Research graph
References from Possible role of bacterial infection in embryo implantation failure. Local targets link to admitted publications; unresolved targets remain external evidence.
The role of the immune system in the development of endometriosis.
10.3390/cells11132028 · 2022 · External reference
Endometrial receptivity markers, the journey to successful embryo implantation.
10.1093/humupd/dml004 · 2006 · External reference
The interplay between reproductive tract microbiota and immunological system in human reproduction.
10.3389/fimmu.2020.00378 · 2020 · External reference
Homeobox genes in endometrium: From development to decidualization.
10.1387/ijdb.190120dm · 2020 · External reference
Inflammation—nature’s way to efficiently respond to all types of challenges: implications for understanding and managing “the epidemic” of chronic diseases.
10.3389/fmed.2018.00316 · 2018 · External reference
Microbial pathogens linked to vaginal microbiome dysbiosis and therapeutic tools for their treatment.
10.3390/amh70020019 · 2025 · External reference
Bacterial and host determinants of group B streptococcal vaginal colonization and ascending infection in pregnancy.
10.3389/fcimb.2021.720789 · 2021 · External reference
Innate immune pattern recognition: A cell biological perspective.
10.1146/annurev-immunol-032414-112240 · 2015 · External reference
Chronic endometritis and altered embryo implantation: a unified pathophysiological theory from a literature systematic review.
10.1007/s10815-020-01955-8 · 2020 · External reference
Mycoplasma genitalium can modulate the local immune response in patients with endometriosis.
10.1016/j.fertnstert.2017.11.009 · 2018 · External reference
Persistent breeding-induced endometritis in mares—a multifaceted challenge: from clinical aspects to immunopathogenesis and pathobiology.
10.3390/ijms21041432 · 2020 · External reference
The effect of the female genital tract and gut microbiome on reproductive dysfunction.
10.5582/bst.2023.01133 · 2023 · External reference
Endometriosis, a disease of the macrophage.
10.3389/fimmu.2013.00009 · 2013 · External reference
Mechanisms linking bacterial infections of the bovine endometrium to disease and infertility.
10.1016/j.repbio.2015.12.002 · 2016 · External reference
Global epidemiology of Neisseria gonorrhoeae in infertile populations: systematic review, meta-analysis and metaregression.
10.1136/sextrans-2020-054515 · 2021 · External reference
Association between chronic endometritis and uterine natural killer cell density in women with recurrent miscarriage: clinical implications.
10.1111/jog.14250 · 2020 · External reference
Interaction between chronic endometritis caused endometrial microbiota disorder and endometrial immune environment change in recurrent implantation failure.
10.3389/fimmu.2021.748447 · 2021 · External reference
Chronic endometritis due to common bacteria is prevalent in women with recurrent miscarriage as confirmed by improved pregnancy outcome after antibiotic treatment.
10.1177/1933719113508817 · 2014 · External reference
Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF success rate after antibiotic therapy.
10.1093/humrep/deu292 · 2015 · External reference
Altered gene expression encoding cytokines, growth factors and cell cycle regulators in the endometrium of women with chronic endometritis.
10.3390/diagnostics11030471 · 2021 · External reference
Endometrial cytokines in women with reproductive disorders.
10.21103/article11(4)_oa20 · 2021 · External reference
Inflammation and implantation.
10.1111/j.1600-0897.2009.00792.x · 2010 · External reference
Molecular cues to implantation.
10.1210/er.2003-0020 · 2004 · External reference
Staphylococcal infections and infertility: mechanisms and management.
10.1007/s11010-020-03833-4 · 2020 · External reference
Relationship of vaginal bacteria and inflammation with conception and early pregnancy loss following in-vitro fertilization.
10.1155/s1064744903000024 · 2003 · External reference
Immunology of the maternal–fetal interface.
10.1146/annurev-immunol-032712-100003 · 2013 · External reference
Inflammation, leukocytes and menstruation.
10.1007/s11154-012-9223-7 · 2012 · External reference
Bacterial infection of the male reproductive system causing infertility.
10.1016/j.jri.2020.103183 · 2020 · External reference
C-type lectin receptors on dendritic cells and Langerhans cells.
10.1038/nri723 · 2002 · External reference
Menstrual cycle dependent fluctuations in NK and T-lymphocyte subsets from non-pregnant human endometrium.
10.1111/j.8755-8920.2000.430405.x · 2000 · External reference
A review of the pathophysiology of recurrent implantation failure.
10.1016/j.fertnstert.2021.09.014 · 2021 · External reference
Genetic variation at chromosome 2q13 and its potential influence on endometriosis susceptibility through effects on the IL-1 family.
10.1177/1933719118768688 · 2018 · External reference
Clinical relevance of vaginal and endometrial microbiome investigation in women with repeated implantation failure and recurrent pregnancy loss.
