Research graph
References from Peripubertal changes in asthma. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2024 · External reference
Unresolved reference
External reference
Natural progression of childhood asthma symptoms and strong influence of sex and puberty
10.1513/annalsats.201402-084oc · 2014 · External reference
Impact of adolescence and gender on asthma hospitalization: a population-based birth cohort study
10.1002/ppul.20108 · 2004 · External reference
Differences in incidence of reported asthma related to age in men and women. A retrospective analysis of the data of the European Respiratory Health Survey
10.1164/ajrccm.162.1.9907008 · 2000 · External reference
Age-specific incidence of new asthma diagnoses in Finland
10.1016/j.jaip.2016.08.015 · 2017 · External reference
Association between obesity and asthma in a twin cohort
10.1111/j.1398-9995.2007.01480.x · 2007 · External reference
Sex differences in large conducting airway anatomy
10.1152/japplphysiol.00440.2018 · 2018 · External reference
Technical standards for respiratory oscillometry
10.1183/13993003.00753-2019 · 2020 · External reference
Reference values for respiratory impedance measured by the forced oscillation technique in adult men and women
10.1111/crj.12783 · 2018 · External reference
Sex differences in paediatric airway anatomy
10.1113/ep088370 · 2020 · External reference
Postnatal human lung growth
10.1136/thx.37.8.564 · 1982 · External reference
Implications of adopting the Global Lungs Initiative 2012 all-age reference equations for spirometry
10.1183/09031936.00195512 · 2013 · External reference
Dysanapsis and the resistive work of breathing during exercise in healthy men and women
10.1152/japplphysiol.00409.2015 · 2015 · External reference
Sex hormone metabolism in lung development and maturation
10.1016/j.tem.2010.09.001 · 2010 · External reference
Neuronal control of breathing: sex and stress hormones
10.1002/cphy.c100027 · 2011 · External reference
Size and mechanical properties of the pharynx in healthy men and women
10.1164/ajrccm/146.6.1394 · 1992 · External reference
Sex differences in thoracic dimensions and configuration
10.1164/rccm.200208-876oc · 2003 · External reference
3D analysis of sexual dimorphism in size, shape and breathing kinematics of human lungs
10.1111/joa.12743 · 2018 · External reference
Exponential analysis of elastic recoil and aging in healthy males and females
10.1152/jappl.1979.47.4.683 · 1979 · External reference
Lung function trajectories: relevance and implementation in clinical practice
10.1016/s0140-6736(24)00016-3 · 2024 · External reference
Lung function in early adulthood and health in later life: a transgenerational cohort analysis
10.1016/s2213-2600(17)30434-4 · 2017 · External reference
Lung-function trajectories leading to chronic obstructive pulmonary disease
10.1056/nejmoa1411532 · 2015 · External reference
Lung function in young adults and risk of cardiovascular events over 29 years: the CARDIA study
10.1161/jaha.118.010672 · 2018 · External reference
Airflow obstruction, impaired lung function and risk of sudden cardiac death: a prospective cohort study
10.1136/thoraxjnl-2020-215632 · 2022 · External reference
General population-based lung function trajectories over the life course: an accelerated cohort study
10.1016/s2213-2600(25)00043-8 · 2025 · External reference
Obstructive and restrictive spirometry from school age to adulthood: three birth cohort studies
10.1016/j.eclinm.2023.102355 · 2024 · External reference
Plasticity of individual lung function states from childhood to adulthood
10.1164/rccm.202203-0444oc · 2023 · External reference
Trajectories of airflow limitation from childhood to early adulthood: an analysis of six population-based birth cohorts
10.1016/s2352-4642(25)00001-x · 2025 · External reference
Evolution of lung function within individuals: clinical insights and data-driven methods
10.1164/rccm.202212-2226ed · 2023 · External reference
Association of height growth in puberty with lung function. a longitudinal study
10.1164/rccm.201802-0274oc · 2018 · External reference
