Research graph
References from Association of white blood cell count with treatment response to cefepime versus piperacillin-tazobactam. Local targets link to admitted publications; unresolved targets remain external evidence.
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
10.1001/jama.2016.0287 · 2016 · External reference
Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations
10.1164/rccm.201504-0781oc · 2016 · External reference
Organ dysfunction in sepsis: an ominous trajectory from infection to death
2019 · External reference
Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock
10.1378/chest.09-0087 · 2009 · External reference
Considerations for empiric antimicrobial therapy in sepsis and septic shock in an era of antimicrobial resistance
10.1093/infdis/jiaa221 · 2020 · External reference
Cefepime vs piperacillin-tazobactam in adults hospitalized with acute infection: the ACORN randomized clinical trial
10.1001/jama.2023.20583 · 2023 · External reference
Mortality of patients with sepsis administered piperacillin-tazobactam vs cefepime
10.1001/jamainternmed.2024.0581 · 2024 · External reference
Sepsis heterogeneity
10.1007/s12519-023-00689-8 · 2023 · External reference
Assessing clinical heterogeneity in sepsis through treatment patterns and machine learning
10.1093/jamia/ocz106 · 2019 · External reference
The complete blood count to diagnose septic shock
10.21037/jtd.2019.12.63 · 2020 · External reference
The immunopathology of sepsis and potential therapeutic targets
10.1038/nri.2017.36 · 2017 · External reference
Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine
10.1016/s2213-2600(23)00330-2 · 2024 · External reference
Exploring extended white blood cell parameters for the evaluation of sepsis among patients admitted to intensive care units
10.3390/diagnostics13142445 · 2023 · External reference
Bacterial perturbation of cytokine networks
10.1128/iai.66.6.2401-2409.1998 · 1998 · External reference
Gram-negative and gram-positive bacterial products induce differential cytokine profiles in the brain: analysis using an integrative molecular-behavioral in vivo model
10.3892/ijmm.1.2.387 · 1998 · External reference
Differential induction of pro- and anti-inflammatory cytokines in whole blood by bacteria: effects of antibiotic treatment
10.1128/aac.41.7.1439 · 1997 · External reference
Immunomodulation and sepsis: impact of the pathogen
10.1097/01.shk.0000140663.80530.73 · 2004 · External reference
Pathogen specific cytokine release reveals an effect of TLR2 Arg753Gln during Candida sepsis in humans
10.1016/j.cyto.2007.12.006 · 2008 · External reference
Effects of inoculum size on cell-mediated and humoral immune responses of foals experimentally infected with Rhodococcus equi: a pilot study
10.1016/j.vetimm.2009.08.004 · 2010 · External reference
Hematological assessment of health status of African catfish Clarias gariepinus (Burchell 1822) experimentally challenged with Escherichia coli and Vibrio fischeri
10.1007/s00580-013-1780-y · 2014 · External reference
A pilot study of cytokine levels and white blood cell counts in the diagnosis of necrotizing fasciitis
10.1016/j.ajem.2005.02.028 · 2006 · External reference
A simple model to help distinguish necrotizing fasciitis from nonnecrotizing soft tissue infection
10.1016/s1072-7515(00)00318-5 · 2000 · External reference
Toward new insights on the white blood cell differential by flow cytometry: a proof of concept study on the sepsis model
10.1002/cyto.b.21027 · 2012 · External reference
Early prognosis in severe sepsis via analyzing the monocyte immunophenotype
10.1007/s001340100962 · 2001 · External reference
Evaluation of leukopenia during sepsis as a marker of sepsis-defining organ dysfunction
10.1371/journal.pone.0252206 · 2021 · External reference
Lymphocyte count trajectories are associated with the prognosis of sepsis patients
10.1186/s13054-024-05186-6 · 2024 · External reference
White blood cell count trajectory and mortality in septic shock: a historical cohort study
10.1007/s12630-022-02282-5 · 2022 · External reference
Cytokine receptors and hematopoietic differentiation
10.1038/sj.onc.1210756 · 2007 · External reference
