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References from Helios is critical for Treg effector differentiation in adipose autoimmunity. Local targets link to admitted publications; unresolved targets remain external evidence.
Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells
10.4049/jimmunol.1200792 · 2013 · External reference
Depletion of fat-resident T cells prevents age-associated insulin resistance
10.1038/nature16151 · 2015 · External reference
Adipose-tissue regulatory T cells: Critical players in adipose-immune crosstalk
10.1002/eji.201646739 · 2017 · External reference
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
10.1038/nature14115 · 2015 · External reference
Regulatory T cells in nonlymphoid tissues
10.1038/ni.2683 · 2013 · External reference
The macrophage switch in obesity development
10.3389/fimmu.2015.00637 · 2015 · External reference
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner
10.1126/science.1172702 · 2009 · External reference
Helios is a key transcriptional regulator of outer hair cell maturation
10.1038/s41586-018-0728-4 · 2018 · External reference
LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6
10.1038/ni.3226 · 2015 · External reference
PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells
10.1038/nature11132 · 2012 · External reference
Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells
10.1084/jem.20202317 · 2021 · External reference
Precursors for nonlymphoid-tissue Treg cells reside in secondary lymphoid organs and are programmed by the transcription factor BATF
10.1016/j.immuni.2019.12.002 · 2020 · External reference
GSEApy: A comprehensive package for performing gene set enrichment analysis in Python
10.1093/bioinformatics/btac757 · 2023 · External reference
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
10.1038/nm.2002 · 2009 · External reference
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
10.1038/nm.1982 · 2009 · External reference
Foxp3-dependent programme of regulatory T-cell differentiation
10.1038/nature05543 · 2007 · External reference
Torpor in mice is induced by both leptin-dependent and -independent mechanisms
10.1073/pnas.96.25.14623 · 1999 · External reference
iDEP: an integrated web application for differential expression and pathway analysis of RNA-Seq data
10.1186/s12859-018-2486-6 · 2018 · External reference
Insulin inhibits IL-10-mediated regulatory T cell function: Implications for obesity
10.4049/jimmunol.1302181 · 2014 · External reference
IL-33 reverses an obesity-induced deficit in visceral adipose tissue ST2+ T regulatory cells and ameliorates adipose tissue inflammation and insulin resistance
10.4049/jimmunol.1500020 · 2015 · External reference
T reg cell-intrinsic requirements for ST2 signaling in health and neuroinflammation
10.1084/jem.20201234 · 2021 · External reference
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability
10.1038/ni.3077 · 2015 · External reference
Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice
10.1073/pnas.0908771107 · 2010 · External reference
Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory
10.1073/pnas.0914127107 · 2010 · External reference
Bach2 regulates homeostasis of Foxp3+ regulatory T cells and protects against fatal lung disease in mice
10.4049/jimmunol.1302378 · 2014 · External reference
Stable inhibitory activity of regulatory T cells requires the transcription factor Helios
10.1126/science.aad0616 · 2015 · External reference
Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice
10.1016/j.cmet.2015.03.005 · 2015 · External reference
Stability and function of regulatory T cells expressing the transcription factor T-bet
10.1038/nature22360 · 2017 · External reference
TCR transgenic mice reveal stepwise, multi-site acquisition of the distinctive fat-Treg phenotype
10.1016/j.cell.2018.05.004 · 2018 · External reference
Visceral adipose tissue Tregs and the cells that nurture them
10.1111/imr.12850 · 2020 · External reference
Autoantibodies to perilipin-1 define a subset of acquired generalized lipodystrophy
10.2337/db21-1172 · 2023 · External reference
T lymphocyte activation gene identification by coregulated expression on DNA microarrays
10.1016/j.ygeno.2003.12.019 · 2004 · External reference
Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice
10.1161/circresaha.110.218867 · 2010 · External reference
Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease
10.1038/ni.2928 · 2014 · External reference
Life without white fat: A transgenic mouse
10.1101/gad.12.20.3168 · 1998 · External reference
Interleukin-33 and interferon-gamma counter-regulate group 2 innate lymphoid cell activation during immune perturbation
10.1016/j.immuni.2015.05.019 · 2015 · External reference
CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8+ T cell antitumor immunity
10.1016/j.immuni.2023.06.003 · 2023 · External reference
Adipose-tissue regulatory T cells are a consortium of subtypes that evolves with age and diet
10.1073/pnas.2320602121 · 2024 · External reference
Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner
10.1371/journal.pbio.1000296 · 2010 · External reference
Tissue Tregs
10.1146/annurev-immunol-032712-095948 · 2016 · External reference
IKZF2 drives leukemia stem cell self-renewal and inhibits myeloid differentiation
10.1016/j.stem.2018.10.016 · 2019 · External reference
Integrated STAT3 and Ikaros zinc finger transcription factor activities regulate Bcl-6 expression in CD4+ Th cells
10.4049/jimmunol.1700106 · 2017 · External reference
BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis
10.1038/nature12199 · 2013 · External reference
Regulatory T cells and Foxp3
10.1111/j.1600-065x.2011.01018.x · 2011 · External reference
The transcriptional repressor Bcl6 controls the stability of regulatory T cells by intrinsic and extrinsic pathways
10.1111/imm.12393 · 2015 · External reference
Helios controls a limited subset of regulatory T cell functions
10.4049/jimmunol.1501704 · 2016 · External reference
AnimalTFDB 4.0: A comprehensive animal transcription factor database updated with variation and expression annotations
10.1093/nar/gkac907 · 2023 · External reference
Biological functions of regulatory T cells
10.1016/b978-0-12-387827-4.00004-8 · 2011 · External reference
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: Model for congenital generalized lipodystrophy
10.1101/gad.12.20.3182 · 1998 · External reference
Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
10.1016/s1097-2765(05)00010-9 · 2000 · External reference
T cells require the phosphatase PTEN to restrain T1 and T cell responses
10.1038/ni.3076 · 2015 · External reference
Helios deficiency predisposes the differentiation of CD4+Foxp3- T cells into peripherally derived regulatory T cells
10.4049/jimmunol.1900388 · 2019 · External reference
Cutting edge: Dynamic expression of Id3 defines the stepwise differentiation of tissue-resident regulatory T cells
10.4049/jimmunol.1800917 · 2019 · External reference
The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases
10.1038/s41577-024-00994-x · 2024 · External reference
GFI1 cooperates with IKZF1/IKAROS to activate gene expression in T-cell acute lymphoblastic leukemia
10.1158/1541-7786.mcr-21-0352 · 2022 · External reference
T-cell activation RhoGTPase-activating protein plays an important role in T(H)17-cell differentiation
10.1038/icb.2017.27 · 2017 · External reference
Helios+ and Helios- Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires
10.1002/eji.201847935 · 2019 · External reference
Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism
10.1038/s41590-024-01753-9 · 2024 · External reference
The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells
10.1038/ni.3085 · 2015 · External reference
Normalization of obesity-associated insulin resistance through immunotherapy
10.1038/nm.2001 · 2009 · External reference
GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
10.1172/jci57456 · 2011 · External reference
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
10.1126/science.1201475 · 2011 · External reference
Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice
10.1172/jci38388 · 2010 · External reference
Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells
10.1084/jem.20182010 · 2019 · External reference
TCF1 and LEF1 control Treg competitive survival and Tfr development to prevent autoimmune diseases
10.1016/j.celrep.2019.05.061 · 2019 · External reference
Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance
10.1038/ni.3053 · 2015 · External reference
Tissue adaptation of regulatory T cells in adipose tissue
10.1002/eji.202149527 · 2022 · External reference
Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells
10.1038/344742a0 · 1990 · External reference