10.3390/ijms25010622 · 2024 · External reference
Regulation of inflammation pathways and inflammasome by sex steroid hormones in endometriosis.
10.3389/fendo.2019.00935 · 2020 · External reference
Endometriosis: future biological perspectives for diagnosis and treatment.
10.3390/ijms252212242 · 2024 · External reference
The role of infection in miscarriage.
10.1093/humupd/dmv041 · 2016 · External reference
Mycoplasma genitalium: a review.
10.1099/mic.0.000830 · 2020 · External reference
Differential rates of group B streptococcus (GBS) colonisation in pregnant women in a racially diverse area of London, UK: a cross-sectional study.
10.1111/1471-0528.15648 · 2019 · External reference
The role of the genital tract microbiome in human fertility: a literature review.
10.3390/jcm14092923 · 2025 · External reference
Role of the gut microbiota in the pathogenesis of endometriosis: a review.
10.3389/fmicb.2024.1363455 · 2024 · External reference
Baicalin inhibits Staphylococcus aureus-induced apoptosis by regulating TLR2 and TLR2-related apoptotic factors in the mouse mammary glands.
10.1016/j.ejphar.2013.10.032 · 2014 · External reference
Mycoplasma genitalium: an emerging cause of pelvic inflammatory disease.
10.1155/2011/959816 · 2011 · External reference
DNaseI protects lipopolysaccharide-induced endometritis in mice by inhibiting neutrophil extracellular traps formation.
10.1016/j.micpath.2020.104686 · 2021 · External reference
Effects of embryo microbial contamination on ART and neonatal outcomes.
10.2147/idr.s478594 · 2024 · External reference
Hemodynamic changes in cytokines, chemokines, acute phase proteins and prostaglandins in mares with subclinical endometritis.
10.1016/j.theriogenology.2021.05.011 · 2021 · External reference
Recurrent urinary tract infections and asymptomatic bacteriuria in adults.
10.1007/s11884-021-00638-z · 2021 · External reference
Interactions between the microbiota and the immune system.
10.1126/science.12234 · 2012 · External reference
Toll-like receptor-4 pathway is required for the pathogenesis of human chronic endometritis.
10.3892/etm.2014.1990 · 2014 · External reference
An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression.
10.1093/humrep/deu172 · 2014 · External reference
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.
10.1016/j.immuni.2011.05.006 · 2011 · External reference
Regulation of hepatocyte growth factor by basal and stimulated macrophages in women with endometriosis.
10.1093/humrep/deh525 · 2005 · External reference
Toll-like receptor 4-mediated growth of endometriosis by human heat-shock protein 70.
10.1093/humrep/den195 · 2008 · External reference
Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosis.
10.1016/j.fertnstert.2010.04.053 · 2010 · External reference
Bacterial contamination hypothesis: a new concept in endometriosis.
10.1002/rmb2.12083 · 2018 · External reference
The role of innate and adaptive immunity in endometriosis.
10.1016/j.jri.2024.104242 · 2024 · External reference
LPS administration during fertilization affects epigenetic inheritance during embryonic development.
10.3390/ani13071135 · 2023 · External reference
Oestrogen and progesterone regulation of inflammatory processes in the human endometrium.
10.1016/j.jsbmb.2010.01.003 · 2010 · External reference
Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis.
10.1038/modpathol.2010.98 · 2010 · External reference
Immunohistochemistrical and clinicopathological characterization of chronic endometritis.
10.1111/j.1600-0897.2011.01051.x · 2011 · External reference
Comprehensive endometrial immunoglobulin subclass analysis in infertile women suffering from repeated implantation failure with or without chronic endometritis.
10.1111/aji.12277 · 2014 · External reference
Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure.
10.1111/aji.12719 · 2017 · External reference
Alteration in endometrial helper T-cell subgroups in chronic endometritis.
10.1111/aji.13372 · 2021 · External reference
Systemic inflammation and autoimmunity in women with chronic endometritis.
10.1111/aji.12508 · 2016 · External reference
Role of endometrial immune cells in implantation.
10.5653/cerm.2011.38.3.119 · 2011 · External reference
Immune cells in the female reproductive tract.
10.4110/in.2015.15.1.16 · 2015 · External reference
PGE2 increases inflammatory damage in Escherichia coli-infected bovine endometrial tissue in vitro via the EP4-PKA signaling pathway.
10.1093/biolre/ioy162 · 2019 · External reference
The interaction between microorganisms, metabolites, and immune system in the female genital tract microenvironment.
10.3389/fcimb.2020.609488 · 2020 · External reference
Evaluation of peripheral and uterine immune status of chronic endometritis in patients with recurrent reproductive failure.
