Research graph
References from Orosomucoid Enhances Insulin Sensitivity via the C–C Chemokine Receptor Type 5/Protein Kinase B Axis. Local targets link to admitted publications; unresolved targets remain external evidence.
Trends in insulin resistance: insights into mechanisms and therapeutic strategy
10.1038/s41392-022-01073-0 · 2022 · External reference
Pharmacological approaches to the prevention of type 2 diabetes mellitus
10.3389/fendo.2023.1118848 · 2023 · External reference
Effects of SGLT2 inhibitors on kidney and cardiovascular function
10.1146/annurev-physiol-031620-095920 · 2021 · External reference
Mapping the effectiveness and risks of GLP-1 receptor agonists
10.1038/s41591-024-03412-w · 2025 · External reference
Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonists
10.3389/fendo.2024.1431292 · 2024 · External reference
Insulin signal transduction perturbations in insulin resistance
10.3390/ijms22168590 · 2021 · External reference
Insulin resistance: from mechanisms to therapeutic strategies
10.4093/dmj.2021.0280 · 2022 · External reference
Insulin resistance and insulin sensitizing agents
10.1016/j.metabol.2021.154892 · 2021 · External reference
Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis
10.1038/s42255-022-00627-4 · 2022 · External reference
Hepatic SerpinA1 improves energy and glucose metabolism through regulation of preadipocyte proliferation and UCP1 expression
10.1038/s41467-024-53835-9 · 2024 · External reference
The association of acute phase proteins in stress and inflammation-induced T2D
10.3390/cells11142163 · 2022 · External reference
Serum orosomucoid is associated with serum adiponectin, adipose tissue insulin resistance index, and a family history of type 2 diabetes in young normal weight Japanese women
10.1155/2022/7153238 · 2022 · External reference
The role of orosomucoid in glucose and lipid metabolism and metabolic diseases
10.1152/ajpendo.00304.2023 · 2025 · External reference
Intermittent fasting-induced Orm2 promotes adipose browning via the GP130/IL23R-p38 cascade
10.1002/advs.202407789 · 2024 · External reference
Orosomucoid, an acute response protein with multiple modulating activities
10.1007/s13105-015-0389-9 · 2015 · External reference
The acute-phase protein orosomucoid regulates food intake and energy homeostasis
10.2337/db15-1193 · 2016 · External reference
The adipokine orosomucoid alleviates adipose tissue fibrosis via the AMPK pathway
10.1038/s41401-021-00666-9 · 2021 · External reference
Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway
10.1016/j.celrep.2023.112697 · 2023 · External reference
Fatigue-induced orosomucoid 1 Acts on C-C chemokine receptor type 5 to enhance muscle endurance
10.1038/srep18839 · 2016 · External reference
CCL5/RANTES contributes to hypothalamic insulin signaling for systemic insulin responsiveness through CCR5
10.1038/srep37659 · 2016 · External reference
CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status
10.2337/db11-1506 · 2012 · External reference
The aetiology and molecular landscape of insulin resistance
10.1038/s41580-021-00390-6 · 2021 · External reference
The PI3K/AKT pathway in obesity and type 2 diabetes
10.7150/ijbs.27173 · 2018 · External reference
The role of adipose tissue dysfunction in hepatic insulin resistance and T2D
10.1530/joe-24-0115 · 2024 · External reference
VEGFB ameliorates insulin resistance in NAFLD via the PI3K/AKT signal pathway
10.1186/s12967-024-05621-w · 2024 · External reference
PACAP ameliorates obesity-induced insulin resistance through FAIM/Rictor/AKT axis
2024 · External reference
Targeting CCR5: a central approach to HIV treatment and cure strategies
10.1016/j.virol.2024.110375 · 2025 · External reference
Loss of CCR5 results in glucose intolerance in diet-induced obese mice
10.1152/ajpendo.00177.2013 · 2013 · External reference
Orosomucoid serum concentrations and fat depot-specific mRNA and protein expression in humans
10.1007/s10059-012-2181-9 · 2012 · External reference
Acute-phase proteins among patients with type 1 diabetes
10.1016/s1262-3636(07)70051-4 · 2003 · External reference
The CCR5 chemokine receptor mediates vasoconstriction and stimulates intimal hyperplasia in human vessels in vitro
10.1093/cvr/cvt333 · 2013 · External reference
Irisin counteracts high glucose and fatty acid-induced cytotoxicity by preserving the AMPK-insulin receptor signaling axis in C2C12 myoblasts
10.1152/ajpendo.00219.2019 · 2020 · External reference
Stop using the misidentified cell line LO2 as a human hepatocyte
10.1016/j.jhep.2023.10.036 · 2024 · External reference
C2C12 myoblasts are more sensitive to the toxic effects of simvastatin than myotubes and show impaired proliferation and myotube formation
10.1016/j.bcp.2021.114649 · 2021 · External reference
