Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from Photobiomodulation: multifaceted therapeutic effects on disorders in the central nervous system. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
10.1016/s1474-4422(18)30499-x · 2016 · External reference
The epidemiology of Parkinson’s disease
10.1016/s0140-6736(23)01419-8 · 2024 · External reference
China stroke surveillance report 2021
10.1186/s40779-023-00463-x · 2023 · External reference
Cause-specific life-years lost in people with mental disorders: a nationwide, register-based cohort study
10.1016/s2215-0366(17)30429-7 · 2017 · External reference
Donanemab in early symptomatic Alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trial
10.1001/jama.2023.13239 · 2023 · External reference
Lecanemab in early Alzheimer’s disease
10.1056/nejmoa2212948 · 2023 · External reference
Prevalence of cerebral amyloid angiopathy: a systematic review and meta-analysis
10.1002/alz.12366 · 2022 · External reference
Repetitive transcranial magnetic stimulation increases the brain’s drainage efficiency in a mouse model of Alzheimer’s disease
10.1186/s40478-021-01198-3 · 2021 · External reference
Transcranial alternating current stimulation for treating depression: a randomized controlled trial
10.1093/brain/awab252 · 2022 · External reference
Low-intensity focused ultrasound for human neuromodulation
10.1038/s43586-024-00368-6 · 2024 · External reference
Photobiomodulation CME part I: overview and mechanism of action
10.1016/j.jaad.2023.10.073 · 2024 · External reference
Effects of home photobiomodulation treatments on cognitive and behavioral function, cerebral perfusion, and resting-state functional connectivity in patients with dementia: a pilot trial
10.1089/photob.2018.4555 · 2019 · External reference
Effect of transcranial low-level light therapy vs sham therapy among patients with moderate traumatic brain injury: a randomized clinical trial
10.1001/jamanetworkopen.2020.17337 · 2020 · External reference
Study of transcranial photobiomodulation at 945-nm wavelength: anxiety and depression
10.1007/s10103-020-02983-7 · 2020 · External reference
Transcranial photobiomodulation for the treatment of children with autism spectrum disorder (ASD): a retrospective study
10.3390/children9050755 · 2022 · External reference
Effectiveness and safety of transcranial laser therapy for acute ischemic stroke
10.1161/strokeaha.109.547547 · 2009 · External reference
History of phototherapy in dermatology
10.1039/c2pp25120e · 2013 · External reference
Phototherapy: from ancient Egypt to the new millennium
10.1038/sj.jp.7210625 · 2001 · External reference
Unresolved reference
1983 · External reference
10.5479/sil.414424.39088007009129
10.5479/sil.414424.39088007009129 · 1810 · External reference
Researches on the effect of light upon bacteria and other organisms
10.1098/rspl.1877.0068 · 1877 · External reference
A brief report on the history of phototherapy
10.1016/j.clindermatol.2016.05.002 · 2016 · External reference
Unresolved reference
1896 · External reference
The effect of laser beams on the growth of hair in mice
1968 · External reference
Low-level light/laser therapy versus photobiomodulation therapy
10.1089/pho.2015.9848 · 2015 · External reference
Biological effects and medical applications of infrared radiation
10.1016/j.jphotobiol.2017.04.014 · 2017 · External reference
Photobiomodulation of cytochrome c oxidase by chronic transcranial laser in young and aged brains
10.3389/fnins.2022.818005 · 2022 · External reference
Mitochondrial fatty acid oxidation is stimulated by red light irradiation
10.1002/1873-3468.70195 · 2026 · External reference
Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer’s disease
10.1186/s13195-022-01022-7 · 2022 · External reference
Transcranial photobiomodulation with 1064-nm laser modulates brain electroencephalogram rhythms
10.1117/1.nph.6.2.025013 · 2019 · External reference
Representation of steady-state visual evoked potentials elicited by luminance flicker in human occipital cortex: an electrocorticography study
10.1016/j.neuroimage.2018.04.006 · 2018 · External reference
Visual gamma stimulation induces 40 Hz neural oscillations in the human hippocampus and alters phase synchrony and lag
10.1038/s42003-025-08766-6 · 2025 · External reference
Brain responses to violet, blue, and green monochromatic light exposures in humans: prominent role of blue light and the brainstem
10.1371/journal.pone.0001247 · 2007 · External reference
Photobiological neuromodulation of resting-state EEG and Steady-state visual-evoked potentials by 40 Hz violet light optical stimulation in healthy individuals
10.3390/jpm11060557 · 2021 · External reference
Gamma frequency entrainment attenuates amyloid load and modifies microglia
10.1038/nature20587 · 2016 · External reference
Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer's disease mouse model
10.1038/s41377-021-00617-3 · 2021 · External reference