10.1016/j.fertnstert.2019.09.001 · 2020 · External reference
TLR2/4 promotes PGE2 production to increase tissue damage in Escherichia coli-infected bovine endometrial explants via MyD88/p38 MAPK pathway.
10.1016/j.theriogenology.2020.04.004 · 2020 · External reference
Analysis of the microbiota composition in the genital tract of infertile patients with chronic endometritis or endometrial polyps.
10.3389/fcimb.2023.1125640 · 2023 · External reference
Endometrial responses to bacterial and viral infection: a scoping review.
10.1093/humupd/dmad013 · 2023 · External reference
Mycoplasma genitalium infection and female reproductive tract disease: a meta-analysis.
10.1093/cid/civ312 · 2015 · External reference
Role of the commensal microbiota in normal and pathogenic host immune responses.
10.1016/j.chom.2011.10.004 · 2011 · External reference
Organoids of human endometrium: a powerful in vitro model for the endometrium-embryo cross-talk at the implantation site.
10.3390/cells9051121 · 2020 · External reference
Ghrelin misbalance affects mice embryo implantation and pregnancy success by uterine immune dysregulation and nitrosative stress.
10.3389/fendo.2023.1288779 · 2023 · External reference
Recurrent implantation failure: a comprehensive summary from etiology to treatment.
10.3389/fendo.2022.1061766 · 2023 · External reference
Implantation failure: where to look up?
10.3390/jcm14228163 · 2025 · External reference
Molecular mechanisms of mucocutaneous immunity against Candida and Staphylococcus species.
10.1016/j.jaci.2012.09.011 · 2012 · External reference
Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: A cross-sectional study.
10.1136/sextrans-2014-051601 · 2014 · External reference
Immunity against Staphylococcus aureus cutaneous infections.
10.1038/nri3010 · 2011 · External reference
C-type lectin receptors in host defense against bacterial pathogens.
10.3389/fcimb.2020.00309 · 2020 · External reference
Physiology of embryo-endometrial cross talk.
10.4103/2349-3666.240622 · 2015 · External reference
Evidence that the endometrial microbiota has an effect on implantation success or failure.
10.1016/j.ajog.2016.09.075 · 2016 · External reference
The diagnosis of chronic endometritis in infertile asymptomatic women: A comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology.
10.1016/j.ajog.2018.02.012 · 2018 · External reference
Endometrial microbiota composition is associated with reproductive outcome in infertile patients.
10.1186/s40168-021-01184-w · 2022 · External reference
Revolutionizing chronic endometritis diagnosis: Real-time polymerase chain reaction unveils microbial pathogens in Indian women with abnormal bleeding and reproductive challenges.
10.1016/j.xagr.2024.100377 · 2024 · External reference
Harmful and beneficial effects of inflammatory response on reproduction: Sterile and pathogen-associated inflammation.
10.1080/25785826.2020.1809951 · 2021 · External reference
The impact of genital infections on women’s fertility.
10.3390/amh70030033 · 2025 · External reference
HOXA-10 gene expression in ectopic and eutopic endometrium tissues: does it differ between fertile and infertile women with endometriosis?
10.1016/j.ejogrb.2018.11.027 · 2019 · External reference
Re-assessing microbiomes in the low-biomass reproductive niche.
10.1111/1471-0528.15974 · 2020 · External reference
Chronic endometritis and infertility.
10.5653/cerm.2016.43.4.185 · 2016 · External reference
Chronic endometritis: Old problem, novel insights and future challenges.
10.22074/ijfs.2020.5779 · 2020 · External reference
The impact of the female genital tract microbiome in women’s health and reproduction: a review.
10.1007/s10815-021-02247-5 · 2021 · External reference
Bacterial biofilms and implant infections: a perspective.
2020 · External reference
Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease.
10.1016/j.ajog.2020.10.019 · 2021 · External reference
The role of viral infection in implantation failure: direct and indirect effects.
10.1186/s12958-024-01303-w · 2024 · External reference
Embryotoxic cytokines—Potential roles in embryo loss and fetal programming.
10.1016/j.jri.2017.12.003 · 2018 · External reference
Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization?
10.1016/j.fertnstert.2004.05.076 · 2004 · External reference
Bacterial agents as a cause of infertility in humans.
2016 · External reference
Chronic endometritis and fertility: a binomial linked by microorganisms.
10.1016/j.ejogrb.2024.11.032 · 2024 · External reference
Human implantation: the complex interplay between endometrial receptivity, inflammation, and the microbiome.
10.1016/j.placenta.2021.12.015 · 2022 · External reference
Gut microbiota imbalance and its correlations with hormone and inflammatory factors in patients with stage 3/4 endometriosis.
10.1007/s00404-021-06057-z · 2021 · External reference
Towards a better understanding of endometriosis-related infertility: a review on how endometriosis affects endometrial receptivity.
