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References from Age-related alterations in the brain ACE2/Ang-(1–7)/Mas receptor axis in normotensive and spontaneously hypertensive rats. Local targets link to admitted publications; unresolved targets remain external evidence.
Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
10.1152/physrev.00038.2017 · 2018 · External reference
Renin-angiotensin system as an emerging target to modulate adult neurogenesis in health and disease
10.1186/s13287-025-04430-2 · 2025 · External reference
The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)
10.1152/physrev.00023.2016 · 2018 · External reference
Revisiting renin-angiotensin-aldosterone system in aging: translational insights from bench to bedside and back
10.1172/jci195633 · 2025 · External reference
Physiopathology of the brain renin-angiotensin system
10.3390/life15081333 · 2025 · External reference
Age-associated changes in the vascular renin-angiotensin system in mice
10.1155/2016/6731093 · 2016 · External reference
Role of circulating molecules in age-related cardiovascular and metabolic disorders
10.1186/s41232-021-00187-2 · 2022 · External reference
Role of angiotensin II in aging
10.3389/fnagi.2022.1002138 · 2022 · External reference
An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy
10.1152/physiol.00002.2008 · 2008 · External reference
How is the brain renin-angiotensin system regulated?
10.1161/hypertensionaha.117.08550 · 2017 · External reference
Age-related effects of AT1 receptor antagonist losartan on cognitive decline in spontaneously hypertensive rats
10.3390/ijms25137340 · 2024 · External reference
Dysregulation of the renin-angiotensin system in vascular dementia
10.1111/bpa.13251 · 2024 · External reference
Angiotensin type-1 receptor inhibition reduces NLRP3 inflammasome upregulation induced by aging and neurodegeneration in the substantia nigra of male rodents and primary mesencephalic cultures
10.3390/antiox11020329 · 2022 · External reference
Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging
10.1152/ajpheart.00300.2009 · 2009 · External reference
Angiotensin receptor blockers are associated with a lower risk of progression from mild cognitive impairment to dementia
10.1161/hypertensionaha.122.19378 · 2022 · External reference
Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain
10.1152/ajpheart.00141.2007 · 2007 · External reference
Angiotensin-(1–7) improves cognitive function and reduces inflammation in mice following mild traumatic brain injury
10.3389/fnbeh.2022.903980 · 2022 · External reference
Identification of angiotensin-(1–7) in rat brain: evidence for differential processing of angiotensin peptides
10.1016/s0021-9258(19)84737-3 · 1989 · External reference
Increased hypothalamic angiotensin-(1–7) levels in rats with aortic coarctation-induced hypertension
10.1016/j.peptides.2007.06.016 · 2007 · External reference
Angiotensin-(1–7) enhances LTP in the hippocampus through the G-protein-coupled receptor Mas
10.1016/j.mcn.2005.03.012 · 2005 · External reference
Paracrine and intracrine angiotensin 1–7/Mas receptor Axis in the substantia nigra of rodents, monkeys, and humans
10.1007/s12035-017-0805-y · 2018 · External reference
The non-peptide angiotensin-(1–7) mimic AVE 0991 attenuates delayed neurocognitive recovery after laparotomy by reducing neuroinflammation and restoring blood-brain barrier integrity in aged rats
10.3389/fnagi.2021.624387 · 2021 · External reference
The hippocampus in spontaneously hypertensive rats: an animal model of vascular dementia?