Exosomes derived from M2 microglial cells modulated by 1070-nm light improve cognition in an Alzheimer’s disease mouse model
10.1002/advs.202304025 · 2023 · External reference
Transcranial low-level laser stimulation in the near-infrared-II region (1064 nm) for brain safety in healthy humans
10.1016/j.brs.2024.11.010 · 2024 · External reference
Neurological and psychological applications of transcranial lasers and LEDs
10.1016/j.bcp.2013.06.012 · 2013 · External reference
Photobiomodulation therapy mitigates depressive-like behaviors by remodeling synaptic links and mitochondrial function
10.1016/j.jphotobiol.2024.112998 · 2024 · External reference
Optical properties of human skin
10.1117/1.jbo.17.9.090901 · 2012 · External reference
Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation
10.1126/science.6836297 · 1983 · External reference
Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidase
10.1074/jbc.m409650200 · 2005 · External reference
G protein-coupled receptor rhodopsin
10.1146/annurev.biochem.75.103004.142743 · 2006 · External reference
Noninvasive evaluation of collagen and hemoglobin contents and scattering property of in vivo keloid scars and normal skin using diffuse reflectance spectroscopy: pilot study
10.1117/1.jbo.17.7.077005 · 2012 · External reference
Optical properties of biological tissues: a review
10.1088/0031-9155/58/11/r37 · 2013 · External reference
Blue light effects on the skin: a post-2015 update
10.36849/jdd.7665 · 2024 · External reference
Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring
2013 · External reference
Light-emitting diodes: a brief review and clinical experience
2015 · External reference
Photobiomodulation in biological tissues: light penetration, dosimetry, and potential applications
10.1016/j.optlaseng.2025.108852 · 2025 · External reference
Direct and quantitative assessments of near-infrared light attenuation and spectroscopic detection depth in biological tissues using surface-enhanced Raman scattering
10.1007/s44258-023-00010-2 · 2023 · External reference
Shedding light on neurons: optical approaches for neuromodulation
10.1093/nsr/nwac007 · 2022 · External reference
Penetration of unfocused laser light into the skin
10.1007/bf00509097 · 1985 · External reference
Poor penetration of infra-red and helium neon low power laser light into the dermal tissue
10.3727/036012993816357566 · 1993 · External reference
Transcranial near-infrared laser transmission (NILT) profiles (800 nm): systematic comparison in four common research species
10.1371/journal.pone.0127580 · 2015 · External reference
Comparison of therapeutic effects between pulsed and continuous wave 810-nm wavelength laser irradiation for traumatic brain injury in mice
10.1371/journal.pone.0026212 · 2011 · External reference
Chapter 6—Near-infrared photonic energy penetration—principles and practice
2019 · External reference
Near-infrared photonic energy penetration: can infrared phototherapy effectively reach the human brain?
10.2147/ndt.s78182 · 2015 · External reference
A biocompatible second near-infrared nanozyme for spatiotemporal and non-invasive attenuation of amyloid deposition through scalp and skull
10.1021/acsnano.0c02733 · 2020 · External reference
Near-infrared photoactivatable oxygenation catalysts of amyloid peptide
10.1016/j.chempr.2018.02.008 · 2018 · External reference
Achieving optical transparency in live animals with absorbing molecules
10.1126/science.adm6869 · 2024 · External reference
10.1007/978-3-662-29626-4
10.1007/978-3-662-29626-4 · 1968 · External reference
Biphasic dose response in low level light therapy
10.2203/dose-response.09-027.hamblin · 2009 · External reference
Biphasic dose response in low level light therapy—an update
10.2203/dose-response.11-009.hamblin · 2011 · External reference
Dose response effects of 810 nm laser light on mouse primary cortical neurons
10.1002/lsm.21100 · 2011 · External reference
Pilot study of transcranial photobiomodulation of lymphatic clearance of beta-amyloid from the mouse brain: breakthrough strategies for non-pharmacologic therapy of Alzheimer’s disease
10.1364/boe.10.004003 · 2019 · External reference
Can transcranial photobiomodulation improve cognitive function? A systematic review of human studies
10.1016/j.arr.2022.101786 · 2023 · External reference
Primary and secondary mechanisms of action of visible to near-IR radiation on cells
10.1016/s1011-1344(98)00219-x · 1999 · External reference
Proposed mechanisms of photobiomodulation or low-level light therapy
10.1109/jstqe.2016.2561201 · 2016 · External reference
Single cell effects of photobiomodulation on mitochondrial membrane potential and reactive oxygen species production in human adipose mesenchymal stem cells
10.3390/cells11060972 · 2022 · External reference
Low-level laser therapy (LLLT) reduces oxidative stress in primary cortical neurons in vitro
10.1002/jbio.201200157 · 2013 · External reference
