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References from IRAP deficiency preserves renal function and attenuates pathology in aged mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Sex-specific differences in hypertension and associated cardiovascular disease
10.1038/nrneph.2017.189 · 2018 · External reference
Angiotensin II blockade: how its molecular targets may signal to mitochondria and slow aging. Coincidences with calorie restriction and mTOR inhibition
10.1152/ajpheart.00459.2014 · 2015 · External reference
Angiotensin IV protects cardiac reperfusion injury by inhibiting apoptosis and inflammation via AT4R in rats
10.1016/j.peptides.2016.03.017 · 2016 · External reference
Continuous infusion of Angiotensin IV protects against acute myocardial infarction via the inhibition of inflammation and autophagy
10.1155/2021/2860488 · 2021 · External reference
Angiotensin IV AT4-receptor system in the rat kidney
10.1152/ajprenal.1998.274.2.f290 · 1998 · External reference
Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP)
10.1046/j.1471-4159.2003.01852.x · 2003 · External reference
Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides
10.1046/j.1432-1327.2001.02221.x · 2001 · External reference
Is there an interplay between the functional domains of IRAP?
10.3389/fcell.2020.585237 · 2020 · External reference
Distinct distribution of GLUT4 and insulin regulated aminopeptidase in the mouse kidney
10.1016/j.regpep.2010.09.003 · 2011 · External reference
Tissue distribution of CysAP activity and its relationship to blood pressure and water balance
10.1016/j.lfs.2015.04.023 · 2015 · External reference
Divergent profile between hypothalamic and plasmatic aminopeptidase activities in WKY and SHR. Influence of beta-adrenergic blockade
10.1016/j.lfs.2017.11.022 · 2018 · External reference
Angiotensinase and vasopressinase activities in hypothalamus, plasma, and kidney after inhibition of angiotensin-converting enzyme: basis for a new working hypothesis
10.1055/s-0031-1299693 · 2012 · External reference
Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress
10.1152/ajprenal.00318.2022 · 2023 · External reference
Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy
10.1042/cs20201233 · 2020 · External reference
Cellular senescence: the good, the bad and the unknown
10.1038/s41581-022-00601-z · 2022 · External reference
Cellular senescence in renal ageing and disease
10.1038/nrneph.2016.183 · 2017 · External reference
Cellular senescence and the kidney: potential therapeutic targets and tools
10.3389/fphar.2019.00770 · 2019 · External reference
Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
10.1016/j.ebiom.2019.08.069 · 2019 · External reference
Molecular mechanisms of renal aging
10.1016/j.kint.2017.02.036 · 2017 · External reference
Clearance of p16 Ink4a-positive senescent cells delays ageing-associated disorders
10.1038/nature10600 · 2011 · External reference
Senolytics improve physical function and increase lifespan in old age
10.1038/s41591-018-0092-9 · 2018 · External reference
Transplanted senescent cells induce an osteoarthritis-like condition in mice
10.1093/gerona/glw154 · 2017 · External reference
Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
10.1016/j.ebiom.2019.08.069 · 2019 · External reference
Gene knockout of insulin-regulated aminopeptidase: loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory
10.1016/j.nlm.2009.07.011 · 2010 · External reference
Sex differences in the pressor and tubuloglomerular feedback response to angiotensin II
10.1161/hypertensionaha.111.178715 · 2012 · External reference
Improved kinetic model for the transcutaneous measurement of glomerular filtration rate in experimental animals
10.1016/j.kint.2016.07.024 · 2016 · External reference
Uteroplacental insufficiency temporally exacerbates salt-induced hypertension associated with a reduced natriuretic response in male rat offspring
10.1113/jp275655 · 2018 · External reference
Angiotensin receptor blockade in juvenile male rat offspring: Implications for long-term cardio-renal health