10.3390/biom13030430 · 2023 · External reference
The role of endometrial B cells in normal endometrium and benign female reproductive pathologies: a systematic review.
10.1093/hropen/hoab043 · 2022 · External reference
Unresolved reference
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Type of inflammation differentially affects expression of interleukin 1β and 6, tumor necrosis factor-α and toll-like receptors in subclinical endometritis in mares.
10.1371/journal.pone.0154934 · 2016 · External reference
Unresolved reference
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How do microorganisms influence the development of endometriosis? Participation of genital, intestinal and oral microbiota in metabolic regulation and immunopathogenesis of endometriosis.
10.3390/ijms241310920 · 2023 · External reference
Unresolved reference
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Endometrial microbiome and reproductive receptivity: Diverse perspectives.
10.3390/ijms262110796 · 2025 · External reference
Immunomorphological characteristics of endometrium in women with chronic endometritis.
10.1007/s10517-006-0105-4 · 2006 · External reference
Staphylococcus aureus phenol-soluble modulins stimulate the release of proinflammatory cytokines from keratinocytes and are required for induction of skin inflammation.
10.1128/iai.00401-15 · 2015 · External reference
Viral infection in endometritis: Is there an important role or not?
10.1111/aji.13930 · 2024 · External reference
Changes of endometrial immune cells in patients with chronic endometritis and recurrent miscarriage.
2017 · External reference
Sexually transmitted diseases and infertility.
10.1016/j.ajog.2016.08.008 · 2017 · External reference
Epidemiology and aetiology of maternal bacterial and viral infections in low- and middle-income countries.
2011 · External reference
The role of genital tract microbiome in fertility: A systematic review.
10.3390/ijms23010180 · 2021 · External reference
Inflammatory cytokines IL-6, IL-10, IL-13, TNF-α and peritoneal fluid flora were associated with infertility in patients with endometriosis.
10.26355/eurrev_201805_14899 · 2018 · External reference
Endometrial TGF-β, IL-10, IL-17 and autophagy are dysregulated in women with recurrent implantation failure with chronic endometritis.
10.1186/s12958-018-0444-9 · 2019 · External reference
Role of inflammatory factors in the etiology and treatment of recurrent implantation failure.
10.1016/j.repbio.2022.100698 · 2022 · External reference
Protective effect of Clostridium butyricum on Escherichia coli-induced endometritis in mice via ameliorating endometrial barrier and inhibiting inflammatory response.
10.1128/spectrum.03286-22 · 2022 · External reference
The effects of microbiota on reproductive health: a review.
10.1080/10408398.2022.2117784 · 2024 · External reference
Playing with fire: Proinflammatory virulence mechanisms of group A streptococcus.
10.3389/fcimb.2021.704099 · 2021 · External reference
The role of sex hormones in immune protection of the female reproductive tract.
10.1038/nri3819 · 2015 · External reference
Advances in endometrial receptivity and embryo implantation by multi-omics techniques.
10.1016/j.azn.2025.05.001 · 2025 · External reference
Fertility factors affect the vaginal microbiome in women of reproductive age.
10.1111/aji.13220 · 2020 · External reference
Chlamydia trachomatis plasmid gene protein 3 is essential for the establishment of persistent infection and associated immunopathology.
10.1128/mbio.01902-20 · 2020 · External reference
T cell receptor Vb usage in human uterine endometrial lymphoid aggregates shows no clonal restriction: evidence that uterine lymphoid aggregates arise by cell trafficking.
10.1046/j.1365-2567.2001.01199.x · 2001 · External reference
Reduced connexin 43 in eutopic endometrium and cultured endometrial stromal cells from subjects with endometriosis.
10.1093/molehr/gat087 · 2014 · External reference
Mycoplasma genitalium infection in the female reproductive system: diseases and treatment.
10.3389/fmicb.2023.1098276 · 2023 · External reference
Research update for the immune microenvironment of chronic endometritis.
10.1016/j.jri.2022.103637 · 2022 · External reference
Inflammatory mediators in bacterial vaginosis: the role of cytokines.
10.1111/apm.13380 · 2024 · External reference
Extracellular superoxide produced by Enterococcus faecalis reduces endometrial receptivity via inflammatory injury.
10.1111/aji.13453 · 2021 · External reference
10.1016/j.jeud.2023.100049 · 2023 · Admitted local publication
Altered endometrial microbiota profile is associated with poor endometrial receptivity of repeated implantation failure.
10.1111/aji.70005 · 2024 · External reference
Chinese expert consensus on diagnosis and management of abnormal endometrium in assisted reproductive technology.
2018 · External reference
The endometrial microbiota profile influenced pregnancy outcomes in patients with repeated implantation failure: a retrospective study.
10.1016/j.jri.2022.103782 · 2023 · External reference
