Research graph
References from Interferon-λ receptor positive monocytes/macrophages orchestrate a pro-fibrotic immune environment in hepatitis B virus-related liver fibrosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Molecular, cellular, tissue, and organismal functions of type III interferons
10.1146/annurev-immunol-083024-032807 · 2026 · External reference
The RNA sensor RIG-I dually functions as an innate sensor and direct antiviral factor for hepatitis B virus
10.1016/j.immuni.2014.12.016 · 2015 · External reference
Lambda and alpha interferons inhibit hepatitis B virus replication through a common molecular mechanism but with different in vivo activities
10.1016/j.virol.2010.02.022 · 2010 · External reference
IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis
10.1038/ng.3836 · 2017 · External reference
Leukocyte-derived IFN-α/β and epithelial IFN-λ constitute a compartmentalized mucosal defense system that restricts enteric virus infections
10.1371/journal.ppat.1004782 · 2015 · External reference
Type III interferon primes pDCs for TLR7 activation and antagonizes immune suppression mediated by TGF-β and PGE2
10.1038/s41467-025-58220-8 · 2025 · External reference
Macrophages and neutrophils express IFNλs in granulomas from Mycobacterium tuberculosis-infected nonhuman primates
10.3389/fimmu.2022.985405 · 2022 · External reference
Macrophage coordination of the interferon lambda immune response
10.3389/fimmu.2019.02674 · 2019 · External reference
Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics
10.1002/hep.26016 · 2013 · External reference
Nomenclature of monocytes and dendritic cells in blood
10.1182/blood-2010-02-258558 · 2010 · External reference
Liver macrophages in tissue homeostasis and disease
10.1038/nri.2017.11 · 2017 · External reference
Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
10.1016/j.cell.2014.11.018 · 2014 · External reference
Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies
10.1038/cmi.2015.104 · 2016 · External reference
Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus
10.1038/s41590-019-0408-z · 2019 · External reference
Interferon-λ–treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells
10.1182/blood-2005-10-4129 · 2006 · External reference
The LXRs: a new class of oxysterol receptors
10.1016/s0959-437x(98)80013-0 · 1998 · External reference
CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway
10.1038/s41419-021-03544-8 · 2021 · External reference
IFN-γ aggravates neointimal hyperplasia by inducing endoplasmic reticulum stress and apoptosis in macrophages by promoting ubiquitin-dependent liver X receptor-α degradation
10.1096/fj.201700327r · 2017 · External reference
EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection
10.1016/j.jhep.2017.03.021 · 2017 · External reference
Type 3 innate lymphoid cell: a new player in liver fibrosis progression
10.1042/cs20180482 · 2018 · External reference
Significance of the balance between regulatory T (Treg) and T helper 17 (Th17) cells during hepatitis B virus related liver fibrosis
10.1371/journal.pone.0039307 · 2012 · External reference
Isolation and culture of murine hepatic stellate cells
10.21769/bioprotoc.3422 · 2019 · External reference
The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa
10.1136/gutjnl-2015-309260 · 2016 · External reference
EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update
10.1016/j.jhep.2021.05.025 · 2021 · External reference
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
10.1073/pnas.1119964109 · 2012 · External reference
Despite IFN-λ receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines
10.1038/gene.2009.72 · 2009 · External reference
Hepatitis B virus-induced imbalance of inflammatory and antiviral signaling by differential phosphorylation of STAT1 in human monocytes
10.4049/jimmunol.1800848 · 2019 · External reference
Role of IL-10 in the crossregulation of prostaglandins and cytokines in monocytes
10.1159/000040831 · 1998 · External reference
Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis
10.1002/hep.29544 · 2018 · External reference
Liver macrophages: old dogmas and new insights
10.1002/hep4.1356 · 2019 · External reference
A mouse model for HBV immunotolerance and immunotherapy
10.1038/cmi.2013.43 · 2013 · External reference
Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells
10.1002/hep.23983 · 2011 · External reference
Non-alcoholic hepatic steatosis attenuates hepatitis B virus replication in an HBV-immunocompetent mouse model
10.1007/s12072-018-9877-7 · 2018 · External reference
Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis
10.1002/hep.22950 · 2009 · External reference
Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease
10.1016/j.jhep.2017.04.023 · 2017 · External reference
Liver fibrosis and CD206+ macrophage accumulation are suppressed by anti-GM-CSF therapy
10.1016/j.jhepr.2019.11.006 · 2020 · External reference
Interleukin-29 uses a type 1 interferon-like program to promote antiviral responses in human hepatocytes
10.1002/hep.21312 · 2006 · External reference
Dynamic shifts in the composition of resident and recruited macrophages influence tissue remodeling in NASH
10.1016/j.celrep.2020.108626 · 2021 · External reference
Regulatory T cells are the most important determinant factor of hepatitis B infection prognosis: a systematic review and meta-analysis
10.1016/j.vaccine.2012.06.063 · 2012 · External reference
Myeloid LXR (liver X receptor) deficiency induces inflammatory gene expression in foamy macrophages and accelerates atherosclerosis
10.1161/atvbaha.122.317583 · 2022 · External reference
Hepatic expression of tumour necrosis factor-alpha in chronic hepatitis B virus infection
10.1136/jcp.47.12.1112 · 1994 · External reference
Macrophage in liver Fibrosis: Identities and mechanisms
10.1016/j.intimp.2023.110357 · 2023 · External reference
IL1β signaling mediates the interaction between hepatitis B and C viruses
10.1097/hep.0000000000001525 · 2025 · External reference