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References from Beyond the Scalpel: Why FLOT Changed Gastric Cancer—Biological Rationale, Evidence, and Regional Relevance. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2024 · External reference
Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries
10.1016/s0140-6736(17)33326-3 · 2018 · External reference
Epidemiological review of gastric cancer in India
2012 · External reference
D2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer
10.1056/nejmoa0707035 · 2008 · External reference
Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction
10.1056/nejmoa010187 · 2001 · External reference
Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial
10.1016/s0140-6736(11)61873-4 · 2012 · External reference
Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer
10.1056/nejmoa055531 · 2006 · External reference
Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial
10.1200/jco.2010.33.0597 · 2011 · External reference
Perioperative FLOT versus ECF/ECX for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4)
10.1016/s0140-6736(18)32557-1 · 2019 · External reference
Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine
10.1056/nejmoa072252 · 2007 · External reference
Multivariate prognostic factor analysis in locally advanced and metastatic esophago-gastric cancer–pooled analysis from three multicenter, randomized, controlled trials using individual patient data
10.1200/jco.2004.08.154 · 2004 · External reference
Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group
10.1200/jco.2006.06.8429 · 2006 · External reference
Phase II trial of fluorouracil, leucovorin, oxaliplatin and docetaxel in patients with locally advanced gastric cancer
2013 · External reference
Immunogenic cell death in cancer and infectious disease
10.1038/nri.2016.107 · 2017 · External reference
Preoperative chemoradiotherapy for esophageal or junctional cancer
10.1056/nejmoa1112088 · 2012 · External reference
Phase III comparison of preoperative chemotherapy compared with chemoradiotherapy in patients with locally advanced adenocarcinoma of the esophagogastric junction
10.1200/jco.2008.17.0506 · 2009 · External reference
Neo-AEGIS: perioperative chemotherapy versus neoadjuvant chemoradiotherapy in esophageal and junctional adenocarcinoma
2023 · External reference
Perioperative chemotherapy or preoperative chemoradiotherapy in esophageal cancer
10.1056/nejmoa2409408 · 2025 · External reference
Preoperative chemoradiotherapy for resectable gastric cancer
10.1056/nejmoa2405195 · 2024 · External reference
The two histological main types of gastric carcinoma
10.1111/apm.1965.64.1.31 · 1965 · External reference
Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes
10.1038/nm.3850 · 2015 · External reference
Comprehensive molecular characterization of gastric adenocarcinoma
10.1038/nature13480 · 2014 · External reference
Signet ring cell histology is associated with poor response to neoadjuvant therapy in gastric cancer
2014 · External reference
Mismatch repair deficiency, microsatellite instability and survival in gastric cancer
2017 · External reference
Comparison of gastric cancer survival following R0 resection in the United States and Korea
2015 · External reference
PRODIGY: neoadjuvant docetaxel, oxaliplatin, and S-1 plus surgery and adjuvant S-1 in resectable advanced gastric cancer
10.1200/jco.20.02914 · 2021 · External reference
Perioperative chemotherapy with S-1 and oxaliplatin in locally advanced gastric cancer: RESOLVE trial
2019 · External reference
Neoadjuvant chemotherapy for type 4 and large type 3 gastric cancer (JCOG0501)
2020 · External reference
Results of the observational prospective RealFLOT study
10.1186/s12885-021-08768-7 · 2021 · External reference
Real-world outcomes of FLOT in gastric and gastroesophageal junction cancer
2020 · External reference
An analysis of tolerance and early survival outcomes with perioperative modified FLOT in gastric cancers
10.1055/s-0041-1733349 · 2022 · External reference
Perioperative modified FLOT versus EOX in locally advanced resectable gastric and gastro-oesophageal junction adenocarcinoma: results of a matched-pair analysis
10.1007/s12029-022-00867-3 · 2023 · External reference
Perioperative chemotherapy with FLOT versus EOX/ECF in resectable gastric or gastroesophageal junction adenocarcinoma: safety and response data from India
2019 · External reference
Epirubicin, oxaliplatin, and capecitabine is just as 'MAGIC'al as epirubicin, cisplatin, and fluorouracil perioperative chemotherapy in locally advanced gastric cancer
10.4103/0973-1482.146122 · 2014 · External reference
Immunological aspects of cancer chemotherapy
2013 · External reference
Neoadjuvant and adjuvant pembrolizumab plus chemotherapy in locally advanced gastric or gastro-oesophageal cancer (KEYNOTE-585): an interim analysis of the multicentre, double-blind, randomised phase 3 study
10.1016/s1470-2045(23)00541-7 · 2024 · External reference
Perioperative durvalumab in gastric and gastroesophageal junction cancer
10.1056/nejmoa2503701 · 2025 · External reference
DANTE: atezolizumab with perioperative FLOT in resectable gastric and gastroesophageal junction cancer
2022 · External reference
ATTRACTION-5: adjuvant nivolumab plus chemotherapy after D2 gastrectomy
2023 · External reference
Adjuvant immunotherapy in patients with resected gastric and oesophagogastric junction cancer following preoperative chemotherapy with high risk for recurrence (ypN+ and/or R1): European Organisation for Research and Treatment of Cancer (EORTC) 1707 VESTIGE study
10.1016/j.annonc.2024.10.829 · 2025 · External reference
Minimal residual disease detection using a plasma-only circulating tumor DNA assay in gastrointestinal cancers
2021 · External reference
White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer
10.1038/s41467-020-14310-3 · 2020 · External reference
Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer
2016 · External reference
Epidemiology of gastric cancer: global trends, risk factors and prevention
2019 · External reference
Real-world long-term outcomes with perioperative EOX in D2 gastrectomy: a meaningful look while we switch to FLOT-4
10.1007/s12029-020-00358-3 · 2020 · External reference
Perioperative FLOT vs EOX regimen and non-metastatic gastric carcinoma survival outcomes: real-world data from a tertiary cancer centre, India
2025 · External reference