Physical activity and body mass related to catch-up lung function growth in childhood: a population-based accelerated cohort study
10.1136/thorax-2022-219666 · 2024 · External reference
Lung function trajectories from pre-school age to adulthood and their associations with early life factors: a retrospective analysis of three population-based birth cohort studies
10.1016/s2213-2600(18)30099-7 · 2018 · External reference
Associations of wheezing phenotypes with late asthma outcomes in the Avon Longitudinal Study of Parents and Children: a population-based birth cohort
10.1016/j.jaci.2016.01.046 · 2016 · External reference
Modeling wheezing spells identifies phenotypes with different outcomes and genetic associates
10.1164/rccm.202108-1821oc · 2022 · External reference
Distinguishing wheezing phenotypes from infancy to adolescence. A pooled analysis of five birth cohorts
10.1513/annalsats.201811-837oc · 2019 · External reference
Lung function trajectories from school age to adulthood and their relationship with markers of cardiovascular disease risk
10.1136/thorax-2023-220485 · 2024 · External reference
Lung function trajectories and determinants from birth to 6 years in an African birth cohort: extending trajectories through infancy using oscillometry
10.1183/13993003.00729-2025 · 2026 · External reference
Determinants of lung function development from birth to age 5 years: an interrupted time series analysis of a South African birth cohort
10.1016/s2352-4642(24)00072-5 · 2024 · External reference
Trajectories of lung function during childhood
10.1164/rccm.201309-1700oc · 2014 · External reference
Longitudinal trajectories of severe wheeze exacerbations from infancy to school age and their association with early-life risk factors and late asthma outcomes
10.1111/cea.13553 · 2020 · External reference
Sex differences in innate anti-viral immune responses to respiratory viruses and in their clinical outcomes in a birth cohort study
10.1038/s41598-021-03044-x · 2021 · External reference
Dysanapsis in normal lungs assessed by the relationship between maximal flow, static recoil, and vital capacity
10.1164/arrd.1980.121.2.339 · 1980 · External reference
Sex differences in growth patterns of the airways and lung parenchyma in children
10.1152/jappl.1984.56.5.1204 · 1984 · External reference
Relationship between lung volume, maximal expiratory flow, forced expiratory volume in one second, and tracheal area in normal men and women
10.1164/arrd.1986.134.5.956 · 1986 · External reference
Growth of airways and air spaces in teenagers is related to sex but not to symptoms
10.1152/jappl.1993.75.5.2045 · 1993 · External reference
Dysanapsis ratio as a predictor for expiratory flow limitation
10.1016/j.resp.2014.04.001 · 2014 · External reference
Dysanapsis: importance of measured lung static recoil pressure
10.1249/mss.0b013e3182508510 · 2012 · External reference
Role of sex hormones in allergic inflammation in mice
10.1111/j.1365-2222.2007.02670.x · 2007 · External reference
Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma
10.1016/j.jaci.2015.05.046 · 2015 · External reference
Effects of estrogenic compounds on immunoglobulin production by mouse splenocytes
10.1248/bpb.25.1263 · 2002 · External reference
17β-estradiol induces hyperresponsiveness in guinea pig airway smooth muscle by inhibiting the plasma membrane Ca(2+)-ATPase
10.1016/j.mce.2024.112273 · 2024 · External reference
Rapid effects of estrogen on intracellular Ca2+ regulation in human airway smooth muscle
10.1152/ajplung.00287.2009 · 2010 · External reference
Differential effects of low and high-dose estradiol on airway reactivity in ovariectomized rats
10.1016/j.resp.2003.08.007 · 2003 · External reference
Perimenstrual asthma: a syndrome without known cause or cure
10.1067/mai.2003.1676 · 2003 · External reference
Premenstrual exacerbation of asthma
10.1136/thx.39.11.833 · 1984 · External reference
Menstrual-linked asthma
10.3109/02770909709055398 · 1997 · External reference
Loss of normal cyclical beta 2 adrenoceptor regulation and increased premenstrual responsiveness to adenosine monophosphate in stable female asthmatic patients