10.1016/j.phrs.2018.06.001 · 2018 · External reference
Serelaxin and the AT2 receptor agonist CGP42112 evoked a similar, nonadditive, cardiac antifibrotic effect in high salt-fed mice that were refractory to candesartan cilexetil
10.1021/acsptsci.9b00095 · 2020 · External reference
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
10.1073/pnas.92.20.9363 · 1995 · External reference
Sex-and age-related differences in renal and cardiac injury and senescence in stroke-prone spontaneously hypertensive rats
10.1186/s13293-023-00519-6 · 2023 · External reference
Chronic low alcohol intake during pregnancy programs sex-specific cardiovascular deficits in rats
10.1186/s13293-019-0235-9 · 2019 · External reference
The aging kidney revisited: a systematic review
10.1016/j.arr.2014.02.003 · 2014 · External reference
Structural and functional changes with the aging kidney
10.1053/j.ackd.2015.08.004 · 2016 · External reference
On standardization of controls in lifespan studies
10.18632/aging.205604 · 2024 · External reference
Patterns of early p21 dynamics determine proliferation-senescence cell fate after chemotherapy
10.1016/j.cell.2019.05.041 · 2019 · External reference
Survey of senescent cell markers with age in human tissues
10.18632/aging.102903 · 2020 · External reference
Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney
10.1111/j.1523-1755.2004.00438.x · 2004 · External reference
Increased expression of p16(INK4a) and p27(Kip1) cyclin-dependent kinase inhibitor genes in aging human kidney and chronic allograft nephropathy
10.1016/s0272-6386(03)00363-9 · 2003 · External reference
The multifaceted role of kidney tubule mitochondrial dysfunction in kidney disease development
10.1016/j.tcb.2022.03.012 · 2022 · External reference
Differential effects of respiratory inhibitors on glycolysis in proximal tubules
10.1152/ajprenal.1990.258.6.f1608 · 1990 · External reference
Multiphoton imaging reveals differences in mitochondrial function between nephron segments
10.1681/asn.2008070759 · 2009 · External reference
Mitochondrial pathology and glycolytic shift during proximal tubule atrophy after ischemic AKI
10.1681/asn.2015020177 · 2016 · External reference
Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells
10.1186/s12882-016-0249-z · 2016 · External reference
Proximal tubular oxidative metabolism in acute kidney injury and the transition to CKD
10.34067/kid.0004772020 · 2021 · External reference
Mitochondrial activity contributes to impaired renal metabolic homeostasis and renal pathology in STZ-induced diabetic mice
10.1152/ajprenal.00076.2019 · 2019 · External reference
Cellular senescence and wound healing in aged and diabetic skin
10.3389/fphys.2024.1344116 · 2024 · External reference
Multi-omic analysis reveals genetic determinants and therapeutic targets of chronic kidney disease and kidney function
10.3390/ijms25116033 · 2024 · External reference
Urinary aminopeptidase activities as early and predictive biomarkers of renal dysfunction in cisplatin-treated rats
10.1371/journal.pone.0040402 · 2012 · External reference
Kidney aminopeptidase activities are related to renal damage in experimental breast cancer
10.15761/jcmm.1000105 · 2018 · External reference
Ablation of Angiotensin IV receptor attenuates hypofibrinolysis via PAI-1 downregulation and reduces occlusive arterial thrombosis
10.1161/atvbaha.109.195057 · 2009 · External reference
The multifaceted role of quercetin derived from its mitochondrial mechanism
10.1007/s11010-023-04833-w · 2024 · External reference
Protective effects of quercetin on mitochondrial biogenesis in experimental traumatic brain injury via the Nrf2 signaling pathway
10.1371/journal.pone.0164237 · 2016 · External reference
Chemical screen identifies a geroprotective role of quercetin in premature aging
10.1007/s13238-018-0567-y · 2019 · External reference
Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells
10.1093/mutage/ger021 · 2011 · External reference
Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase
10.1096/fj.08-112227 · 2008 · External reference