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References from The Inflammation–Thrombosis Genetic Axis in Abdominal Aortic Aneurysm: A Shared Roadmap to Precision Medicine. Local targets link to admitted publications; unresolved targets remain external evidence.
Pathobiology of aortic aneurysms and dissections: synthesis of recent investigations and evolving insights
10.1016/j.jacadv.2025.101682 · 2025 · External reference
Rupture of huge thoracic aortic aneurysm in a young man: case report and literature review
10.1016/j.jflm.2025.102805 · 2025 · External reference
A rare case of thoracic-abdominal aortic aneurysm in conjunction with bilateral superficial femoral artery occlusion, documented with computed tomography angiography
10.1016/j.radcr.2021.11.036 · 2021 · External reference
Deficiency of cystathionine gamma-lyase promotes aortic elastolysis and medial degeneration in aged mice
10.1016/j.yjmcc.2022.06.011 · 2022 · External reference
Tricaprin can prevent the development of AAA by attenuating aortic degeneration
10.1016/j.biopha.2023.114299 · 2023 · External reference
Single-cell RNA sequencing identifies interferon-inducible monocytes/macrophages as a cellular target for mitigating the progression of abdominal aortic aneurysm and rupture risk
10.1093/cvr/cvae117 · 2024 · External reference
Unraveling novel subsets of lymphocytes involved in sac expansion in the tertiary lymphoid structure within an abdominal aortic aneurysm
10.1161/jaha.124.040279 · 2025 · External reference
GP VI-mediated platelet activation and procoagulant activity aggravate inflammation and aortic wall remodeling in abdominal aortic aneurysm
10.1161/atvbaha.123.320615 · 2024 · External reference
Unraveling epigenetic interplay between inflammation, thrombosis, and immune-related disorders through a network meta-analysis
10.1055/a-2222-9126 · 2024 · External reference
Genetic pathogenesis of abdominal aortic aneurysm and the role of PCSK9 (proprotein convertase subtilisin/kexin type 9)
10.5758/vsi.250043 · 2025 · External reference
Whole aorta imaging shows increased risk for thoracic aortic aneurysms and dilatations in relatives of abdominal aortic aneurysm patients
10.1016/j.jvs.2024.10.067 · 2025 · External reference
Polygenic risk score informed clinical model for improving abdominal aortic aneurysm screening
10.1016/j.avsg.2024.06.036 · 2024 · External reference
Systematic review of genome-wide association studies of abdominal aortic aneurysm
10.1016/j.atherosclerosis.2021.05.001 · 2021 · External reference
Veterans affairs million veteran program†. Genetic architecture of abdominal aortic aneurysm in the million veteran program
10.1161/circulationaha.120.047544 · 2020 · External reference
Identification of novel genetic susceptibility loci for thoracic and abdominal aortic aneurysms via genome-wide association study using the UK biobank cohort
10.1371/journal.pone.0247287 · 2021 · External reference
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target
10.1038/s41588-023-01510-y · 2023 · External reference
Spontaneous coronary artery dissection and a family history of aortic dissection: a genetic association study
10.1161/jaha.124.037921 · 2025 · External reference
Abdominal aortic aneurysm and cardiometabolic traits share strong genetic susceptibility to lipid metabolism and inflammation
10.1038/s41467-024-49921-7 · 2024 · External reference
Proteomics analysis of genetic liability of abdominal aortic aneurysm identifies plasma neogenin and kit ligand: the ARIC study
10.1161/atvbaha.122.317984 · 2023 · External reference
Single-cell transcriptomics reveals dynamic role of smooth muscle cells and enrichment of immune cell subsets in human abdominal aortic aneurysms
10.1097/sla.0000000000005551 · 2022 · External reference
Resveratrol suppresses GATA4/Sortilin pathway to attenuate vascular smooth muscle cell senescence-associated secretory phenotype and vascular aging-related atherosclerosis
10.1016/j.cellsig.2026.112669 · 2026 · External reference
The role of sortilin in cardiovascular calcification: mechanisms and therapeutic potential
10.3389/fcvm.2026.1805742 · 2026 · External reference
Single-cell spatial transcriptomics unravels the cellular landscape of abdominal aortic aneurysm
10.1172/jci.insight.190534 · 2025 · External reference
Tunica-specific transcriptome of abdominal aortic aneurysm and the effect of intraluminal thrombus, smoking, and diameter growth rate
10.1161/atvbaha.120.314264 · 2020 · External reference
The histone methyltransferase SETDB2 modulates tissue inhibitors of metalloproteinase-matrix metalloproteinase activity during abdominal aortic aneurysm development
10.1097/sla.0000000000005963 · 2023 · External reference
Integration of machine learning and bulk sequencing revealed exosome-related gene FOSB was involved in the progression of abdominal aortic aneurysm
10.3389/fcell.2025.1554972 · 2025 · External reference
BAF60a deficiency in vascular smooth muscle cells prevents abdominal aortic aneurysm by reducing inflammation and extracellular matrix degradation
10.1161/atvbaha.120.314955 · 2020 · External reference
Identification of potential proteases for abdominal aortic aneurysm by weighted gene coexpression network analysis
10.1139/gen-2020-0041 · 2020 · External reference