10.1136/thx.52.7.608 · 1997 · External reference
Comparative study of progesterone, estradiol and cortisol concentrations in asthmatic and non-asthmatic women
1988 · External reference
Progesterone amplifies allergic inflammation and airway pathology in association with higher lung ILC2 responses
10.1152/ajplung.00207.2023 · 2024 · External reference
Progesterone modulates the immune microenvironment to suppress ovalbumin-induced airway inflammation by inhibiting NETosis
10.1038/s41598-024-66439-6 · 2024 · External reference
Severe premenstrual exacerbations of asthma: effect of intramuscular progesterone
10.1016/s0140-6736(88)92837-1 · 1988 · External reference
Sex hormones and allergies: exploring the gender differences in immune responses
10.3389/falgy.2024.1483919 · 2024 · External reference
Sex steroid hormones and asthma in males: a state-of-the-art review
10.1080/17476348.2025.2501276 · 2025 · External reference
Testosterone decreases house dust mite-induced type 2 and IL-17A-mediated airway inflammation
10.4049/jimmunol.1800293 · 2018 · External reference
Sex-related differences in the initiation of allergic rhinitis in mice
10.1034/j.1398-9995.2001.056006525.x · 2001 · External reference
Reduced pulmonary function is associated with lower levels of endogenous total and free testosterone: the Tromsø study
10.1007/s10654-006-9095-9 · 2007 · External reference
Higher serum testosterone and dihydrotestosterone, but not oestradiol, are independently associated with favourable indices of lung function in community-dwelling men
10.1111/cen.12738 · 2015 · External reference
Benefits of airway androgen receptor expression in human asthma
10.1164/rccm.202009-3720oc · 2021 · External reference
Elevated testosterone is associated with decreased likelihood of current asthma regardless of sex
10.1016/j.jaip.2020.05.022 · 2020 · External reference
Nebulized dehydroepiandrosterone-3-sulfate improves asthma control in the moderate-to-severe asthma results of a 6-week, randomized, double-blind, placebo-controlled study
10.2500/aap.2010.31.3384 · 2010 · External reference
Androgen receptor-mediated regulation of intracellular calcium in human airway smooth muscle cells
10.33594/000000131 · 2019 · External reference
Androgens are bronchoactive drugs that act by relaxing airway smooth muscle and preventing bronchospasm
10.1530/joe-14-0074 · 2014 · External reference
Estrogen alters thresholds for B cell apoptosis and activation
10.1172/jci14873 · 2002 · External reference
Estrogen receptor-dependent regulation of dendritic cell development and function
10.3389/fimmu.2017.00108 · 2017 · External reference
Estrogen as an immunomodulator
10.1016/j.clim.2004.05.011 · 2004 · External reference
Sex differences in asthma: a key role of androgen-signaling in group 2 innate lymphoid cells
10.3389/fimmu.2017.01069 · 2017 · External reference
Understanding sex biases in immunity: effects of estrogen on the differentiation and function of antigen-presenting cells
10.1385/ir:31:2:091 · 2005 · External reference
Estrogen prevents bone loss through transforming growth factor beta signaling in T cells
10.1073/pnas.0404888101 · 2004 · External reference
The roles of sex hormones in the course of atopic dermatitis
10.3390/ijms20194660 · 2019 · External reference
Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation
10.1172/jci153397 · 2022 · External reference
The functional role of group 2 innate lymphoid cells in asthma
10.3390/biom13060893 · 2023 · External reference
A major population of functional KLRG1(-) ILC2s in female lungs contributes to a sex bias in ILC2 numbers
10.4049/immunohorizons.1800008 · 2018 · External reference
Testosterone attenuates group 2 innate lymphoid cell-mediated airway inflammation
10.1016/j.celrep.2017.10.110 · 2017 · External reference
Sex steroids as inflammatory regulators
10.1016/j.jsbmb.2009.12.015 · 2010 · External reference
Genetic and hormonal factors in female-biased autoimmunity
10.1016/j.autrev.2010.02.008 · 2010 · External reference
Menopausal asthma: a new biological phenotype?