10.1016/s0047-6374(01)00362-1 · 2002 · External reference
Hippocampus under pressure: molecular mechanisms of development of cognitive impairments in SHR rats
10.1134/s0006297924040102 · 2024 · External reference
Spontaneously hypertensive rat as a model of vascular brain disorder: microanatomy, neurochemistry and behavior
10.1016/j.jns.2012.05.047 · 2012 · External reference
Biological variability In Wistar-Kyoto rats. Implications for research with the spontaneously hypertensive rat
10.1161/01.hyp.10.1.127 · 1987 · External reference
Myocardial hypertrophy of normotensive Wistar-Kyoto rats
10.1152/ajpheart.00779.2003 · 2004 · External reference
Plasmatic renin-angiotensin system in normotensive and hypertensive patients hospitalized with COVID-19
10.1016/j.biopha.2022.113201 · 2022 · External reference
Measurement of angiotensin peptides: HPLC-RIA
10.1007/978-1-4939-6625-7_7 · 2017 · External reference
Interaction between the angiotensin-(1–7) Mas receptor and the dopamine D2 receptor: implications in inflammation
10.1161/hypertensionaha.120.16614 · 2021 · External reference
Angiotensin II, blood-brain barrier permeability, and microglia interplay during the transition from pre-to hypertensive phase in spontaneously hypertensive rats
10.3389/fphys.2024.1452959 · 2024 · External reference
Angiotensin-(1–7) in paraventricular nucleus contributes to the enhanced cardiac sympathetic afferent reflex and sympathetic activity in chronic heart failure rats
10.1159/000480214 · 2017 · External reference
Blockade of endogenous angiotensin-(1–7) in hypothalamic paraventricular nucleus attenuates high salt-induced sympathoexcitation and hypertension
10.1007/s12264-018-0297-4 · 2019 · External reference
Cerebroprotection by angiotensin-(1–7) in endothelin-1-induced ischaemic stroke
10.1113/expphysiol.2011.058578 · 2011 · External reference
Activation of the ACE2/Ang-(1–7)/Mas pathway reduces oxygen-glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction
10.1016/j.neuroscience.2014.04.060 · 2014 · External reference
Angiotensin converting enzyme 2/Ang-(1–7)/Mas axis protects brain from ischemic injury with a tendency of age-dependence
10.1111/cns.12233 · 2014 · External reference
Angiotensin-(1–7) protective effects in neurocognitive disorders: molecular mechanisms to therapeutic implications
10.3389/fphys.2025.1565270 · 2025 · External reference
Increased expression of angiotensin peptides in the brain of transgenic hypertensive rats
10.1016/0196-9781(94)90051-5 · 1994 · External reference
Mas receptor is translocated to the nucleus upon agonist stimulation in brainstem neurons from spontaneously hypertensive rats but not normotensive rats
10.1093/cvr/cvz332 · 2020 · External reference
Kidneys from normotensive donors lower blood pressure in young transplanted spontaneously hypertensive rats
10.1152/ajpregu.1997.273.1.r175 · 1997 · External reference
Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats
10.1152/ajprenal.0197.2001 · 2002 · External reference
Angiotensin peptides in spontaneously hypertensive and normotensive donryu rats
10.1161/01.hyp.25.5.928 · 1995 · External reference
Insufficient overexpression of angiotensin-converting enzyme 2 is associated with hypertension in SHR rats
10.18632/oncotarget.15666 · 2017 · External reference
Chronic exercise modulates RAS components and improves balance between pro- and anti-inflammatory cytokines in the brain of SHR
10.1007/s00395-011-0231-7 · 2011 · External reference
Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats
10.1161/01.hyp.0000259942.38108.20 · 2007 · External reference
Angiotensin II-mediated hippocampal hypoperfusion and vascular dysfunction contribute to vascular cognitive impairment in aged hypertensive rats
10.1002/alz.13491 · 2024 · External reference
Angiotensin-(1–7) immunoreactivity in the hypothalamus of the (mRen-2d)27 transgenic rat
10.1016/s0006-8993(98)00384-9 · 1998 · External reference
Memory impairment in spontaneously hypertensive rats is associated with hippocampal hypoperfusion and hippocampal vascular dysfunction
10.1177/0271678x19848510 · 2020 · External reference
Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets
10.1038/nrcardio.2014.59 · 2014 · External reference
Brain renin-angiotensin system: does it exist?
10.1161/hypertensionaha.116.08922 · 2017 · External reference
Definitive evidence for the identification and function of renin-expressing cholinergic neurons in the nucleus ambiguus
10.1161/hypertensionaha.124.23740 · 2025 · External reference
Immunohistochemical localization of the angiotensin-(1–7) receptor Mas in the murine forebrain
10.1007/s00441-012-1354-3 · 2012 · External reference
Activation of central Angiotensin-(1-7)/Mas receptor alleviates synaptic damage in diabetes-associated cognitive impairment via modulating AKT/FOXO1/PACAP axis
10.7150/ijbs.99617 · 2025 · External reference
Cross-talk between CB1, AT1, AT2 and Mas receptors responsible for blood pressure control in the paraventricular nucleus of the hypothalamus in conscious spontaneously hypertensive rats and their normotensive controls
10.3390/cells11091542 · 2022 · External reference
The ageing cortical synapse: hallmarks and implications for cognitive decline
10.1038/nrn3200 · 2012 · External reference
Altered gene expression within the renin-angiotensin system in normal aging and dementia
10.1093/gerona/glad241 · 2024 · External reference
The expression of angiotensin-converting enzyme 2-angiotensin-(1–7)-mas receptor axis are upregulated after acute cerebral ischemic stroke in rats
10.1016/j.npep.2013.09.002 · 2013 · External reference
Dynamic dysregulation of transcriptomic networks in brainstem autonomic nuclei during hypertension development in the female spontaneously hypertensive rat
10.1152/physiolgenomics.00073.2023 · 2024 · External reference
Multi-organ gene expression analysis and network modeling reveal regulatory control cascades during the development of hypertension in female spontaneously hypertensive rat
10.1371/journal.pone.0313252 · 2024 · External reference