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References from The IKKε-GABPA axis regulates STING transcription to orchestrate antiviral immunity and inflammation. Local targets link to admitted publications; unresolved targets remain external evidence.
EULAR/ACR classification criteria for SLE
10.1016/j.semarthrit.2019.09.009 · 2019 · External reference
The structure of GABPalpha/beta: An ETS domain- ankyrin repeat heterodimer bound to DNA
10.1126/science.279.5353.1037 · 1998 · External reference
The core cellular network modulates immune phenotype switching in hepatitis B
10.1016/j.scib.2025.03.038 · 2025 · External reference
TBK1-Mediated DRP1 targeting confers nucleic acid sensing to reprogram mitochondrial dynamics and physiology
10.1016/j.molcel.2020.10.018 · 2020 · External reference
Identification of redox-sensitive cysteines in GA-binding protein-α that regulate DNA binding and heterodimerization
10.1074/jbc.273.11.6203 · 1998 · External reference
TMEFF1 is a neuron-specific restriction factor for herpes simplex virus
10.1038/s41586-024-07670-z · 2024 · External reference
Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence
10.1016/j.molcel.2024.08.006 · 2024 · External reference
DNA-sensing pathways in health, autoinflammatory and autoimmune diseases
10.1038/s41590-024-01966-y · 2024 · External reference
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion
10.1038/s41556-025-01627-8 · 2025 · External reference
Single-cell transcriptomics reveals distinct effector profiles of infiltrating T cells in lupus skin and kidney
10.1172/jci.insight.156341 · 2022 · External reference
Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING
10.1016/j.immuni.2021.03.011 · 2021 · External reference
IKKε and TBK1 are essential components of the IRF3 signaling pathway
10.1038/ni921 · 2003 · External reference
Self-guarding of MORC3 enables virulence factor-triggered immunity
10.1038/s41586-021-04054-5 · 2021 · External reference
Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease
10.1038/s41467-023-40156-6 · 2023 · External reference
A STAT3–STING–IFN axis controls the metastatic spread of small cell lung cancer
10.1038/s41590-024-02014-5 · 2024 · External reference
GABPA is a master regulator of luminal identity and restrains aggressive diseases in bladder cancer
10.1038/s41418-019-0466-7 · 2019 · External reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · 2024 · External reference
Second-strand synthesis-based massively parallel scRNA-seq reveals cellular states and molecular features of human inflammatory skin pathologies
10.1016/j.immuni.2020.09.015 · 2020 · External reference
Genome-wide mapping of in vivo protein-DNA interactions
10.1126/science.1141319 · 2007 · External reference
Fast, sensitive and accurate integration of single-cell data with Harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes
10.1038/s41556-023-01098-9 · 2023 · External reference
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway
10.1016/j.immuni.2025.03.005 · 2025 · External reference
NRF1-mediated innate immune response drives inflammaging
10.1038/s41467-025-66368-6 · 2025 · External reference
STING signaling activation inhibits HBV replication and attenuates the severity of liver injury and HBV-induced fibrosis
10.1038/s41423-021-00801-w · 2022 · External reference
Vimentin inhibits type I interferon production by disrupting the TBK1-IKKepsilon-IRF3 axis
10.1016/j.celrep.2022.111469 · 2022 · External reference
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
10.1126/science.aaa2630 · 2015 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Ets transcription factor GABP controls T cell homeostasis and immunity
10.1038/s41467-017-01020-6 · 2017 · External reference
Porcine IKKepsilon is involved in the STING-induced type I IFN antiviral response of the cytosolic DNA signaling pathway
10.1016/j.jbc.2023.105213 · 2023 · External reference
Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes
10.1038/s41467-022-32401-1 · 2022 · External reference
A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis
10.1038/s41422-023-00790-7 · 2023 · External reference
Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice
10.1038/s41598-019-50656-5 · 2019 · External reference
Type I interferons in infectious disease
10.1038/nri3787 · 2015 · External reference
Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity
10.1016/j.molcel.2021.07.040 · 2021 · External reference
Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis
10.1038/s41467-024-45665-6 · 2024 · External reference
Cytokines in inflammatory bowel disease
10.1038/nri3661 · 2014 · External reference
Apoptotic caspases suppress type I interferon production via the cleavage of cGAS, MAVS, and IRF3
10.1016/j.molcel.2019.02.013 · 2019 · External reference
Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus
10.1126/science.abf1970 · 2022 · External reference
ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation
10.1016/j.cell.2025.01.027 · 2025 · External reference
Reconstruction of cell spatial organization from single-cell RNA sequencing data based on ligand-receptor mediated self-assembly
10.1038/s41422-020-0353-2 · 2020 · External reference
An IKBKE variant conferring functional cGAS/STING pathway deficiency and susceptibility to recurrent HSV-2 meningitis
10.1172/jci.insight.173066 · 2023 · External reference
PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection
10.1016/j.molcel.2024.06.001 · 2024 · External reference
A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function
10.1016/j.cmet.2014.08.001 · 2014 · External reference
Identification of key interferon-stimulated genes for indicating the condition of patients with systemic lupus erythematosus
10.3389/fimmu.2022.962393 · 2022 · External reference
The IFN-γ receptor promotes immune dysregulation and disease in STING gain-of-function mice
10.1172/jci.insight.155250 · 2022 · External reference
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
10.1126/science.1232458 · 2013 · External reference
Mitochondrial-derived vesicles: At the crossroads of mitochondrial functions and metabolites
10.1016/j.mitoco.2025.06.001 · 2025 · External reference
Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity
10.1126/science.1136567 · 2007 · External reference
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection
10.1002/hep.28685 · 2016 · External reference
The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA
10.1016/j.immuni.2010.10.013 · 2010 · External reference
Pharmacological inhibition of TBK1/IKKepsilon blunts immunopathology in a murine model of SARS-CoV-2 infection
10.1038/s41467-023-41381-9 · 2023 · External reference
Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection
10.1016/j.immuni.2017.02.011 · 2017 · External reference
Mechanisms of transcriptional activation of the stimulator of interferon genes by transcription factors CREB and c-Myc
10.18632/oncotarget.13183 · 2016 · External reference
Mitochondrial DNA stress primes the antiviral innate immune response
10.1038/nature14156 · 2015 · External reference
Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function
10.1038/s41467-020-19205-x · 2020 · External reference
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense
10.1016/j.celrep.2013.04.020 · 2013 · External reference
Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity
10.1016/j.immuni.2024.05.025 · 2024 · External reference
The RNA-binding E3 ligase MKRN2 selectively disrupts Il6 translation to restrain inflammation
10.1038/s41590-025-02183-x · 2025 · External reference
STEEP mediates STING ER exit and activation of signaling
10.1038/s41590-020-0730-5 · 2020 · External reference
Single-cell RNA sequencing reveals intrahepatic and peripheral immune characteristics related to disease phases in HBV-infected patients
10.1136/gutjnl-2021-325915 · 2023 · External reference
Structural basis of STING binding with and phosphorylation by TBK1
10.1038/s41586-019-1000-2 · 2019 · External reference
AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity
10.1016/j.molcel.2022.10.026 · 2022 · External reference
NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity
10.15252/embj.2022113258 · 2023 · External reference
HBsAg dampened STING associated activation of NK cells in HBeAg-negative CHB patients
10.3390/ijms22147643 · 2021 · External reference
Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus
10.1038/s41467-022-35209-1 · 2022 · External reference
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
10.1016/j.immuni.2008.09.003 · 2008 · External reference
The transcription factor GABPA is a master regulator of naive pluripotency
10.1038/s41556-024-01554-0 · 2025 · External reference
SNORD3A regulates STING transcription to promote ferroptosis in acute kidney injury
10.1002/advs.202400305 · 2024 · External reference
