Research graph
References from Complementary fish models for brain ageing: insights from killifish and zebrafish. Local targets link to admitted publications; unresolved targets remain external evidence.
Hallmarks of aging: an expanding universe
10.1016/j.cell.2022.11.001 · 2023 · External reference
The aging brain
10.1146/annurev.pathmechdis.2.010506.092044 · 2008 · External reference
Ageing as a risk factor for neurodegenerative disease
10.1038/s41582-019-0244-7 · 2019 · External reference
Mechanisms underlying brain aging under normal and pathological conditions
10.1007/s12264-022-00969-9 · 2023 · External reference
What is normal in normal aging? Effects of aging, amyloid and Alzheimer’s disease on the cerebral cortex and the hippocampus
10.1016/j.pneurobio.2014.02.004 · 2014 · External reference
Ageing, neurodegeneration and brain rejuvenation
10.1038/nature20411 · 2016 · External reference
Non-canonical aging model systems and why we need them
10.15252/embj.201796837 · 2017 · External reference
Mouse models of ageing and their relevance to disease
10.1016/j.mad.2016.10.001 · 2016 · External reference
With mouse age comes wisdom: a review and suggestions of relevant mouse models for age-related conditions
10.1016/j.mad.2016.07.005 · 2016 · External reference
Invertebrates as model organisms for research on aging biology
10.1080/07924259.2014.970002 · 2015 · External reference
Is the yeast a relevant model for aging of multicellular organisms? An insight from the total lifespan of Saccharomyces cerevisiae
10.2174/1874609810801030159 · 2008 · External reference
Modeling neuroregeneration and neurorepair in an aging context: the power of a teleost model
10.3389/fcell.2021.619197 · 2021 · External reference
Small laboratory fish as models for aging research
10.1016/j.arr.2007.02.007 · 2007 · External reference
The short-lived African turquoise killifish: an emerging experimental model for ageing
10.1242/dmm.023226 · 2016 · External reference
The short-lived fish Nothobranchius furzeri as a new model system for aging studies
10.1016/j.exger.2006.06.039 · 2007 · External reference
A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate
10.1016/j.cell.2015.01.038 · 2015 · External reference
The African turquoise killifish genome provides insights into evolution and genetic architecture of lifespan
10.1016/j.cell.2015.11.008 · 2015 · External reference
Cognitive aging in zebrafish
10.1371/journal.pone.0000014 · 2006 · External reference
Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates—a mini-review
10.1159/000228892 · 2009 · External reference
The African turquoise killifish (Nothobranchius furzeri): a model of age-related diseases and declining regenerative capability across multiple organs
10.1016/j.mad.2025.112087 · 2025 · External reference
Standardizing zebrafish behavioral paradigms across life stages: an effort towards translational pharmacology
10.3389/fphar.2022.833227 · 2022 · External reference
Zebrafish as an animal model for biomedical research
10.1038/s12276-021-00571-5 · 2021 · External reference
The turquoise killifish (Nothobranchius furzeri) as emerging ageing model: systematic review and comparison with zebrafish, medaka and fugu
10.1016/j.arr.2026.103064 · 2026 · External reference
Zebrafish, medaka and turquoise killifish for understanding human neurodegenerative/neurodevelopmental disorders
10.3390/ijms23031399 · 2022 · External reference
The biology of proteostasis in aging and disease
10.1146/annurev-biochem-060614-033955 · 2015 · External reference
The multifaceted role of nutrient sensing and mTORC1 signaling in physiology and aging
10.3389/fragi.2021.707372 · 2021 · External reference
Targeting the biology of aging with mTOR inhibitors
10.1038/s43587-023-00416-y · 2023 · External reference
Altered translation elongation contributes to key hallmarks of aging in the killifish brain
10.1126/science.adk3079 · 2025 · External reference
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
10.15252/msb.20209596 · 2020 · External reference
Characterization of the heat shock response in mature zebrafish (Danio rerio)
10.1016/s0531-5565(03)00067-6 · 2003 · External reference
Top-down proteomics study of aging and sexual dimorphism of zebrafish brains
10.1002/jms.70009 · 2026 · External reference
A novel transgenic zebrafish line allows for in vivo quantification of autophagic activity in neurons
10.1080/15548627.2019.1580511 · 2019 · External reference
A new zebrafish model to measure neuronal α-synuclein clearance in vivo
10.3390/genes13050868 · 2022 · External reference
Identification of protein aggregates in the aging vertebrate brain with prion-like and phase-separation properties
10.1016/j.celrep.2023.112787 · 2024 · External reference
A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction
10.1093/brain/awx005 · 2017 · External reference