Reversal of nitric oxide-, peroxynitrite- and S-nitrosothiol-induced inhibition of mitochondrial respiration or complex I activity by light and thiols
10.1016/s0005-2728(00)00178-x · 2000 · External reference
Nitric oxide and cytochrome c oxidase: mechanisms of inhibition and NO degradation
10.1006/bbrc.2000.3117 · 2000 · External reference
Photobiomodulation enhancement of cell proliferation at 660 nm does not require cytochrome c oxidase
10.1016/j.jphotobiol.2019.03.015 · 2019 · External reference
Far infrared radiation (FIR): its biological effects and medical applications
10.1515/plm-2012-0034 · 2012 · External reference
Tuning nanoscopic water layers on hydrophobic and hydrophilic surfaces with laser light
10.1021/la7032737 · 2008 · External reference
Water as an active constituent in cell biology
10.1021/cr068037a · 2008 · External reference
Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer’s disease-like mice
10.1186/s12974-022-02521-y · 2022 · External reference
An expanding role for nonvisual opsins in extraocular light sensing physiology
10.1146/annurev-vision-100820-094018 · 2023 · External reference
G protein signaling in the retina and beyond: the Cogan lecture
10.1167/iovs.14-15928 · 2014 · External reference
A photic visual cycle of rhodopsin regeneration is dependent on Rgr
10.1038/90089 · 2001 · External reference
Homologs of vertebrate Opn3 potentially serve as a light sensor in nonphotoreceptive tissue
10.1073/pnas.1219416110 · 2013 · External reference
Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain
10.1523/jneurosci.19-10-03681.1999 · 1999 · External reference
Endogenous opsin 3 (OPN3) protein expression in the adult brain using a novel OPN3-mCherry knock-in mouse model
10.1523/eneuro.0107-20.2020 · 2020 · External reference
Male rat hypothalamic extraretinal photoreceptor Opsin3 is sensitive to osmotic stimuli and light
10.1111/jne.13363 · 2024 · External reference
Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN
10.1038/nature03387 · 2005 · External reference
Melanopsin-encoded response properties of intrinsically photosensitive retinal ganglion cells
10.1016/j.neuron.2016.04.016 · 2016 · External reference
Aberrant light directly impairs mood and learning through melanopsin-expressing neurons
10.1038/nature11673 · 2012 · External reference
Near-infrared light induces neurogenesis and modulates anxiety-like behavior
10.1186/s13287-024-04114-3 · 2024 · External reference
Nongenetic optical modulation of neural stem cell proliferation and neuronal/glial differentiation
10.1016/j.biomaterials.2019.119539 · 2019 · External reference
Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue
10.1016/s0014-5793(03)01212-2 · 2003 · External reference
Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation
10.1074/jbc.m113.514075 · 2014 · External reference
Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea
10.1073/pnas.1516259112 · 2015 · External reference
Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons
10.1038/s41586-020-2683-0 · 2020 · External reference
Direct photoreception by pituitary endocrine cells regulates hormone release and pigmentation
10.1126/science.adj9687 · 2025 · External reference
Sensory TRP channels in three dimensions
10.1146/annurev-biochem-032620-105738 · 2022 · External reference
TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases
10.1038/s41392-023-01464-x · 2023 · External reference
Involvement of substance P in the analgesic effect of low-level laser therapy in a mouse model of chronic widespread muscle pain
10.1093/pm/pnz056 · 2019 · External reference
Photobiomodulation with 630-nm LED radiation inhibits the proliferation of human synoviocyte MH7A cells possibly via TRPV4/PI3K/AKT/mTOR signaling pathway
10.1007/s10103-020-02977-5 · 2020 · External reference
Low-level laser therapy alleviates mechanical and cold allodynia induced by oxaliplatin administration in rats
10.1007/s00520-015-2773-y · 2016 · External reference
Laser modulation of heat and capsaicin receptor TRPV1 leads to thermal antinociception
10.1177/0022034510381394 · 2010 · External reference
TRPV4 channels mediate the infrared laser-evoked response in sensory neurons
10.1152/jn.00424.2011 · 2012 · External reference
Brain oscillations and the importance of waveform shape
10.1016/j.tics.2016.12.008 · 2017 · External reference
α-band oscillations, attention, and controlled access to stored information
10.1016/j.tics.2012.10.007 · 2012 · External reference
New vistas for alpha-frequency band oscillations
10.1016/j.tins.2007.02.001 · 2007 · External reference
Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception
10.1038/s41467-019-08873-z · 2019 · External reference
In sync: gamma oscillations and emotional memory
10.3389/fnbeh.2013.00170 · 2013 · External reference
Development of sensory gamma oscillations and cross-frequency coupling from childhood to early adulthood
