Research graph
References from Powering the liver toxicity assessment in the organoid era. Local targets link to admitted publications; unresolved targets remain external evidence.
Global burden of liver disease: 2023 update
10.1016/j.jhep.2023.03.017 · 2023 · External reference
Drug withdrawal due to safety: a review of the data supporting withdrawal decision
10.2174/1574886314666191004092520 · 2020 · External reference
Epidemiological features of NAFLD From 1999 to 2018 in China
10.1002/hep.31150 · 2020 · External reference
Three-dimensional (3D) liver cell models—a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials
10.1007/s13346-022-01147-0 · 2022 · External reference
Adipose tissue-derived mesenchymal stem cells extend the lifespan and enhance liver function in hepatocyte organoids
10.3390/ijms242015429 · 2023 · External reference
Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of adeno-associated virus vectors
10.1089/hum.2022.188 · 2023 · External reference
Three-dimensional in vitro cell cultures as a feasible and promising alternative to two-dimensional and animal models in cancer research
10.7150/ijbs.96469 · 2024 · External reference
Vascularized and functional human liver from an iPSC-derived organ bud transplant
10.1038/nature12271 · 2013 · External reference
Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation
10.1038/nbt.3275 · 2015 · External reference
Long-term culture of genome-stable bipotent stem cells from adult human liver
10.1016/j.cell.2014.11.050 · 2015 · External reference
Long-term expansion of functional mouse and human hepatocytes as 3D organoids
10.1016/j.cell.2018.11.013 · 2018 · External reference
In vitro expansion of primary human hepatocytes with efficient liver repopulation capacity
10.1016/j.stem.2018.10.018 · 2018 · External reference
Probing the tumor suppressor function of BAP1 in CRISPR-engineered human liver organoids
10.1016/j.stem.2019.04.017 · 2019 · External reference
Generation of hepatobiliary organoids from human induced pluripotent stem cells
10.1016/j.jhep.2018.12.028 · 2019 · External reference
Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis
10.1038/s41587-023-01680-4 · 2023 · External reference
Generation of human adult hepatocyte organoids with metabolic functions
10.1038/s41586-025-08861-y · 2025 · External reference
Multi-zonal liver organoids from human pluripotent stem cells
10.1038/s41586-025-08850-1 · 2025 · External reference
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
10.1038/srep25187 · 2016 · External reference
Liver organoid culture methods
10.1186/s13578-023-01136-x · 2023 · External reference
Modeling immune lineage co-development in human pluripotent stem cell-derived liver organoids
10.1016/j.jhep.2025.11.018 · 2026 · External reference
A high-throughput microfluidic platform for functional hiPSC-derived liver organoids with bile duct- and lobule-like structures
10.1039/d5lc00154d · 2025 · External reference
High-throughput bioengineering of homogenous and functional human-induced pluripotent stem cells-derived liver organoids via micropatterning technique
10.3389/fbioe.2022.937595 · 2022 · External reference
Elimination of reprogramming transgenes facilitates the differentiation of induced pluripotent stem cells into hepatocyte-like cells and hepatic organoids
10.3390/biology11040493 · 2022 · External reference
hESCs-derived organoids achieve liver zonation features through LSEC modulation
10.1002/advs.202411667 · 2025 · External reference
Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion
10.1016/j.isci.2021.103303 · 2021 · External reference
Modeling alcohol-associated liver disease in humans using adipose stromal or stem cell-derived organoids
10.1016/j.crmeth.2024.100778 · 2024 · External reference
Patient-derived liver organoids recapitulate liver epithelial heterogeneity and enable precision modeling of alcohol-related liver disease
10.1016/j.jhep.2025.07.014 · 2026 · External reference
Patient-induced pluripotent stem cell-derived hepatostellate organoids establish a basis for liver pathologies in telomeropathies
10.1016/j.jcmgh.2023.06.003 · 2023 · External reference
MSC-derived exosomes attenuate hepatic fibrosis in primary sclerosing cholangitis through inhibition of Th17 differentiation
10.1016/j.ajps.2024.100889 · 2024 · External reference
Reproducible generation of human liver organoids (HLOs) on a pillar plate platform via microarray 3D bioprinting
10.1039/d4lc00149d · 2024 · External reference
A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis
10.1002/adhm.202302502 · 2024 · External reference
Bioprinting functional hepatocyte organoids derived from human chemically induced pluripotent stem cells to treat liver failure
