell.2016.06.028 · 2016 · External reference
Hallmarks of cancer: new dimensions
10.1158/2159-8290.cd-21-1059 · 2022 · External reference
Otto Warburg’s contributions to current concepts of cancer metabolism
10.1038/nrc3038 · 2011 · External reference
Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells
10.1016/j.cmet.2015.02.002 · 2015 · External reference
Metabolic switching and cell fate decisions: implications for pluripotency, reprogramming and development
10.1016/j.gde.2017.06.008 · 2017 · External reference
The global burden of lung cancer: current status and future trends
10.1038/s41571-023-00798-3 · 2023 · External reference
Cellular plasticity and regenerative mechanisms in the lung
10.1183/16000617.0168-2025 · 2026 · External reference
Emergence of a high-plasticity cell state during lung cancer evolution
10.1016/j.ccell.2020.06.012 · 2020 · External reference
An atlas of epithelial cell states and plasticity in lung adenocarcinoma
10.1038/s41586-024-07113-9 · 2024 · External reference
A developmental constraint model of cancer cell states and tumor heterogeneity
10.1016/j.cell.2024.04.032 · 2024 · External reference
Comprehensive molecular profiling of lung adenocarcinoma
10.1038/nature13385 · 2014 · External reference
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
10.1038/nature05945 · 2007 · External reference
Oncogene-addicted metastatic non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up*
10.1016/j.annonc.2022.12.009 · 2023 · External reference
Tyrosine kinase inhibitors in cancer: breakthrough and challenges of targeted therapy
10.3390/cancers12030731 · 2020 · External reference
Concurrent RB1 and TP53 alterations define a subset of EGFR-mutant lung cancers at risk for histologic transformation and inferior clinical outcomes
10.1016/j.jtho.2019.06.002 · 2019 · External reference
Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model
10.1016/s1535-6108(03)00220-4 · 2003 · External reference
RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer
10.1038/ncomms7377 · 2015 · External reference
Outcome of EGFR-mutated adenocarcinoma NSCLC patients with changed phenotype to squamous cell carcinoma after tyrosine kinase inhibitors: a pooled analysis with an additional case
10.1016/j.lungcan.2018.11.016 · 2019 · External reference
Molecular landscape and therapeutic strategies of lung cancer lineage plasticity
10.1016/j.jtho.2025.06.012 · 2025 · External reference
Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2
10.1038/ncomms14922 · 2017 · External reference
NOTCH alteration in EGFR-mutated lung adenocarcinoma leads to histological small-cell carcinoma transformation under EGFR-TKI treatment
10.21037/tlcr-21-536 · 2021 · External reference
Multiomic analysis of lung tumors defines pathways activated in neuroendocrine transformation
10.1158/2159-8290.cd-20-1863 · 2021 · External reference
Clonal history and genetic predictors of transformation into small-cell carcinomas from lung adenocarcinomas
10.1200/jco.2016.71.9096 · 2017 · External reference
Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer
10.1038/s41467-018-06162-9 · 2018 · External reference
Significantly mutated genes and regulatory pathways in SCLC—a meta-analysis
10.1016/j.cancergen.2017.05.003 · 2017 · External reference
Resistance to anaplastic lymphoma kinase inhibitors: knowing the enemy is half the battle won
10.21037/tlcr-20-372 · 2020 · External reference
ALK-rearranged adenocarcinoma transformed to small-cell lung cancer: a new entity with specific prognosis and treatment?
