Research graph
References from RNA-guided transposases: the successors to CRISPR. Local targets link to admitted publications; unresolved targets remain external evidence.
Patient-specific in vivo gene editing to treat a rare genetic disease.
10.1056/nejmoa2504747 · 2025 · External reference
CRISPR-Cas9 gene editing for sickle cell disease and β-thalassemia.
10.1056/nejmoa2031054 · 2021 · External reference
Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements.
10.1038/nbt.4192 · 2018 · External reference
Therapeutic in vivo genome editing: innovations and challenges in rAAV vector-based CRISPR delivery.
10.1038/s41434-025-00573-2 · 2026 · External reference
Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease.
10.1038/s41586-021-04058-1 · 2021 · External reference
Bridge RNAs direct programmable recombination of target and donor DNA.
10.1038/s41586-024-07552-4 · 2024 · External reference
Structures of the holo CRISPR RNA-guided transposon integration complex.
10.1038/s41586-022-05573-5 · 2023 · External reference
Recruitment of CRISPR-Cas systems by Tn7-like transposons.
10.1073/pnas.1709035114 · 2017 · External reference
RNA-guided DNA insertion with CRISPR-associated transposases.
10.1126/science.aax9181 · 2019 · External reference
Transposon-encoded CRISPR-Cas systems direct RNA-guided DNA integration.
10.1038/s41586-019-1323-z · 2019 · External reference
Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon.
10.1038/s41467-022-33504-5 · 2022 · External reference
Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases.
10.1038/s41587-023-01748-1 · 2024 · External reference
CRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering.
10.1038/s41587-020-00745-y · 2021 · External reference
Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase.
10.1126/science.adt5199 · 2025 · External reference
Bacterial insertion sequences: their genomic impact and diversity.
10.1111/1574-6976.12067 · 2014 · External reference
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
10.1126/science.1225829 · 2012 · External reference
The widespread IS200/IS605 transposon family encodes diverse programmable RNA-guided endonucleases.
10.1126/science.abj6856 · 2021 · External reference
Evolutionary mining and functional characterization of TnpB nucleases identify efficient miniature genome editors.
10.1038/s41587-023-01857-x · 2024 · External reference
Structural mechanism of bridge RNA-guided recombination.
10.1038/s41586-024-07570-2 · 2024 · External reference
A programmable seekRNA guides target selection by IS1111 and IS110 type insertion sequences.
10.1038/s41467-024-49474-9 · 2024 · External reference
Structural mechanism governing the directionality of bridge recombination.
10.1038/s41586-026-10903-y · 2026 · External reference
Programmable genome editing in human cells using RNA-guided bridge recombinases.
10.1126/science.adz1884 · 2026 · External reference
Megabase-scale human genome rearrangement with programmable bridge recombinases.
10.1126/science.adz0276 · 2026 · External reference
TIGR-Tas: a family of modular RNA-guided DNA-targeting systems in prokaryotes and their viruses.
10.1126/science.adv9789 · 2025 · External reference
TIGRa: an ultra-compact programmable activator enabling multiplexed and efficient gene regulation.
10.1016/j.stem.2026.07.008 · 2026 · External reference
Development of an adeno-associated virus vector for gene replacement therapy of NF1-related tumors.
10.1038/s41467-025-63619-4 · 2025 · External reference
A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modelling.
10.1038/s41551-025-01538-x · 2025 · External reference
Genome engineering for crop improvement and future agriculture.
10.1016/j.cell.2021.01.005 · 2021 · External reference
The promise and challenge of therapeutic genome editing.
10.1038/s41586-020-1978-5 · 2020 · External reference
Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire.
10.1038/s41576-019-0172-9 · 2020 · External reference
Genome engineering for crop improvement and future agriculture.
10.1016/j.cell.2021.01.005 · ExternalCitation · doi-reference
TIGRa: an ultra-compact programmable activator enabling multiplexed and efficient gene regulation.
10.1016/j.stem.2026.07.008 · ExternalCitation · doi-reference
Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements.
10.1038/nbt.4192 · ExternalCitation · doi-reference
Therapeutic in vivo genome editing: innovations and challenges in rAAV vector-based CRISPR delivery.
10.1038/s41434-025-00573-2 · ExternalCitation · doi-reference
Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon.
10.1038/s41467-022-33504-5 · ExternalCitation · doi-reference
A programmable seekRNA guides target selection by IS1111 and IS110 type insertion sequences.
10.1038/s41467-024-49474-9 · ExternalCitation · doi-reference
Development of an adeno-associated virus vector for gene replacement therapy of NF1-related tumors.
10.1038/s41467-025-63619-4 · ExternalCitation · doi-reference
A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modelling.
10.1038/s41551-025-01538-x · ExternalCitation · doi-reference
Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire.
10.1038/s41576-019-0172-9 · ExternalCitation · doi-reference
Transposon-encoded CRISPR-Cas systems direct RNA-guided DNA integration.
10.1038/s41586-019-1323-z · ExternalCitation · doi-reference
The promise and challenge of therapeutic genome editing.
10.1038/s41586-020-1978-5 · ExternalCitation · doi-reference
Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease.
10.1038/s41586-021-04058-1 · ExternalCitation · doi-reference
Structures of the holo CRISPR RNA-guided transposon integration complex.
10.1038/s41586-022-05573-5 · ExternalCitation · doi-reference
Bridge RNAs direct programmable recombination of target and donor DNA.
10.1038/s41586-024-07552-4 · ExternalCitation · doi-reference
Structural mechanism of bridge RNA-guided recombination.
10.1038/s41586-024-07570-2 · ExternalCitation · doi-reference
Structural mechanism governing the directionality of bridge recombination.
10.1038/s41586-026-10903-y · ExternalCitation · doi-reference
CRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering.
10.1038/s41587-020-00745-y · ExternalCitation · doi-reference
Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases.
10.1038/s41587-023-01748-1 · ExternalCitation · doi-reference
Evolutionary mining and functional characterization of TnpB nucleases identify efficient miniature genome editors.
10.1038/s41587-023-01857-x · ExternalCitation · doi-reference
CRISPR-Cas9 gene editing for sickle cell disease and β-thalassemia.
10.1056/nejmoa2031054 · ExternalCitation · doi-reference
Patient-specific in vivo gene editing to treat a rare genetic disease.
10.1056/nejmoa2504747 · ExternalCitation · doi-reference
Recruitment of CRISPR-Cas systems by Tn7-like transposons.
10.1073/pnas.1709035114 · ExternalCitation · doi-reference
Bacterial insertion sequences: their genomic impact and diversity.
10.1111/1574-6976.12067 · ExternalCitation · doi-reference
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
10.1126/science.1225829 · ExternalCitation · doi-reference
RNA-guided DNA insertion with CRISPR-associated transposases.
10.1126/science.aax9181 · ExternalCitation · doi-reference
The widespread IS200/IS605 transposon family encodes diverse programmable RNA-guided endonucleases.
10.1126/science.abj6856 · ExternalCitation · doi-reference
Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase.
10.1126/science.adt5199 · ExternalCitation · doi-reference
TIGR-Tas: a family of modular RNA-guided DNA-targeting systems in prokaryotes and their viruses.
10.1126/science.adv9789 · ExternalCitation · doi-reference
Megabase-scale human genome rearrangement with programmable bridge recombinases.
10.1126/science.adz0276 · ExternalCitation · doi-reference
Programmable genome editing in human cells using RNA-guided bridge recombinases.
10.1126/science.adz1884 · ExternalCitation · doi-reference
