Research graph
References from circNfix attenuates acute kidney injury by driving m6A-dependent degradation of YTHDF2 to stabilize DAPK2 mRNA. Local targets link to admitted publications; unresolved targets remain external evidence.
Acute kidney injury
10.1016/s0140-6736(24)02385-7 · 2025 · External reference
Inhibition of CCL4 prevents renal inflammation and fibrosis in acute kidney injury
10.1042/cs20257231 · 2026 · External reference
Acute kidney injury: pathogenesis and therapeutic interventions
10.1186/s43556-025-00293-4 · 2025 · External reference
ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury
10.1038/s41419-019-1483-7 · 2019 · External reference
CircAASS alleviates renal injury and fibrosis by regulating mitochondrial homeostasis in tubular epithelial cells
10.1080/15548627.2025.2581212 · 2026 · External reference
Epigenetic alterations and memory: key players in the development/progression of chronic kidney disease promoted by acute kidney injury and diabetes
10.1016/j.kint.2024.10.031 · 2025 · External reference
Non-coding RNAs regulate autophagy in kidney disease: friend or foe?
10.1080/15548627.2025.2551683 · 2025 · External reference
The therapeutic potential of circular RNAs
10.1038/s41576-024-00806-x · 2025 · External reference
Intranuclear paraspeckle-circular RNA TACC3 assembly forms RNA–DNA hybrids to facilitate MASH-related hepatocellular carcinoma growth in an m6A-dependent manner
10.1002/cac2.70061 · 2025 · External reference
Examining the evidence for mutual modulation between m6A modification and circular RNAs: current knowledge and future prospects
10.1186/s13046-024-03136-2 · 2024 · External reference
YTHDF2: a key RNA reader and antitumor target
10.1016/j.it.2025.04.003 · 2025 · External reference
O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N6-methyladenosine-dependent manner
10.1038/s41392-023-01316-8 · 2023 · External reference
HSP90β impedes STUB1-induced ubiquitination of YTHDF2 to drive sorafenib resistance in hepatocellular carcinoma
10.1002/advs.202302025 · 2023 · External reference
DNA methylation of FTO promotes renal inflammation by enhancing m6A of PPAR-α in alcohol-induced kidney injury
10.1016/j.phrs.2020.105286 · 2021 · External reference
Immunodesign of experimental sepsis by cecal ligation and puncture
10.1038/nprot.2008.214 · 2009 · External reference
Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair
10.1038/s41467-022-34287-5 · 2022 · External reference
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016
10.1097/ccm.0000000000002255 · 2017 · External reference
Summary of the KDIGO guideline on anemia and comment: reading between the (guide)line(s)
10.1038/ki.2012.270 · 2012 · External reference
Temporal proteomic and phosphoproteomic profiling deciphers molecular dynamics of acute-to-chronic kidney disease after ischemia–reperfusion injury, with Dock2 emerging as a key regulator
10.1016/j.mcpro.2026.101509 · 2026 · External reference
Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway
10.1126/scitranslmed.eaat2039 · 2018 · External reference
Neat1 promotes acute kidney injury to chronic kidney disease by facilitating tubular epithelial cells apoptosis via sequestering miR-129-5p
10.1016/j.ymthe.2022.05.019 · 2022 · External reference
Regulatory networks of circRNA- centred ceRNAs in sepsis-induced acute kidney injury
10.1080/15592294.2023.2278960 · 2023 · External reference
Targeting mitochondria-located circRNA SCAR alleviates NASH via reducing mROS output
10.1016/j.cell.2020.08.009 · 2020 · External reference
DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome
10.1038/nature21715 · 2017 · External reference
starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data
10.1093/nar/gkt1248 · 2014 · External reference
Peroxiredoxin 1 aggravates acute kidney injury by promoting inflammation through Mincle/Syk/NF-κB signaling
10.1016/j.kint.2023.04.013 · 2023 · External reference
The impact of the cytoplasmic ubiquitin ligase TNFAIP3 gene variation on transcription factor NF-κB activation in acute kidney injury