10.1136/gutjnl-2024-333885 · 2025 · External reference
A high-throughput microphysiological liver chip system to model drug-induced liver injury using human liver organoids
10.1016/j.gastha.2024.08.004 · 2024 · External reference
Development of NAFLD-specific human liver organoid models on a microengineered array chip for semaglutide efficacy evaluation
10.1111/cpr.70118 · 2025 · External reference
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation
10.1038/nprot.2016.097 · 2016 · External reference
Modeling steatohepatitis in humans with pluripotent stem cell-derived organoids
10.1016/j.cmet.2019.05.007 · 2019 · External reference
Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells
10.1038/nprot.2017.011 · 2017 · External reference
Regional differences in human biliary tissues and corresponding in vitro-derived organoids
10.1002/hep.31252 · 2021 · External reference
Establishment of human induced pluripotent stem cell-derived hepatobiliary organoid with bile duct for pharmaceutical research use
10.1016/j.biomaterials.2024.122621 · 2024 · External reference
Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids
10.1016/j.jhep.2019.06.030 · 2019 · External reference
Scalable production of tissue-like vascularized liver organoids from human PSCs
10.1038/s12276-023-01074-1 · 2023 · External reference
Generation of hepatic stellate cells from human pluripotent stem cells enables in vitro modeling of liver fibrosis
10.1016/j.stem.2018.05.027 · 2018 · External reference
Bioprinting of human liver-derived epithelial organoids for toxicity studies
10.1002/mabi.202100327 · 2021 · External reference
Modeling drug-induced liver injury and screening for anti-hepatofibrotic compounds using human PSC-derived organoids
10.1186/s13619-022-00148-1 · 2023 · External reference
Hepatotoxic assessment in a microphysiological system: simulation of the drug absorption and toxic process after an overdosed acetaminophen on intestinal-liver-on-chip
10.1016/j.fct.2024.115016 · 2024 · External reference
Drug compound screening in single and integrated multi-organoid body-on-a-chip systems
10.1088/1758-5090/ab6d36 · 2020 · External reference
Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform
10.1016/j.actbio.2020.02.015 · 2020 · External reference
Acetaminophen absorption and metabolism in an intestine/liver microphysiological system
10.1016/j.cbi.2018.11.010 · 2019 · External reference
A multi-organ-chip co-culture of liver and testis equivalents: a first step toward a systemic male reprotoxicity model
10.1093/humrep/deaa057 · 2020 · External reference
Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform
10.1038/s41598-017-08879-x · 2017 · External reference
Development of human pluripotent stem cell-derived hepatic organoids as an alternative model for drug safety assessment
10.1016/j.biomaterials.2022.121575 · 2022 · External reference
Decellularized liver scaffolds for constructing drug-metabolically functional ex vivo human liver models
2024 · External reference
Integration of in vitro data from three dimensionally cultured HepaRG cells and physiologically based pharmacokinetic modeling for assessment of acetaminophen hepatotoxicity
10.1016/j.yrtph.2020.104661 · 2020 · External reference
Prediction for oxaliplatin-induced liver injury using patient-derived liver organoids
10.1002/cam4.7042 · 2024 · External reference
High-fidelity drug-induced liver injury screen using human pluripotent stem cell-derived organoids
10.1053/j.gastro.2020.10.002 · 2021 · External reference
3D hepatic organoid production from human pluripotent stem cells
10.1016/j.diff.2023.100742 · 2024 · External reference
Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation
10.1016/j.omtm.2023.08.003 · 2023 · External reference
hiPSC-derived macrophages improve drug sensitivity and selectivity in a macrophage-incorporating organoid culture model
10.1088/1758-5090/ad4c0a · 2024 · External reference
An immune-liver microphysiological system method for evaluation and quality control of hepatotoxicity induced by Polygonum multiflorum thunb
10.1016/j.jep.2025.119633 · 2025 · External reference
Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein
10.1016/j.phymed.2017.01.004 · 2017 · External reference
Patient-derived organoids for personalized gallbladder cancer modelling and drug screening
10.1002/ctm2.678 · 2022 · External reference
Evidence of adult features and functions of hepatocytes differentiated from human induced pluripotent stem cells and self-organized as organoids
10.3390/cells11030537 · 2022 · External reference
Alcohol-induced CYP2E1, mitochondrial dynamics and retrograde signaling in human hepatic 3D organoids
