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References from One adaptor, multiple outcomes: decoding TRIFosome heterogeneity. Local targets link to admitted publications; unresolved targets remain external evidence.
SMOCs: supramolecular organizing centres that control innate immunity
10.1038/nri3757 · 2014 · External reference
Toll-like receptors and the control of immunity
10.1016/j.cell.2020.02.041 · 2020 · External reference
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
10.1038/nri2079 · 2007 · External reference
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
10.1016/s1097-2765(00)80136-7 · 1998 · External reference
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
10.1016/s1074-7613(00)80596-8 · 1998 · External reference
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
10.1126/science.1087262 · 2003 · External reference
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
10.1038/nature01889 · 2003 · External reference
Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling
10.1038/nsmb.3444 · 2017 · External reference
Structural basis for TIR domain–mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM
10.1073/pnas.2418988122 · 2025 · External reference
Toll-like receptor signalling through macromolecular protein complexes
10.1016/j.molimm.2014.06.033 · 2015 · External reference
Probing cellular protein complexes using single-molecule pull-down
10.1038/nature10016 · 2011 · External reference
Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway
10.1016/j.molimm.2009.12.002 · 2010 · External reference
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
10.1126/science.aaa2630 · 2015 · External reference
TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-β
10.1074/jbc.m305820200 · 2003 · External reference
An alanine to proline mutation in the BB-loop of Toll-like receptor 3 TIR domain switches signalling adaptor specificity from TRIF to MyD88
10.4049/jimmunol.1300849 · 2013 · External reference
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation
10.1038/ni1061 · 2004 · External reference
Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL
10.1074/jbc.m113.462341 · 2013 · External reference
Toll-like receptor signaling outcome is determined by the stoichiometry of the endogenous TRIFosome
10.1126/sciadv.aeb9507 · 2026 · External reference
ASC speck formation as a readout for inflammasome activation
10.1007/978-1-62703-523-1_8 · 2013 · External reference
Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex
10.1073/pnas.1402911111 · 2014 · External reference
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis
10.1016/j.cell.2012.06.019 · 2012 · External reference
Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling
10.1073/pnas.1222811110 · 2013 · External reference
Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization
10.1038/s41467-023-43180-8 · 2023 · External reference
TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation
10.1038/s41556-018-0229-6 · 2018 · External reference
ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1
10.1038/s41467-020-20357-z · 2021 · External reference
Neutrophils and macrophages drive TNF-induced lethality via TRIF/CD14-mediated responses
10.1126/sciimmunol.add0665 · 2022 · External reference
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
10.1038/35092578 · 2001 · External reference
MyD88 oligomer size functions as a physical threshold to trigger IL1R Myddosome signaling
10.1083/jcb.202012071 · 2021 · External reference
Inflammasomes: mechanism of assembly, regulation and signalling
10.1038/nri.2016.58 · 2016 · External reference
MyD88 dimerization inhibitor ST2825 targets the aggressiveness of synovial fibroblasts in rheumatoid arthritis patients
10.1186/s13075-023-03145-0 · 2023 · External reference
Targeting RIPK1 for the treatment of human diseases
10.1073/pnas.1901179116 · 2019 · External reference
Discovery of a first-in-class receptor interacting protein 1 (RIP1) kinase specific clinical candidate (GSK2982772) for the treatment of inflammatory diseases
10.1021/acs.jmedchem.6b01751 · 2017 · External reference
A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death
10.1016/j.immuni.2024.04.025 · 2024 · External reference
Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling
10.1038/nature09121 · 2010 · External reference
Interleukin-1 receptor-associated kinase 4 (IRAK4) degraders for treating inflammatory diseases: advances and prospects
10.1021/acs.jmedchem.4c01322 · 2025 · External reference
ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases
10.1038/s41467-024-53547-0 · 2024 · External reference
Assessment of ASC specks as a putative biomarker of pyroptosis in myelodysplastic syndromes: an observational cohort study
10.1016/s2352-3026(18)30109-1 · 2018 · External reference
A method for the acute and rapid degradation of endogenous proteins
10.1016/j.cell.2017.10.033 · 2017 · External reference