10.1111/j.1398-9995.2009.02314.x · 2010 · External reference
Hormone replacement therapy in postmenopausal asthmatic women
10.1046/j.1365-2710.2000.00310.x · 2000 · External reference
Prospective study of postmenopausal hormone use and newly diagnosed asthma and chronic obstructive pulmonary disease
10.1001/archinte.164.4.379 · 2004 · External reference
Sex differences in activation of lung-related type 2 innate lymphoid cells in experimental asthma
10.1016/j.anai.2016.11.011 · 2017 · External reference
Progesterone inhibits inducible nitric oxide synthase gene expression and nitric oxide production in murine macrophages
10.1002/jlb.59.3.442 · 1996 · External reference
Toll-like receptor-4–mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors
10.1111/j.1365-2567.2008.02820.x · 2008 · External reference
Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones
10.4049/jimmunol.155.1.128 · 1995 · External reference
Personalized treatment of asthma: the importance of sex and gender differences
10.1016/j.jaip.2022.02.002 · 2022 · External reference
Sex hormones and gender disparity in immunity and autoimmunity
10.1723/2188.23636 · 2015 · External reference
The association between free testosterone and current asthma
10.1016/j.jaip.2020.07.029 · 2020 · External reference
Allergic endotypes and phenotypes of asthma
10.1016/j.jaip.2019.11.008 · 2020 · External reference
Neutrophilic inflammation in asthma and association with disease severity
10.1016/j.it.2017.07.003 · 2017 · External reference
Paucigranulocytic asthma: uncoupling of airway obstruction from inflammation
10.1016/j.jaci.2018.06.008 · 2019 · External reference
T2-Low asthma: a discussed but still orphan disease
10.3390/biomedicines11041226 · 2023 · External reference
Sex disparities in asthma development and clinical outcomes: implications for treatment strategies
10.2147/jaa.s282667 · 2022 · External reference
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program
10.1164/rccm.200906-0896oc · 2010 · External reference
Sex-specific asthma phenotypes, inflammatory patterns, and asthma control in a cluster analysis
10.1016/j.jaip.2018.08.008 · 2019 · External reference
Sex hormones and systemic inflammation are modulators of the obese-asthma phenotype
10.1111/all.12891 · 2016 · External reference
Low serum adiponectin predicts future risk for asthma in women
10.1164/rccm.201110-1767oc · 2012 · External reference
New insight into adiponectin role in obesity and obesity-related diseases
10.1155/2014/658913 · 2014 · External reference
Global, regional, national burden of asthma from 1990 to 2021, with projections of incidence to 2050: a systematic analysis of the global burden of disease study 2021
10.1016/j.eclinm.2024.103051 · 2025 · External reference
Obesity and asthma
10.1016/j.jaci.2018.02.004 · 2018 · External reference
Cluster analysis and clinical asthma phenotypes
10.1164/rccm.200711-1754oc · 2008 · External reference
Heterogeneity of obesity-asthma association disentangled by latent class analysis, the SAPALDIA cohort
10.1016/j.rmed.2017.02.014 · 2017 · External reference
Obesity and hormonal influences on asthma: Mechanisms, management challenges, and emerging therapeutic strategies
10.1016/j.jaci.2024.09.018 · 2024 · External reference
Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma
10.1186/s12890-018-0612-x · 2018 · External reference
Sex differences in the relationship of sleep-disordered breathing and asthma control among children with severe asthma
10.1080/02770903.2021.1897838 · 2022 · External reference
Sex-based differences in asthma: pathophysiology, hormonal influence, and genetic mechanisms
10.3390/ijms26115288 · 2025 · External reference
Estrogen and the cystic fibrosis gender gap
10.1016/j.steroids.2013.11.023 · 2014 · External reference