10.1016/j.freeradbiomed.2020.06.030 · 2020 · External reference
Culture and establishment of self-renewing human liver 3D organoids with high uric acid for screening antihyperuricemic functional compounds
10.1016/j.foodchem.2021.131634 · 2022 · External reference
Human chemically-derived hepatic progenitors (hCdHs) as a source of liver organoid generation: Application in regenerative medicine, disease modeling, and toxicology testing
10.1016/j.biomaterials.2023.122360 · 2023 · External reference
Generation of fibrotic liver organoids using hepatocytes, primary liver sinusoidal endothelial cells, hepatic stellate cells, and macrophages
10.3390/cells12212514 · 2023 · External reference
Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma
10.7554/elife.60747 · 2021 · External reference
A model of hepatic steatosis with declined viability and function in a liver-organ-on-a-chip
10.1038/s41598-023-44198-0 · 2023 · External reference
Liver-kidney-on-chip to study toxicity of drug metabolites
10.1021/acsbiomaterials.7b00417 · 2018 · External reference
Tissue organoid cultures metabolize dietary carcinogens proficiently and are effective models for DNA adduct formation
10.1021/acs.chemrestox.3c00255 · 2024 · External reference
Recapitulating cholangiopathy-associated necroptotic cell death in vitro using human cholangiocyte organoids
10.1016/j.jcmgh.2021.10.009 · 2022 · External reference
LCK inhibition downregulates YAP activity and is therapeutic in patient-derived models of cholangiocarcinoma
10.1016/j.jhep.2022.09.014 · 2023 · External reference
Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model
10.1016/j.tox.2020.152637 · 2021 · External reference
Computerized predictive approaches of genotoxicity and mutagenesis in 3D Hepoid of normal and transformed human hepatocytes
10.1016/j.tox.2025.154242 · 2025 · External reference
Novel inositol 1,4,5-trisphosphate receptor inhibitor antagonizes hepatic stellate cell activation: a potential drug to treat liver fibrosis
10.3390/cells13090765 · 2024 · External reference
Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids
10.1016/j.scitotenv.2021.150328 · 2022 · External reference
Aged fragmented-polypropylene microplastics induced ageing statues-dependent bioenergetic imbalance and reductive stress: In vivo and liver organoids-based in vitro study
10.1016/j.envint.2024.108949 · 2024 · External reference
Integrated transcriptomics and metabolomics to explore the varied hepatic toxicity induced by aged- and pristine-microplastics: in vivo and human-originated liver organoids-based in vitro study
10.1016/j.envres.2025.121820 · 2025 · External reference
The iron matters: aged microplastics disrupted the iron homeostasis in the liver organoids
10.1016/j.scitotenv.2023.167529 · 2024 · External reference
Combined effect of polystyrene microplastics and bisphenol A on the human embryonic stem cells-derived liver organoids: the hepatotoxicity and lipid accumulation
10.1016/j.scitotenv.2022.158585 · 2023 · External reference
Human multi-lineage liver organoid model reveals impairment of CYP3A4 expression upon repeated exposure to graphene oxide
10.3390/cells13181542 · 2024 · External reference
Early warnings by liver organoids on short- and long-chain PFAS toxicity
10.3390/toxics10020091 · 2022 · External reference
A three-dimensional mouse liver organoid platform for assessing EDCs metabolites simulating liver metabolism
10.1016/j.envint.2024.109184 · 2025 · External reference
Chlordecone-induced hepatotoxicity and fibrosis are mediated by the proteasomal degradation of septins
10.1016/j.jhazmat.2024.135177 · 2024 · External reference
Environmental toxin screening using human-derived 3D bioengineered liver and cardiac organoids
10.3389/fpubh.2018.00103 · 2018 · External reference
Efficacy and hepatotoxicity of tamoxifen-loaded fructose-based nanodrug for breast cancer treatment
10.1039/d5tb00468c · 2025 · External reference
Liver organoids uncover tire-derived 6-PPDQ-induced hepatotoxicity: a preliminary application of environmental toxicology and safety assessment
10.1016/j.ecoenv.2025.118215 · 2025 · External reference
Mitigation of polystyrene microplastic-induced hepatotoxicity in human hepatobiliary organoids through bile extraction
10.1016/j.ecoenv.2024.117330 · 2024 · External reference
Effect of microbial short-chain fatty acids on CYP3A4-mediated metabolic activation of human pluripotent stem cell-derived liver organoids
10.3390/cells10010126 · 2021 · External reference
Spike structure of gold nanobranches induces hepatotoxicity in mouse hepatocyte organoid models
10.1186/s12951-024-02363-1 · 2024 · External reference
Reproducing human and cross-species drug toxicities using a Liver-Chip