10.2217/pme-2017-0069 · 2018 · External reference
Genomic and transcriptomic analysis of neuroendocrine transformation in ALK-rearranged lung adenocarcinoma after treatments with sequential ALK inhibitors: a brief report
10.1016/j.jtocrr.2022.100338 · 2022 · External reference
FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer
10.7554/elife.38579 · 2018 · External reference
Opposing lineage specifiers induce a protumor hybrid identity state in lung adenocarcinoma
10.1101/gad.352742.125 · 2025 · External reference
Prototypical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer
10.1126/sciadv.abc2578 · 2021 · External reference
USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity
10.1186/s12943-023-01892-x · 2023 · External reference
An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer
10.1038/s41556-021-00743-5 · 2021 · External reference
Epigenetic modulations and lineage plasticity in advanced prostate cancer
10.1016/j.annonc.2020.02.002 · 2020 · External reference
Detecting small cell transformation in patients with advanced EGFR mutant lung adenocarcinoma through epigenomic cfDNA profiling
10.1158/1078-0432.ccr-24-0466 · 2024 · External reference
EHMT2-mediated transcriptional reprogramming drives neuroendocrine transformation in non-small cell lung cancer
10.1073/pnas.2317790121 · 2024 · External reference
Structural basis for PRC2 engagement with chromatin
10.1016/j.sbi.2020.10.017 · 2021 · External reference
EZH2 promotes progression of small cell lung cancer by suppressing the TGF-β-Smad-ASCL1 pathway
10.1038/celldisc.2015.26 · 2015 · External reference
EZH2 endorses cell plasticity to non-small cell lung cancer cells facilitating mesenchymal to epithelial transition and tumour colonization
10.1038/s41388-022-02375-x · 2022 · External reference
Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer
10.1371/journal.pone.0071670 · 2013 · External reference
KMT2D loss drives adeno-to-squamous transition and sensitizes TKI-resistant lung cancer to AURKA inhibition
10.1038/s41418-025-01657-7 · 2026 · External reference
Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1
10.1038/s41467-022-31998-7 · 2022 · External reference
The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis
10.1101/gad.328336.119 · 2019 · External reference
Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition
10.1126/scisignal.aau2922 · 2019 · External reference
Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation
10.1016/s0065-230x(02)86002-x · 2002 · External reference
Transcriptomic heterogeneity of EGFR-mutant non-small cell lung cancer evolution toward small-cell lung cancer
10.1158/1078-0432.ccr-24-0160 · 2024 · External reference
Randomized phase II trial of erlotinib with and without entinostat in patients with advanced non-small-cell lung cancer who progressed on prior chemotherapy
10.1200/jco.2011.38.9411 · 2012 · External reference
Phase I study of vorinostat with gefitinib in BIM deletion polymorphism/epidermal growth factor receptor mutation double-positive lung cancer
10.1111/cas.14260 · 2020 · External reference
Epigenetic switch between SOX2 and SOX9 regulates cancer cell plasticity
10.1158/0008-5472.can-15-3178 · 2016 · External reference
AUTX-703, a novel and potent KAT2A and KAT2B protein degrader, induces profound and persistent cell state differentiation and inhibits growth in SCLC model systems
10.1016/j.jtho.2025.07.035 · 2025 · External reference
A phase 1 dose escalation and dose optimization study to evaluate the preliminary safety, tolerability, pharmacokinetic, pharmacodynamic, and clinical activity profile of AUTX703 in participants with relapsed/refractory acute myeloid leukemia and myelodysplastic syndromes
10.1182/blood-2025-6952 · 2025 · External reference
Lactate modulates cellular metabolism through histone lactylation-mediated gene expression in non-small cell lung cancer
10.3389/fonc.2021.647559 · 2021 · External reference
Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis
10.1186/s12967-023-04403-0 · 2023 · External reference
LDOC1 connects histone H2B monoubiquitination to tumor cell plasticity in non-small cell lung cancer
10.1186/s12964-025-02607-z · 2026 · External reference
Histone H4K12 lactylation promotes malignancy progression in triple-negative breast cancer through SLFN5 downregulation
10.1016/j.cellsig.2024.111468 · 2024 · External reference
Connections between metabolism and epigenetics: mechanisms and novel anti-cancer strategy
10.3389/fphar.2022.935536 · 2022 · External reference
Metabolic reprogramming of stem cell epigenetics
10.1016/j.stem.2015.11.012 · 2015 · External reference
miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency
10.15252/embj.201490441 · 2015 · External reference
Metabolic heterogeneity in human lung tumors
10.1016/j.cell.2015.12.034 · 2016 · External reference
PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity
10.1073/pnas.2416882121 · 2024 · External reference
Intrinsic electrical activity drives small-cell lung cancer progression
10.1038/s41586-024-08575-7 · 2025 · External reference