Novel targets for Huntington’s disease in an mTOR-independent autophagy pathway
10.1038/nchembio.79 · 2008 · External reference
Tau accumulation is cleared by the induced expression of VCP via autophagy
10.1007/s00401-024-02804-z · 2024 · External reference
Single-cell sequencing unveils the impact of aging on the progenitor cell diversity in the telencephalon of the female killifish N. furzeri
10.1111/acel.14251 · 2024 · External reference
An automated feeding system for the African killifish reveals the impact of diet on lifespan and allows scalable assessment of associative learning
10.7554/elife.69008 · 2022 · External reference
Dietary and pharmacological interventions that inhibit mammalian target of rapamycin activity alter the brain expression levels of neurogenic and glial markers in an age-and treatment-dependent manner
10.1089/rej.2019.2297 · 2020 · External reference
Caloric restriction reinforces the stem cell pool in the aged brain without affecting overall proliferation status
10.1016/j.gene.2022.147026 · 2023 · External reference
Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retina
10.18632/aging.101966 · 2019 · External reference
Age-dependent regulation of Notch family members in the neuronal stem cell niches of the short-lived killifish Nothobranchius furzeri
10.3389/fcell.2021.640958 · 2021 · External reference
Aging impairs the essential contributions of non-glial progenitors to neurorepair in the dorsal telencephalon of the killifish Nothobranchius furzeri
10.1111/acel.13464 · 2021 · External reference
Adult neurogenesis in the short-lived teleost Nothobranchius furzeri: localization of neurogenic niches, molecular characterization and effects of aging
10.1111/j.1474-9726.2011.00781.x · 2012 · External reference
Conserved and acquired features of adult neurogenesis in the zebrafish telencephalon
10.1016/j.ydbio.2006.03.023 · 2006 · External reference
Neurogenesis in the olfactory bulb of adult zebrafish
10.1016/s0306-4522(01)00215-9 · 2001 · External reference
Increased radial glia quiescence, decreased reactivation upon injury and unaltered neuroblast behavior underlie decreased neurogenesis in the aging zebrafish telencephalon
10.1002/cne.23347 · 2013 · External reference
Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors
10.1242/dev.072587 · 2011 · External reference
The killifish visual system as an in vivo model to study brain aging and rejuvenation
10.1038/s41514-021-00077-4 · 2021 · External reference
The age factor in optic nerve regeneration: intrinsic and extrinsic barriers hinder successful recovery in the short-living killifish
10.1111/acel.13537 · 2022 · External reference
Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate
10.1016/j.cub.2005.12.038 · 2006 · External reference
RNA-seq of the aging brain in the short-lived fish N. furzeri—conserved pathways and novel genes associated with neurogenesis
10.1111/acel.12257 · 2014 · External reference
Age- and α-synuclein-dependent degeneration of dopamine and noradrenaline neurons in the annual killifish Nothobranchius furzeri
10.1016/j.celrep.2019.01.015 · 2019 · External reference
Quantification of noradrenergic-, dopaminergic-, and tectal-neurons during aging in the short-lived killifish Nothobranchius furzeri
10.1111/acel.13689 · 2022 · External reference
Zebrafish as a model organism for neurodegenerative disease
10.3389/fnmol.2022.940484 · 2022 · External reference
Advances of zebrafish in neurodegenerative disease: from models to drug discovery
10.3389/fphar.2021.713963 · 2021 · External reference
Loss of PINK1 function affects development and results in neurodegeneration in zebrafish
10.1523/jneurosci.0979-08.2008 · 2008 · External reference
p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson’s disease
10.1111/j.1471-4159.2006.04291.x · 2007 · External reference
Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death
10.1093/hmg/ddv369 · 2015 · External reference
The zebrafish homologue of Parkinson’s disease ATP13A2 is essential for embryonic survival
10.1016/j.brainresbull.2012.09.017 · 2013 · External reference
Hypokinesia and reduced dopamine levels in zebrafish lacking β- and γ1-synucleins
10.1074/jbc.m111.308312 · 2012 · External reference
A critical review of zebrafish models of Parkinson’s disease
10.3389/fphar.2022.835827 · 2022 · External reference
Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri
10.1534/genetics.109.108670 · 2009 · External reference
Insights into sex chromosome evolution and aging from the genome of a short-lived fish
10.1016/j.cell.2015.10.071 · 2015 · External reference
Gene expression changes in aging Zebrafish (Danio rerio) brains are sexually dimorphic
10.1186/1471-2202-15-29 · 2014 · External reference
Polygenic sex determination system in zebrafish
10.1371/journal.pone.0034397 · 2012 · External reference
