Research graph
References from 3-layer lung cancer invasion model for evaluating MMP-targeted anti-metastatic therapeutics. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer statistics, 2023
10.3322/caac.21763 · 2023 · External reference
Lung Cancer
10.1056/nejmra0802714 · 2008 · External reference
Key molecular mechanisms in lung cancer invasion and metastasis: a comprehensive review
10.1016/j.critrevonc.2012.12.007 · 2013 · External reference
Matrix metalloproteinases: regulators of the tumor microenvironment
10.1016/j.cell.2010.03.015 · 2010 · External reference
Hallmarks of cancer:the next generation
10.1016/j.cell.2011.02.013 · 2011 · External reference
MMP9: a tough target for targeted therapy for cancer
10.3390/cancers14071847 · 2022 · External reference
Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease nexin-1
10.1158/0008-5472.can-10-0242 · 2010 · External reference
Matrix metalloproteinase-9 (MMP-9) expression in non-small cell lung carcinoma and its association with clinicopathologic factors
10.30699/ijp.2020.95177.1940 · 2020 · External reference
Matrix metalloproteinase inhibitors and cancer—trials and tribulations
10.1126/science.1067100 · 2002 · External reference
Matrix metalloproteinases: new targets in cancer therapy
10.4172/1948-5956.1000406 · 2016 · External reference
Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer
10.1080/15384101.2016.1241929 · 2017 · External reference
Andecaliximab/GS-5745 alone and combined with mFOLFOX6 in advanced gastric and gastroesophageal junction adenocarcinoma:results from a phase I study
10.1158/1078-0432.ccr-17-2469 · 2018 · External reference
Is there new hope for therapeutic matrix metalloproteinase inhibition?
10.1038/nrd4390 · 2014 · External reference
A rapid in vitro assay for quantitating the invasive potential of tumor cells
1987 · External reference
Cancer metastasis‐on‐a‐chip for modeling metastatic cascade and drug screening
10.1002/adhm.202302436 · 2024 · External reference
Evaluation of the cell invasion and migration process: a comparison of the video microscope-based scratch wound assay and the boyden chamber assay
10.3791/55277 · 2017 · External reference
Human tumor microenvironment chip evaluates the consequences of platelet extravasation and combinatorial antitumor-antiplatelet therapy in ovarian cancer
10.1126/sciadv.abg5283 · 2020 · External reference
A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens
10.1038/s41551-019-0400-9 · 2019 · External reference
A microfluidic cell-migration assay for the prediction of progression-free survival and recurrence time of patients with glioblastoma
10.1038/s41551-020-00621-9 · 2020 · External reference
Human organ chip models recapitulate orthotopic lung cancer growth, therapeutic responses, and tumor dormancy in vitro
10.1016/j.celrep.2017.09.043 · 2017 · External reference
From individual to collective 3D cancer dissemination: roles of collagen concentration and TGF-β
10.1038/s41598-018-30683-4 · 2018 · External reference
High throughput drug screening platform utilizing capillary and artery cell layered models based on tumor-vascular cell interactions
10.1039/d4lc00950a · 2025 · External reference
Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation
10.1073/pnas.1417115112 · 2015 · External reference
Engineers are from PDMS-land, biologists are from polystyrenia
10.1039/c2lc20982a · 2012 · External reference
All-inkjet-printed 3D alveolar barrier model with physiologically relevant microarchitecture
10.1002/advs.202004990 · 2021 · External reference
3D-printed airway model as a platform for SARS-CoV-2 infection and antiviral drug testing
10.1016/j.biomaterials.2024.122689 · 2024 · External reference
Use of a 3D inkjet-printed model to access dust particle toxicology in the human alveolar barrier
10.1002/bit.28220 · 2022 · External reference
Toxicity assessment of humidifier disinfectant component CMIT/MIT using bioprinted thin-layer human alveolar model
10.1007/s13206-024-00172-0 · 2024 · External reference
Evaluation of a bioprinted 3D airway tissue model for toxicity testing of nanomaterials; Pathway to integration into a tiered testing strategy for hazard assessment to support safety-by-design
10.1016/j.nantod.2025.102655 · 2025 · External reference
3D pulmonary fibrosis model for anti-fibrotic drug discovery by inkjet-bioprinting
10.1088/1748-605x/aca8e3 · 2023 · External reference
Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated t cells
10.4049/jimmunol.178.9.5552 · 2007 · External reference
The CXCL8-CXCR1/2 pathways in cancer
10.1016/j.cytogfr.2016.08.002 · 2016 · External reference
Human endothelial cells promote arsenic-transformed lung epithelial cells to induce tumor growth and angiogenesis through interleukin-8 induction
10.18632/aging.203930 · 2022 · External reference
IL-8, a novel messenger to cross-link inflammation and tumor EMT via autocrine and paracrine pathways (Review)
10.3892/ijo.2015.3234 · 2016 · External reference
Small-Molecule Anticancer Compounds Selectively Target the Hemopexin Domain of Matrix Metalloproteinase-9
10.1158/0008-5472.can-10-4552 · 2011 · External reference
Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat
10.1016/s0163-7258(97)00023-5 · 1997 · External reference
Mutational drivers of cancer cell migration and invasion
10.1038/s41416-020-01149-0 · 2021 · External reference
Cancer invasion and the microenvironment: plasticity and reciprocity
10.1016/j.cell.2011.11.016 · 2011 · External reference
Single cell analysis of mechanical properties and EMT-related gene expression profiles in cancer fingers
10.1016/j.isci.2022.103917 · 2022 · External reference
MicroRNA-7 inhibits cell proliferation, migration and invasion in human non-small cell lung cancer cells by targeting FAK through ERK/MAPK signaling pathway
10.18632/oncotarget.12684 · 2016 · External reference
Dichotomy of astrocytoma migration and proliferation
10.1002/(sici)1097-0215(19960717)67:2<275::aid-ijc20>3.0.co;2-9 · 1996 · External reference
‘Go or grow’: the key to the emergence of invasion in tumour progression?
