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References from ADAMTS14 is a novel modulator of fibroblast mechanoactivation in pulmonary fibrosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Diagnosis of idiopathic pulmonary fibrosis. An official ATS/ERS/JRS/ALAT clinical practice guideline
10.1164/rccm.201807-1255st · 2018 · External reference
Interstitial lung diseases
10.1016/s0140-6736(22)01052-2 · 2022 · External reference
Registration of the extracellular matrix components constituting the fibroblastic focus in idiopathic pulmonary fibrosis
10.1172/jci.insight.125185 · 2019 · External reference
Mechanobiology and the extracellular matrix in pulmonary fibrosis
10.1016/j.isci.2025.113993 · 2025 · External reference
Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis
10.1152/ajplung.00300.2014 · 2015 · External reference
Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression
10.1083/jcb.201004082 · 2010 · External reference
Matrices of physiologic stiffness potently inactivate idiopathic pulmonary fibrosis fibroblasts
10.1165/rcmb.2012-0335oc · 2013 · External reference
Significance of early intra-alveolar fibrotic lesions and integrin expression in lung biopsy specimens from patients with idiopathic pulmonary fibrosis
10.1016/0046-8177(95)90114-0 · 1995 · External reference
The UIP/IPF fibroblastic focus is a collagen biosynthesis factory embedded in a distinct extracellular matrix
10.1172/jci.insight.156115 · 2022 · External reference
Fibrillar collagens
10.1007/978-3-319-49674-0_14 · 2017 · External reference
Turnover of type I and III collagen predicts progression of idiopathic pulmonary fibrosis
10.1186/s12931-021-01801-0 · 2021 · External reference
Fibroblastic foci in usual interstitial pneumonia: idiopathic versus collagen vascular disease
10.1164/rccm.200204-373oc · 2003 · External reference
Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
10.1126/sciadv.aba1972 · 2020 · External reference
Screening for YAP inhibitors identifies statins as modulators of fibrosis
10.1165/rcmb.2019-0296oc · 2020 · External reference
Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases
10.1016/j.xgen.2025.101066 · 2026 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices
10.1074/mcp.m111.014647 · 2012 · External reference
Matrisome AnalyzeR—a suite of tools to annotate and quantify ECM molecules in big datasets across organisms
10.1242/jcs.261255 · 2023 · External reference
Cell-derived matrices for studying cell proliferation and directional migration in a complex 3D microenvironment
10.1038/nprot.2017.107 · 2017 · External reference
Evaluation and refinement of sample preparation methods for extracellular matrix proteome coverage
10.1016/j.mcpro.2021.100079 · 2021 · External reference
ECM-focused proteomic analysis of ear punch regeneration in Acomys cahirinus
10.1021/acs.jproteome.4c00810 · 2025 · External reference
MatrisomeDB: the ECM-protein knowledge database
10.1093/nar/gkz849 · 2020 · External reference
The extracellular matrix: tools and insights for the “omics” era
10.1016/j.matbio.2015.06.003 · 2016 · External reference
MatrisomeDB 2.0: 2023 updates to the ECM-protein knowledge database
10.1093/nar/gkac1009 · 2023 · External reference
1D and 2D annotation enrichment: a statistical method integrating quantitative proteomics with complementary high-throughput data
10.1186/1471-2105-13-s16-s12 · 2012 · External reference
A network module for the Perseus software for computational proteomics facilitates proteome interaction graph analysis
10.1021/acs.jproteome.8b00927 · 2019 · External reference
Proteomic maps of breast cancer subtypes
10.1038/ncomms10259 · 2016 · External reference
Unresolved reference
2018 · External reference
The MaxQuant computational platform for mass spectrometry-based shotgun proteomics
10.1038/nprot.2016.136 · 2016 · External reference
The Perseus computational platform for comprehensive analysis of (prote)omics data
10.1038/nmeth.3901 · 2016 · External reference
VolcaNoseR is a web app for creating, exploring, labeling and sharing volcano plots
10.1038/s41598-020-76603-3 · 2020 · External reference
The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest
10.1093/nar/gkac1000 · 2023 · External reference
Screening for inhibitors of YAP nuclear localization identifies aurora kinase a as a modulator of lung fibrosis
10.1165/rcmb.2021-0428oc · 2022 · External reference
Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis
10.1038/s41586-024-07660-1 · 2024 · External reference
Matrix stiffness regulates profibrotic fibroblast differentiation and fibrotic niche activation in systemic sclerosis
10.1016/j.ard.2025.05.016 · 2025 · External reference
Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis
10.1038/s41467-023-44645-6 · 2024 · External reference
Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin
10.1164/ajrccm.163.3.2006084 · 2001 · External reference
The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices
10.1074/mcp.m111.014647 · 2012 · External reference
In vivo N-terminomics highlights novel functions of ADAMTS2 and ADAMTS14 in skin collagen matrix building
10.3389/fmolb.2021.643178 · 2021 · External reference
Brillouin light scattering: applications in biomedical sciences
10.1021/acs.chemrev.9b00019 · 2019 · External reference
Brillouin microscopy
10.1038/s43586-023-00286-z · 2024 · External reference
Artificial neural network identified the significant genes to distinguish idiopathic pulmonary fibrosis
10.1038/s41598-023-28536-w · 2023 · External reference
Collagen V is a dominant regulator of collagen fibrillogenesis: dysfunctional regulation of structure and function in a corneal-stroma-specific Col5a1-null mouse model
10.1242/jcs.091363 · 2011 · External reference
Type V collagen controls the initiation of collagen fibril assembly
10.1074/jbc.m409622200 · 2004 · External reference
Type V collagen in health, disease, and fibrosis
10.1002/ar.23330 · 2016 · External reference
Immunoquantification of type I, III, IV and V collagen in small samples of human lung parenchyma
10.1016/1357-2725(95)00047-s · 1995 · External reference
Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators
10.1016/j.ceb.2008.06.008 · 2008 · External reference
Murine model of the Ehlers-Danlos syndrome: col5a1 haploinsufficiency disrupts collagen fibril assembly at multiple stages
10.1074/jbc.m511528200 · 2006 · External reference
Rheology of heterotypic collagen networks
10.1021/bm200553x · 2011 · External reference
PI3K/Akt in IPF: untangling fibrosis and charting therapies
10.3389/fimmu.2025.1549277 · 2025 · External reference
Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis
10.1016/j.apsb.2021.07.023 · 2022 · External reference
A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis
10.1183/13993003.01992-2018 · 2019 · External reference
PI3K/Akt/mTOR signaling pathway as a target for colorectal cancer treatment
10.3390/ijms25063178 · 2024 · External reference
FN1 from cancer-associated fibroblasts orchestrates pancreatic cancer metastasis via integrin-PI3K/AKT signaling
10.3389/fonc.2025.1595523 · 2025 · External reference
Targeting the PI3K/Akt/mTOR pathway in non-small cell lung cancer (NSCLC)
10.1111/1759-7714.13328 · 2020 · External reference
The Hippo-YAP pathway: new connections between regulation of organ size and cancer
10.1016/j.ceb.2008.10.001 · 2008 · External reference
Ablation of integrin-mediated cell-collagen communication alleviates fibrosis
10.1136/ard-2023-224129 · 2023 · External reference
Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-β signaling as primary targets
10.1096/fj.15-279869 · 2016 · External reference
Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function
10.1002/path.6214 · 2024 · External reference
YAP/TAZ are mechanoregulators of TGF-β-Smad signaling and renal fibrogenesis
10.1681/asn.2015050499 · 2016 · External reference
YAP/TAZ are essential for TGF-β2-mediated conjunctival fibrosis
10.1167/iovs.18-24258 · 2018 · External reference
Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis
10.1242/dev.02308 · 2006 · External reference
Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14
10.1016/j.matbio.2018.04.002 · 2018 · External reference
Fibroblast-specific deletion of Yap/Taz impairs mouse postnatal dermal development by diminishing collagenous matrix [published online ahead of print June 18, 2026]
10.1016/j.jid.2026.05.034 · External reference
Emerging perspectives of YAP/TAZ in human skin epidermal and dermal aging
10.5021/ad.23.156 · 2024 · External reference
YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING
10.1038/s41586-022-04924-6 · 2022 · External reference
Epithelial Yap/Taz are required for functional alveolar regeneration following acute lung injury
10.1172/jci.insight.173374 · 2023 · External reference