Multiple sex-associated regions and a putative sex chromosome in zebrafish revealed by RAD mapping and population genomics
10.1371/journal.pone.0040701 · 2012 · External reference
The African turquoise killifish (Nothobranchius furzeri): biology and research applications
10.1016/b978-0-12-821099-4.00011-0 · 2022 · External reference
The evolution of an annual life cycle in killifish: adaptation to ephemeral aquatic environments through embryonic diapause
10.1111/brv.12194 · 2016 · External reference
The short-lived fish Nothobranchius furzeri as a new model system for aging studies
10.1016/j.exger.2006.06.039 · 2007 · External reference
From the bush to the bench: the annual Nothobranchius fishes as a new model system in biology
10.1111/brv.12183 · 2016 · External reference
The African turquoise killifish: a research organism to study vertebrate aging and diapause
10.1111/acel.12757 · 2018 · External reference
The African turquoise killifish: a model for exploring vertebrate aging and diseases in the fast lane
10.1101/sqb.2015.80.027524 · 2015 · External reference
Mapping of quantitative trait loci controlling lifespan in the short-lived fish Nothobranchius furzeri - a new vertebrate model for age research
10.1111/j.1474-9726.2011.00780.x · 2012 · External reference
Neither caloric nor protein restriction increases the male lifespan of outbred short-lived fish
10.1093/gerona/glaf278 · 2026 · External reference
Amyloid-beta precursor protein contributes to brain aging and learning decline
10.1101/2024.10.11.617841 · 2024 · External reference
A short-lived fish with long-lasting effects: hallmarks of aging in Nothobranchius furzeri
10.3389/fragi.2025.1741819 · 2026 · External reference
Production of clones of homozygous diploid zebra fish (Brachydanio rerio)
10.1038/291293a0 · 1981 · External reference
A genetic screen for mutations affecting embryogenesis in zebrafish
10.1242/dev.123.1.37 · 1996 · External reference
The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio
10.1242/dev.123.1.1 · 1996 · External reference
The technic of handling the zebra fish (Brachydanio rerio) for the production of eggs which are favorable for embryological research and are available at any specified time throughout the year
10.2307/1435845 · 1934 · External reference
The development and the regeneration of the color pattern in Brachydanio rerio
10.1002/jmor.1050520207 · 1931 · External reference
The zebrafish as a gerontology model in nervous system aging, disease, and repair
10.1016/j.arr.2015.10.004 · 2015 · External reference
Functional aging and gradual senescence in zebrafish
10.1196/annals.1297.097 · 2004 · External reference
A call to fins! Zebrafish as a gerontological model
10.1046/j.1474-9728.2002.00012.x · 2002 · External reference
Aging in zebrafish is associated with reduced locomotor activity and strain dependent changes in bottom dwelling and thigmotaxis
10.1371/journal.pone.0300227 · 2024 · External reference
Behaviour of telomere and telomerase during aging and regeneration in zebrafish
10.1371/journal.pone.0016955 · 2011 · External reference
Simple and fast quantification of DNA damage by real-time PCR, and its application to nuclear and mitochondrial DNA from multiple tissues of aging zebrafish
10.1186/s13104-017-2593-x · 2017 · External reference
Zebrafish (Danio rerio) as a model for the study of aging and exercise: physical ability and trainability decrease with age
10.1016/j.exger.2013.11.013 · 2014 · External reference
Age-dependent dysfunction of the cerebrovascular system in the zebrafish telencephalon
10.1016/j.exger.2023.112206 · 2023 · External reference
The proteostasis network and its decline in ageing
10.1038/s41580-019-0101-y · 2019 · External reference
mTOR as a central regulator of lifespan and aging
10.12688/f1000research.17196.1 · 2019 · External reference
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
10.1038/nature08221 · 2009 · External reference
TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast
10.1111/acel.12080 · 2013 · External reference
TOR Signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
10.1016/j.cmet.2012.04.007 · 2012 · External reference
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
10.1016/j.cmet.2009.11.010 · 2010 · External reference
Targeting the translation machinery in cancer
10.1038/nrd4505 · 2015 · External reference
Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
10.7164/antibiotics.28.721 · 1975 · External reference
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
10.1126/science.1715094 · 1991 · External reference
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
10.1038/369756a0 · 1994 · External reference
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
10.1126/science.1115535 · 2005 · External reference
Influence of TOR kinase on lifespan in C. elegans