ADORA2A-driven proline synthesis triggers epigenetic reprogramming in neuroendocrine prostate and lung cancers
10.1172/jci168670 · 2023 · External reference
Lactate controls cancer stemness and plasticity through epigenetic regulation
10.1016/j.cmet.2025.01.002 · 2025 · External reference
Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity
10.1126/scitranslmed.adw4689 · 2026 · External reference
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
10.1038/nature09132 · 2010 · External reference
Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas
10.1038/s43018-024-00865-3 · 2025 · External reference
PHGDH defines a metabolic subtype in lung adenocarcinomas with poor prognosis
10.1016/j.celrep.2017.05.067 · 2017 · External reference
High expression of PHGDH predicts poor prognosis in non-small cell lung cancer
10.1016/j.tranon.2016.08.003 · 2016 · External reference
PSPH mediates the metastasis and proliferation of non-small cell lung cancer through MAPK signaling pathways
10.7150/ijbs.29203 · 2019 · External reference
CD44 regulates epigenetic plasticity by mediating iron endocytosis
10.1038/s41557-020-0513-5 · 2020 · External reference
A druggable copper-signalling pathway that drives inflammation
10.1038/s41586-023-06017-4 · 2023 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Copper induces cell death by targeting lipoylated TCA cycle proteins
10.1126/science.abf0529 · 2022 · External reference
An overview of autophagy: morphology, mechanism, and regulation
10.1089/ars.2013.5371 · 2014 · External reference
LC3A-mediated autophagy regulates lung cancer cell plasticity
10.1080/15548627.2021.1964224 · 2022 · External reference
Methionine restriction reduces lung cancer progression and increases chemotherapy response
10.1101/2024.06.25.599795. · 2024 · External reference
Tumour hypoxia in driving genomic instability and tumour evolution
10.1038/s41568-024-00781-9 · 2025 · External reference
HIF1α and HIF2α regulate non-small-cell lung cancer dedifferentiation via expression of Sox2 and Oct4 under hypoxic conditions
10.1016/j.gene.2023.147288 · 2023 · External reference
Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer
10.1038/s41467-021-24537-3 · 2021 · External reference
Estrogen receptor beta promotes lung cancer invasion via increasing CXCR4 expression
10.1038/s41419-022-04514-4 · 2022 · External reference
Insights into androgen receptor action in lung cancer
10.3390/endocrines4020022 · 2023 · External reference
Androgen receptor regulates lung cancer progress through modulation of OCT-4 expression
10.1158/1538-7445.am2011-2126 · 2011 · External reference
A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma
10.1038/nature22334 · 2017 · External reference
Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma
10.1016/j.celrep.2023.112212 · 2023 · External reference
Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling
10.1038/ncomms4472 · 2014 · External reference
Dynamic phenotypic reprogramming and chemoresistance induced by lung fibroblasts in small cell lung cancer
10.1038/s41598-024-52687-z · 2024 · External reference
LKB1 modulates lung cancer differentiation and metastasis
10.1038/nature06030 · 2007 · External reference
The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer
10.1038/s42255-020-00316-0 · 2020 · External reference
Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer
10.1038/s42255-024-01066-z · 2024 · External reference
Co-occurring KRAS mutation/LKB1 loss in non-small cell lung cancer cells results in enhanced metabolic activity susceptible to caloric restriction: an in vitro integrated multilevel approach
10.1186/s13046-018-0954-5 · 2018 · External reference
LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin
10.1016/j.ccr.2012.12.008 · 2013 · External reference
LKB1 inactivation elicits a redox imbalance to modulate non-small cell lung cancer plasticity and therapeutic response
10.1016/j.ccell.2015.04.001 · 2015 · External reference
Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer
10.1016/j.ccell.2024.01.012 · 2024 · External reference
TET2-STAT3-CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition
10.1084/jem.20240111 · 2024 · External reference
In colorectal cancer cells with mutant KRAS, SLC25A22-mediated glutaminolysis reduces DNA demethylation to increase WNT signaling, stemness, and drug resistance
10.1053/j.gastro.2020.08.016 · 2020 · External reference
Epigenetic and metabolic rewiring in metastatic pheochromocytomas and paragangliomas driven by SDHB mutations
10.1038/s42003-026-09543-9 · 2026 · External reference
Spatial omics at the forefront: emerging technologies, analytical innovations, and clinical applications
10.1016/j.ccell.2025.12.009 · 2026 · External reference
Spatially resolved epigenomic profiling of single cells in complex tissues
10.1016/j.cell.2022.09.035 · 2022 · External reference
Spatial-CUT&Tag: spatially resolved chromatin modification profiling at the cellular level
10.1126/science.abg7216 · 2022 · External reference
Spatial profiling of chromatin accessibility in mouse and human tissues
10.1038/s41586-022-05094-1 · 2022 · External reference