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References from Ruscus aculeatus Extract Inhibits Amyloid Beta Production and Upregulates the Active form of ADAM10 in Human Neural Progenitor Cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Lifetime risk and projected burden of dementia
10.1038/s41591-024-03340-9 · 2025 · External reference
NIA-AA research framework: toward a biological definition of Alzheimer’s disease
10.1016/j.jalz.2018.02.018 · 2018 · External reference
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
10.1172/jci20864 · 2004 · External reference
Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of notch
10.1093/embo-reports/kve180 · 2001 · External reference
Presenilins: members of the gamma-secretase quartets, but part-time soloists too
2008 · External reference
Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
10.1038/nm0103-3 · 2003 · External reference
Visualization of a beta 42(43) and a beta 40 in senile plaques with end-specific a beta monoclonals: evidence that an initially deposited species is a beta 42(43)
10.1016/0896-6273(94)90458-8 · 1994 · External reference
BACE-1 and γ-secretase as therapeutic targets for Alzheimer’s disease
2019 · External reference
BACE failures lower AD expectations, again
10.1038/nrd.2018.94 · 2018 · External reference
Combination of alpinia oxyphylla fructus and schisandra chinensis fructus ameliorates aluminum-induced Alzheimer’s disease via reducing BACE1 expression
10.1016/j.jchemneu.2022.102180 · 2022 · External reference
Effects of gentiana delavayi flower extract on APP processing in APP/PS1 CHO cells
10.1248/bpb.b19-00720 · 2020 · External reference
Phenolic compounds and bioactive properties of Ruscus aculeatus L. (Asparagaceae): the pharmacological potential of an underexploited subshrub
10.3390/molecules26071882 · 2021 · External reference
Chromatographic behaviour of steroidal saponins studied by high-performance liquid chromatography-mass spectrometry
10.1016/j.chroma.2007.03.012 · 2007 · External reference
Shifting the balance: soluble ADAM10 as a potential treatment for Alzheimer’s disease
10.3389/fnagi.2023.1171123 · 2023 · External reference
Increased CSF APPs-α levels in patients with Alzheimer disease treated with acitretin
10.1212/wnl.0000000000001017 · 2014 · External reference
Protective effect of caffeic acid against Alzheimer’s disease pathogenesis via modulating cerebral insulin signaling, β-amyloid accumulation, and synaptic plasticity in hyperinsulinemic rats
10.1021/acs.jafc.9b02078 · 2019 · External reference
Flavonoids as promising multitarget agents in Alzheimer’s disease therapy
10.3390/app13084651 · 2023 · External reference
Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation
10.1038/ncomms1781 · 2012 · External reference
A γ-secretase inhibitor blocks notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish
10.1093/embo-reports/kvf124 · 2002 · External reference
Efficacy and safety of a butcher’s broom preparation (Ruscus aculeatus L. extract) compared to placebo in patients suffering from chronic venous insufficiency
2002 · External reference
Quercetin stimulates the non-amyloidogenic pathway via activation of ADAM10 and ADAM17 gene expression in aluminum chloride-induced Alzheimer’s disease rat model
10.1016/j.lfs.2021.119964 · 2021 · External reference
Friedelin attenuates neuronal dysfunction and memory impairment by inhibition of the activated JNK/NF-κB signalling pathway in scopolamine-induced mice model of neurodegeneration
10.3390/molecules27144513 · 2022 · External reference
RaNA-Seq: interactive RNA-Seq analysis from FASTQ files to functional analysis
10.1093/bioinformatics/btz854 · 2020 · External reference
A web-based integrative transcriptome analysis, RNAseqChef, uncovers the cell/tissue type-dependent action of sulforaphane
10.1016/j.jbc.2023.104810 · 2023 · External reference