10.1093/cercor/bht341 · 2015 · External reference
Driving motor cortex oscillations modulates bradykinesia in Parkinson’s disease
10.1093/brain/awab257 · 2022 · External reference
Gamma oscillations in the basolateral amygdala: localization, microcircuitry, and behavioral correlates
10.1523/jneurosci.3159-20.2021 · 2021 · External reference
Apolipoprotein E4 causes age-dependent disruption of slow gamma oscillations during hippocampal sharp-wave ripples
10.1016/j.neuron.2016.04.009 · 2016 · External reference
Dopamine-dependent scaling of subthalamic gamma bursts with movement velocity in patients with Parkinson's disease
10.7554/elife.31895 · 2018 · External reference
Gamma oscillations as a biomarker for major depression: an emerging topic
10.1038/s41398-018-0239-y · 2018 · External reference
Cognitive tasks propagate the neural entrainment in response to a visual 40 Hz stimulation in humans
10.3389/fnagi.2022.1010765 · 2022 · External reference
40-Hz blue light changes hippocampal activation and functional connectivity underlying recognition memory
10.3389/fnhum.2021.739333 · 2021 · External reference
BrainWAVE: a flexible method for noninvasive stimulation of brain rhythms across species
10.1523/eneuro.0257-22.2022 · 2023 · External reference
Neuroglial advances: new roles for established players
10.1111/jnc.70080 · 2025 · External reference
Microglia emerge as central players in brain disease
10.1038/nm.4397 · 2017 · External reference
Alzheimer disease: an update on pathobiology and treatment strategies
10.1016/j.cell.2019.09.001 · 2019 · External reference
Astrocytes in human central nervous system diseases: a frontier for new therapies
10.1038/s41392-023-01628-9 · 2023 · External reference
Physiology of oligodendroglia
10.1152/physrev.00023.2025 · 2026 · External reference
Gamma entrainment binds higher-order brain regions and offers neuroprotection
10.1016/j.neuron.2019.04.011 · 2019 · External reference
Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer’s disease model mice
10.1038/s41593-023-01270-2 · 2023 · External reference
Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease
10.1038/s41597-021-01054-y · 2021 · External reference
Frequency-specific transcranial photobiomodulation elicits complementary glial mechanisms for neurovascular protection and amyloid clearance in Alzheimer disease
10.34133/cbsystems.0551 · 2026 · External reference
Low-level laser therapy regulates microglial function through Src-mediated signaling pathways: implications for neurodegenerative diseases
10.1186/1742-2094-9-219 · 2012 · External reference
Photobiomodulation inhibits the activation of neurotoxic microglia and astrocytes by inhibiting Lcn2/JAK2-STAT3 crosstalk after spinal cord injury in male rats
10.1186/s12974-021-02312-x · 2021 · External reference
Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1 mouse model of Alzheimer’s disease
10.1186/s13195-025-01714-w · 2025 · External reference
Non-invasive photobiomodulation treatment in an Alzheimer disease-like transgenic rat model
10.7150/thno.70756 · 2022 · External reference
Photobiomodulation reduces gliosis in the basal ganglia of aged mice
10.1016/j.neurobiolaging.2018.02.019 · 2018 · External reference
Promoted CD4+ T cell-derived IFN-γ/IL-10 by photobiomodulation therapy modulates neurogenesis to ameliorate cognitive deficits in APP/PS1 and 3xTg-AD mice
10.1186/s12974-022-02617-5 · 2022 · External reference
Photobiomodulation of human adipose-derived stem cells using 810 nm and 980 nm lasers operates via different mechanisms of action
10.1016/j.bbagen.2016.10.008 · 2016 · External reference
Updates on mouse models of Alzheimer’s disease
10.1186/s13024-024-00712-0 · 2024 · External reference
Activation of PKA/SIRT1 signaling pathway by photobiomodulation therapy reduces Aβ levels in Alzheimer’s disease models
10.1111/acel.13054 · 2020 · External reference
Transcranial laser therapy attenuates amyloid-β peptide neuropathology in amyloid-β protein precursor transgenic mice
10.3233/jad-2010-100894 · 2011 · External reference
Near-infrared light therapy normalizes amyloid load, neuronal lipid membrane order, rafts and cholesterol level in Alzheimer's disease
10.1016/j.jphotobiol.2024.113086 · 2025 · External reference
Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β-amyloid load in Alzheimer’s disease model
10.1111/acel.13573 · 2022 · External reference
Photobiomodulation using a low-level light-emitting diode improves cognitive dysfunction in the 5XFAD mouse model of Alzheimer’s disease
2020 · External reference
Near infrared light treatment reduces synaptic levels of toxic tau oligomers in two transgenic mouse models of human tauopathies
10.1007/s12035-018-1248-9 · 2019 · External reference
New insight into Alzheimer’s disease: light reverses Aβ-obstructed interstitial fluid flow and ameliorates memory decline in APP/PS1 mice
10.1016/j.trci.2019.09.007 · 2019 · External reference
Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models
10.1186/alzrt232 · 2014 · External reference
The transcranial light therapy improves synaptic plasticity in the Alzheimer’s disease mouse model
10.3390/brainsci12101272 · 2022 · External reference
Photoactivation of TGFβ/SMAD signaling pathway ameliorates adult hippocampal neurogenesis in Alzheimer’s disease model
10.1186/s13287-021-02399-2 · 2021 · External reference
Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer's disease-associated pathology and cognition in mice
10.1038/s41467-024-45656-7 · 2024 · External reference
Neuroprotection of midbrain dopaminergic cells in MPTP-treated mice after near-infrared light treatment
10.1002/cne.22207 · 2010 · External reference
Near-infrared light is neuroprotective in a monkey model of Parkinson disease
10.1002/ana.24542 · 2016 · External reference
Effects of a higher dose of near-infrared light on clinical signs and neuroprotection in a monkey model of Parkinson’s disease
10.1016/j.brainres.2016.07.005 · 2016 · External reference
Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model
10.1371/journal.pone.0078562 · 2013 · External reference
The impact of near-infrared light on dopaminergic cell survival in a transgenic mouse model of parkinsonism
10.1016/j.brainres.2013.08.047 · 2013 · External reference
Low-level light emitting diode therapy promotes long-term functional recovery after experimental stroke in mice
10.1002/jbio.201700038 · 2017 · External reference
Study of transcranial therapy 904 nm in experimental model of stroke
10.1007/s10103-019-02758-9 · 2019 · External reference
Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells
10.1016/j.expneurol.2017.10.013 · 2018 · External reference
Transcranial near infrared laser treatment (NILT) increases cortical adenosine-5′-triphosphate (ATP) content following embolic strokes in rabbits
10.1016/j.brainres.2009.10.022 · 2010 · External reference
Near-infrared II photobiomodulation preconditioning ameliorates stroke injury via phosphorylation of eNOS
10.1161/strokeaha.123.045358 · 2024 · External reference
Non-invasive treatment with near-infrared light: a novel mechanisms-based strategy that evokes sustained reduction in brain injury after stroke
10.1177/0271678x19845149 · 2020 · External reference
Pre-conditioning with transcranial low-level light therapy reduces neuroinflammation and protects blood-brain barrier after focal cerebral ischemia in mice
10.3233/rnn-150559 · 2016 · External reference
Low-level light emitting diode (LED) therapy suppresses inflammasome-mediated brain damage in experimental ischemic stroke
10.1002/jbio.201600244 · 2017 · External reference
Benefits of a skull-interfaced flexible and implantable multilight emitting diode array for photobiomodulation in ischemic stroke
10.1002/advs.202104629 · 2022 · External reference
Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits
10.1161/01.str.0000242775.14642.b8 · 2006 · External reference
low-level laser therapy applied transcranially to mice following traumatic brain injury significantly reduces long-term neurological deficits
10.1089/neu.2006.0198 · 2007 · External reference
Low-level laser therapy for closed-head traumatic brain injury in mice: effect of different wavelengths
10.1002/lsm.22003 · 2012 · External reference
Transcranial low-level laser therapy enhances learning, memory, and neuroprogenitor cells after traumatic brain injury in mice
10.1117/1.jbo.19.10.108003 · 2014 · External reference
Preventive effects of transcranial photobiomodulation on epileptogenesis in a kainic acid-induced rat epilepsy model
10.1016/j.expneurol.2024.115005 · 2025 · External reference
Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3
10.1186/s13578-022-00949-6 · 2023 · External reference
Low-level laser irradiation improves depression-like behaviors in mice
10.1007/s12035-016-9983-2 · 2017 · External reference
Transcranial photobiomodulation prevents PTSD-like comorbidities in rats experiencing underwater trauma
10.1038/s41398-021-01389-5 · 2021 · External reference
Photobiomodulation attenuates oligodendrocyte dysfunction and prevents adverse neurological consequences in a rat model of early life adversity
10.7150/thno.78777 · 2023 · External reference
Photobiomodulation attenuated cognitive dysfunction and neuroinflammation in a prenatal valproic acid-induced autism spectrum disorder mouse model
10.3390/ijms232416099 · 2022 · External reference
Glymphatic failure as a final common pathway to dementia
10.1126/science.abb8739 · 2020 · External reference
Clearance of amyloid beta and tau in Alzheimer’s disease: from mechanisms to therapy
10.1007/s12640-018-9895-1 · 2018 · External reference
Metabolic regulation of brain Abeta by neprilysin
10.1126/science.1059946 · 2001 · External reference
Characterization of insulin degrading enzyme and other amyloid-β degrading proteases in human serum: a role in Alzheimer's disease?