Cathepsin K gene disruption does not affect murine aneurysm formation
10.1016/j.atherosclerosis.2009.09.001 · 2010 · External reference
AAAKB: a manually curated database for tracking and predicting genes of abdominal aortic aneurysm (AAA)
10.1371/journal.pone.0289966 · 2023 · External reference
An update on safe anticoagulation
10.1055/a-1717-7958 · 2022 · External reference
The role of thrombin in haemostasis
10.1097/mbc.0000000000001130 · 2022 · External reference
EPCR in wound healing: mechanisms of action and therapeutic potential
10.3390/cells15060567 · 2026 · External reference
Plasma tissue factor pathway inhibitor levels correlate with disease activity and are associated with altered thrombin generation in pediatric inflammatory bowel disease
10.3390/ph19050738 · 2026 · External reference
Soluble glycoprotein VI predicts abdominal aortic aneurysm growth rate and is a novel therapeutic target
10.1182/blood.2023021655 · 2024 · External reference
The endothelial-independent effect of desmopressin, in vitro, on platelet function
10.1155/ah/9928082 · 2025 · External reference
Platelet extracellular vesicles preserve lymphatic endothelial cell integrity and enhance lymphatic vessel function
10.1038/s42003-024-06675-8 · 2024 · External reference
Yeast carboxymethyl-glucan improves endothelial function and inhibits platelet aggregation in spontaneously hypertensive rats
10.1039/d1fo03492h · 2022 · External reference
Children smoke prevention group*. Impact of heat-not-burn cigarette passive smoking on children’s oxidative stress, endothelial and platelet function
10.1016/j.envpol.2024.123304 · 2024 · External reference
Interplay between inflammation and thrombosis in cardiovascular pathology
10.1038/s41569-021-00552-1 · 2021 · External reference
Thromboinflammatory biomarkers in lymphomas: linking inflammation to thrombosis risk
10.3390/ijms26052058 · 2025 · External reference
Functional and structural consequences of fibrinogen γ-chain variants associated with thrombotic phenotype in congenital fibrinogen disorders
10.1016/j.thromres.2026.109664 · 2026 · External reference
The role and therapeutic potential of NF-kappa-B pathway in severe COVID-19 patients
10.1007/s10787-020-00773-9 · 2021 · External reference
Effect of Rubus extract on TLR4/NF-kappa B signaling pathway in alcoholic liver fibrosis rats
2022 · External reference
SLAMF8 and NINJ2 promote neuroinflammation and oxidative stress through TLR4 NF kappa B pathway in Alzheimer’s disease
10.1038/s41598-025-02097-6 · 2025 · External reference
E3 ubiquitin ligase TRIM7 negatively regulates NF-kappa B signaling pathway by degrading p65 in lung cancer
10.1016/j.cellsig.2020.109543 · 2020 · External reference
YKL-40 promotes chemokine expression following drug-induced liver injury via TF-PAR1 pathway in mice
10.3389/fphar.2023.1205062 · 2023 · External reference
KLF2 is a novel transcriptional regulator of endothelial proinflammatory activation
10.1084/jem.20031132 · 2004 · External reference
Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically KLF2
10.1182/blood-2002-01-0046 · 2002 · External reference
KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endothelium
10.1182/blood-2005-08-3465 · 2006 · External reference
Piezo1 impairs endothelial barrier and drives aortic aneurysm and dissection via STAT3-dependent
10.34133/research.1351 · 2026 · External reference
Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and emerging therapeutic strategies
10.3389/fmolb.2025.1693456 · 2025 · External reference
11,12-EET suppressed LPS induced TF expression and thrombus formation by accelerating mRNA degradation rate via strengthening PI3K-Akt signaling pathway and inhibiting p38-TTP pathway
10.1016/j.prostaglandins.2023.106740 · 2023 · External reference
Open targets genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics
10.1093/nar/gkaa840 · 2021 · External reference
Genetic susceptibility for schizophrenia after adjustment by genetic susceptibility for smoking: implications in identification of risk genes and genetic correlation with related traits
10.1017/s0033291723000326 · 2023 · External reference
Pharmacogenomics: driving personalized medicine
10.1124/pharmrev.122.000810 · 2023 · External reference
Harnessing pharmacogenomics for personalized medicine: tailoring drug therapy to genetic profiles
2024 · External reference
Review of personalized medicine and pharmacogenomics of anti-cancer compounds and natural products
10.3390/genes15040468 · 2024 · External reference
Catalyzing clinical implementation of pharmacogenomics and personalized medicine interventions in Africa
10.2217/pgs-2020-0101 · 2021 · External reference
Differential cellular effects of old and new oral anticoagulants: consequences to the genesis and progression of atherosclerosis
2014 · External reference
Environmental exposures influence multigenerational epigenetic transmission
10.1186/s13148-024-01762-3 · 2024 · External reference
A review of epigenetic contributions to post-traumatic stress disorder
10.31887/dcns.2019.21.4/kressler · 2019 · External reference
Multi-omics integration strategies for animal epigenetic studies - a review
10.5713/ab.21.0042 · 2021 · External reference
Role of reactive oxygen species in regulating epigenetic modifications
10.1016/j.cellsig.2024.111502 · 2025 · External reference