10.1038/426620a · 2003 · External reference
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
10.1016/j.cub.2004.03.059 · 2004 · External reference
Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration
10.18632/aging.100665 · 2014 · External reference
Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart
10.1111/acel.12203 · 2014 · External reference
mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging
10.1111/acel.13057 · 2020 · External reference
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-β levels in a mouse model of Alzheimer’s disease
10.1371/journal.pone.0009979 · 2010 · External reference
Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits
10.1371/journal.pone.0025416 · 2011 · External reference
Effects of sex, strain, and energy intake on hallmarks of aging in mice
10.1016/j.cmet.2016.05.027 · 2016 · External reference
Sex-specific aging in animals: perspective and future directions
10.1111/acel.13542 · 2022 · External reference
Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish
10.1172/jci.insight.154215 · 2021 · External reference
Therapeutic targeting of vascular malformation in a zebrafish model of hereditary haemorrhagic telangiectasia
10.1242/dmm.049567 · 2023 · External reference
Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish
10.1242/dmm.011494 · 2013 · External reference
Intracellular insulin and impaired autophagy in a zebrafish model and a cell model of type 2 diabetes
10.7150/ijbs.19249 · 2017 · External reference
Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish
10.7554/elife.54935 · 2020 · External reference
Neurogenesis in aging and age-related neurodegenerative diseases
10.1016/j.arr.2022.101636 · 2022 · External reference
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain
10.1098/rstb.2006.2016 · 2008 · External reference
Adult neurogenesis and neuronal regeneration in the brain of teleost fish
10.1016/j.jphysparis.2008.10.007 · 2008 · External reference
Notch activity levels control the balance between quiescence and recruitment of adult neural stem cells
10.1523/jneurosci.6170-09.2010 · 2010 · External reference
Notch receptor expression in neurogenic regions of the adult zebrafish brain
10.1371/journal.pone.0073384 · 2013 · External reference
Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons
10.1016/s0896-6273(00)80778-3 · 1999 · External reference
Immunolocalization of S100-like protein in the brain of an emerging model organism: Nothobranchius furzeri
10.1002/jemt.21075 · 2012 · External reference
Identification and expression of neurotrophin-6 in the brain of Nothobranchius furzeri: one more piece in neurotrophin research
10.3390/jcm8050595 · 2019 · External reference
Neurotrophin-4 in the brain of adult Nothobranchius furzeri
10.1016/j.aanat.2016.02.005 · 2016 · External reference
Nerve growth factor in the adult brain of a teleostean model for aging research: Nothobranchius furzeri
10.1016/j.aanat.2014.02.004 · 2014 · External reference
Brain-derived neurotrophic factor: mRNA expression and protein distribution in the brain of the teleost Nothobranchius furzeri
10.1002/cne.23457 · 2014 · External reference
Neurotrophin Trk receptors in the brain of a teleost fish, Nothobranchius furzeri
10.1002/jemt.21028 · 2012 · External reference
Cholinergic system and NGF receptors: insights from the brain of the short-lived fish Nothobranchius furzeri
10.3390/brainsci10060394 · 2020 · External reference
Brain ageing and neurodegenerative disease: the role of cellular waste management
10.1016/j.bcp.2018.10.030 · 2018 · External reference
The utility of small fishes for the genetic study of human age-related disorders
10.3389/fgene.2022.928597 · 2022 · External reference
Modeling familial and sporadic Parkinson’s disease in small fishes
10.1111/dgd.12904 · 2024 · External reference
Using the zebrafish model for Alzheimer’s disease research
10.3389/fgene.2014.00189 · 2014 · External reference
A zebrafish melanophore model of amyloidβ toxicity
10.1089/zeb.2009.0628 · 2010 · External reference
Considering sex and gender in Alzheimer disease and other dementias
10.31887/dcns.2016.18.4/cepperson · 2016 · External reference
Sex differences in Alzheimer’s disease
10.1016/j.ncl.2023.01.001 · 2023 · External reference
TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency
10.1002/ana.23999 · 2013 · External reference
Impaired dopaminergic neuron development and locomotor function in zebrafish with loss of pink1 function
10.1111/j.1460-9568.2010.07091.x · 2010 · External reference
Dysregulation in the brain protein profile of zebrafish lacking the Parkinson’s disease-related protein DJ-1
10.1007/s12035-019-01667-w · 2019 · External reference
Thinking outside the boxes: analyzing the current landscape of popular behavioral tests for adult zebrafish
10.1038/s41684-026-01694-w · 2026 · External reference