10.1016/j.kint.2023.02.030 · 2023 · External reference
The negative feedback loop of NF-κB/miR-376b/NFKBIZ in septic acute kidney injury
10.1172/jci.insight.142272 · 2020 · External reference
circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity
10.1038/s41467-020-20527-z · 2021 · External reference
Exosome-based mitochondrial delivery of circRNA mSCAR alleviates sepsis by orchestrating macrophage activation
10.1002/advs.202205692 · 2023 · External reference
The structure and function of YTHDF epitranscriptomic m6A readers
10.1016/j.tips.2023.03.004 · 2023 · External reference
YTHDF2 inhibition potentiates radiotherapy antitumor efficacy
10.1016/j.ccell.2023.04.019 · 2023 · External reference
SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features
10.1093/nar/gkw104 · 2016 · External reference
Adipose METTL14-elicited N6 -methyladenosine promotes obesity, insulin resistance, and NAFLD through suppressing β adrenergic signaling and lipolysis
10.1002/advs.202301645 · 2023 · External reference
Condensin I and II complexes license full estrogen receptor α-dependent enhancer activation
10.1016/j.molcel.2015.06.002 · 2015 · External reference
METTL3 mediates epithelial–mesenchymal transition by modulating FOXO1 mRNA N6-methyladenosine-dependent YTHDF2 binding: a novel mechanism of radiation-induced lung injury
10.1002/advs.202204784 · 2023 · External reference
YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m6A modification to activate NF-κB and promote the malignant progression of glioma
10.1186/s13045-021-01124-z · 2021 · External reference
Cigarette smoking induces aberrant N6-methyladenosine of DAPK2 to promote non-small cell lung cancer progression by activating NF-κB pathway
10.1016/j.canlet.2021.07.022 · 2021 · External reference
DAPK2 is a novel modulator of TRAIL-induced apoptosis
10.1038/cdd.2014.93 · 2014 · External reference
Discovery and verification of mmu_Circ_26986/hsa_Circ_0072463 as a potential biomarker and intervention target for sepsis-associated acute kidney injury
10.1007/s00018-023-05079-x · 2024 · External reference
Discovery and validation of miR-452 as an effective biomarker for acute kidney injury in sepsis
10.7150/thno.50093 · 2020 · External reference
The biomarker TCONS_00016233 drives septic AKI by targeting the miR-22-3p/AIFM1 signaling axis
10.1016/j.omtn.2019.12.037 · 2020 · External reference
Fatty acid-binding protein 4 is a therapeutic target for septic acute kidney injury by regulating inflammatory response and cell apoptosis
10.1038/s41419-022-04794-w · 2022 · External reference
Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury
10.1172/jci188358 · 2025 · External reference
Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer
10.7554/elife.02734 · 2014 · External reference
Circ_0114427 promotes LPS-induced septic acute kidney injury by modulating miR-495-3p/TRAF6 through the NF-κB pathway
10.1080/08916934.2021.1995861 · 2022 · External reference
The Circ_35953 induced by the NF-κB mediated the septic AKI via targeting miR-7219-5p/HOOK3 and IGFBP7 axis
10.1111/jcmm.17731 · 2023 · External reference
FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke
10.1038/s41467-023-36008-y · 2023 · External reference
N6-methyladenosine hypomethylation of circGPATCH2L regulates DNA damage and apoptosis through TRIM28 in intervertebral disc degeneration
10.1038/s41418-023-01190-5 · 2023 · External reference
Cancer-associated loss-of-function mutations implicate DAPK3 as a tumor-suppressing kinase
10.1158/0008-5472.can-10-3543 · 2011 · External reference
Redox DAPK1 destabilizes Pellino1 to govern inflammation-coupling tubular damage during septic AKI
10.7150/thno.49870 · 2020 · External reference
Transcriptome analysis of renal cortex from mice subjected to cecal ligation and puncture compared to control mice
2023 · External reference
CircRNA profile of renal cortex from mice subjected to cecal ligation and puncture compared to control mice
2023 · External reference
