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References from Val325Met Mutation Affects N-glycosylation and Impairs the Function of Protein C. Local targets link to admitted publications; unresolved targets remain external evidence.
Activated protein C
10.1111/j.1538-7836.2007.02491.x · 2007 · External reference
The nucleotide sequence of the gene for human protein C
10.1073/pnas.82.14.4673 · 1985 · External reference
The function of calcium in protein C activation by thrombin and the thrombin-thrombomodulin complex can be distinguished by mutational analysis of protein C derivatives
10.1016/s0021-9258(18)35723-5 · 1992 · External reference
The 2.8 A crystal structure of Gla-domainless activated protein C
10.1002/j.1460-2075.1996.tb01073.x · 1996 · External reference
Glycosylation of human protein C affects its secretion, processing, functional activities, and activation by thrombin
10.1016/s0021-9258(18)92888-7 · 1991 · External reference
Human plasma protein C: isolation, characterization, and mechanism of activation by alpha-thrombin
10.1172/jci109521 · 1979 · External reference
Structure-function relationships of the thrombin-thrombomodulin interaction
1993 · External reference
The roles of protein C and thrombomodulin in the regulation of blood coagulation
10.1016/s0021-9258(18)83649-3 · 1989 · External reference
Multiple roles of the endothelial cell protein C receptor
10.1111/j.1538-7836.2007.02685.x · 2007 · External reference
Laboratory issues in diagnosing abnormalities of protein C, thrombomodulin, and endothelial cell protein C receptor
10.5858/2002-126-1337-liidao · 2002 · External reference
The cytoprotective protein C pathway
10.1182/blood-2006-09-003004 · 2007 · External reference
Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model
10.1016/s1079-9796(03)00034-2 · 2003 · External reference
Activation of endothelial cell protease activated receptor 1 by the protein C pathway
10.1126/science.1071699 · 2002 · External reference
New players in the sepsis-protective activated protein C pathway
10.1172/jci44266 · 2010 · External reference
Inflammation-associated activation of coagulation and immune regulation by the protein C pathway
10.1016/j.thromres.2014.03.015 · 2014 · External reference
Evaluation of prothrombotic risk of two PROC hotspot mutations (Arg189Trp and Lys193del) in Chinese population: a retrospective study
10.1186/s12959-023-00548-6 · 2023 · External reference
Anticoagulant protein C p.Lys193del mutation and promoter region polymorphisms: genetic risk factors of deep venous thrombosis
10.1016/j.lmd.2025.100046 · 2025 · External reference
Severe congenital protein C deficiency: the use of protein C concentrates (human) as replacement therapy for life-threatening blood-clotting complications
2008 · External reference
Protein C deficiency
10.1111/j.1365-2516.2008.01838.x · 2008 · External reference
Fetal hydrocephalus and neonatal stroke as the first presentation of protein C deficiency
10.1016/j.braindev.2015.07.004 · 2016 · External reference
Clinical guidelines for testing for heritable thrombophilia
10.1111/j.1365-2141.2009.08022.x · 2010 · External reference
Protein C and protein S assessment in hospital laboratories: which strategy and what role for DNA sequencing?
10.1097/00001721-200309000-00003 · 2003 · External reference
Thirty-three novel mutations in the protein C gene. French INSERM network on molecular abnormalities responsible for protein C and protein S
10.1055/s-0037-1613762 · 2000 · External reference
Heterozygous prothrombin mutation-associated thrombophilia
10.1055/a-2350-8338 · 2025 · External reference
Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assays
10.1182/blood-2014-12-617274 · 2015 · External reference
Calibrated automated thrombin generation measurement in clotting plasma
10.1159/000071636 · 2003 · External reference
Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C
10.1016/s0021-9258(20)81925-5 · 1983 · External reference
Phosphatidylethanolamine incorporation into vesicles selectively enhances factor Va inactivation by activated protein C
10.1016/s0021-9258(17)42183-1 · 1994 · External reference
Gly197Arg mutation in protein C causes recurrent thrombosis in a heterozygous carrier
10.1111/jth.14777 · 2020 · External reference
The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells
10.1182/blood-2007-06-096651 · 2007 · External reference
Multifunctional specificity of the protein C/activated protein C Gla domain
10.1074/jbc.m604966200 · 2006 · External reference
Burden, causes, and treatment approaches of recurrent pregnancy loss: a scoping review
2025 · External reference
aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis
10.1073/pnas.2106623118 · 2021 · External reference
Beta protein C is not glycosylated at asparagine 329. The rate of translation may influence the frequency of usage at asparagine-X-cysteine sites
10.1016/s0021-9258(19)38606-5 · 1990 · External reference
Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC). Sodium ion in the APC crystal structure is coordinated to four carbonyl groups from two separate loops
10.1074/jbc.m201892200 · 2002 · External reference