10.1126/scitranslmed.aax5516 · 2019 · External reference
Evaluation of the utility of the Beta Human Liver Emulation System (BHLES) for CFSAN’s regulatory toxicology program
10.1016/j.fct.2022.112828 · 2022 · External reference
A multicellular liver organoid model for investigating hepatitis C virus infection and nonalcoholic fatty liver disease progression
10.1097/hep.0000000000000683 · 2024 · External reference
Growth differentiation factor 7 autocrine signaling promotes hepatic progenitor cell expansion in liver fibrosis
10.1186/s13287-023-03493-3 · 2023 · External reference
Systematic in vitro assessment of responses of roGFP2-based probes to physiologically relevant oxidant species
10.1016/j.freeradbiomed.2017.02.044 · 2017 · External reference
Multiparametric analysis of cells with different mitochondrial membrane potential during apoptosis by polychromatic flow cytometry
10.1038/nprot.2007.405 · 2007 · External reference
Mucopolysaccharidoses type I gene therapy
10.1002/jimd.12414 · 2021 · External reference
Human pluripotent stem cell-derived organoids as models of liver disease
10.1053/j.gastro.2020.06.010 · 2020 · External reference
Guide to light-sheet microscopy for adventurous biologists
10.1038/nmeth.3222 · 2015 · External reference
Long-term three-dimensional high-resolution imaging of live unlabeled small intestinal organoids via low-coherence holotomography
10.1038/s12276-024-01312-0 · 2024 · External reference
Hepatic organoids as a platform for liver disease modeling and the development of novel therapies
10.1016/j.clinre.2025.102647 · 2025 · External reference
Protocol for generating liver organoids containing Kupffer cells using human iPSCs
10.1016/j.xpro.2025.104138 · 2025 · External reference
Human assembloids recapitulate periportal liver tissue in vitro
10.1038/s41586-025-09884-1 · 2026 · External reference
Establishment of human induced pluripotent stem cell-derived hepatobiliary organoid with bile duct for pharmaceutical research use
10.1016/j.biomaterials.2024.122621 · 2024 · External reference
Wnt/β-catenin signaling in liver development, homeostasis, and pathobiology
10.1146/annurev-pathol-020117-044010 · 2018 · External reference
Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes
10.1016/j.jhep.2014.10.016 · 2015 · External reference
Rethinking matrigel: the complex journey to matrix alternatives in organoid culture
10.1002/advs.202508734 · 2025 · External reference
Ethical frontiers in liver transplantation
10.5500/wjt.v14.i4.96687 · 2024 · External reference
OrganoID: a versatile deep learning platform for tracking and analysis of single-organoid dynamics
10.1371/journal.pcbi.1010584 · 2022 · External reference
Challenges in developing cell culture media using machine learning
10.1016/j.biotechadv.2023.108293 · 2024 · External reference
Development of an AI model for DILI-level prediction using liver organoid brightfield images
10.1038/s42003-025-08205-6 · 2025 · External reference
Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells
10.1126/science.adk5864 · 2024 · External reference
AI-designed microenvironment scaffolds for predictable organoid morphogenesis and functional reliability
2025 · External reference
Digital biological twin platform: multiomics in patient derived organoids combined with machine learning
10.1158/1538-7445.am2025-4606 · 2025 · External reference
An AI-Cyborg system for adaptive intelligent modulation of organoid maturation
10.1101/2024.12.07.627355 · 2024 · External reference
Human hepatic organoids for the analysis of human genetic diseases
10.1172/jci.insight.176034 · 2023 · External reference
A combined model of human iPSC-derived liver organoids and hepatocytes reveals ferroptosis in DGUOK mutant mtDNA depletion syndrome
10.1002/advs.202004680 · 2021 · External reference
Diversity in a dish: leveraging organoids to reflect genetic ancestry and sex differences in health and disease
10.1016/j.cobme.2025.100592 · 2025 · External reference
Guidelines for manufacturing and application of organoids: liver
10.15283/ijsc24044 · 2024 · External reference
Application of organoid technology in the human health risk assessment of microplastics: a review of progresses and challenges
10.1016/j.envint.2024.108744 · 2024 · External reference
Human organoids and organ-on-chip for biotoxin assessment: applications, best practices, and a translational roadmap
10.3390/toxins18030149 · 2026 · External reference
Development of portable whole-cell biosensing platform with lyophilized bacteria and its application for rapid on-site detection of heavy metal toxicity without pre-resuscitation
10.1016/j.aca.2022.340354 · 2022 · External reference