17beta-estradiol inhibits Ca2+-dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia
10.1172/jci33893 · 2008 · External reference
Sex differences in airway disease: estrogen and airway surface liquid dynamics
10.1186/s13293-024-00633-z · 2024 · External reference
Sex hormone-dependent regulation of cilia beat frequency in airway epithelium
10.1165/rcmb.2011-0107oc · 2012 · External reference
The genetics of asthma and the promise of genomics-guided drug target discovery
10.1016/s2213-2600(20)30363-5 · 2020 · External reference
TSLP polymorphisms are associated with asthma in a sex-specific fashion
10.1111/j.1398-9995.2010.02415.x · 2010 · External reference
IFNG genotype and sex interact to influence the risk of childhood asthma
10.1016/j.jaci.2011.06.016 · 2011 · External reference
An African-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severity
10.1093/hmg/ddn168 · 2008 · External reference
Association of estrogen receptor α polymorphism rs1999805 with asthma
10.1016/j.anai.2018.11.005 · 2019 · External reference
HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma
10.1073/pnas.1918819117 · 2020 · External reference
Lung proinflammatory microRNA and cytokine expression in a mouse model of allergic inflammation: role of sex chromosome complement and gonadal hormones
10.1152/physiolgenomics.00049.2023 · 2024 · External reference
Potential role of Let-7 family microRNAs in sex disparity in asthma
10.1183/13993003.congress-2024.oa2004 · 2025 · External reference
MicroRNA-98-5p inhibits IL-13-induced proliferation and migration of human airway smooth muscle cells by targeting RAC1
10.1007/s10753-022-01640-1 · 2022 · External reference
DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis
10.1016/j.ajhg.2016.02.019 · 2016 · External reference
Suppressive effects of androgens on the immune system
10.1016/j.cellimm.2015.02.004 · 2015 · External reference
Estrogen, estrogen-like molecules and autoimmune diseases
10.1016/j.autrev.2020.102468 · 2020 · External reference
The effect of pregnancy on the course of asthma
10.1016/j.iac.2005.10.008 · 2006 · External reference
Incidence and risk factors for exacerbations of asthma during pregnancy
10.2147/jaa.s43183 · 2013 · External reference
Severe asthma exacerbations during pregnancy
10.1097/01.aog.0000185281.21716.02 · 2005 · External reference
Inflammatory subtypes in asthma: assessment and identification using induced sputum
10.1111/j.1440-1843.2006.00784.x · 2006 · External reference
Significance of human neutrophil antigen-2a (NB1) expression and neutrophil number in pregnancy
10.1111/j.1537-2995.2004.03298.x · 2004 · External reference
Influence of asthma in pregnancy on labor and the newborn
10.1159/000029244 · 1998 · External reference
Unresolved reference
1986 · External reference
Asma ed orticaria nell’anziano: ruolo degli ormoni ipofiso-gonadici in menopausa
1988 · External reference
Studio degli ormoni ipofiso-gonadici ad insorgenza post-menopausale in alcuni casi di asma bronchiale [Study of hypophyseal and gonadal hormones and cases of postmenopausal occurrence of bronchial asthma]
1986 · External reference
Predictive and prognostic value of leptin status in asthma
10.1038/s41533-023-00332-z · 2023 · External reference
Connections between obesity and puberty
10.1016/j.coemr.2020.08.004 · 2020 · External reference
Leptin/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages
10.1186/s10020-023-00702-w · 2023 · External reference
Pediatric obesity-related asthma
10.56164/pediatrrespirj.2023.16 · 2023 · External reference
Testosterone-to-estradiol ratio and lung function in a prospective study of Puerto Rican youth
10.1016/j.anai.2021.04.013 · 2021 · External reference
Sex steroid hormones and asthma in a nationwide study of U.S. adults
10.1164/rccm.201905-0996oc · 2020 · External reference