Research graph
References from Genetic and pharmacologic activation of BECLIN1 prevents aldosterone-induced cardiovascular damage. Local targets link to admitted publications; unresolved targets remain external evidence.
Aldosterone as a mediator of cardiovascular damage
10.1161/hypertensionaha.122.17964 · 2022 · External reference
NLRP3 inflammasome mediates aldosterone-induced vascular damage
10.1161/circulationaha.116.024369 · 2016 · External reference
Role of the CCL5 and its receptor, CCR5, in the genesis of aldosterone-induced hypertension, vascular dysfunction, and end-organ damage
10.1161/hypertensionaha.123.21888 · 2024 · External reference
Endothelial cell mineralocorticoid receptors: turning cardiovascular risk factors into cardiovascular dysfunction
10.1161/hypertensionaha.114.01997 · 2014 · External reference
Mineralocorticoid receptor activation and antagonism in cardiovascular disease: cellular and molecular mechanisms
10.1016/j.kisu.2021.11.001 · 2022 · External reference
Mineralocorticoid receptor regulates vascular damage by inducing autophagy in mice with obesity and hypertension
10.1016/j.numecd.2025.104191 · 2025 · External reference
Autophagy: a crucial moderator of redox balance, inflammation, and apoptosis in lung disease
10.1089/ars.2013.5373 · 2014 · External reference
Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease
10.1038/s41419-022-04906-6 · 2022 · External reference
Beclin-1-dependent autophagy protects perivascular adipose tissue function from hyperaldosteronism effects
10.1152/ajpheart.00829.2024 · 2025 · External reference
Endothelial autophagy promotes atheroprotective communication between endothelial and smooth muscle cells via exosome-mediated delivery of miR-204-5p
10.1161/atvbaha.123.319993 · 2024 · External reference
Reconstitution of autophagy ameliorates vascular function and arterial stiffening in spontaneously hypertensive rats
10.1152/ajpheart.00227.2019 · 2019 · External reference
Role of autophagy in endothelial damage and blood-brain barrier disruption in ischemic stroke
10.1161/strokeaha.117.017287 · 2018 · External reference
Autophagy in healthy aging and disease
10.1038/s43587-021-00098-4 · 2021 · External reference
Adipocyte-specific Beclin1 deletion impairs lipolysis and mitochondrial integrity in adipose tissue
10.1016/j.molmet.2020.101005 · 2020 · External reference
Vascular contractility relies on integrity of progranulin pathway: insights into mitochondrial function
10.1161/jaha.124.037640 · 2025 · External reference
Cardioprotection and lifespan extension by the natural polyamine spermidine
10.1038/nm.4222 · 2016 · External reference
Age-independent cardiac protection by pharmacological activation of Beclin-1 during endotoxemia and its association with energy metabolic reprograming in myocardium—a targeted metabolomics study
10.1161/jaha.122.025310 · 2022 · External reference
Beclin-1-dependent autophagy protects the heart during sepsis
10.1161/circulationaha.117.032821 · 2018 · External reference
Progranulin maintains blood pressure and vascular tone dependent on EphrinA2 and Sortilin1 receptors and endothelial nitric oxide synthase activation
10.1161/jaha.123.030353 · 2023 · External reference
NADPH oxidase 4-derived hydrogen peroxide counterbalances testosterone-induced endothelial dysfunction and migration
10.1152/ajpendo.00365.2023 · 2024 · External reference
Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress
10.1016/j.lfs.2019.01.043 · 2019 · External reference
Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice
10.1096/fj.13-245415 · 2014 · External reference
Targeting mineralocorticoid receptors in diet-induced hepatic steatosis and insulin resistance
10.1152/ajpregu.00316.2021 · 2022 · External reference
Regulation of TFEB activity and its potential as a therapeutic target against kidney diseases
10.1038/s41420-020-0265-4 · 2020 · External reference
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
10.1038/nrm3565 · 2013 · External reference
Spermidine influence on the nitric oxide synthase and arginase activity relationship during experimentally induced seizures
10.1515/jbcpp.2010.21.2.169 · 2010 · External reference
Autophagy protein ATG7 is a critical regulator of endothelial cell inflammation and permeability
10.1038/s41598-020-70126-7 · 2020 · External reference
Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor
10.1038/nm.3288 · 2013 · External reference
Autophagy in endothelial cells and tumor angiogenesis
10.1038/s41418-019-0287-8 · 2019 · External reference
T regulatory lymphocytes prevent aldosterone-induced vascular injury
10.1161/hypertensionaha.111.181123 · 2012 · External reference