10.3233/jad-2011-111472 · 2012 · External reference
Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease
10.1016/j.neurobiolaging.2006.05.001 · 2007 · External reference
Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia
10.1016/j.neurobiolaging.2009.07.013 · 2011 · External reference
PEGylated-liposomal astaxanthin ameliorates Aβ neurotoxicity and Alzheimer-related phenotypes by scavenging formaldehyde
10.1016/j.jconrel.2024.01.019 · 2024 · External reference
Potential implications of endogenous aldehydes in beta-amyloid misfolding, oligomerization and fibrillogenesis
10.1111/j.1471-4159.2006.04181.x · 2006 · External reference
Formaldehyde-crosslinked nontoxic Aβ monomers to form toxic Aβ dimers and aggregates: pathogenicity and therapeutic perspectives
10.1002/cmdc.202100428 · 2021 · External reference
Hippocampal hyperperfusion in Alzheimer’s disease
10.1016/j.neuroimage.2008.06.006 · 2008 · External reference
Cerebral perfusion insufficiency and relationships with cognitive deficits in Alzheimer’s disease: a multiparametric neuroimaging study
10.1038/s41598-018-19387-x · 2018 · External reference
The glymphatic system: a beginner’s guide
10.1007/s11064-015-1581-6 · 2015 · External reference
Targeted increase in cerebral blood flow by transcranial near-infrared laser irradiation
10.1002/lsm.20938 · 2010 · External reference
Cell biology: power games
10.1038/443901a · 2006 · External reference
Photostimulation of brain lymphatics in male newborn and adult rodents for therapy of intraventricular hemorrhage
10.1038/s41467-023-41710-y · 2023 · External reference
Tau in physiology and pathology
10.1038/nrn.2015.1 · 2016 · External reference
Photobiomodulation by low-power laser irradiation attenuates Aβ-induced cell apoptosis through the Akt/GSK3β/β-catenin pathway
10.1016/j.freeradbiomed.2012.08.003 · 2012 · External reference
Astroglial atrophy in Alzheimer’s disease
10.1007/s00424-019-02310-2 · 2019 · External reference
Microglia in neurodegenerative diseases
10.1007/978-3-031-55529-9_27 · 2024 · External reference
Neuroglia in neurodegeneration: Alzheimer, Parkinson, and Huntington disease
10.1016/b978-0-443-19102-2.00012-0 · 2025 · External reference
Neuroinflammation in Alzheimer’s disease: current evidence and future directions
10.1016/j.jalz.2016.02.010 · 2016 · External reference
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
10.1038/ni.1836 · 2010 · External reference
Scavenger Receptor-A deficiency impairs immune response of microglia and astrocytes potentiating Alzheimer’s disease pathophysiology
10.1016/j.bbi.2017.12.007 · 2018 · External reference
Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration
10.1074/jbc.m117.784983 · 2017 · External reference
TREM2 lipid sensing sustains the microglial response in an Alzheimer’s disease model
10.1016/j.cell.2015.01.049 · 2015 · External reference
Repurposing ibudilast to mitigate Alzheimer’s disease by targeting inflammation
10.1093/brain/awac136 · 2023 · External reference
Astrocyte-microglia cross talk through complement activation modulates amyloid pathology in mouse models of Alzheimer’s disease
10.1523/jneurosci.2117-15.2016 · 2016 · External reference
Low-level laser therapy for beta amyloid toxicity in rat hippocampus
10.1016/j.neurobiolaging.2016.10.003 · 2017 · External reference
808 nm wavelength light induces a dose-dependent alteration in microglial polarization and resultant microglial induced neurite growth
10.1002/lsm.22133 · 2013 · External reference
Astrocyte-immune cell interactions in physiology and pathology
10.1016/j.immuni.2021.01.013 · 2021 · External reference
Low energy laser light (632.8 nm) suppresses amyloid-β peptide-induced oxidative and inflammatory responses in astrocytes
10.1016/j.neuroscience.2010.09.025 · 2010 · External reference
Photobiomodulation regulates astrocyte activity and ameliorates scopolamine-induced cognitive behavioral decline
10.3389/fncel.2024.1448005 · 2024 · External reference
Astrocytes modulate neuronal development by S100A6 signaling
10.1038/s41467-025-64405-y · 2023 · External reference
Synaptic plasticity: multiple forms, functions, and mechanisms
10.1038/sj.npp.1301559 · 2008 · External reference
Near-infrared laser diode mitigates Aβ1-42-induced neurodegeneration in cortical neurons
10.1016/j.jphotobiol.2024.113021 · 2024 · External reference
C5aR1 signaling promotes region- and age-dependent synaptic pruning in models of Alzheimer’s disease
10.1002/alz.13682 · 2024 · External reference
A functional aged human iPSC-cortical neuron model recapitulates Alzheimer’s disease, senescence, and the response to therapeutics
10.1002/alz.14044 · 2024 · External reference
Modulating adult neurogenesis affects synaptic plasticity and cognitive functions in mouse models of Alzheimer’s disease
10.1016/j.stemcr.2021.11.003 · 2021 · External reference
The reemergence of long-term potentiation in aged Alzheimer’s disease mouse model
10.1038/srep29152 · 2016 · External reference
Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer’s disease
10.1523/jneurosci.0918-13.2013 · 2013 · External reference
Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential
10.1186/s40035-022-00279-0 · 2022 · External reference
Transcranial laser stimulation improves human cerebral oxygenation
10.1002/lsm.22471 · 2016 · External reference
