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References from Monitoring huntingtin aggregation in Huntington’s disease: methods, challenges and future opportunities. Local targets link to admitted publications; unresolved targets remain external evidence.
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Probing initial transient oligomerization events facilitating Huntingtin fibril nucleation at atomic resolution by relaxation-based NMR
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Quantitative NMR analysis of the kinetics of prenucleation oligomerization and aggregation of pathogenic huntingtin exon-1 protein
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A Targetable Self-association Surface of the Huntingtin exon1 Helical Tetramer Required for Assembly of Amyloid Pre-nucleation Oligomers
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Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Manner in Vitro and in Vivo
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Super-Resolution Fluorescence of Huntingtin Reveals Growth of Globular Species into Short Fibers and Coexistence of Distinct Aggregates
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Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules
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Direct Observation of Secondary Nucleation in Huntingtin Amyloid Formation by High-Speed Atomic Force Microscopy
10.1021/jacs.5c05571 · 2025 · External reference
Integrative determination of atomic structure of mutant huntingtin exon 1 fibrils implicated in Huntington disease
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Huntingtin fibrils with different toxicity, structure, and seeding potential can be interconverted
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In Situ Architecture and Cellular Interactions of PolyQ Inclusions
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Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates
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Dynamic recruitment of active proteasomes into polyglutamine initiated inclusion bodies
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Unresolved reference
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Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity
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Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice
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Label-free identification of protein aggregates using deep learning
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Fluorescent protein tagging promotes phase separation and alters the aggregation pathway of huntingtin exon-1
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Quantification assays for total and polyglutamine-expanded huntingtin proteins
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Fragments of HdhQ150 mutant huntingtin form a soluble oligomer pool that declines with aggregate deposition upon aging
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A method for the analysis of the oligomerization profile of the Huntington’s disease-associated, aggregation-prone mutant huntingtin protein by isopycnic ultracentrifugation
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Recent advances in fluorescent probes development for interrogating protein misfolding and aggregation
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Global Proteome and Ubiquitinome Changes in the Soluble and Insoluble Fractions of Q175 Huntington Mice Brains
10.1074/mcp.ra119.001486 · 2019 · External reference
Interaction of huntingtin with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity
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Huntingtin interactome reveals huntingtin role in regulation of double strand break DNA damage response (DSB/DDR), chromatin remodeling and RNA processing pathways
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Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity
10.1074/jbc.m513507200 · 2006 · External reference
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Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects
10.1073/pnas.2007667117 · 2020 · External reference
Unresolved reference
2026 · External reference
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High throughput quantification of mutant huntingtin aggregates
10.1016/j.jneumeth.2008.02.007 · 2008 · External reference
Self-driving microscopy detects the onset of protein aggregation and enables intelligent Brillouin imaging
10.1038/s41467-025-60912-0 · 2025 · External reference
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10.1093/hmg/ddt625 · External reference
Real-time imaging of Huntingtin aggregates diverting target search and gene transcription
2016 · External reference
Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies
10.1038/s41598-018-19538-0 · 2018 · External reference
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Visualization of cell-to-cell transmission of mutant huntingtin oligomers
10.1371/currents.rrn1210 · 2011 · External reference
FLIM-FRET Investigation of Heterogeneous Huntingtin Aggregation in HeLa Cells
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Fluorescence Correlation Spectroscopy: A Tool to Study Protein Oligomerization and Aggregation In Vitro and In Vivo
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Mapping the number of molecules and brightness in the laser scanning microscope
10.1529/biophysj.107.114645 · 2008 · External reference
A two-step path to inclusion formation of huntingtin peptides revealed by number and brightness analysis
10.1016/j.bpj.2010.02.058 · 2010 · External reference
Detecting protein aggregation and interaction in live cells: A guide to number and brightness
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Cellular Inclusion Bodies of Mutant Huntingtin Exon 1 Obscure Small Fibrillar Aggregate Species
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Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease
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A human single-chain Fv intrabody preferentially targets amino-terminal Huntingtin’s fragments in striatal models of Huntington’s disease
10.1016/j.nbd.2004.11.003 · 2005 · External reference
Development of a novel VHH intrabody targeting the N17 region of huntingtin exon 1 protein that prevents inclusion body formation
External reference
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D001 Development of an HTT exon1-selective MSD immunoassay with novel HTT P90 neo-epitope-specific antibodies
2024 · External reference
Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment
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Epitope-specific antibodies can distinguish between soluble huntingtin exon-1 and its diverse cellular aggregates
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