The role of peripheral white blood cell counts in the association between central adiposity and glycemic status
10.1038/s41387-024-00271-9 · 2024 · External reference
Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients
10.1016/j.ebiom.2020.102763 · 2020 · External reference
The hematologic consequences of obesity
10.1111/ejh.13560 · 2021 · External reference
Unraveling the immunological landscape and gut microbiome in sepsis: a comprehensive approach to diagnosis and prognosis
10.1016/j.ebiom.2025.105586 · 2025 · External reference
Causal effects of gut microbiota on sepsis and sepsis-related death: insights from genome-wide Mendelian randomization, single-cell RNA, bulk RNA sequencing, and network pharmacology
10.1186/s12967-023-04835-8 · 2024 · External reference
The predictive approaches to treatment effect heterogeneity (PATH) statement: explanation and elaboration
10.7326/m18-3668 · 2020 · External reference
Reading and conducting instrumental variable studies: guide, glossary, and checklist
10.1136/bmj-2023-078093 · 2024 · External reference
A gentle introduction to instrumental variables
10.1016/j.jclinepi.2022.06.022 · 2022 · External reference
Toward rapid sepsis diagnosis and patient stratification: what’s new from microbiology and omics science
10.1093/infdis/jiz585 · 2020 · External reference
The clinical impact of rapid molecular microbiological diagnostics for pathogen and resistance gene identification in patients with sepsis: a systematic review
10.1093/ofid/ofaa352 · 2020 · External reference
The gut microbiome’s role in the development, maintenance, and outcomes of sepsis
10.1186/s13054-020-02989-1 · 2020 · External reference
In critically ill patients, anti-anaerobic antibiotics increase risk of adverse clinical outcomes
10.1183/13993003.00910-2022 · 2023 · External reference
The role of the gut microbiota in sepsis
10.1016/s2468-1253(16)30119-4 · 2017 · External reference
Classification of the gut microbiota of patients in intensive care units during development of sepsis and septic shock
10.1016/j.gpb.2020.06.011 · 2020 · External reference
Unravelling the collateral damage of antibiotics on gut bacteria
10.1038/s41586-021-03986-2 · 2021 · External reference
The central and biodynamic role of gut microbiota in critically ill patients
10.1186/s13054-022-04127-5 · 2022 · External reference
Effects of antibiotic treatment with piperacillin/tazobactam versus ceftriaxone on the composition of the murine gut microbiota
10.1128/aac.01504-20 · 2021 · External reference
Third generation cephalosporins and piperacillin/tazobactam have distinct impacts on the microbiota of critically ill patients
10.1038/s41598-021-85946-4 · 2021 · External reference
The interplay between antibiotics and the host immune response in sepsis: from basic mechanisms to clinical considerations: a comprehensive narrative review
10.3390/antibiotics13050406 · 2024 · External reference
Antibiotics regulate the immune response in both presence and absence of lipopolysaccharide through modulation of Toll-like receptors, cytokine production and phagocytosis in vitro
10.1016/j.intimp.2013.10.025 · 2014 · External reference
Protection against endotoxic shock and lipopolysaccharide-induced local inflammation by tetracycline: correlation with inhibition of cytokine secretion
10.1128/iai.64.3.825-828.1996 · 1996 · External reference
Differential effects of three antibiotics on T helper cell cytokine expression
10.1093/jac/dki251 · 2005 · External reference
Linezolid, vancomycin and daptomycin modulate cytokine production, Toll-like receptors and phagocytosis in a human in vitro model of sepsis
10.1038/ja.2015.18 · 2015 · External reference
Immunomodulatory properties of antibiotics
10.2174/1874467210801010068 · 2008 · External reference
The presentation, pace, and profile of infection and sepsis patients hospitalized through the emergency department: an exploratory analysis
10.1097/cce.0000000000000344 · 2021 · External reference
Sepsis prediction, early detection, and identification using clinical text for machine learning: a systematic review
10.1093/jamia/ocab236 · 2022 · External reference