Effects of photobiomodulation on changes in cognitive function and regional cerebral blood flow in patients with mild cognitive impairment: a pilot uncontrolled trial
10.3233/jad-210386 · 2021 · External reference
Home-based transcranial photobiomodulation improves cognitive function in mild cognitive impairment due to Alzheimer’s disease: a randomized, double-blind, placebo-controlled confirmatory trial
10.1177/13872877261443973 · 2026 · External reference
Transcranial photobiomodulation increases intrinsic brain activity within irradiated areas in early Alzheimer’s disease: potential link with cerebral metabolism
10.1016/j.brs.2024.02.012 · 2024 · External reference
Animal models of Parkinson’s disease: bridging the gap between disease hallmarks and research questions
10.1186/s40035-023-00368-8 · 2023 · External reference
Parkinson’s disease: etiopathogenesis and treatment
10.1136/jnnp-2019-322338 · 2020 · External reference
Photoactivation of ERK/CREB/VMAT2 pathway attenuates MPP+-induced neuronal injury in a cellular model of Parkinson’s disease
10.1016/j.cellsig.2017.06.007 · 2017 · External reference
Photobiomodulation-induced changes in a monkey model of Parkinson’s disease: changes in tyrosine hydroxylase cells and GDNF expression in the striatum
10.1007/s00221-017-4937-0 · 2017 · External reference
Mitochondrial quality control in health and in Parkinson’s disease
10.1152/physrev.00041.2021 · 2022 · External reference
A randomized placebo-controlled study of a transcranial photobiomodulation helmet in Parkinson’s disease: post-hoc analysis of motor outcomes
10.3390/jcm12082846 · 2023 · External reference
A novel transcranial photobiomodulation device to address motor signs of Parkinson’s disease: a parallel randomised feasibility study
10.1016/j.eclinm.2023.102338 · 2023 · External reference
Posture stability and functional activity changes after transcranial photobiomodulation for patients with Parkinson’s disease: a randomized controlled trial
10.1007/s10103-025-04628-z · 2025 · External reference
Parkinson’s disease, aerobic exercise and photobiomodulation: a randomised controlled trial
10.1007/s00702-025-03050-7 · 2025 · External reference
Effectiveness of photobiomodulation to treat motor and non-motor symptoms of Parkinson’s disease: a randomised clinical trial with extended treatment
10.3390/jcm14217463 · 2025 · External reference
Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1)
10.1161/strokeaha.106.478230 · 2007 · External reference
Transcranial laser therapy in acute stroke treatment: results of neurothera effectiveness and safety trial 3, a phase III clinical end point device trial
10.1161/strokeaha.114.005795 · 2014 · External reference
The effect of transcranial near-infrared laser therapy on chronic ischemic stroke patients: a randomized, single-blind, sham-controlled Trial
10.37616/2212-5043.1481 · 2026 · External reference
Significant improvement in cognition in mild to moderately severe dementia cases treated with transcranial plus intranasal photobiomodulation: case series report
10.1089/pho.2016.4227 · 2017 · External reference
A randomized, double-blind, and sham-controlled trial of an innovative brain-gut photobiomodulation therapy: safety and patient compliance
10.3233/jad-220467 · 2022 · External reference
Effects of low-level light therapy on resting-state connectivity following moderate traumatic brain injury: secondary analyses of a double-blinded placebo-controlled study
10.1148/radiol.230999 · 2024 · External reference
Bright light therapy for symptoms of anxiety and depression in focal epilepsy: randomised controlled trial
10.1192/bjp.bp.112.122119 · 2013 · External reference
Bright light therapy as an add on treatment for medically intractable epilepsy
10.1016/j.yebeh.2012.04.123 · 2012 · External reference
Long-term near-infrared photobiomodulation for anxious depression complicated by takotsubo cardiomyopathy
10.1097/jcp.0000000000000883 · 2018 · External reference
Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety
10.1186/1744-9081-5-46 · 2009 · External reference
Multi-Watt near-infrared phototherapy for the treatment of comorbid depression: an open-label single-arm study
10.3389/fpsyt.2017.00187 · 2017 · External reference
Very low-level transcranial photobiomodulation for major depressive disorder: the ELATED-3 multicenter, randomized, sham-controlled trial
10.4088/jcp.21m14226 · 2022 · External reference
Wearable, self-administered transcranial photobiomodulation for major depressive disorder and sleep: a randomized, double blind, sham-controlled trial
10.1016/j.jad.2024.12.065 · 2024 · External reference
Effects of low-level laser therapy in autism spectrum disorder
10.1007/5584_2018_234 · 2018 · External reference
Transcranial photobiomodulation in children aged 2-6 years: a randomized sham-controlled clinical trial assessing safety, efficacy, and impact on autism spectrum disorder symptoms and brain electrophysiology
10.3389/fneur.2024.1221193 · 2024 · External reference
Transcranial photobiomodulation in adults with high-functioning autism spectrum disorder: positive findings from a proof-of-concept study
10.1089/photob.2020.4986 · 2022 · External reference
Transcranial photobiomodulation for autism spectrum disorder: prospective open-label case series across age groups
10.1016/j.psycr.2026.100315 · 2026 · External reference
Cellular and molecular pathophysiology of traumatic brain injury: what have we learned so far?
