Research graph
References from MMP12 induces fibrogenic macrophage differentiation to drive granuloma-associated cardiac fibrosis. Local targets link to admitted publications; unresolved targets remain external evidence.
The extracellular matrix: not just pretty fibrils
10.1126/science.1176009 · 2009 · External reference
Contractility, focal adhesion orientation, and stress fiber orientation drive cancer cell polarity and migration along wavy ECM substrates
10.1073/pnas.2021135118 · 2021 · External reference
Matricellular proteins in cardiac adaptation and disease
10.1152/physrev.00008.2011 · 2012 · External reference
Proteomic analysis of the cardiac extracellular matrix: clinical research applications
10.1080/14789450.2018.1421947 · 2018 · External reference
Matrix modeling and remodeling: a biological interplay regulating tissue homeostasis and diseases
10.1016/j.matbio.2018.08.007 · 2019 · External reference
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
10.1172/jci31487 · 2007 · External reference
Diffuse myocardial fibrosis: mechanisms, diagnosis and therapeutic approaches
10.1038/s41569-020-00504-1 · 2021 · External reference
Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression
10.1083/jcb.201004082 · 2010 · External reference
Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration
10.1126/sciadv.abg6497 · 2021 · External reference
Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart
10.1172/jci98215 · 2018 · External reference
Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation
10.1126/sciimmunol.add8945 · 2023 · External reference
Challenges of sarcoidosis and its management
10.1056/nejmra2101555 · 2021 · External reference
Isolated cardiac sarcoidosis: a focused review of an under-recognized entity
10.1007/s12350-016-0658-1 · 2018 · External reference
Utility of endomyocardial biopsy in the diagnosis of cardiac sarcoidosis
10.1378/chest.90.4.528 · 1986 · External reference
Diagnosis and management of cardiac sarcoidosis: a scientific statement from the American Heart Association
10.1161/cir.0000000000001240 · 2024 · External reference
An mTORC1-dependent mouse model for cardiac sarcoidosis
10.1161/jaha.123.030478 · 2023 · External reference
Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation
10.1016/j.cmet.2006.05.011 · 2006 · External reference
Macrophage activation and polarization: nomenclature and experimental guidelines
10.1016/j.immuni.2014.06.008 · 2014 · External reference
CD163 protein inhibits lipopolysaccharide-induced macrophage transformation from M2 to M1 involved in disruption of the TWEAK-Fn14 interaction
10.1016/j.heliyon.2023.e23223 · 2024 · External reference
Matrix metalloproteinase-27 is expressed in CD163+/CD206+ M2 macrophages in the cycling human endometrium and in superficial endometriotic lesions
10.1093/molehr/gau034 · 2014 · External reference
Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humans
10.1164/rccm.201202-0302oc · 2012 · External reference
Lipocalin 2 is a regulator of macrophage polarization and NF-κB/STAT3 pathway activation
10.1210/me.2014-1092 · 2014 · External reference
Upregulation of monocyte/macrophage HGFIN (Gpnmb/Osteoactivin) expression in end-stage renal disease
10.2215/cjn.03390509 · 2010 · External reference
The upregulation of integrin αDβ2 (CD11d/CD18) on inflammatory macrophages promotes macrophage retention in vascular lesions and development of atherosclerosis
10.4049/jimmunol.1602175 · 2017 · External reference
In vitro degradation of human tropoelastin by MMP-12 and the generation of matrikines from domain 24
10.1016/j.matbio.2008.12.002 · 2009 · External reference
Galectin-3 regulates the adhesive interaction between breast carcinoma cells and elastin
10.1002/(sici)1097-4644(19991201)75:3<505::aid-jcb14>3.3.co;2-9 · 1999 · External reference
The elastin receptor complex transduces signals through the catalytic activity of its Neu-1 subunit
10.1074/jbc.m609505200 · 2007 · External reference
First-in-man safety, tolerability, and pharmacokinetics of a novel and highly selective inhibitor of matrix metalloproteinase-12, FP-025: results from two randomized studies in healthy subjects
10.1007/s40261-020-00981-9 · 2021 · External reference
Fibrosis: from mechanisms to medicines
10.1038/s41586-020-2938-9 · 2020 · External reference
Common pathway signature in lung and liver fibrosis
10.1080/15384101.2016.1152435 · 2016 · External reference
Targeting fibrosis: mechanisms and clinical trials
10.1038/s41392-022-01070-3 · 2022 · External reference
Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression
10.1038/ni.3655 · 2017 · External reference
Phagosome-regulated mTOR signalling during sarcoidosis granuloma biogenesis
10.1183/13993003.02695-2020 · 2021 · External reference
Monocyte chemotactic activity in human abdominal aortic aneurysms: role of elastin degradation peptides and the 67-kD cell surface elastin receptor
10.1067/mva.2002.120382 · 2002 · External reference
Serum concentrations of elastin-derived peptides in patients with specific manifestations of atherosclerotic disease
10.1053/ejvs.2002.1750 · 2002 · External reference
Effects of collagen-derived bioactive peptides and natural antioxidant compounds on proliferation and matrix protein synthesis by cultured normal human dermal fibroblasts
10.1038/s41598-018-28492-w · 2018 · External reference
The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?
10.1016/j.biocel.2007.08.011 · 2008 · External reference
Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis
10.1164/rccm.200803-490oc · 2009 · External reference
Matrix metalloproteinase-12 is required for granuloma progression
10.3389/fimmu.2020.553949 · 2020 · External reference
Essential role of MMP-12 in Fas-induced lung fibrosis
10.1165/rcmb.2006-0471oc · 2007 · External reference
Multiscale drug screening for cardiac fibrosis identifies MD2 as a therapeutic target
10.1016/j.cell.2024.09.034 · 2024 · External reference
The current landscape of antifibrotic therapy across different organs: a systematic approach
10.1016/j.phrs.2024.107245 · 2024 · External reference
Targeting immune-fibroblast cell communication in heart failure
10.1038/s41586-024-08008-5 · 2024 · External reference
Immune responses in checkpoint myocarditis across heart, blood and tumour
10.1038/s41586-024-08105-5 · 2024 · External reference