10.1093/imammb/dqq011 · 2012 · External reference
Morphological quantification of proliferation-to-invasion transition in tumor spheroids
10.1016/j.bbagen.2019.129460 · 2020 · External reference
Efficient deformation mechanisms enable invasive cancer cells to migrate faster in 3D collagen networks
10.1038/s41598-022-11581-2 · 2022 · External reference
Spatial collagen stiffening promotes collective breast cancer cell invasion by reinforcing extracellular matrix alignment
10.1038/s41388-022-02258-1 · 2022 · External reference
MKL1 potentiates lung cancer cell migration and invasion by epigenetically activating MMP9 transcription
10.1038/onc.2015.14 · 2015 · External reference
MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis
10.1016/s1535-6108(02)00153-8 · 2002 · External reference
MiR-133b inhibits cell growth, migration, and invasion by targeting MMP9 in non-small cell lung cancer
10.3727/096504016x14800889609439 · 2017 · External reference
Specificity of short interfering RNA determined through gene expression signatures
10.1073/pnas.1131959100 · 2003 · External reference
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
10.1038/35888 · 1998 · External reference
Gene silencing in mammals by small interfering RNAs
10.1038/nrg908 · 2002 · External reference
Generation of stable expression mammalian cell lines using lentivirus
10.21769/bioprotoc.3073 · 2018 · External reference
Gelatinase-mediated migration and invasion of cancer cells
10.1016/j.bbcan.2005.03.001 · 2005 · External reference
Induction of cell migration by matrix metalloprotease-2 cleavage of Laminin-5
10.1126/science.277.5323.225 · 1997 · External reference
New functions for the matrix metalloproteinases in cancer progression
10.1038/nrc745 · 2002 · External reference
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
10.1038/ncb1616 · 2007 · External reference
ROCK1 promotes migration and invasion of non-small-cell lung cancer cells through the PTEN/PI3K/FAK pathway
10.3892/ijo.2019.4864 · 2019 · External reference
Actomyosin contractility confers mechanoprotection against TNFα-induced disruption of the intervertebral disc
10.1126/sciadv.aba2368 · 2020 · External reference
Suppressing migration and invasion of H1299 lung cancer cells by honokiol through disrupting expression of an HDAC6-mediated matrix metalloproteinase 9
10.1002/fsn3.1439 · 2020 · External reference
Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy
10.1038/nrc1821 · 2006 · External reference
Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
10.1126/science.284.5415.808 · 1999 · External reference
Randomized phase III trial of marimastat versus placebo in patients with metastatic breast cancer who have responding or stable disease after first-line chemotherapy: eastern cooperative oncology group TrialE2196
10.1200/jco.2004.08.054 · 2004 · External reference
Inhibition of MMPs supports amoeboid angiogenesis hampering VEGF-targeted therapies via MLC and ERK 1/2 signaling
10.1186/s12967-023-03954-6 · 2023 · External reference
Breast fibroblasts and ECM components modulate breast cancer cell migration through the secretion of MMPs in a 3D microfluidic co-culture model
10.3390/cancers12051173 · 2020 · External reference
Effect of IL-8 on hepatocellular carcinoma-associated metastasis by targeting MMP9 in mice
10.21037/tcr-22-37 · 2022 · External reference
Biochemical and morphological changes in endothelial cells in response to hypoxic interstitial edema
10.1186/1465-9921-7-7 · 2006 · External reference