10.3390/biology12081139 · 2023 · External reference
The complexity of secondary cascade consequent to traumatic brain injury: pathobiology and potential treatments
10.2174/1570159x19666210215123914 · 2021 · External reference
The suppression of neural epileptic activity on stimulation with a near-infrared laser
10.1109/lifetech.2019.8884031 · 2019 · External reference
Glutathione depletion, lipid peroxidation and mitochondrial dysfunction are induced by chronic stress in rat brain
10.1016/s0893-133x(00)00208-6 · 2001 · External reference
Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression
10.1016/j.neuint.2008.09.012 · 2008 · External reference
Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness
10.1176/ajp.156.5.675 · 1999 · External reference
Subgenual prefrontal cortex abnormalities in mood disorders
10.1038/386824a0 · 1997 · External reference
Mitochondrial dysfunction in psychiatric disorders
10.1016/j.schres.2022.08.027 · 2024 · External reference
White matter abnormalities and illness severity in major depressive disorder
10.1192/bjp.bp.111.100594 · 2012 · External reference
Chronic stress disrupts the homeostasis and progeny progression of oligodendroglial lineage cells, associating immune oligodendrocytes with prefrontal cortex hypomyelination
10.1038/s41380-022-01512-y · 2022 · External reference
Oligodendrocytes matter: a review of animal studies on early adversity
10.1007/s00702-023-02643-4 · 2023 · External reference
Hippocampal gamma and sharp-wave ripple oscillations are altered in a Cntnap2 mouse model of autism spectrum disorder
10.1016/j.celrep.2021.109970 · 2021 · External reference
Optogenetic gamma stimulation rescues memory impairments in an Alzheimer’s disease mouse model
10.1038/s41467-019-13260-9 · 2019 · External reference
A new treatment protocol using photobiomodulation and muscle/bone/joint recovery techniques having a dramatic effect on a stroke patient's recovery: a new weapon for clinicians
10.1136/bcr.08.2011.4689 · 2012 · External reference
Transcranial laser stimulation: mitochondrial and cerebrovascular effects in younger and older healthy adults
10.1016/j.brs.2021.02.011 · 2021 · External reference
Non-invasive auditory and visual stimulation attenuates α-synuclein deposition and improves motor and non-motor symptoms in PD mice
10.1016/j.expneurol.2023.114396 · 2023 · External reference
Rhythmic light flicker rescues hippocampal low gamma and protects ischemic neurons by enhancing presynaptic plasticity
10.1038/s41467-020-16826-0 · 2020 · External reference
Protocol report on the transcranial photobiomodulation for Alzheimer’s Disease (TRAP-AD) study
10.3390/healthcare11142017 · 2023 · External reference
A pilot study of near-infrared light treatment for Alzheimer’s disease
10.3233/jad-220866 · 2023 · External reference
Transcranial photobiomodulation for the treatment of major depressive disorder. The ELATED-2 pilot trial
10.1089/pho.2018.4490 · 2018 · External reference
Enhanced combined effect of thymoquinone and transcranial photobiomodulation on cerebral ischemia-induced injuries in animal model
10.1007/s11011-026-01849-1 · 2026 · External reference
Dosimetry in cranial photobiomodulation therapy: effect of cranial thickness and bone density
10.1007/s10103-024-04024-z · 2024 · External reference
Chapter 5—Safety and penetration of light into the brain
2019 · External reference
A shape-morphing cortex-adhesive sensor for closed-loop transcranial ultrasound neurostimulation
10.1038/s41928-024-01240-x · 2024 · External reference
Dementia and cognitive impairment reduction after laser transcatheter treatment of Alzheimer’s disease
10.4236/wjns.2015.53021 · 2015 · External reference
